Searching for up to 100 curated homologs for WP_015799097.1 NCBI__GCF_000023265.1:WP_015799097.1 (310 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Q5SK66 aspartate carbamoyltransferase (EC 2.1.3.2) from Thermus thermophilus (see paper)
44% identity, 86% coverage of query (189 bits)
6pnzA / Q5HGN2 The structure of the aspartate transcarbamoylase trimer from staphylococcus aureus complexed with pala at 2.27 resolution.
36% identity, 96% coverage of query (176 bits)
pyrB / P05654 aspartate carbamoyltransferase (EC 2.1.3.2) from Bacillus subtilis (strain 168) (see 3 papers)
P05654 aspartate carbamoyltransferase (EC 2.1.3.2) from Bacillus subtilis (see paper)
37% identity, 85% coverage of query (172 bits)
3r7dA / P05654 Crystal structure of unliganded aspartate transcarbamoylase from bacillus subtilis (see paper)
37% identity, 89% coverage of query (172 bits)
3r7lA Crystal structure of pala-bound aspartate transcarbamoylase from bacillus subtilis
37% identity, 89% coverage of query (172 bits)
P05654 Aspartate carbamoyltransferase catalytic subunit; Aspartate transcarbamylase; ATCase; EC 2.1.3.2 from Bacillus subtilis (strain 168)
37% identity, 85% coverage of query (172 bits)
3r7fA Crystal structure of cp-bound aspartate transcarbamoylase from bacillus subtilis
37% identity, 89% coverage of query (172 bits)
P20054 Multifunctional protein pyr1-3; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Dictyostelium discoideum (Social amoeba)
36% identity, 91% coverage of query (152 bits)
5g1nE / P27708 Aspartate transcarbamoylase domain of human cad bound to pala (see paper)
35% identity, 85% coverage of query (141 bits)
PYR1_SQUAC / Q91437 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Squalus acanthias (Spiny dogfish) (see paper)
34% identity, 85% coverage of query (141 bits)
PYR1_DROME / P05990 Multifunctional protein r; Protein rudimentary; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Drosophila melanogaster (Fruit fly) (see paper)
36% identity, 85% coverage of query (140 bits)
PYR1_MESAU / P08955 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Mesocricetus auratus (Golden hamster) (see 2 papers)
P08955 dihydroorotase (EC 3.5.2.3) from Mesocricetus auratus (see 2 papers)
35% identity, 85% coverage of query (139 bits)
CAD / P27708 CAD protein (EC 3.5.2.3; EC 6.3.5.5; EC 2.1.3.2) from Homo sapiens (see 6 papers)
PYR1_HUMAN / P27708 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Homo sapiens (Human) (see 11 papers)
P27708 aspartate carbamoyltransferase (EC 2.1.3.2); dihydroorotase (EC 3.5.2.3); carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 6.3.5.5) from Homo sapiens (see 7 papers)
35% identity, 85% coverage of query (139 bits)
O66726 aspartate carbamoyltransferase (EC 2.1.3.2) from Aquifex aeolicus (see paper)
4bjhB / O66726 Crystal structure of the aquifex reactor complex formed by dihydroorotase (h180a, h232a) with dihydroorotate and aspartate transcarbamoylase with n-(phosphonacetyl)-l-aspartate (pala) (see paper)
36% identity, 84% coverage of query (138 bits)
3d6nB Crystal structure of aquifex dihydroorotase activated by aspartate transcarbamoylase
36% identity, 84% coverage of query (138 bits)
5g1pA Aspartate transcarbamoylase domain of human cad bound to carbamoyl phosphate
36% identity, 85% coverage of query (137 bits)
7zstB Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum in complex with fla-01
30% identity, 93% coverage of query (136 bits)
Build an alignment for WP_015799097.1 and 17 homologs with ≥ 30% identity
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7zeaB / A0A5K1K910 Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum with bound inhibitor o-benzylhydroxylamine (see paper)
29% identity, 96% coverage of query (135 bits)
Q55338 aspartate carbamoyltransferase (EC 2.1.3.2) from Sulfolobus acidocaldarius (see paper)
32% identity, 88% coverage of query (135 bits)
4eknB / Q58976 Structure of the catalytic chain of methanococcus jannaschii aspartate transcarbamoylase in a hexagonal crystal form (see paper)
35% identity, 96% coverage of query (135 bits)
6fbaA Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum with bound inhibitor 2,3-naphthalenediol
29% identity, 93% coverage of query (135 bits)
O15804 aspartate carbamoyltransferase (EC 2.1.3.2) from Plasmodium falciparum (see 2 papers)
29% identity, 93% coverage of query (134 bits)
PYRB_METJA / Q58976 Aspartate carbamoyltransferase catalytic subunit; Aspartate transcarbamylase; ATCase; EC 2.1.3.2 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
35% identity, 96% coverage of query (134 bits)
PYRB_PYRAB / P77918 Aspartate carbamoyltransferase catalytic subunit; Aspartate transcarbamylase; ATCase; EC 2.1.3.2 from Pyrococcus abyssi (strain GE5 / Orsay) (see paper)
34% identity, 85% coverage of query (134 bits)
pyrB2 / AAA62444.1 aspartate transcarbamoylase from Pisum sativum (see 2 papers)
36% identity, 92% coverage of query (134 bits)
1ml4A / P77918 The pala-liganded aspartate transcarbamoylase catalytic subunit from pyrococcus abyssi (see paper)
34% identity, 85% coverage of query (134 bits)
7zidB Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum in complex with bda-14
29% identity, 93% coverage of query (134 bits)
PYR1_SCHPO / Q09794 Multifunctional protein ura1; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
ura1 / RF|NP_593055.1 carbamoyl-phosphate synthase (glutamine hydrolyzing), aspartate carbamoyltransferase Ura1; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5 from Schizosaccharomyces pombe (see 3 papers)
31% identity, 85% coverage of query (133 bits)
8bplA / G0S583 Aspartate transcarbamoylase mutant (n2045c, r2238c) from chaetomium thermophilum cad-like bound to carbamoyl phosphate (see paper)
33% identity, 85% coverage of query (132 bits)
pyrABCN protein pyrABCN [Includes glutamine-dependent carbamoyl-phosphate; Aspartate carbamoyltransferase]; EC 2.1.3.2; EC 6.3.5.5 from Emericella nidulans (see paper)
33% identity, 95% coverage of query (129 bits)
6hl7A Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum with mutated active site (r109a/k138a) and n- carbamoyl-l-phosphate bound
29% identity, 93% coverage of query (129 bits)
PYR1_NEUCR / Q7S8A6 Multifunctional protein pyr-3; PyrABCN; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see 6 papers)
33% identity, 96% coverage of query (127 bits)
pyrB1 / AAA62443.1 aspartate carbamoyltransferase from Pisum sativum (see 2 papers)
36% identity, 93% coverage of query (127 bits)
6yvbC / P49077 Arabidopsis aspartate transcarbamoylase complex with carbamoyl phosphate (see paper)
36% identity, 92% coverage of query (125 bits)
AT3G20330 / P49077 aspartate carbamoyltransferase (EC 2.1.3.2) from Arabidopsis thaliana (see paper)
35% identity, 92% coverage of query (125 bits)
6ys6B Arabidopsis aspartate transcarbamoylase complex with pala
36% identity, 92% coverage of query (125 bits)
6ypoA Arabidopsis aspartate transcarbamoylase bound to ump
36% identity, 92% coverage of query (125 bits)
P49077 Aspartate carbamoyltransferase, chloroplastic; Aspartate transcarbamylase; ATCase; EC 2.1.3.2 from Arabidopsis thaliana (Mouse-ear cress)
35% identity, 92% coverage of query (125 bits)
7zp2A Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum in complex with bda-04
28% identity, 93% coverage of query (125 bits)
7zhiA Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum with bound inhibitor indole
28% identity, 93% coverage of query (125 bits)
7zczA Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum with bound inhibitor 1-(4-chlorophenyl) methanamine
28% identity, 93% coverage of query (125 bits)
URA2 / P07259 carbamoyl phosphate synthase/aspartate carbamoyltransferase (EC 2.1.3.2; EC 6.3.5.5) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 8 papers)
PYR1_YEAST / P07259 Multifunctional protein URA2; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 15 papers)
31% identity, 95% coverage of query (124 bits)
Q8EHC7 nitrite reductase (cytochrome; ammonia-forming) (EC 1.7.2.2) from Shewanella oneidensis (see paper)
31% identity, 95% coverage of query (124 bits)
2a0fA / P0A786 Structure of d236a mutant e. Coli aspartate transcarbamoylase in presence of phosphonoacetamide at 2.90 a resolution (see paper)
34% identity, 85% coverage of query (124 bits)
2hseA Structure of d236a e. Coli aspartate transcarbamoylase in the presence of phosphonoacetamide and l-aspartate at 2.60 a resolution
34% identity, 85% coverage of query (124 bits)
2ipoA E. Coli aspartate transcarbamoylase complexed with n-phosphonacetyl-l- asparagine
34% identity, 85% coverage of query (123 bits)
2h3eA Structure of wild-type e. Coli aspartate transcarbamoylase in the presence of n-phosphonacetyl-l-isoasparagine at 2.3a resolution
34% identity, 85% coverage of query (123 bits)
2fzkA The structure of wild-type e. Coli aspartate transcarbamoylase in complex with novel t state inhibitors at 2.50 resolution
34% identity, 85% coverage of query (123 bits)
2fzgA The structure of wild-type e. Coli aspartate transcarbamoylase in complex with novel t state inhibitors at 2.25 resolution
34% identity, 85% coverage of query (123 bits)
2fzcA The structure of wild-type e. Coli aspartate transcarbamoylase in complex with novel t state inhibitors at 2.10 resolution
34% identity, 85% coverage of query (123 bits)
2airA T-state active site of aspartate transcarbamylase:crystal structure of the carbamyl phosphate and l-alanosine ligated enzyme
34% identity, 85% coverage of query (123 bits)
1za2A Structure of wild-type e. Coli aspartate transcarbamoylase in the presence of ctp, carbamoyl phosphate at 2.50 a resolution
34% identity, 85% coverage of query (123 bits)
1r0cA Products in the t state of aspartate transcarbamylase: crystal structure of the phosphate and n-carbamyl-l-aspartate ligated enzyme
34% identity, 85% coverage of query (123 bits)
1r0bA Aspartate transcarbamylase (atcase) of escherichia coli: a new crystalline r state bound to pala, or to product analogues phosphate and citrate
34% identity, 85% coverage of query (123 bits)
PyrB / b4245 aspartate carbamoyltransferase catalytic subunit from Escherichia coli K-12 substr. MG1655 (see 4 papers)
PYRB_ECOLI / P0A786 Aspartate carbamoyltransferase catalytic subunit; Aspartate transcarbamylase; ATCase; EC 2.1.3.2 from Escherichia coli (strain K12) (see 2 papers)
34% identity, 85% coverage of query (122 bits)
pyrB / CAC85728.1 aspartate carbamoyltransferase from Solanum tuberosum (see paper)
37% identity, 85% coverage of query (122 bits)
2at1A Crystal structures of phosphonoacetamide ligated t and phosphonoacetamide and malonate ligated r states of aspartate carbamoyltransferase at 2.8-angstroms resolution and neutral ph
34% identity, 85% coverage of query (122 bits)
1at1A Crystal structures of phosphonoacetamide ligated t and phosphonoacetamide and malonate ligated r states of aspartate carbamoyltransferase at 2.8-angstroms resolution and neutral p H
34% identity, 85% coverage of query (122 bits)
pyrB aspartate carbamoyltransferase catalytic chain; EC 2.1.3.2 from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
34% identity, 86% coverage of query (120 bits)
5vmqC Structure of the r105a mutant catalytic trimer of escherichia coli aspartate transcarbamoylase at 2.0-a resolution
34% identity, 86% coverage of query (120 bits)
Q6F4D1 dihydroorotate dehydrogenase (fumarate) (EC 1.3.98.1) from Neobodo saliens (see paper)
33% identity, 85% coverage of query (119 bits)
1acmA Arginine 54 in the active site of escherichia coli aspartate transcarbamoylase is critical for catalysis: a site-specific mutagenesis, nmr and x-ray crystallography study
33% identity, 86% coverage of query (119 bits)
7zgsA Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum with bound inhibitor 2-phenylethan-1-amine
28% identity, 93% coverage of query (116 bits)
6jksD / Q4D3W3 Crystal structure of aspartate transcarbamoylase from trypanosoma cruzi in complex with carbamoyl phosphate (cp) and aspartate (asp)
32% identity, 85% coverage of query (115 bits)
6jktA Crystal structure of aspartate transcarbamoylase from trypanosoma cruzi in complex with n-(phosphonacetyl)-l-aspartic acid (pala).
31% identity, 90% coverage of query (111 bits)
PYR1_CAEEL / Q18990 Multifunctional protein pyr-1; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Caenorhabditis elegans (see 2 papers)
32% identity, 96% coverage of query (109 bits)
6hl7C / O15804 Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum with mutated active site (r109a/k138a) and n- carbamoyl-l-phosphate bound (see paper)
26% identity, 96% coverage of query (108 bits)
6jkrE / O15636 Crystal structure of aspartate transcarbamoylase from trypanosoma cruzi in complex with carbamoyl phosphate (cp)
30% identity, 90% coverage of query (107 bits)
6jl4A Crystal structure of aspartate transcarbamoylase from trypanosoma cruzi in complex with carbamoyl aspartate (ca) and phosphate (pi)
30% identity, 90% coverage of query (106 bits)
6jksB Crystal structure of aspartate transcarbamoylase from trypanosoma cruzi in complex with carbamoyl phosphate (cp) and aspartate (asp)
30% identity, 90% coverage of query (105 bits)
6jktF Crystal structure of aspartate transcarbamoylase from trypanosoma cruzi in complex with n-(phosphonacetyl)-l-aspartic acid (pala).
30% identity, 90% coverage of query (99.4 bits)
Rxyl_2847 / Q1AS69 ureidoglycine carbamoyltransferase monomer (EC 2.1.3.16) from Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1) (see paper)
URGC_RUBXD / Q1AS69 Ureidoglycine carbamoyltransferase; UGTCase; EC 2.1.3.16 from Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1) (see paper)
32% identity, 91% coverage of query (93.6 bits)
O93656 ornithine carbamoyltransferase (EC 2.1.3.3) from Pyrococcus abyssi (see paper)
28% identity, 80% coverage of query (87.8 bits)
OTCA_PYRFU / Q51742 Ornithine carbamoyltransferase, anabolic; OTCase; EC 2.1.3.3 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 2 papers)
Q51742 ornithine carbamoyltransferase (EC 2.1.3.3) from Pyrococcus furiosus (see 2 papers)
28% identity, 80% coverage of query (87.4 bits)
PTC_STRMU / Q8DW19 Putrescine carbamoyltransferase; PTC; PTCase; Putrescine transcarbamoylase; Putrescine transcarbamylase; EC 2.1.3.6 from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see paper)
25% identity, 86% coverage of query (80.5 bits)
pyrBI / CAA71345.1 aspartate carbamoyltransferase with fused catalytic and regulatory chains from Thermotoga maritima (see paper)
30% identity, 79% coverage of query (78.2 bits)
pyrBI / P96111 PyrBI (EC 2.1.3.2) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
P96111 aspartate carbamoyltransferase (EC 2.1.3.2) from Thermotoga maritima (see paper)
30% identity, 79% coverage of query (78.2 bits)
argF / P18186 ArgF (EC 2.1.3.3) from Bacillus subtilis (strain 168) (see 2 papers)
27% identity, 79% coverage of query (76.6 bits)
4a8hA Crystal structure of putrescine transcarbamylase from enterococcus faecalis with n-(phosphonoacetyl)-putrescine
25% identity, 84% coverage of query (76.6 bits)
PTC_ENTFA / Q837U7 Putrescine carbamoyltransferase; PTC; PTCase; Agmatine catabolism protein B; Putrescine transcarbamoylase; Putrescine transcarbamylase; EC 2.1.3.6 from Enterococcus faecalis (strain ATCC 700802 / V583) (see 4 papers)
Q837U7 ornithine carbamoyltransferase (EC 2.1.3.3); putrescine carbamoyltransferase (EC 2.1.3.6) from Enterococcus faecalis (see 2 papers)
25% identity, 84% coverage of query (76.3 bits)
OTC_THET2 / P96134 Ornithine carbamoyltransferase; OTC; OTCase; EC 2.1.3.3 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see paper)
31% identity, 79% coverage of query (76.3 bits)
Q5SJ15 ornithine carbamoyltransferase (EC 2.1.3.3) from Thermus thermophilus (see paper)
31% identity, 79% coverage of query (75.1 bits)
OTC_MYCBO / P0A5M9 Ornithine carbamoyltransferase; OTCase; EC 2.1.3.3 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
OTC_MYCTU / P9WIT9 Ornithine carbamoyltransferase; OTCase; EC 2.1.3.3 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P0A5M9 ornithine carbamoyltransferase (EC 2.1.3.3) from Mycobacterium tuberculosis variant bovis (see paper)
P9WIT9 ornithine carbamoyltransferase (EC 2.1.3.3) from Mycobacterium tuberculosis (see 2 papers)
31% identity, 83% coverage of query (74.3 bits)
7nnvA / P9WIT9 Crystal structure of mycobacterium tuberculosis argf in complex with carbamoyl phosphate.
31% identity, 83% coverage of query (74.3 bits)
2i6uA Crystal structure of ornithine carbamoyltransferase complexed with carbamoyl phosphate and l-norvaline from mycobacterium tuberculosis (rv1656) at 2.2 a
31% identity, 83% coverage of query (74.3 bits)
7nouA Crystal structure of mycobacterium tuberculosis argf in complex with (3,5-dichlorophenyl)boronic acid.
31% identity, 83% coverage of query (74.3 bits)
7nosA Crystal structure of mycobacterium tuberculosis argf in complex with 4-bromo-6-(trifluoromethyl)-1h-benzo[d]imidazole.
31% identity, 83% coverage of query (74.3 bits)
7norA Crystal structure of mycobacterium tuberculosis argf in complex with 2-fluoro-4-hydroxybenzonitrile.
31% identity, 83% coverage of query (74.3 bits)
7nnyA Crystal structure of mycobacterium tuberculosis argf in complex with naphthalen-1-ol.
31% identity, 83% coverage of query (74.3 bits)
7nnwA Crystal structure of mycobacterium tuberculosis argf in complex with methyl 4-hydroxy-3-iodobenzoate.
31% identity, 83% coverage of query (74.3 bits)
ArgF / CAA45530.1 ornithine carbamoyltransferase from Mycobacterium tuberculosis variant bovis (see paper)
31% identity, 83% coverage of query (73.9 bits)
4am8D / Q837U7 Crystal structure of the r54g mutant of putrescine transcarbamylase from enterococcus faecalis bound to a curing guanidinium ion
24% identity, 84% coverage of query (73.2 bits)
4am8A Crystal structure of the r54g mutant of putrescine transcarbamylase from enterococcus faecalis bound to a curing guanidinium ion
24% identity, 84% coverage of query (73.2 bits)
7nnzB Crystal structure of mycobacterium tuberculosis argf in complex with 5-methyl-4-phenylthiazol-2-amine.
31% identity, 83% coverage of query (72.4 bits)
Q98BB6 ornithine carbamoyltransferase (EC 2.1.3.3) from Mesorhizobium loti (see paper)
27% identity, 80% coverage of query (71.2 bits)
OTC_MYCS2 / A0QYS8 Ornithine carbamoyltransferase; OTCase; EC 2.1.3.3 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
32% identity, 80% coverage of query (70.1 bits)
7np0A Crystal structure of mycobacterium tuberculosis argf in complex with (4-nitrophenyl)boronic acid.
31% identity, 83% coverage of query (69.3 bits)
7novA Crystal structure of mycobacterium tuberculosis argf in complex with (4-methyl-3-nitrophenyl)boronic acid.
31% identity, 83% coverage of query (66.6 bits)
OTCC_MALP2 / Q8EVF5 Ornithine carbamoyltransferase, catabolic; OTCase; EC 2.1.3.3 from Malacoplasma penetrans (strain HF-2) (Mycoplasma penetrans) (see paper)
26% identity, 75% coverage of query (65.9 bits)
Q9PNU6 ornithine carbamoyltransferase (EC 2.1.3.3) from Campylobacter jejuni (see paper)
24% identity, 80% coverage of query (64.3 bits)
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