Searching for up to 100 curated homologs for WP_019555908.1 NCBI__GCF_000381085.1:WP_019555908.1 (401 a.a.)
Found high-coverage hits (≥70%) to 83 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
trpB / RF|YP_045379.1 tryptophan synthase, beta subunit; EC 4.2.1.20 from Acinetobacter calcoaceticus (see paper)
73% identity, 100% coverage of query (618 bits)
trpB / GI|28971664 tryptophan synthase, beta subunit; EC 4.2.1.20 from Burkholderia multivorans ATCC 17616 (see paper)
trpB / BAC65264.1 tryptophan synthase beta chain from Burkholderia multivorans (see paper)
70% identity, 98% coverage of query (595 bits)
5ey5B Lbcats
72% identity, 96% coverage of query (572 bits)
trpB / CAB55324.2 tryptophan synthase beta subunit from Rhizobium etli (see paper)
65% identity, 99% coverage of query (541 bits)
TRPB_RHIEC / Q2KE82 Tryptophan synthase beta chain; EC 4.2.1.20 from Rhizobium etli (strain ATCC 51251 / DSM 11541 / JCM 21823 / NBRC 15573 / CFN 42) (see paper)
66% identity, 99% coverage of query (541 bits)
trpB / AAD29261.1 tryptophan synthase beta chain from Rhodobacter sphaeroides (see paper)
64% identity, 99% coverage of query (532 bits)
TSB1 / P14671 tryptophan synthase, beta subunit (EC 4.2.1.122) from Arabidopsis thaliana (see 3 papers)
P14671 tryptophan synthase (EC 4.2.1.20) from Arabidopsis thaliana (see paper)
63% identity, 97% coverage of query (522 bits)
Q8U093 tryptophan synthase (subunit 2/2) (EC 4.2.1.20) from Pyrococcus furiosus (see paper)
63% identity, 96% coverage of query (518 bits)
5dw0A Trpb from pyrococcus furiosus with l-serine bound as the external aldimine
63% identity, 96% coverage of query (518 bits)
5t6mB Structure of the tryptophan synthase b-subunit from pyroccus furiosus with b-methyltryptophan non-covalently bound
63% identity, 96% coverage of query (518 bits)
1v8zA X-ray crystal structure of the tryptophan synthase b2 subunit from hyperthermophile, pyrococcus furiosus
63% identity, 96% coverage of query (518 bits)
A0A2U8JPY3 tryptophan synthase (indole-salvaging) (EC 4.2.1.122); tryptophan synthase (EC 4.2.1.20) from Psilocybe cubensis (see paper)
63% identity, 96% coverage of query (513 bits)
6am8B Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9 with trp bound as e(aex2)
63% identity, 95% coverage of query (512 bits)
5ixjD / Q8U093 Tryptophan synthase beta-subunit from pyrococcus furiosus with l- threonine non-covalently bound in the active site (see paper)
63% identity, 96% coverage of query (511 bits)
5dw3A Tryptophan synthase beta-subunit from pyrococcus furiosus with product l-tryptophan non-covalently bound in the active site
63% identity, 95% coverage of query (511 bits)
5t6mA Structure of the tryptophan synthase b-subunit from pyroccus furiosus with b-methyltryptophan non-covalently bound
63% identity, 95% coverage of query (509 bits)
7rnpA Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9_h275e with 4-cl-trp non-covalently bound
63% identity, 95% coverage of query (508 bits)
6cutA Engineered holo trpb from pyrococcus furiosus, pftrpb7e6 with (2s,3s)- isopropylserine bound as the external aldimine
63% identity, 95% coverage of query (507 bits)
6cuzA Engineered trpb from pyrococcus furiosus, pftrpb7e6 with (2s,3r)- ethylserine bound as the amino-acrylate
63% identity, 95% coverage of query (506 bits)
5vm5D Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9, with ser bound
63% identity, 95% coverage of query (504 bits)
trpB / Q9YGB0 tryptophan synthase β subunit (EC 4.2.1.122) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
Q9YGB0 tryptophan synthase (indole-salvaging) (EC 4.2.1.122); tryptophan synthase (subunit 2/2) (EC 4.2.1.20) from Thermococcus kodakarensis (see paper)
62% identity, 95% coverage of query (503 bits)
TSB2 / AAA33491.1 tryptophan synthase beta-subunit from Zea mays (see paper)
61% identity, 97% coverage of query (501 bits)
O28672 tryptophan synthase (EC 4.2.1.20) from Archaeoglobus fulgidus (see paper)
62% identity, 95% coverage of query (497 bits)
5tciH / P9WFX9 Crystal structure of tryptophan synthase from m. Tuberculosis - brd4592-bound form (see paper)
60% identity, 98% coverage of query (497 bits)
TRPB_MYCTU / P9WFX9 Tryptophan synthase beta chain; EC 4.2.1.20 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
60% identity, 98% coverage of query (497 bits)
6usaB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk1-bound form
60% identity, 98% coverage of query (497 bits)
6dweB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and brd0059-bound form
60% identity, 98% coverage of query (497 bits)
6uapB Crystal structure of tryptophan synthase from m. Tuberculosis - open form with brd6309 bound
60% identity, 98% coverage of query (497 bits)
6u6cB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form
60% identity, 98% coverage of query (497 bits)
5ocwB Structure of mycobacterium tuberculosis tryptophan synthase in space group f222
60% identity, 98% coverage of query (496 bits)
trpB1 / P50909 β subunit of tryptophan synthase (EC 4.2.1.122) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
P50909 tryptophan synthase (EC 4.2.1.20) from Thermotoga maritima (see paper)
63% identity, 95% coverage of query (494 bits)
TSB1 / AAA33490.1 tryptophan synthase beta-subunit, partial from Zea mays (see paper)
61% identity, 95% coverage of query (492 bits)
8vhhA / P50909 Engineered holo tryptophan synthase (tm9d8 ) Derived from t. Maritima trpb (see paper)
61% identity, 95% coverage of query (491 bits)
8eh0A Engineered tyrosine synthase (tmtyrs1) derived from t. Maritima trpb with ser bound as the amino-acrylate intermediate and complexed with quinoline n-oxide
61% identity, 95% coverage of query (485 bits)
8egzA Engineered tyrosine synthase (tmtyrs1) derived from t. Maritima trpb with ser bound as the amino-acrylate intermediate
61% identity, 95% coverage of query (485 bits)
8eh1A Engineered tyrosine synthase (tmtyrs1) derived from t. Maritima trpb with ser bound as the amino-acrylate intermediate and complexed with 4-hydroxyquinoline
61% identity, 95% coverage of query (484 bits)
trpB bifunctional tryptophan synthase TRPB from Emericella nidulans (see 2 papers)
59% identity, 95% coverage of query (475 bits)
TRP5 likely tryptophan synthetase alpha chain from Candida albicans (see paper)
58% identity, 96% coverage of query (469 bits)
Q60142 tryptophan synthase (EC 4.2.1.20) from Bacillus subtilis (see paper)
58% identity, 97% coverage of query (468 bits)
TRP_YEAST / P00931 Tryptophan synthase; EC 4.2.1.20 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
54% identity, 97% coverage of query (455 bits)
TRPB_SALTY / P0A2K1 Tryptophan synthase beta chain; EC 4.2.1.20 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
trpB / PDB|1KFJ_B tryptophan synthase beta chain; EC 4.2.1.20 from Salmonella enterica subsp. enterica serovar Typhimurium (see 10 papers)
57% identity, 96% coverage of query (454 bits)
5cgqB Crystal structure of tryptophan synthase from salmonella typhimurium in complex with f9 ligand in the alpha-site and the product l- tryptophan in the beta-site.
57% identity, 96% coverage of query (454 bits)
1qopB Crystal structure of wild-type tryptophan synthase complexed with indole propanol phosphate
57% identity, 96% coverage of query (454 bits)
3pr2B Tryptophan synthase indoline quinonoid structure with f9 inhibitor in alpha site
57% identity, 96% coverage of query (454 bits)
7lv5B The internal aldimine form of the wild-type salmonella typhimurium tryptophan synthase in complex with inhibitor n-(4'- trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (f9f) at the enzyme alpha-site, cesium ion at the metal coordination site and l-histidine at the enzyme beta-site at 1.55 angstrom resolution
57% identity, 96% coverage of query (454 bits)
3cepB Structure of a tryptophan synthase quinonoid intermediate
57% identity, 96% coverage of query (454 bits)
4kkxB Crystal structure of tryptophan synthase from salmonella typhimurium with 2-aminophenol quinonoid in the beta site and the f6 inhibitor in the alpha site
57% identity, 96% coverage of query (454 bits)
4hpxB Crystal structure of tryptophan synthase at 1.65 a resolution in complex with alpha aminoacrylate e(a-a) and benzimidazole in the beta site and the f9 inhibitor in the alpha site
57% identity, 96% coverage of query (454 bits)
4hpjB Crystal structure of tryptophan synthase at 1.45 a resolution in complex with 2-aminophenol quinonoid in the beta site and the f9 inhibitor in the alpha site
57% identity, 96% coverage of query (454 bits)
4hn4B Tryptophan synthase in complex with alpha aminoacrylate e(a-a) form and the f9 inhibitor in the alpha site
57% identity, 96% coverage of query (454 bits)
8b05B Tryptophan synthase - cryo-trapping by the spitrobot crystal plunger after 20 sec
57% identity, 96% coverage of query (454 bits)
2j9xB Tryptophan synthase in complex with gp, alpha-d,l-glycerol-phosphate, cs, ph6.5 - alpha aminoacrylate form - (gp)e(a-a)
57% identity, 96% coverage of query (454 bits)
6xt0B Salmonella typhimurium tryptophan synthase complexed with dioxindolyl- l-alanine and d-glycerol-3-phosphate
57% identity, 96% coverage of query (454 bits)
6xrhB Salmonella typhimurium tryptophan synthase complexed with oxindolyl-l- alanine and d-glycerol-3-phosphate
57% identity, 96% coverage of query (454 bits)
6xoyB Salmonella typhimurium tryptophan synthase complexed with d-tryptophan and d-glycerol-3-phosphate
57% identity, 96% coverage of query (454 bits)
6xinB The crystal structure of tryptophan synthase from salmonella enterica serovar typhimurium in complex with (2s)-3-amino-3-imino-2- phenyldiazenylpropanamide at the enzyme alpha-site.
57% identity, 96% coverage of query (454 bits)
7jmqB / P0A2K1 The external aldimine form of the mutant beta-s377a salmonella thypi tryptophan synthase in open conformation showing dual side chain conformations for the residue beta-q114, sodium ion at the metal coordination site, and f9 inhibitor at the alpha-site. One of the beta-q114 rotamer conformations allows a hydrogen bond to form with the plp oxygen at the position 3 in the ring
57% identity, 96% coverage of query (453 bits)
5kzmB / Q5NE79 Crystal structure of tryptophan synthase alpha-beta chain complex from francisella tularensis (see paper)
58% identity, 96% coverage of query (452 bits)
7jqwB The external aldimine crystal structure of salmonella typhimurium tryptophan synthase mutant beta-s377a in complex with cesium ion at the metal coordination site. The single beta-q114 rotamer conformation allows a hydrogen bond to form with the plp oxygen at the position 3 in the ring
57% identity, 96% coverage of query (452 bits)
1a50B Crystal structure of wild-type tryptophan synthase complexed with 5- fluoroindole propanol phosphate
57% identity, 96% coverage of query (452 bits)
2j9yB Tryptophan synthase q114n mutant in complex with compound ii
57% identity, 96% coverage of query (452 bits)
2clfB Tryptophan synthase in complex with n-(4'- trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (f6) - highf6 complex
57% identity, 96% coverage of query (452 bits)
1beuB Trp synthase (d60n-ipp-ser) with k+
57% identity, 96% coverage of query (452 bits)
6ducB Crystal structure of mutant beta-k167t tryptophan synthase in complex with inhibitor n-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1- ethylphosphate (f9f) at the alpha-site, cesium ion at the metal coordination site, and 2-aminophenol quinonoid (1d0) at the beta-site
57% identity, 96% coverage of query (452 bits)
6o1hB Tryptophan synthase q114a mutant in complex with n-(4'- trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (f9f) at the enzyme alpha-site, cesium ion at the metal coordination site, and 2-aminophenol quinonoid at the enzyme beta site
57% identity, 96% coverage of query (452 bits)
1a5sB Crystal structure of wild-type tryptophan synthase complexed with 5- fluoroindole propanol phosphate and l-ser bound as amino acrylate to the beta site
57% identity, 95% coverage of query (451 bits)
2tysB Crystal structures of mutant (betak87t) tryptophan synthase alpha2 beta2 complex with ligands bound to the active sites of the alpha and beta subunits reveal ligand-induced conformational changes
57% identity, 96% coverage of query (450 bits)
TrpB / b1261 tryptophan synthase subunit β (EC 4.2.1.122) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
trpB / P0A879 tryptophan synthase subunit β (EC 4.2.1.122) from Escherichia coli (strain K12) (see 7 papers)
57% identity, 96% coverage of query (449 bits)
P0A879 Tryptophan synthase beta chain; EC 4.2.1.20 from Escherichia coli (strain K12)
57% identity, 96% coverage of query (449 bits)
6v82B / O84172 Crystal structure of tryptophan synthase from chlamydia trachomatis d/uw-3/cx (see paper)
56% identity, 95% coverage of query (448 bits)
2rhgB / P0A2K1 Tryptophan synthase complexed with igp, ph 7.0, internal aldimine
52% identity, 96% coverage of query (400 bits)
Q5JDJ1 tryptophan synthase (indole-salvaging) (EC 4.2.1.122); tryptophan synthase (subunit 1/2) (EC 4.2.1.20) from Thermococcus kodakarensis (see paper)
32% identity, 92% coverage of query (139 bits)
6hulB / P50383 Sulfolobus solfataricus tryptophan synthase ab complex (see paper)
32% identity, 83% coverage of query (135 bits)
trpB2 / Q9WZ09 tryptophan synthase β2 subunit (EC 4.2.1.122) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
33% identity, 92% coverage of query (135 bits)
TSBType2 / Q9FFW8 tryptophan synthase, beta subunit (EC 4.2.1.122) from Arabidopsis thaliana (see paper)
Q9FFW8 tryptophan synthase (EC 4.2.1.20) from Arabidopsis thaliana (see paper)
32% identity, 86% coverage of query (125 bits)
4qysA Trpb2 enzymes
30% identity, 92% coverage of query (120 bits)
Q97TX6 tryptophan synthase (EC 4.2.1.20) from Saccharolobus solfataricus (see paper)
30% identity, 92% coverage of query (116 bits)
4qysB / Q97TX6 Trpb2 enzymes (see paper)
30% identity, 87% coverage of query (116 bits)
Build an alignment for WP_019555908.1 and 78 homologs with ≥ 30% identity
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THRC_METAC / Q8TQD4 Threonine synthase; TS; EC 4.2.3.1 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
GB|AAM05023.1 threonine synthase; EC 4.2.3.1 from Methanosarcina acetivorans C2A (see paper)
25% identity, 90% coverage of query (60.5 bits)
ORTB_ACESD / E3PY97 2-amino-4-ketopentanoate thiolase beta subunit; AKP thiolase; AKPT; EC 2.3.1.263 from Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / CCUG 9281 / NCIMB 10654 / HF) (Clostridium sticklandii) (see paper)
25% identity, 78% coverage of query (52.4 bits)
6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
24% identity, 83% coverage of query (48.5 bits)
6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
24% identity, 83% coverage of query (48.1 bits)
6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
24% identity, 83% coverage of query (47.8 bits)
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Lawrence Berkeley National Laboratory