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Searching for up to 100 curated homologs for WP_018232951.1 NCBI__GCF_000378965.1:WP_018232951.1 (521 a.a.)

Found high-coverage hits (≥70%) to 39 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

1m21A / Q8RJN5 Crystal structure analysis of the peptide amidase pam in complex with the competitive inhibitor chymostatin (see paper)
    38% identity, 93% coverage of query (259 bits)

pam / GI|19744118 peptide amidase from Stenotrophomonas maltophilia (see paper)
pam / CAC93616.1 peptide amidase from Stenotrophomonas maltophilia (see paper)
    38% identity, 93% coverage of query (258 bits)

AMI4G_ARATH / A0A1P8B760 Probable amidase At4g34880; EC 3.5.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    30% identity, 93% coverage of query (218 bits)

Build an alignment

Build an alignment for WP_018232951.1 and 3 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

A2965_ARTBC / D4B3C8 Putative amidase ARB_02965; EC 3.5.1.- from Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) (see 2 papers)
    29% identity, 93% coverage of query (180 bits)

cahA / BAC15598.1 carbaryl hydrolase from Arthrobacter sp. RC100 (see paper)
    34% identity, 90% coverage of query (174 bits)

gatA / Q9RTA9 glutamyl-tRNAGln amidotransferase subunit A (EC 6.3.5.7; EC 6.3.5.6) from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see paper)
    31% identity, 85% coverage of query (163 bits)

YI01_SCHPO / Q9URY4 Putative amidase C869.01; EC 3.5.1.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    28% identity, 92% coverage of query (156 bits)

3h0lA / O66610 Structure of tRNA-dependent amidotransferase gatcab from aquifex aeolicus (see paper)
    27% identity, 91% coverage of query (153 bits)

3h0mA Structure of tRNA-dependent amidotransferase gatcab from aquifex aeolicus
    27% identity, 91% coverage of query (153 bits)

Q9X0Z9 glutaminyl-tRNA synthase (glutamine-hydrolysing) (EC 6.3.5.7) from Thermotoga maritima (see paper)
    29% identity, 88% coverage of query (151 bits)

gatA / O06491 glutamyl-tRNAGln amidotransferase subunit A (EC 6.3.5.7) from Bacillus subtilis (strain 168) (see paper)
GATA_BACSU / O06491 Glutamyl-tRNA(Gln) amidotransferase subunit A; Glu-ADT subunit A; EC 6.3.5.7 from Bacillus subtilis (strain 168) (see 2 papers)
    30% identity, 92% coverage of query (148 bits)

P63488 glutaminyl-tRNA synthase (glutamine-hydrolysing) (subunit 2/2) (EC 6.3.5.7) from Staphylococcus aureus (see paper)
2dqnA / P63488 Structure of tRNA-dependent amidotransferase gatcab complexed with asn (see paper)
    29% identity, 83% coverage of query (144 bits)

2f2aA Structure of tRNA-dependent amidotransferase gatcab complexed with gln
    29% identity, 83% coverage of query (144 bits)

MANHY_PSEPU / Q84DC4 Mandelamide hydrolase; EC 3.5.1.86 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
    29% identity, 93% coverage of query (143 bits)

GATA_ARATH / Q9LI77 Glutamyl-tRNA(Gln) amidotransferase subunit A, chloroplastic/mitochondrial; Glu-AdT subunit A; EC 6.3.5.7 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    28% identity, 89% coverage of query (139 bits)

Q9CZN8 glutaminyl-tRNA synthase (glutamine-hydrolysing) (EC 6.3.5.7) from Mus musculus (see paper)
    26% identity, 91% coverage of query (137 bits)

6te4A / Q9HWL8 Structural insights into pseudomonas aeruginosa type six secretion system exported effector 8: tse8 in complex with a peptide (see paper)
    29% identity, 93% coverage of query (136 bits)

3kfuE / Q9LCX3 Crystal structure of the transamidosome (see paper)
    31% identity, 90% coverage of query (131 bits)

FAAH2 / Q6GMR7 fatty-acid amide hydrolase 2 (EC 3.5.1.99; EC 3.5.1.60) from Homo sapiens (see 2 papers)
FAAH2_HUMAN / Q6GMR7 Fatty-acid amide hydrolase 2; Amidase domain-containing protein; Anandamide amidohydrolase 2; Oleamide hydrolase 2; EC 3.5.1.99 from Homo sapiens (Human) (see 2 papers)
B2C6G4 fatty acid amide hydrolase (EC 3.5.1.99) from Homo sapiens (see paper)
Q6GMR7 amidase (EC 3.5.1.4); fatty acid amide hydrolase (EC 3.5.1.99) from Homo sapiens (see 2 papers)
    24% identity, 89% coverage of query (120 bits)

FAAH_MEDTR / G7ISB0 Fatty acid amide hydrolase; N-acylethanolamine amidohydrolase; EC 3.5.1.- from Medicago truncatula (Barrel medic) (Medicago tribuloides) (see paper)
    26% identity, 79% coverage of query (119 bits)

FAAH_ARATH / Q7XJJ7 Fatty acid amide hydrolase; AtFAAH; N-acylethanolamine amidohydrolase; EC 3.5.1.99 from Arabidopsis thaliana (Mouse-ear cress) (see 10 papers)
Q7XJJ7 fatty acid amide hydrolase (EC 3.5.1.99) from Arabidopsis thaliana (see paper)
    25% identity, 84% coverage of query (119 bits)

6diiH / Q7XJJ7 Structure of arabidopsis fatty acid amide hydrolase in complex with methyl linolenyl fluorophosphonate (see paper)
    25% identity, 84% coverage of query (118 bits)

8ey9B Structure of arabidopsis fatty acid amide hydrolase mutant s305a in complex with 9-hydroxy-10,12-octadecadienoyl-ethanolamide
    25% identity, 84% coverage of query (117 bits)

8ey1D Structure of arabidopsis fatty acid amide hydrolase mutant s305a in complex with n-(3-oxododecanoyl)-l-homoserine lactone
    25% identity, 84% coverage of query (117 bits)

P22984 amidase (EC 3.5.1.4) from Rhodococcus erythropolis (see 2 papers)
Q7DKE4 amidase (EC 3.5.1.4) from Rhodococcus sp. N-771 (see paper)
amdA / AAA62721.1 enantiomer-selective amidase from Brevibacterium sp (see paper)
CAA38009.1 amidase from Rhodococcus sp (see paper)
    29% identity, 77% coverage of query (115 bits)

B1GY01 nitrilase (EC 3.5.5.1) from Rhodococcus erythropolis (see paper)
    29% identity, 77% coverage of query (115 bits)

3a1iA / Q7DKE4 Crystal structure of rhodococcus sp. N-771 amidase complexed with benzamide (see paper)
    29% identity, 77% coverage of query (114 bits)

tms2 / P0A2X0 indoleacetamide hydrolase (EC 3.5.1.4) from Rhizobium radiobacter (see paper)
    25% identity, 92% coverage of query (113 bits)

atzF / Q936X2 allophanate hydrolase subunit from Pseudomonas sp. (strain ADP) (see 2 papers)
ATZF_PSESD / Q936X2 Allophanate hydrolase; EC 3.5.1.54 from Pseudomonas sp. (strain ADP) (see 2 papers)
Q936X2 allophanate hydrolase (EC 3.5.1.54) from Pseudomonas sp. ADP (see paper)
    29% identity, 79% coverage of query (110 bits)

atzE / Q936X3 1-carboxybiuret hydrolase catalytic subunit (EC 3.5.1.3; EC 3.5.1.131) from Pseudomonas sp. (strain ADP) (see 2 papers)
ATZE_PSESD / Q936X3 1-carboxybiuret hydrolase subunit AtzE; EC 3.5.1.131 from Pseudomonas sp. (strain ADP) (see 2 papers)
Q936X3 1-carboxybiuret hydrolase (EC 3.5.1.131) from Pseudomonas sp. ADP (see paper)
6c6gA / Q936X3 An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme. Inhibitor bound complex. (see paper)
    30% identity, 89% coverage of query (108 bits)

CNBH_COMTE / Q38M35 2-amino-5-chloromuconic acid deaminase; 2-aminomuconate deaminase; EC 3.5.99.5 from Comamonas testosteroni (Pseudomonas testosteroni) (see paper)
    27% identity, 87% coverage of query (107 bits)

Q9ALV2 allophanate hydrolase (EC 3.5.1.54) from Enterobacter cloacae (see 2 papers)
    26% identity, 82% coverage of query (99.8 bits)

tpdC / M1X895 (Z)-N,N'-(but-2-ene-2,3-diyl)diacetamide hydrolase from Rhodococcus sp. TMP1 (see paper)
tpdC / CCN27361.1 amidase from Rhodococcus sp. TMP1 (see paper)
    29% identity, 79% coverage of query (97.1 bits)

DUR1,2 / P32528 urea amidolyase (EC 6.3.4.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
DUR1_YEAST / P32528 Urea amidolyase; EC 6.3.4.6; EC 3.5.1.54 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P32528 allophanate hydrolase (EC 3.5.1.54); urea carboxylase (EC 6.3.4.6) from Saccharomyces cerevisiae (see 3 papers)
    25% identity, 79% coverage of query (94.0 bits)

Q0BRB0 allophanate hydrolase (EC 3.5.1.54) from Granulibacter bethesdensis (see 2 papers)
    27% identity, 77% coverage of query (92.4 bits)

4gysB / Q0BRB0 Granulibacter bethesdensis allophanate hydrolase co-crystallized with malonate (see paper)
    27% identity, 77% coverage of query (92.0 bits)

DUR1.2 / AAC41643.1 urea amidolyase from Saccharomyces cerevisiae (see paper)
    25% identity, 79% coverage of query (90.5 bits)

DUR1_LACKL / A5H0J2 Urea amidolyase; Pyrimidine-degrading protein 13,15; Uracil catabolism protein 3,5; EC 6.3.4.6; EC 3.5.1.54 from Lachancea kluyveri (Yeast) (Saccharomyces kluyveri) (see paper)
    25% identity, 78% coverage of query (86.3 bits)

3a2qA / P13398 Structure of 6-aminohexanoate cyclic dimer hydrolase complexed with substrate (see paper)
    26% identity, 89% coverage of query (79.0 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory