Searching for up to 100 curated homologs for WP_017866878.1 NCBI__GCF_000349725.1:WP_017866878.1 (424 a.a.)
Found high-coverage hits (≥70%) to 38 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Q5M5B5 L-ascorbate oxidase (EC 1.10.3.3) from Cucumis melo (see paper)
47% identity, 97% coverage of query (358 bits)
mvaE / Q9FD70 acetyl-CoA acetyltransferase/HMG-CoA reductase (EC 1.1.1.34; EC 2.3.1.16) from Enterococcus faecalis (see 2 papers)
44% identity, 98% coverage of query (358 bits)
7m1zB / Q835L3 Targeting enterococcus faecalis hmg-coa reductase with a novel non- statin inhibitor
45% identity, 97% coverage of query (357 bits)
7m1zC Targeting enterococcus faecalis hmg-coa reductase with a novel non- statin inhibitor
45% identity, 97% coverage of query (357 bits)
7m3hA Targeting enterococcus faecalis hmg-coa reductase with a novel non- statin inhibitor
45% identity, 97% coverage of query (357 bits)
5wpkB / Q8DNS5 Structure of the class ii 3-hydroxy-3-methylglutaryl-coa reductase from streptococcus pneumoniae bound to hmg-coa and in a partially closed conformation (see paper)
47% identity, 98% coverage of query (353 bits)
5wpjA Structure of the class ii 3-hydroxy-3-methylglutaryl-coa reductase from streptococcus pneumoniae bound to NADPH in open conformations
48% identity, 86% coverage of query (318 bits)
6dioC / A9BQX8 Structure of class ii hmg-coa reductase from delftia acidovorans with NAD bound (see paper)
40% identity, 92% coverage of query (278 bits)
Daci_0287 / A9BQX8 hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) from Delftia acidovorans (strain DSM 14801 / SPH-1) (see paper)
40% identity, 92% coverage of query (278 bits)
1qaxA / P13702 Ternary complex of pseudomonas mevalonii hmg-coa reductase with hmg- coa and NAD+ (see paper)
40% identity, 90% coverage of query (268 bits)
mvaA / P13702 3-hydroxy-3-methylglutaryl-coenzyme A reductase monomer (EC 1.1.1.88) from Pseudomonas mevalonii (see 11 papers)
40% identity, 90% coverage of query (268 bits)
P13702 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.88 from Pseudomonas mevalonii
40% identity, 90% coverage of query (268 bits)
8vlqA 3-hydroxy-3-methylglutaryl-coenzyme A reductase
40% identity, 90% coverage of query (267 bits)
8gdnA Structure of pmhmgr bound to mevalonate, coa and NAD.
40% identity, 90% coverage of query (267 bits)
4i4bA Hmg-coa reductase from pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of hmg-coa
40% identity, 89% coverage of query (262 bits)
B4EKH5 hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) from Burkholderia cenocepacia (see 2 papers)
38% identity, 92% coverage of query (261 bits)
1qayA Ternary complex of pseudomonas mevalonii hmg-coa reductase with mevalonate and NAD+
40% identity, 86% coverage of query (253 bits)
6eevA Structure of class ii hmg-coa reductase from delftia acidovorans with mevalonate bound
39% identity, 86% coverage of query (251 bits)
4i6yB 3-hydroxy-3-methyl (hmg) coenzyme a reductase bound to r-mevalonate
40% identity, 84% coverage of query (244 bits)
8sz6B Pmhmgr bound to mevaldehyde and coa
40% identity, 84% coverage of query (243 bits)
8sz6A Pmhmgr bound to mevaldehyde and coa
40% identity, 84% coverage of query (243 bits)
4i4bB Hmg-coa reductase from pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of hmg-coa
40% identity, 84% coverage of query (243 bits)
1r31A Hmg-coa reductase from pseudomonas mevalonii complexed with hmg-coa
40% identity, 84% coverage of query (243 bits)
4i56A Hmg-coa reductase from pseudomonas mevalonii complexed with dithio- hmg-coa
39% identity, 83% coverage of query (236 bits)
1t02A Crystal structure of a statin bound to class ii hmg-coa reductase
39% identity, 83% coverage of query (236 bits)
6p7kA Structure of hmg-coa reductase from burkholderia cenocepacia (see paper)
38% identity, 86% coverage of query (233 bits)
Build an alignment for WP_017866878.1 and 26 homologs with ≥ 30% identity
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HMDH_RAT / P51639 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34 from Rattus norvegicus (Rat) (see paper)
23% identity, 79% coverage of query (53.1 bits)
HMDH_MOUSE / Q01237 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34 from Mus musculus (Mouse) (see 2 papers)
Q01237 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) from Mus musculus (see paper)
23% identity, 79% coverage of query (52.0 bits)
HMDH_XENLA / P20715 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34 from Xenopus laevis (African clawed frog) (see paper)
23% identity, 79% coverage of query (51.6 bits)
HMDH_MESAU / P09610 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34 from Mesocricetus auratus (Golden hamster) (see 2 papers)
23% identity, 79% coverage of query (51.2 bits)
HMDH_CRIGR / P00347 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34 from Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (see 8 papers)
23% identity, 79% coverage of query (51.2 bits)
HMDH_PIG / Q1W675 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34 from Sus scrofa (Pig) (see paper)
Q1W675 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) from Sus scrofa (see paper)
21% identity, 79% coverage of query (48.5 bits)
1dqaA Complex of the catalytic portion of human hmg-coa reductase with hmg, coa, and NADP+
22% identity, 79% coverage of query (48.5 bits)
HMGCR / P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase monomer (EC 1.1.1.34) from Homo sapiens (see 8 papers)
HMDH_HUMAN / P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34 from Homo sapiens (Human) (see 18 papers)
TC 2.A.6.6.5 / P04035 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase of 888 aas and 6 - 10 TMSs from Homo sapiens (Human) (see 5 papers)
22% identity, 79% coverage of query (47.8 bits)
hmgA / A0A4V8GZY0 hydroxymethylglutaryl-CoA reductase monomer (EC 1.1.1.34) from Methanothermococcus thermolithotrophicus DSM 2095 (see 3 papers)
23% identity, 78% coverage of query (47.4 bits)
6hr8A / A0A4V8GZY0 Hmg-coa reductase from methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 a resolution (see paper)
23% identity, 77% coverage of query (47.0 bits)
HMG1 HMG-CoA reductase from Candida albicans (see 2 papers)
24% identity, 78% coverage of query (46.2 bits)
HMDH_CANAL / A0A1D8PD39 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1; HMG-CoA reductase 1; EC 1.1.1.34 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
24% identity, 78% coverage of query (46.2 bits)
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Lawrence Berkeley National Laboratory