Searching for up to 100 curated homologs for WP_018869600.1 NCBI__GCF_001995255.1:WP_018869600.1 (380 a.a.)
Found high-coverage hits (≥70%) to 60 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
O66740 threonine synthase (EC 4.2.3.1) from Aquifex aeolicus (see paper)
53% identity, 98% coverage of query (382 bits)
2zsjA / O66740 Crystal structure of threonine synthase from aquifex aeolicus vf5
53% identity, 97% coverage of query (381 bits)
6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
52% identity, 97% coverage of query (378 bits)
6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
52% identity, 97% coverage of query (376 bits)
P83823 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see paper)
Q5SL02 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see 2 papers)
3aexA / Q5SL02 Catalytic intermediate analogue of threonine synthase from thermus thermophilus hb8 (see paper)
54% identity, 95% coverage of query (375 bits)
3aeyA Apo form of threonine synthase from thermus thermophilus hb8
54% identity, 95% coverage of query (375 bits)
1uimA Crystal structure of threonine synthase from thermus thermophilus hb8, orthorhombic crystal form
54% identity, 95% coverage of query (375 bits)
1v7cA Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue
54% identity, 95% coverage of query (375 bits)
A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
56% identity, 96% coverage of query (371 bits)
THRC_MYCTU / P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG59 threonine synthase (EC 4.2.3.1) from Mycobacterium tuberculosis (see 2 papers)
58% identity, 92% coverage of query (366 bits)
2d1fA / P9WG59 Structure of mycobacterium tuberculosis threonine synthase (see paper)
58% identity, 92% coverage of query (366 bits)
thrC / CAA82669.1 threonine synthase from Bacillus sp. (see paper)
52% identity, 97% coverage of query (362 bits)
6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
51% identity, 97% coverage of query (360 bits)
THRC_METAC / Q8TQD4 Threonine synthase; TS; EC 4.2.3.1 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
GB|AAM05023.1 threonine synthase; EC 4.2.3.1 from Methanosarcina acetivorans C2A (see paper)
46% identity, 96% coverage of query (301 bits)
THRC2_ARATH / Q9SSP5 Threonine synthase 2, chloroplastic; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
32% identity, 95% coverage of query (176 bits)
THRC1_ARATH / Q9S7B5 Threonine synthase 1, chloroplastic; Protein METHIONINE OVER-ACCUMULATOR 2; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
34% identity, 89% coverage of query (170 bits)
2c2bA Crystallographic structure of arabidopsis thaliana threonine synthase complexed with pyridoxal phosphate and s-adenosylmethionine
34% identity, 91% coverage of query (170 bits)
2c2gA / Q9S7B5 Crystal structure of threonine synthase from arabidopsis thaliana in complex with its cofactor pyridoxal phosphate (see paper)
32% identity, 91% coverage of query (159 bits)
DvMF_1945 threonine synthase (EC 4.2.3.1) from Desulfovibrio vulgaris Miyazaki F
33% identity, 70% coverage of query (125 bits)
Build an alignment for WP_018869600.1 and 19 homologs with ≥ 30% identity
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SRR_SCHPO / O59791 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
O59791 serine racemase (EC 5.1.1.18) from Schizosaccharomyces pombe (see 2 papers)
26% identity, 84% coverage of query (67.0 bits)
2zpuA / O59791 Crystal structure of modified serine racemase from s.Pombe. (see paper)
26% identity, 84% coverage of query (66.6 bits)
1wtcA Crystal structure of s.Pombe serine racemase complex with amppcp
26% identity, 84% coverage of query (66.6 bits)
1v71A Crystal structure of s.Pombe serine racemase
26% identity, 84% coverage of query (66.6 bits)
2zr8A Crystal structure of modified serine racemase complexed with serine
26% identity, 84% coverage of query (66.6 bits)
MA_3297 / Q8TKU7 cysteate synthase monomer (EC 2.5.1.76) from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
CYAS_METAC / Q8TKU7 Cysteate synthase; CS; Cya synthase; EC 2.5.1.76 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
Q8TKU7 cysteate synthase (EC 2.5.1.76) from Methanosarcina acetivorans (see paper)
23% identity, 92% coverage of query (62.4 bits)
Q8VBT2 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse)
25% identity, 78% coverage of query (62.0 bits)
cdl / Q8L0X3 L-cysteine desulfhydrase (EC 4.4.1.1) from Fusobacterium nucleatum (see paper)
Q8L0X3 L-cysteine desulfidase (EC 4.4.1.28) from Fusobacterium nucleatum (see paper)
25% identity, 77% coverage of query (61.6 bits)
LTHAD_YEAST / P36007 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; EC 4.3.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
25% identity, 72% coverage of query (61.6 bits)
Q04513 threonine ammonia-lyase (EC 4.3.1.19) from Corynebacterium glutamicum (see paper)
26% identity, 77% coverage of query (61.6 bits)
SRR / Q9GZT4 Serine racemase (EC 5.1.1.10) from Homo sapiens (see 4 papers)
SRR_HUMAN / Q9GZT4 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Homo sapiens (Human) (see 8 papers)
25% identity, 84% coverage of query (60.5 bits)
L0N5C4 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. N99 (see paper)
25% identity, 75% coverage of query (60.1 bits)
T1KF23 L-3-cyanoalanine synthase (EC 4.4.1.9) from Tetranychus urticae (see paper)
26% identity, 84% coverage of query (59.7 bits)
7nbgDDD structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
25% identity, 77% coverage of query (59.7 bits)
7nbcAAA / Q9GZT4 structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
25% identity, 77% coverage of query (59.3 bits)
7nbhAAA structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen
25% identity, 77% coverage of query (59.3 bits)
3l6bA X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor
25% identity, 77% coverage of query (59.3 bits)
7nbfAAA structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen
25% identity, 77% coverage of query (59.3 bits)
7nbdAAA structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen
25% identity, 77% coverage of query (59.3 bits)
7nbcCCC structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen
25% identity, 77% coverage of query (59.3 bits)
7nbgAAA structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
25% identity, 77% coverage of query (59.3 bits)
mecA cystathionine beta-synthase; EC 4.2.1.22 from Emericella nidulans (see 2 papers)
24% identity, 82% coverage of query (58.5 bits)
A0QX60 threonine ammonia-lyase (EC 4.3.1.19) from Mycolicibacterium smegmatis (see paper)
25% identity, 81% coverage of query (58.5 bits)
Q54HH2 D-Serine ammonia-lyase (EC 4.3.1.18) from Dictyostelium discoideum (see paper)
24% identity, 77% coverage of query (57.8 bits)
2bhtA / P16703 Crystal structure of o-acetylserine sulfhydrylase b (see paper)
26% identity, 77% coverage of query (57.8 bits)
CysM / b2421 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1; EC 4.4.1.28) from Escherichia coli K-12 substr. MG1655 (see 18 papers)
cysM / P16703 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1) from Escherichia coli (strain K12) (see 15 papers)
CYSM_ECOLI / P16703 Cysteine synthase B; CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B; EC 2.5.1.47 from Escherichia coli (strain K12) (see paper)
26% identity, 77% coverage of query (57.4 bits)
7mfjBBB / T1KF23 7mfjBBB (see paper)
26% identity, 83% coverage of query (57.0 bits)
thadh / A4F2N8 L-threo-3-hydroxy aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. (see 2 papers)
LTHAD_PSESP / A4F2N8 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; L-THA DH; EC 4.3.1.16 from Pseudomonas sp. (see 2 papers)
A4F2N8 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. T62 (see paper)
26% identity, 75% coverage of query (56.6 bits)
6xo2A / T1KF23 Structural characterization of beta cyanoalanine synthase from tetranychus urticae (two-spotted spider mite) (see paper)
25% identity, 84% coverage of query (56.2 bits)
6zspAAA serine racemase bound to atp and malonate.
25% identity, 77% coverage of query (56.2 bits)
cysK / P56067 cystathionine β-synthase (O-acetyl-L-serine) monomer (EC 4.2.1.22; EC 2.5.1.134; EC 2.5.1.47) from Helicobacter pylori (strain ATCC 700392 / 26695) (see 2 papers)
6ahiB / P56067 Crystal structure of o-acetylserine dependent cystathionine beta- synthase from helicobacter pylori. (see paper)
24% identity, 82% coverage of query (55.8 bits)
SDS / P20132 L-serine dehydratase (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens (see 2 papers)
SDHL_HUMAN / P20132 L-serine dehydratase/L-threonine deaminase; SDH; Hepatic serine dehydratase; hSDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Homo sapiens (Human) (see 5 papers)
P20132 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens (see 3 papers)
26% identity, 78% coverage of query (55.5 bits)
1p5jA / P20132 Crystal structure analysis of human serine dehydratase (see paper)
25% identity, 78% coverage of query (55.1 bits)
Cbs / P32232 cystathionine β-synthase subunit (EC 4.2.1.22) from Rattus norvegicus (see 2 papers)
CBS_RAT / P32232 Cystathionine beta-synthase; Beta-thionase; Hemoprotein H-450; Serine sulfhydrase; EC 4.2.1.22 from Rattus norvegicus (Rat) (see 3 papers)
25% identity, 77% coverage of query (54.7 bits)
6hulB / P50383 Sulfolobus solfataricus tryptophan synthase ab complex (see paper)
24% identity, 89% coverage of query (53.9 bits)
5xemA / Q8RE94 Crystal structure of a hydrogen sulfide-producing enzyme (fn1220) from fusobacterium nucleatum in complex with l-lanthionine-plp schiff base
24% identity, 83% coverage of query (53.9 bits)
5xenA Crystal structure of a hydrogen sulfide-producing enzyme (fn1220) from fusobacterium nucleatum in complex with l-serine-plp schiff base
24% identity, 83% coverage of query (53.5 bits)
P29848 S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent) (EC 2.5.1.144); cysteine synthase (EC 2.5.1.47) from Salmonella enterica subsp. enterica serovar Typhimurium (see 9 papers)
25% identity, 78% coverage of query (52.8 bits)
SRR_MOUSE / Q9QZX7 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Mus musculus (Mouse) (see 6 papers)
24% identity, 77% coverage of query (51.6 bits)
3hmkA Crystal structure of serine racemase
24% identity, 77% coverage of query (48.5 bits)
SRR_RAT / Q76EQ0 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Rattus norvegicus (Rat) (see 3 papers)
Q76EQ0 serine racemase (EC 5.1.1.18) from Rattus norvegicus (see 6 papers)
24% identity, 77% coverage of query (48.1 bits)
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Lawrence Berkeley National Laboratory