Searching for up to 100 curated homologs for WP_014448908.1 NCBI__GCF_000284315.1:WP_014448908.1 (314 a.a.)
Found high-coverage hits (≥70%) to 69 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
43% identity, 95% coverage of query (227 bits)
TC 3.A.1.105.3 / Q70J75 CmrA, component of The 4A-4E-O-dideacetyl-chromomycin A3 (biosynthetic precursor of chromomycin) exporter (may also export chromomycin and mithramycin from Streptomyces griseus subsp. griseus
37% identity, 97% coverage of query (187 bits)
LNRL_BACSU / P94440 Linearmycin resistance ATP-binding protein LnrL; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 2 papers)
42% identity, 73% coverage of query (187 bits)
DRRA_STRPE / P32010 Daunorubicin/doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.- from Streptomyces peucetius (see 2 papers)
P32010 ABC-type xenobiotic transporter (EC 7.6.2.2) from Streptomyces peucetius (see paper)
TC 3.A.1.105.1 / P32010 DrrA, component of Daunorubicin, doxorubicin etc. (multidrug resistance) exporter, DrrAB from Streptomyces peucetius (see 2 papers)
39% identity, 91% coverage of query (186 bits)
DRRA_MYCTU / P9WQL9 Doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
37% identity, 97% coverage of query (176 bits)
YadG / b0127 putative ABC transporter ATP-binding protein YadG from Escherichia coli K-12 substr. MG1655 (see 7 papers)
YADG_ECOLI / P36879 Uncharacterized ABC transporter ATP-binding protein YadG from Escherichia coli (strain K12) (see paper)
yadG / MB|P36879 uncharacterized ABC transporter ATP-binding protein yadG from Escherichia coli K12 (see paper)
39% identity, 76% coverage of query (169 bits)
ABCAH_MOUSE / E9PX95 ATP-binding cassette sub-family A member 17 from Mus musculus (Mouse) (see 2 papers)
39% identity, 73% coverage of query (169 bits)
TC 3.A.1.105.8 / Q7UE58 ABC-type multidrug transport system, ATPase component, component of ABC-2 transporter from Rhodopirellula baltica (strain SH1)
35% identity, 97% coverage of query (162 bits)
TC 3.A.1.105.2 / Q53716 OleC4, component of Oleandomycin (drug resistance) exporter from Streptomyces antibioticus (see paper)
33% identity, 91% coverage of query (162 bits)
ABCA2_MOUSE / P41234 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Mus musculus (Mouse) (see 5 papers)
39% identity, 73% coverage of query (160 bits)
ABCA5_MOUSE / Q8K448 Cholesterol transporter ABCA5; ATP-binding cassette sub-family A member 5; EC 7.6.2.- from Mus musculus (Mouse) (see 7 papers)
34% identity, 96% coverage of query (160 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
39% identity, 73% coverage of query (158 bits)
TC 3.A.1.211.3 / Q9BZC7 Multidrug resistance pump, ABCA2 (ABC2) from Homo sapiens (Human) (see 6 papers)
ABCA2 / GI|55962682 ATP-binding cassette sub-family A member 2 from Homo sapiens
39% identity, 73% coverage of query (158 bits)
ABCA2_RAT / Q9ESR9 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Rattus norvegicus (Rat) (see 6 papers)
38% identity, 73% coverage of query (157 bits)
ABCA5_RAT / Q8CF82 Cholesterol transporter ABCA5; ATP-binding cassette sub-family A member 5; EC 7.6.2.- from Rattus norvegicus (Rat) (see 2 papers)
33% identity, 96% coverage of query (155 bits)
ABCA5_HUMAN / Q8WWZ7 Cholesterol transporter ABCA5; ATP-binding cassette sub-family A member 5; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.9 / Q8WWZ7 ABCA5 of 1642 aas and 12 TMSs. It is related to lysosomal diseases and plays important roles, especially in cardiomyocytes and follicular cells (Kubo et al. 2005). It mediates cholesterol efflux to HDL3 (Voloshyna and Reiss, 2011) and functions in autolysosomes from Homo sapiens (see 3 papers)
32% identity, 96% coverage of query (150 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
36% identity, 85% coverage of query (150 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
37% identity, 73% coverage of query (149 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
31% identity, 98% coverage of query (149 bits)
TC 3.A.1.102.1 / P50332 NodI, component of Lipooligosaccharide exporter (nodulation proteins, NodIJ) from Rhizobium galegae (see paper)
35% identity, 92% coverage of query (148 bits)
ABCA3_RAT / A0A0G2K1Q8 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Rattus norvegicus (Rat) (see paper)
36% identity, 73% coverage of query (148 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
36% identity, 73% coverage of query (148 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
32% identity, 92% coverage of query (148 bits)
TC 3.A.1.211.1 / P41233 The cholesterol/phospholipid flippase, ABC1 (called ABCA1 in humans; Tangier disease proteins; 2261 aas; sp: O95477). An amphipathic helical region of the N-terminal barrel of the phospholipid transfer protein (PLTP) is critical for ABCA1-dependent cholesterol efflux (Oram et al., 2008). PLTP helix 144-163 removes lipid domains formed by ABCA1, stabilizing ABCA1, interacting with phospholipids, and promoting phospholipid transfer by direct interactions with ABCA1. May transport sphingosine-1-phosphate (Kobayashi et al., 2009). May protect from cardiovascular disease and diabetes from Mus musculus (Mouse) (see 7 papers)
Abca1 ATP-binding cassette sub-family A member 1 from Mus musculus (see paper)
37% identity, 73% coverage of query (146 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
37% identity, 73% coverage of query (146 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
37% identity, 73% coverage of query (146 bits)
AB9A_ARATH / Q9FLT5 ABC transporter A family member 9; ABC transporter ABCA.9; AtABCA9; ABC2 homolog 11 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
40% identity, 75% coverage of query (145 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
32% identity, 91% coverage of query (145 bits)
cbiO1 / Q18CJ0 energy-coupling factor transporter ATP-bindind protein 1 from Clostridioides difficile (strain 630) (see 10 papers)
35% identity, 70% coverage of query (145 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
40% identity, 72% coverage of query (144 bits)
ABCAC_HUMAN / Q86UK0 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; ATP-binding cassette transporter 12; ATP-binding cassette 12; EC 7.6.2.1 from Homo sapiens (Human) (see 16 papers)
TC 3.A.1.211.13 / Q86UK0 ABCA12 keratinocyte lipid transporter of 2595 aas from Homo sapiens
30% identity, 98% coverage of query (137 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
30% identity, 98% coverage of query (137 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
34% identity, 91% coverage of query (137 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
30% identity, 96% coverage of query (135 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
32% identity, 91% coverage of query (132 bits)
7lkpA Structure of atp-free human abca4
33% identity, 91% coverage of query (132 bits)
Build an alignment for WP_014448908.1 and 36 homologs with ≥ 30% identity
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ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
29% identity, 96% coverage of query (132 bits)
ABCAD_MOUSE / Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see 3 papers)
33% identity, 93% coverage of query (131 bits)
7lkzA Structure of atp-bound human abca4
32% identity, 91% coverage of query (130 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
37% identity, 74% coverage of query (129 bits)
ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
32% identity, 70% coverage of query (127 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
32% identity, 70% coverage of query (118 bits)
7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
29% identity, 91% coverage of query (114 bits)
7m1qA / P78363 Human abca4 structure in complex with n-ret-pe (see paper)
31% identity, 88% coverage of query (114 bits)
8g4cB / O34697 Bceabs atpgs high res tm (see paper)
30% identity, 70% coverage of query (114 bits)
7tchB Bceab e169q variant atp-bound conformation
29% identity, 70% coverage of query (113 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
31% identity, 73% coverage of query (111 bits)
MacB / b0879 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli K-12 substr. MG1655 (see 14 papers)
MacB / P75831 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli (strain K12) (see 16 papers)
MACB_ECOLI / P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.122.1 / P75831 MacB aka B0879, component of Macrolide (14- and 15- but not 16-membered lactone macrolides including erythromycin) exporter, MacAB (formerly YbjYZ). Both MacA and MacB are required for activity (Tikhonova et al., 2007). MacAB functions with TolC to export multiple drugs and heat-stable enterotoxin II (enterotoxin STII) (Yamanaka et al., 2008). The crystal structure of MacA is available (Yum et al., 2009). MacB is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA (Lin et al., 2009). Xu et al. (2009) have reported the crystal structure of the periplasmic region of MacB which they claim resembles the periplasmic domain of RND-type transporters such as AcrB (TC# 2.A.6.2.2). Also exports L-cysteine (Yamada et al., 2006). The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by the MacB transporter from Escherichia coli (see 5 papers)
macB / BAB64542.1 macrolide-specific ABC-type efflux carrier from Escherichia coli (see paper)
31% identity, 73% coverage of query (110 bits)
8igqA / O05779 Cryo-em structure of mycobacterium tuberculosis adp bound ftsex/ripc complex in peptidisc (see paper)
34% identity, 71% coverage of query (110 bits)
8iddA Cryo-em structure of mycobacterium tuberculosis atp bound ftsex/ripc complex in peptidisc
34% identity, 71% coverage of query (109 bits)
FTSE_MYCTA / A5U7B7 Cell division ATP-binding protein FtsE from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) (see 2 papers)
34% identity, 71% coverage of query (109 bits)
5ws4A / A0A0D8G707 Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
31% identity, 72% coverage of query (109 bits)
6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
31% identity, 70% coverage of query (102 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
30% identity, 70% coverage of query (102 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
28% identity, 70% coverage of query (93.6 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
28% identity, 70% coverage of query (93.6 bits)
2olkA Abc protein artp in complex with adp-beta-s
28% identity, 70% coverage of query (93.6 bits)
2oljA Abc protein artp in complex with adp/mg2+
28% identity, 70% coverage of query (93.6 bits)
8hprC Lpqy-sugabc in state 4
29% identity, 72% coverage of query (91.3 bits)
8hprD Lpqy-sugabc in state 4
29% identity, 72% coverage of query (91.3 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
29% identity, 72% coverage of query (89.7 bits)
P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
29% identity, 82% coverage of query (87.8 bits)
4fwiB / Q8RDH4 Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
30% identity, 73% coverage of query (86.7 bits)
DPPD_CALS4 / Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
30% identity, 73% coverage of query (86.7 bits)
ABCB7_ORYLA / H2LNR5 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial from Oryzias latipes (Japanese rice fish) (Japanese killifish) (see paper)
26% identity, 72% coverage of query (78.2 bits)
8dneA Cryoem structure of the a.Aeolicus wzmwzt transporter bound to atp
23% identity, 74% coverage of query (75.1 bits)
8dncA Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen and adp
23% identity, 74% coverage of query (74.7 bits)
8dkuA / O67181 Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen (see paper)
23% identity, 74% coverage of query (74.7 bits)
7roqA / O95477 Alternative structure of human abca1
26% identity, 72% coverage of query (72.8 bits)
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Lawrence Berkeley National Laboratory