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Searching for up to 100 curated homologs for WP_015799002.1 NCBI__GCF_000023265.1:WP_015799002.1 (506 a.a.)

Found high-coverage hits (≥70%) to 28 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ILVX_MYCTU / O53554 Putative acetolactate synthase large subunit IlvX; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
O53554 acetolactate synthase (EC 2.2.1.6) from Mycobacterium tuberculosis (see paper)
    34% identity, 97% coverage of query (174 bits)

Build an alignment

Build an alignment for WP_015799002.1 and 1 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Q2UKV4 phenylpyruvate decarboxylase (EC 4.1.1.43) from Aspergillus oryzae (see paper)
    23% identity, 94% coverage of query (72.0 bits)

4k9qA / A4SXU0 The crystal structure of benzoylformate decarboxylase from polynucleobacter necessarius
    23% identity, 99% coverage of query (68.6 bits)

Q836A5 acetolactate synthase (EC 2.2.1.6) from Enterococcus faecalis (see 2 papers)
    23% identity, 97% coverage of query (67.8 bits)

P42463 acetolactate synthase (EC 2.2.1.6) from Corynebacterium glutamicum (see paper)
    25% identity, 97% coverage of query (67.4 bits)

dpgB / A3RJV5 benzoylformate decarboxylase monomer (EC 4.1.1.7) from Stutzerimonas stutzeri (see paper)
    23% identity, 97% coverage of query (65.5 bits)

ILVG_ECOLI / P0DP90 Acetolactate synthase isozyme 2 large subunit; AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit; EC 2.2.1.6 from Escherichia coli (strain K12) (see 2 papers)
ilvG / GB|CAA28573.1 acetolactate synthase isozyme 2 large subunit; EC 2.2.1.6 from Escherichia coli K12 (see 8 papers)
    25% identity, 97% coverage of query (63.2 bits)

ilvB / AAB38426.1 acetolactate synthase from Mycobacterium avium (see paper)
    26% identity, 94% coverage of query (59.7 bits)

A0A1X9M8K4 sulfoacetaldehyde acetyltransferase (EC 2.3.3.15) from Alkalihalobacillus krulwichiae (see paper)
    24% identity, 94% coverage of query (59.7 bits)

5d6rB Acetolactate synthase from klebsiella pneumoniae in complex with mechanism-based inhibitor
    25% identity, 97% coverage of query (59.7 bits)

8rphD 8rphD (see paper)
    23% identity, 88% coverage of query (58.5 bits)

8rpjA Janthe from janthinobacterium sp. Hh01
    23% identity, 88% coverage of query (58.5 bits)

8rpiA Janthe from janthinobacterium sp. Hh01, lactyl-thdp
    23% identity, 88% coverage of query (58.5 bits)

5dx6B / P27696 Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
    24% identity, 97% coverage of query (58.2 bits)

PDC5 / P16467 pyruvate decarboxylase 2 monomer (EC 4.1.1.1; EC 4.1.1.43; EC 4.1.1.74; EC 4.1.1.72) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 8 papers)
PDC5_YEAST / P16467 Pyruvate decarboxylase isozyme 2; Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase; 2ODC; EC 4.1.1.-; EC 4.1.1.43; EC 4.1.1.72; EC 4.1.1.74 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 15 papers)
P16467 pyruvate decarboxylase (EC 4.1.1.1) from Saccharomyces cerevisiae (see 2 papers)
    24% identity, 96% coverage of query (57.4 bits)

PDC1_CANGA / Q6FJA3 Pyruvate decarboxylase; EC 4.1.1.1 from Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus) (see paper)
    23% identity, 92% coverage of query (57.0 bits)

1ozgA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate
    24% identity, 97% coverage of query (57.0 bits)

budB / P27696 catabolic acetolactate synthase (EC 2.2.1.6) from Klebsiella pneumoniae (see 2 papers)
    24% identity, 97% coverage of query (56.6 bits)

P37251 acetolactate synthase (EC 2.2.1.6) from Bacillus subtilis (see paper)
    24% identity, 94% coverage of query (56.6 bits)

1ozfA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactors
    25% identity, 97% coverage of query (56.2 bits)

IlvI / b0077 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
ilvI / P00893 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli (strain K12) (see 7 papers)
P00893 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
    25% identity, 97% coverage of query (55.8 bits)

Q8RL88 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Geobacillus stearothermophilus (see paper)
ilvB / AAL99356.1 acetohydroxy acid synthase large subunit from Geobacillus stearothermophilus (see paper)
    23% identity, 94% coverage of query (55.1 bits)

Q8U2A4 acetolactate synthase (EC 2.2.1.6) from Pyrococcus furiosus (see paper)
    24% identity, 100% coverage of query (53.5 bits)

5wdgA Acetolactate synthase from klebsiella pneumoniae in complex with a reaction intermediate
    25% identity, 97% coverage of query (53.5 bits)

1qpbA Pyruvate decarboyxlase from yeast (form b) complexed with pyruvamide
    23% identity, 96% coverage of query (51.2 bits)

PDC1 / P06169 pyruvate decarboxylase (EC 4.1.1.1; EC 4.1.1.80; EC 4.1.1.43; EC 4.1.1.74; EC 4.1.1.72) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 8 papers)
PDC1_YEAST / P06169 Pyruvate decarboxylase isozyme 1; Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase; 2ODC; EC 4.1.1.-; EC 4.1.1.43; EC 4.1.1.72; EC 4.1.1.74 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 20 papers)
P06169 pyruvate decarboxylase (EC 4.1.1.1) from Saccharomyces cerevisiae (see 4 papers)
    23% identity, 96% coverage of query (50.4 bits)

Q6TA05 N2-(2-carboxyethyl)arginine synthase (EC 2.5.1.66) from Streptomyces clavuligerus (see 2 papers)
    25% identity, 96% coverage of query (50.1 bits)

2vk1A / P06169 Crystal structure of the saccharomyces cerevisiae pyruvate decarboxylase variant d28a in complex with its substrate (see paper)
    23% identity, 96% coverage of query (49.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory