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Searching for up to 100 curated homologs for WP_015798815.1 NCBI__GCF_000023265.1:WP_015798815.1 (755 a.a.)

Found high-coverage hits (≥70%) to 45 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q8RP87 aconitate hydratase (EC 4.2.1.3) from Bacteroides fragilis (see paper)
    57% identity, 97% coverage of query (874 bits)

ACO1 aconitate hydratase; EC 4.2.1.3 from Candida albicans (see 2 papers)
    57% identity, 97% coverage of query (869 bits)

ACON_EMENI / C8VG90 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; Homocitrate dehydratase; EC 4.2.1.3; EC 4.2.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
    58% identity, 97% coverage of query (869 bits)

ACON_YEAST / P19414 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 8 papers)
P19414 aconitate hydratase (EC 4.2.1.3) from Saccharomyces cerevisiae (see 2 papers)
    57% identity, 96% coverage of query (868 bits)

ACON_SCHPO / O13966 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    56% identity, 97% coverage of query (864 bits)

ACON_CAEEL / P34455 Probable aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Caenorhabditis elegans (see paper)
    56% identity, 97% coverage of query (860 bits)

Aco / O74699 aconitase from Aspergillus terreus (see paper)
    57% identity, 97% coverage of query (857 bits)

ACON_ASPFU / Q4WLN1 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; Homocitrate dehydratase; EC 4.2.1.3; EC 4.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
    58% identity, 97% coverage of query (855 bits)

Q99KI0 aconitate hydratase (EC 4.2.1.3) from Mus musculus (see paper)
    56% identity, 97% coverage of query (838 bits)

ACON_RAT / Q9ER34 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Rattus norvegicus (Rat) (see paper)
Q9ER34 aconitate hydratase (EC 4.2.1.3) from Rattus norvegicus (see 3 papers)
    56% identity, 97% coverage of query (837 bits)

ACO2 / Q99798 mitochondrial aconitate hydratase from Homo sapiens (see 7 papers)
ACON_HUMAN / Q99798 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Homo sapiens (Human) (see 2 papers)
Q99798 aconitate hydratase (EC 4.2.1.3) from Homo sapiens (see paper)
    56% identity, 97% coverage of query (836 bits)

5acnA / P16276 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal (see paper)
    56% identity, 97% coverage of query (836 bits)

ACON_PIG / P16276 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) (see 4 papers)
    56% identity, 97% coverage of query (835 bits)

1b0kA S642a:fluorocitrate complex of aconitase
    56% identity, 97% coverage of query (835 bits)

ACON_BOVIN / P20004 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) (see paper)
    56% identity, 97% coverage of query (834 bits)

8acnA Crystal structures of aconitase with isocitrate and nitroisocitrate bound
    56% identity, 97% coverage of query (832 bits)

1fghA Complex with 4-hydroxy-trans-aconitate
    56% identity, 97% coverage of query (832 bits)

1amjA Steric and conformational features of the aconitase mechanism
    56% identity, 97% coverage of query (832 bits)

1amiA Steric and conformational features of the aconitase mechanism
    56% identity, 97% coverage of query (832 bits)

1acoA Crystal structure of aconitase with transaconitate bound
    56% identity, 97% coverage of query (832 bits)

1nisA Crystal structure of aconitase with trans-aconitate and nitrocitrate bound
    56% identity, 97% coverage of query (830 bits)

ACON2_SCHPO / Q9P7D4 Aconitase-ribosomal protein bL21m fusion protein; EC 4.2.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
Q9P7D4 aconitate hydratase (EC 4.2.1.3) from Schizosaccharomyces pombe (see paper)
    50% identity, 98% coverage of query (766 bits)

ACON2_ASPFU / Q4WJ90 Putative aconitate hydratase, mitochondrial; Aconitase 2; EC 4.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
    52% identity, 98% coverage of query (753 bits)

ACON2_EMENI / Q5B6D6 Putative aconitate hydratase, mitochondrial; Aconitase 2; EC 4.2.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
    51% identity, 99% coverage of query (750 bits)

ACON2_YEAST / P39533 Homocitrate dehydratase, mitochondrial; Aconitase 2; EC 4.2.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
    49% identity, 97% coverage of query (739 bits)

citB / P09339 aconitate hydratase (bifunctional aconitase) (EC 4.2.1.99; EC 4.2.1.3) from Bacillus subtilis (strain 168) (see 21 papers)
ACNA_BACSU / P09339 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) (see 7 papers)
P09339 aconitate hydratase (EC 4.2.1.3) from Bacillus subtilis (see paper)
    30% identity, 91% coverage of query (238 bits)

Build an alignment

Build an alignment for WP_015798815.1 and 26 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ACNA_BRADU / P70920 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) (see paper)
    27% identity, 96% coverage of query (235 bits)

ACO1 / Q42560 aconitase from Arabidopsis thaliana (see paper)
ACO1_ARATH / Q42560 Aconitate hydratase 1; Aconitase 1; Citrate hydro-lyase 1; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q42560 aminocyclopropanecarboxylate oxidase (EC 1.14.17.4) from Arabidopsis thaliana (see paper)
    28% identity, 94% coverage of query (234 bits)

ACO1 / P21399 cytoplasmic aconitate hydratase from Homo sapiens (see 6 papers)
ACOHC_HUMAN / P21399 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) (see 8 papers)
P21399 aconitate hydratase (EC 4.2.1.3) from Homo sapiens (see 3 papers)
    29% identity, 95% coverage of query (234 bits)

2b3xA / P21399 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) (see paper)
    29% identity, 95% coverage of query (233 bits)

D3GQL2 aconitate hydratase (EC 4.2.1.3) from Citrus clementina (see paper)
    28% identity, 93% coverage of query (233 bits)

HP15_3433 Aconitate hydratase (EC 4.2.1.3) from Marinobacter adhaerens HP15
    28% identity, 95% coverage of query (233 bits)

acnD / Q8EJW3 2-methylcitrate dehydratase (EC 4.2.1.117) from Shewanella oneidensis (strain MR-1) (see paper)
ACND_SHEON / Q8EJW3 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming); Aconitate hydratase; ACN; Aconitase; EC 4.2.1.117; EC 4.2.1.3 from Shewanella oneidensis (strain ATCC 700550 / JCM 31522 / CIP 106686 / LMG 19005 / NCIMB 14063 / MR-1) (see paper)
Q8EJW3 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) (EC 4.2.1.117) from Shewanella oneidensis (see paper)
    30% identity, 98% coverage of query (231 bits)

ACO2M_ARATH / Q94A28 Aconitate hydratase 2, mitochondrial; Aconitase 2; mACO2; Citrate hydro-lyase 2; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    29% identity, 91% coverage of query (231 bits)

ACO3M_ARATH / Q9SIB9 Aconitate hydratase 3, mitochondrial; Aconitase 3; mACO1; Citrate hydro-lyase 3; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
Q9SIB9 aconitate hydratase (EC 4.2.1.3) from Arabidopsis thaliana (see paper)
    28% identity, 92% coverage of query (229 bits)

ACOHC_CAEEL / Q23500 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Gex-3-interacting protein 22; EC 4.2.1.3 from Caenorhabditis elegans (see 2 papers)
Q23500 aconitate hydratase (EC 4.2.1.3) from Caenorhabditis elegans (see paper)
    29% identity, 92% coverage of query (227 bits)

D3GQL0 aconitate hydratase (EC 4.2.1.3) from Citrus clementina (see paper)
    27% identity, 97% coverage of query (224 bits)

Q4JFF1 phosphinomethylmalate isomerase (EC 4.2.1.166) from Streptomyces viridochromogenes (see paper)
    32% identity, 88% coverage of query (223 bits)

ACNA_CUPNE / Q937N8 Aconitate hydratase A; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha) (see paper)
    30% identity, 90% coverage of query (221 bits)

pmi / Q5IW57 phosphinomethylmalate isomerase (EC 4.2.1.166) from Streptomyces viridochromogenes (see paper)
PMI_STRVT / D9XF46 Phosphinomethylmalate isomerase; EC 4.2.1.166 from Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494) (see paper)
    31% identity, 88% coverage of query (221 bits)

D3GQL1 aconitate hydratase (EC 4.2.1.3) from Citrus clementina (see paper)
    29% identity, 93% coverage of query (219 bits)

ACNA_THET8 / Q5SMF6 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    30% identity, 87% coverage of query (219 bits)

rpfa / CAA05170.1 aconitase from Xanthomonas campestris (see paper)
    28% identity, 90% coverage of query (218 bits)

ACNA_CORGL / Q8NQ98 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see 5 papers)
    28% identity, 92% coverage of query (216 bits)

3snpA / Q01059 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA (see paper)
    29% identity, 84% coverage of query (189 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory