Sites on a Tree

 

Searching for up to 100 curated homologs for WP_015887821.1 NCBI__GCF_000018545.1:WP_015887821.1 (345 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YOAD_BACSU / O34815 Putative 2-hydroxyacid dehydrogenase YoaD; EC 1.1.1.- from Bacillus subtilis (strain 168) (see paper)
    36% identity, 77% coverage of query (174 bits)

HPR_THEMA / Q9X1C1 Hydroxypyruvate reductase; HPR; EC 1.1.1.81 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    39% identity, 78% coverage of query (166 bits)

HPR_BLAHS / C0CMQ8 Hydroxypyruvate reductase; EC 1.1.1.81 from Blautia hydrogenotrophica (strain DSM 10507 / JCM 14656 / S5a33) (Ruminococcus hydrogenotrophicus) (see paper)
    32% identity, 81% coverage of query (164 bits)

Q9Z564 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Streptomyces coelicolor (see paper)
    38% identity, 80% coverage of query (163 bits)

3dc2A / P9WNX3 Crystal structure of serine bound d-3-phosphoglycerate dehydrogenase from mycobacterium tuberculosis (see paper)
    38% identity, 77% coverage of query (160 bits)

P9WNX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mycobacterium tuberculosis (see 5 papers)
    38% identity, 77% coverage of query (160 bits)

3ddnB Crystal structure of hydroxypyruvic acid phosphate bound d-3- phosphoglycerate dehydrogenase in mycobacterium tuberculosis
    38% identity, 77% coverage of query (160 bits)

serA / GB|AAC83943.1 phosphoglycerate dehydrogenase; EC 1.1.1.95 from Bacillus subtilis (see paper)
serA / AAC83943.1 phosphoglycerate dehydrogenase from Bacillus subtilis (see 3 papers)
    34% identity, 77% coverage of query (153 bits)

1wwkA / O50095 Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
    34% identity, 83% coverage of query (152 bits)

A0A2R6X868 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Marchantia polymorpha (see paper)
    37% identity, 72% coverage of query (150 bits)

hprA / P73821 glycerate dehydrogenase (EC 1.1.1.29) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
    33% identity, 80% coverage of query (150 bits)

hprA / Q59516 hydroxypyruvate reductase subunit (EC 1.1.1.81) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see 2 papers)
    34% identity, 83% coverage of query (149 bits)

SERA2_ARATH / O04130 D-3-phosphoglycerate dehydrogenase 2, chloroplastic; PGDH; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O04130 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 3 papers)
    32% identity, 88% coverage of query (144 bits)

A0A1Z4EAX4 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris (see paper)
    33% identity, 83% coverage of query (143 bits)

SERA1_ARATH / O49485 D-3-phosphoglycerate dehydrogenase 1, chloroplastic; Protein EMBRYO SAC DEVELOPMENT ARREST 9; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O49485 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 4 papers)
    35% identity, 77% coverage of query (143 bits)

Q8U3Y2 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus furiosus (see paper)
    34% identity, 81% coverage of query (140 bits)

5aovA / Q8U3Y2 Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
    34% identity, 81% coverage of query (139 bits)

O66939 D-lactate dehydrogenase (EC 1.1.1.28) from Aquifex aeolicus (see paper)
3kb6B / O66939 Crystal structure of d-lactate dehydrogenase from aquifex aeolicus complexed with NAD and lactic acid (see paper)
    32% identity, 74% coverage of query (138 bits)

A0A1Z4EAX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris (see paper)
    34% identity, 80% coverage of query (137 bits)

fdh / O08375 NAD-dependent formate dehydrogenase subunit (EC 1.17.1.9) from Moraxella sp. (see 2 papers)
O08375 formate dehydrogenase (EC 1.17.1.9) from Moraxella sp. C-1 (see paper)
    31% identity, 85% coverage of query (135 bits)

2gsdA / O08375 NAD-dependent formate dehydrogenase from bacterium moraxella sp.C2 in complex with NAD and azide (see paper)
    31% identity, 85% coverage of query (135 bits)

fldH / G9EZR6 aromatic 2-oxoacid reductase (EC 1.1.1.110) from Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679) (see 6 papers)
FLDH_CLOS3 / G9EZR6 Aromatic 2-oxoacid reductase; Phenyllactate dehydrogenase; EC 1.1.1.110 from Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679) (see paper)
    33% identity, 70% coverage of query (134 bits)

FLDH_CLOS1 / J7SHB8 Aromatic 2-oxoacid reductase; Indolelactate dehydrogenase; EC 1.1.1.110 from Clostridium sporogenes (strain ATCC 15579) (see 2 papers)
    33% identity, 70% coverage of query (133 bits)

6v89A Human ctbp1 (28-375) in complex with amp
    34% identity, 77% coverage of query (132 bits)

6cdfA / Q13363 Human ctbp1 (28-378) (see paper)
    34% identity, 77% coverage of query (131 bits)

1hl3A Ctbp/bars in ternary complex with NAD(h) and pidlskk peptide
    34% identity, 77% coverage of query (131 bits)

1hkuA Ctbp/bars: a dual-function protein involved in transcription corepression and golgi membrane fission
    34% identity, 77% coverage of query (131 bits)

4u6sA Ctbp1 in complex with substrate phenylpyruvate
    34% identity, 77% coverage of query (131 bits)

4u6qA Ctbp1 bound to inhibitor 2-(hydroxyimino)-3-phenylpropanoic acid
    34% identity, 77% coverage of query (131 bits)

4lceA Ctbp1 in complex with substrate mtob
    34% identity, 77% coverage of query (131 bits)

slcC / Q1QWN6 S-sulfolactate dehydrogenase subunit (EC 1.1.1.310) from Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11) (see paper)
SLCC_CHRSD / Q1QWN6 (S)-sulfolactate dehydrogenase; (2S)-3-sulfolactate dehydrogenase; (S)-sulfolactate oxidoreductase; EC 1.1.1.310 from Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11) (see paper)
    32% identity, 76% coverage of query (130 bits)

CTBP1 / Q13363 C-terminal-binding protein 1 (EC 1.1.1.428) from Homo sapiens (see 22 papers)
CTBP1_HUMAN / Q13363 C-terminal-binding protein 1; CtBP1; EC 1.1.1.- from Homo sapiens (Human) (see 24 papers)
    34% identity, 75% coverage of query (130 bits)

CTBP1_MOUSE / O88712 C-terminal-binding protein 1; CtBP1; EC 1.1.1.- from Mus musculus (Mouse) (see 11 papers)
    34% identity, 75% coverage of query (130 bits)

CTBP1_RAT / Q9Z2F5 C-terminal-binding protein 1; CtBP1; 50 kDa BFA-dependent ADP-ribosylation substrate; BARS-50; C-terminal-binding protein 3; CtBP3; EC 1.1.1.- from Rattus norvegicus (Rat) (see 6 papers)
    34% identity, 77% coverage of query (130 bits)

Q9I530 D-lactate dehydrogenase (EC 1.1.1.28) from Pseudomonas aeruginosa (see 2 papers)
    34% identity, 72% coverage of query (130 bits)

5z20F / Q9I530 The ternary structure of d-lactate dehydrogenase from pseudomonas aeruginosa with nadh and oxamate (see paper)
    34% identity, 72% coverage of query (130 bits)

6plfA Crystal structure of human phgdh complexed with compound 1
    30% identity, 82% coverage of query (130 bits)

7dkmA / O43175 Phgdh covalently linked to oridonin (see paper)
    31% identity, 80% coverage of query (129 bits)

6biiA / F8AEA4 Crystal structure of pyrococcus yayanosii glyoxylate hydroxypyruvate reductase in complex with NADP and malonate (re-refinement of 5aow) (see paper)
    35% identity, 81% coverage of query (129 bits)

6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution
    31% identity, 80% coverage of query (129 bits)

6rj2A Crystal structure of phgdh in complex with compound 40
    31% identity, 80% coverage of query (129 bits)

6rj3A Crystal structure of phgdh in complex with compound 15
    31% identity, 80% coverage of query (129 bits)

6rj5A Crystal structure of phgdh in complex with compound 39
    31% identity, 80% coverage of query (129 bits)

6plgA Crystal structure of human phgdh complexed with compound 15
    31% identity, 80% coverage of query (129 bits)

7ewhA Crystal structure of human phgdh in complex with homoharringtonine
    31% identity, 80% coverage of query (129 bits)

6rihA Crystal structure of phgdh in complex with compound 9
    31% identity, 80% coverage of query (129 bits)

F8AEA4 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus yayanosii (see paper)
    35% identity, 81% coverage of query (128 bits)

PHGDH / O43175 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 3 papers)
SERA_HUMAN / O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 7 papers)
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 8 papers)
    30% identity, 82% coverage of query (128 bits)

Build an alignment

Build an alignment for WP_015887821.1 and 48 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

Echvi_2777 fused D-3-phosphoglycerate dehydrogenase / phosphoserine phosphatase (EC 1.1.1.95; EC 3.1.3.3) from Echinicola vietnamensis KMM 6221, DSM 17526
    28% identity, 89% coverage of query (128 bits)

CTBP2_XENLA / Q9W758 C-terminal-binding protein 2; CtBP2; C-terminal-binding protein B; TCF-3 corepressor CtBP; XCtBP from Xenopus laevis (African clawed frog) (see paper)
    32% identity, 75% coverage of query (128 bits)

6plfB Crystal structure of human phgdh complexed with compound 1
    31% identity, 81% coverage of query (128 bits)

7arzA / A9SQZ2 Ternary complex of NAD-dependent formate dehydrogenase from physcomitrium patens
    29% identity, 80% coverage of query (127 bits)

CTBP2_BOVIN / Q0VCQ1 C-terminal-binding protein 2; CtBP2 from Bos taurus (Bovine) (see paper)
    34% identity, 75% coverage of query (127 bits)

Phgdh / O08651 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95) from Rattus norvegicus (see paper)
SERA_RAT / O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95 from Rattus norvegicus (Rat) (see paper)
O08651 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Rattus norvegicus (see paper)
    30% identity, 82% coverage of query (127 bits)

SERA_MOUSE / Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95 from Mus musculus (Mouse) (see paper)
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mus musculus (see 2 papers)
    29% identity, 82% coverage of query (126 bits)

8atiA / P56545 Human ctbp2(31-364) in complex with rai2 peptide(315-322)
    33% identity, 75% coverage of query (126 bits)

A0A0R1RJ30 D-lactate dehydrogenase (EC 1.1.1.28) from Furfurilactobacillus rossiae (see 2 papers)
    30% identity, 76% coverage of query (126 bits)

CTBP2_HUMAN / P56545 C-terminal-binding protein 2; CtBP2 from Homo sapiens (Human) (see 5 papers)
    33% identity, 75% coverage of query (126 bits)

4lcjA Ctbp2 in complex with substrate mtob
    33% identity, 75% coverage of query (126 bits)

GYAR_THELN / Q9C4M5 Glyoxylate reductase; EC 1.1.1.26 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
Q9C4M5 glyoxylate reductase (EC 1.1.1.26) from Thermococcus litoralis (see paper)
    31% identity, 81% coverage of query (125 bits)

6ttbA / A0A0H3JSR9 Crystal structure of NAD-dependent formate dehydrogenase from staphylococcus aureus in complex with NAD
    30% identity, 76% coverage of query (125 bits)

CTBP2_MOUSE / P56546 C-terminal-binding protein 2; CtBP2 from Mus musculus (Mouse) (see 4 papers)
    33% identity, 75% coverage of query (125 bits)

D6CJK0 formate dehydrogenase (EC 1.17.1.9) from Bacillus sp. (in: Bacteria) (see paper)
    30% identity, 80% coverage of query (125 bits)

CTBP2_RAT / Q9EQH5 C-terminal-binding protein 2; CtBP2 from Rattus norvegicus (Rat) (see paper)
    33% identity, 75% coverage of query (125 bits)

PS417_12555 phosphogluconate 2-dehydrogenase KguD (EC 1.1.1.43) from Pseudomonas simiae WCS417
    34% identity, 73% coverage of query (124 bits)

FDH2_YEASC / P0CT22 Formate dehydrogenase 2; FDH 2; NAD-dependent formate dehydrogenase 2; EC 1.17.1.9 from Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) (see paper)
    31% identity, 79% coverage of query (124 bits)

FDH1_YEASC / N1P3Y5 Formate dehydrogenase 1; FDH 1; NAD-dependent formate dehydrogenase 1; EC 1.17.1.9 from Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) (see paper)
FDH1_YEAST / Q08911 Formate dehydrogenase 1; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    30% identity, 80% coverage of query (122 bits)

AO353_26885 phosphogluconate 2-dehydrogenase KguD (EC 1.1.1.43) from Pseudomonas fluorescens FW300-N2E3
    33% identity, 73% coverage of query (122 bits)

CTBP_DROME / O46036 C-terminal-binding protein; CtBP protein; dCtBP from Drosophila melanogaster (Fruit fly) (see 2 papers)
    33% identity, 75% coverage of query (122 bits)

2gcgA / Q9UBQ7 Ternary crystal structure of human glyoxylate reductase/hydroxypyruvate reductase (see paper)
    30% identity, 72% coverage of query (122 bits)

GRHPR / Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.81; EC 1.1.1.79) from Homo sapiens (see 2 papers)
GRHPR_HUMAN / Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase; EC 1.1.1.79; EC 1.1.1.81 from Homo sapiens (Human) (see 4 papers)
Q9UBQ7 glyoxylate reductase (EC 1.1.1.26); glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Homo sapiens (see 2 papers)
    30% identity, 72% coverage of query (121 bits)

P87228 Putative D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    29% identity, 85% coverage of query (120 bits)

2eklA / Q972A9 Structure of st1218 protein from sulfolobus tokodaii
    29% identity, 79% coverage of query (118 bits)

2nadA High resolution structures of holo and apo formate dehydrogenase
    31% identity, 78% coverage of query (118 bits)

FDH_PSESR / P33160 Formate dehydrogenase; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Pseudomonas sp. (strain 101) (Achromobacter parvulus T1) (see 2 papers)
P33160 formate dehydrogenase (EC 1.17.1.9) from Pseudomonas sp. 101 (see paper)
    31% identity, 78% coverage of query (118 bits)

4zgsA / B0LUZ5 Identification of the pyruvate reductase of chlamydomonas reinhardtii (see paper)
    30% identity, 72% coverage of query (117 bits)

3wr5A / Q76EB7 Structural basis on the efficient co2 reduction of acidophilic formate dehydrogenase
    31% identity, 81% coverage of query (117 bits)

6jujA Crystal structure of formate dehydrogenase mutant v198i/c256i/p260s/e261p/s381n/s383f from pseudomonas sp. 101in complex with non-natural cofactor nicotinamide cytosine dinucleotide
    31% identity, 78% coverage of query (117 bits)

8oq2A Binding of NADP to a formate dehydrogenase from starkeya novella.
    30% identity, 78% coverage of query (117 bits)

P30901 D-lactate dehydrogenase (EC 1.1.1.28) from Lactobacillus helveticus (see paper)
2dldA / P30901 D-lactate dehydrogenase complexed with nadh and oxamate
GB|CAA47255.1 D-lactate dehydrogenase; EC 1.1.1.28 from Lactobacillus helveticus (see 2 papers)
    32% identity, 71% coverage of query (115 bits)

P30901 D-lactate dehydrogenase; D-LDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.28 from Lactobacillus helveticus (Lactobacillus suntoryeus)
    32% identity, 71% coverage of query (115 bits)

5z21B / Q8RG11 The ternary structure of d-lactate dehydrogenase from fusobacterium nucleatum with nadh and oxamate (see paper)
    30% identity, 73% coverage of query (114 bits)

8bxxAA Formate dehydrogenase
    29% identity, 72% coverage of query (113 bits)

3bazA / Q65CJ7 Structure of hydroxyphenylpyruvate reductase from coleus blumei in complex with NADP+ (see paper)
    31% identity, 75% coverage of query (112 bits)

4e5kA Thermostable phosphite dehydrogenase in complex with NAD and sulfite
    29% identity, 81% coverage of query (112 bits)

HPPR / Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see paper)
HPPR_PLESU / Q65CJ7 Hydroxyphenylpyruvate reductase; HPPR; EC 1.1.1.237 from Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides) (see paper)
Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see 2 papers)
hppr / CAD47810.2 hydroxyphenylpyruvate reductase (HPPR) from Plectranthus scutellarioides (see paper)
    31% identity, 75% coverage of query (112 bits)

8j3oA Formate dehydrogenase wild-type enzyme from candida dubliniensis complexed with nadh
    29% identity, 72% coverage of query (112 bits)

8j3oB Formate dehydrogenase wild-type enzyme from candida dubliniensis complexed with nadh
    29% identity, 72% coverage of query (112 bits)

4e5pA / O69054 Thermostable phosphite dehydrogenase a176r variant in complex with nad (see paper)
    29% identity, 81% coverage of query (111 bits)

4e5mA Thermostable phosphite dehydrogenase e175a/a176r in complex with NADP
    29% identity, 81% coverage of query (110 bits)

FDH1 / O13437 formate dehydrogenase (EC 1.17.1.9) from Candida boidinii (see 3 papers)
FDH_CANBO / O13437 Formate dehydrogenase; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Candida boidinii (Yeast) (see 6 papers)
O13437 formate dehydrogenase (EC 1.17.1.9) from [Candida] boidinii (see 12 papers)
fdh3 / CAB54834.1 formate dehydrogenase from [Candida] boidinii (see paper)
    29% identity, 81% coverage of query (110 bits)

8j3pA / B9WHT3 Formate dehydrogenase mutant from from candida dubliniensis m4 complexed with NADP+ (see paper)
    29% identity, 72% coverage of query (110 bits)

6t9wB / G8NTI5 Crystal structure of formate dehydrogenase fdh2 d222a/q223r enzyme from granulicella mallensis mp5actx8 in complex with NADP and azide.
    29% identity, 72% coverage of query (109 bits)

CTBP1_CAEEL / Q20595 C-terminal-binding protein 1 from Caenorhabditis elegans (see 4 papers)
    32% identity, 72% coverage of query (107 bits)

6d4bA / A0A0A1EQY0 Crystal structure of candida boidinii formate dehydrogenase v123a mutant complexed with NAD+ and azide
    28% identity, 78% coverage of query (105 bits)

7ya4A Formate dehydrogenase from novosphingobium sp. Ap12 with NAD and azide
    27% identity, 79% coverage of query (105 bits)

7ya3B / J2HCX1 Formate dehydrogenase from novosphingobium sp. Ap12 with NADP and azide
    27% identity, 79% coverage of query (105 bits)

5vg6B / A7IIH0 Crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase from xanthobacter autotrophicus py2 in complex with NADPH and mes.
    36% identity, 75% coverage of query (105 bits)

6t8yBBB / G0SGU4 6t8yBBB (see paper)
    30% identity, 78% coverage of query (104 bits)

6t8zAAA Formate dehydrogenase
    30% identity, 78% coverage of query (104 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory