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Searching for up to 100 curated homologs for WP_018231340.1 NCBI__GCF_000378965.1:WP_018231340.1 (379 a.a.)

Found high-coverage hits (≥70%) to 63 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

O66740 threonine synthase (EC 4.2.3.1) from Aquifex aeolicus (see paper)
    54% identity, 98% coverage of query (377 bits)

2zsjA / O66740 Crystal structure of threonine synthase from aquifex aeolicus vf5
    54% identity, 98% coverage of query (377 bits)

6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
    53% identity, 97% coverage of query (369 bits)

P83823 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see paper)
Q5SL02 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see 2 papers)
3aexA / Q5SL02 Catalytic intermediate analogue of threonine synthase from thermus thermophilus hb8 (see paper)
    54% identity, 91% coverage of query (369 bits)

1uimA Crystal structure of threonine synthase from thermus thermophilus hb8, orthorhombic crystal form
    54% identity, 91% coverage of query (369 bits)

3aeyA Apo form of threonine synthase from thermus thermophilus hb8
    54% identity, 91% coverage of query (369 bits)

1v7cA Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue
    54% identity, 91% coverage of query (369 bits)

6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    55% identity, 92% coverage of query (368 bits)

thrC / CAA82669.1 threonine synthase from Bacillus sp. (see paper)
    51% identity, 97% coverage of query (367 bits)

A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    55% identity, 92% coverage of query (363 bits)

THRC_MYCTU / P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG59 threonine synthase (EC 4.2.3.1) from Mycobacterium tuberculosis (see 2 papers)
    56% identity, 92% coverage of query (360 bits)

2d1fA / P9WG59 Structure of mycobacterium tuberculosis threonine synthase (see paper)
    56% identity, 92% coverage of query (360 bits)

6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    52% identity, 96% coverage of query (352 bits)

THRC_METAC / Q8TQD4 Threonine synthase; TS; EC 4.2.3.1 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
GB|AAM05023.1 threonine synthase; EC 4.2.3.1 from Methanosarcina acetivorans C2A (see paper)
    46% identity, 96% coverage of query (303 bits)

THRC2_ARATH / Q9SSP5 Threonine synthase 2, chloroplastic; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    36% identity, 89% coverage of query (178 bits)

THRC1_ARATH / Q9S7B5 Threonine synthase 1, chloroplastic; Protein METHIONINE OVER-ACCUMULATOR 2; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    34% identity, 87% coverage of query (171 bits)

2c2bA Crystallographic structure of arabidopsis thaliana threonine synthase complexed with pyridoxal phosphate and s-adenosylmethionine
    33% identity, 92% coverage of query (171 bits)

2c2gA / Q9S7B5 Crystal structure of threonine synthase from arabidopsis thaliana in complex with its cofactor pyridoxal phosphate (see paper)
    32% identity, 89% coverage of query (159 bits)

DvMF_1945 threonine synthase (EC 4.2.3.1) from Desulfovibrio vulgaris Miyazaki F
    30% identity, 91% coverage of query (124 bits)

Build an alignment

Build an alignment for WP_018231340.1 and 19 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

L0N5C4 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. N99 (see paper)
    25% identity, 82% coverage of query (65.5 bits)

A2GMG5 cysteine synthase (EC 2.5.1.47) from Trichomonas vaginalis (see paper)
    29% identity, 73% coverage of query (62.8 bits)

SRR_SCHPO / O59791 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
O59791 serine racemase (EC 5.1.1.18) from Schizosaccharomyces pombe (see 2 papers)
    26% identity, 83% coverage of query (62.8 bits)

LTHAD_YEAST / P36007 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; EC 4.3.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    24% identity, 75% coverage of query (62.4 bits)

2zpuA / O59791 Crystal structure of modified serine racemase from s.Pombe. (see paper)
    26% identity, 83% coverage of query (62.4 bits)

2zr8A Crystal structure of modified serine racemase complexed with serine
    26% identity, 83% coverage of query (62.4 bits)

1wtcA Crystal structure of s.Pombe serine racemase complex with amppcp
    26% identity, 83% coverage of query (62.4 bits)

1v71A Crystal structure of s.Pombe serine racemase
    26% identity, 83% coverage of query (62.4 bits)

SRR / Q9GZT4 Serine racemase (EC 5.1.1.10) from Homo sapiens (see 4 papers)
SRR_HUMAN / Q9GZT4 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Homo sapiens (Human) (see 8 papers)
    24% identity, 86% coverage of query (61.6 bits)

2bhtA / P16703 Crystal structure of o-acetylserine sulfhydrylase b (see paper)
    26% identity, 78% coverage of query (61.2 bits)

CS1 / A2EI82 O-phosphoserine sulfhydrylase monomer (EC 2.5.1.47; EC 2.5.1.65) from Trichomonas vaginalis (strain ATCC PRA-98 / G3) (see paper)
    29% identity, 73% coverage of query (60.8 bits)

CysM / b2421 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1; EC 4.4.1.28) from Escherichia coli K-12 substr. MG1655 (see 18 papers)
cysM / P16703 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1) from Escherichia coli (strain K12) (see 15 papers)
CYSM_ECOLI / P16703 Cysteine synthase B; CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B; EC 2.5.1.47 from Escherichia coli (strain K12) (see paper)
    25% identity, 78% coverage of query (60.5 bits)

Q54HH2 D-Serine ammonia-lyase (EC 4.3.1.18) from Dictyostelium discoideum (see paper)
    24% identity, 79% coverage of query (59.7 bits)

7nbhAAA structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen
    23% identity, 82% coverage of query (59.7 bits)

7nbgAAA structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
    23% identity, 82% coverage of query (59.7 bits)

7nbcAAA / Q9GZT4 structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
    23% identity, 82% coverage of query (59.3 bits)

7nbfAAA structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen
    23% identity, 82% coverage of query (59.3 bits)

7nbdAAA structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen
    23% identity, 82% coverage of query (59.3 bits)

7nbcCCC structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen
    23% identity, 82% coverage of query (59.3 bits)

7nbgDDD structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
    23% identity, 82% coverage of query (58.9 bits)

3l6bA X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor
    23% identity, 82% coverage of query (58.2 bits)

ortB / C1FW07 AKP thiolase β subunit (EC 2.3.1.263) from Unknown prokaryotic organism (see 2 papers)
ORTB_UNKP / C1FW07 2-amino-4-ketopentanoate thiolase beta subunit; AKP thiolase; AKPT; EC 2.3.1.263 from Unknown prokaryotic organism (see paper)
C1FW07 2-amino-4-oxopentanoate thiolase (subunit 2/2) (EC 2.3.1.263) from Acetoanaerobium sticklandii (see paper)
    23% identity, 80% coverage of query (57.8 bits)

4pcuA Crystal structure of delta516-525 e201s human cystathionine beta- synthase with adomet
    24% identity, 82% coverage of query (57.0 bits)

Cbs / P32232 cystathionine β-synthase subunit (EC 4.2.1.22) from Rattus norvegicus (see 2 papers)
CBS_RAT / P32232 Cystathionine beta-synthase; Beta-thionase; Hemoprotein H-450; Serine sulfhydrase; EC 4.2.1.22 from Rattus norvegicus (Rat) (see 3 papers)
    24% identity, 82% coverage of query (56.6 bits)

CA265_RS15860 threonine deaminase (EC 4.3.1.19) from Pedobacter sp. GW460-11-11-14-LB5
    25% identity, 78% coverage of query (55.8 bits)

6zspAAA serine racemase bound to atp and malonate.
    24% identity, 82% coverage of query (55.5 bits)

P29848 S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent) (EC 2.5.1.144); cysteine synthase (EC 2.5.1.47) from Salmonella enterica subsp. enterica serovar Typhimurium (see 9 papers)
    25% identity, 78% coverage of query (54.3 bits)

1jbqA Structure of human cystathionine beta-synthase: a unique pyridoxal 5'- phosphate dependent hemeprotein
    24% identity, 82% coverage of query (54.3 bits)

mecA cystathionine beta-synthase; EC 4.2.1.22 from Emericella nidulans (see 2 papers)
    23% identity, 82% coverage of query (53.9 bits)

8s5hA / P35520 Full-length human cystathionine beta-synthase with c-terminal 6xhis- tag, basal state, helical reconstruction (see paper)
    24% identity, 82% coverage of query (53.9 bits)

CBS / P35520 cystathionine β-synthase monomer (EC 4.2.1.22) from Homo sapiens (see 12 papers)
CBS_HUMAN / P35520 Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Homo sapiens (Human) (see 43 papers)
P35520 cystathionine beta-synthase (EC 4.2.1.22) from Homo sapiens (see 18 papers)
    24% identity, 82% coverage of query (53.9 bits)

7qgtB Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with aoaa.
    24% identity, 82% coverage of query (53.9 bits)

7mfjBBB / T1KF23 7mfjBBB (see paper)
    22% identity, 84% coverage of query (53.5 bits)

ilvA / AAA96639.1 threonine dehydratase from Bacillus subtilis (see 3 papers)
    23% identity, 87% coverage of query (53.1 bits)

A0A0U5AKI6 serine racemase (EC 5.1.1.18) from Crassostrea gigas (see paper)
    25% identity, 77% coverage of query (52.8 bits)

cysK / P56067 cystathionine β-synthase (O-acetyl-L-serine) monomer (EC 4.2.1.22; EC 2.5.1.134; EC 2.5.1.47) from Helicobacter pylori (strain ATCC 700392 / 26695) (see 2 papers)
6ahiB / P56067 Crystal structure of o-acetylserine dependent cystathionine beta- synthase from helicobacter pylori. (see paper)
    23% identity, 82% coverage of query (52.8 bits)

SRR_MOUSE / Q9QZX7 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Mus musculus (Mouse) (see 6 papers)
    23% identity, 82% coverage of query (52.0 bits)

SRR_ORYSJ / Q7XSN8 Serine racemase; D-serine dehydratase; D-serine ammonia-lyase; L-serine dehydratase; L-serine ammonia-lyase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
Q7XSN8 serine racemase (EC 5.1.1.18) from Oryza sativa (see paper)
    26% identity, 78% coverage of query (52.0 bits)

3hmkA Crystal structure of serine racemase
    23% identity, 82% coverage of query (51.6 bits)

SRR_RAT / Q76EQ0 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Rattus norvegicus (Rat) (see 3 papers)
Q76EQ0 serine racemase (EC 5.1.1.18) from Rattus norvegicus (see 6 papers)
    23% identity, 86% coverage of query (51.2 bits)

thadh / A4F2N8 L-threo-3-hydroxy aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. (see 2 papers)
LTHAD_PSESP / A4F2N8 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; L-THA DH; EC 4.3.1.16 from Pseudomonas sp. (see 2 papers)
A4F2N8 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. T62 (see paper)
    23% identity, 80% coverage of query (50.1 bits)

SDS / P20132 L-serine dehydratase (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens (see 2 papers)
SDHL_HUMAN / P20132 L-serine dehydratase/L-threonine deaminase; SDH; Hepatic serine dehydratase; hSDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Homo sapiens (Human) (see 5 papers)
P20132 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens (see 3 papers)
    25% identity, 75% coverage of query (49.3 bits)

1p5jA / P20132 Crystal structure analysis of human serine dehydratase (see paper)
    25% identity, 75% coverage of query (47.0 bits)

6xo2A / T1KF23 Structural characterization of beta cyanoalanine synthase from tetranychus urticae (two-spotted spider mite) (see paper)
    23% identity, 84% coverage of query (43.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory