Searching for up to 100 curated homologs for WP_020174657.1 NCBI__GCF_000385335.1:WP_020174657.1 (520 a.a.)
Found high-coverage hits (≥70%) to 64 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Q84FW2 formate dehydrogenase (EC 1.17.1.9) from Methylorubrum extorquens (see paper)
66% identity, 98% coverage of query (697 bits)
6vw7D / Q0KDY2 Formate dehydrogenase fdsabg subcomplex fdsbg from c. Necator - nadh bound (see paper)
68% identity, 97% coverage of query (668 bits)
fdsB / GI|3724144 NAD-dependent formate dehydrogenase, beta subunit from Ralstonia eutropha H16 (see 2 papers)
fdsB / CAA11234.1 NAD-dependent formate dehydrogenase beta subunit from Cupriavidus necator (see paper)
67% identity, 97% coverage of query (647 bits)
6tg9B / D5AQH1 Cryo-em structure of nadh reduced form of NAD+-dependent formate dehydrogenase from rhodobacter capsulatus (see paper)
65% identity, 98% coverage of query (638 bits)
8oh5B / A0A0U1KYM9 Cryo-em structure of the electron bifurcating transhydrogenase stnabc complex from sporomusa ovata (state 2) (see paper)
43% identity, 98% coverage of query (407 bits)
7q4vB / H6LFG4 Electron bifurcating hydrogenase - hydabc from a. Woodii (see paper)
43% identity, 98% coverage of query (402 bits)
8a6tB / A0A097ATG4 Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from thermoanaerobacter kivui in the reduced state (see paper)
48% identity, 80% coverage of query (396 bits)
HNDC_SOLFR / Q46507 NADP-reducing hydrogenase subunit HndC; Hydrogen dehydrogenase (NADP(+)); EC 1.12.1.3 from Solidesulfovibrio fructosivorans (Desulfovibrio fructosivorans) (see 2 papers)
48% identity, 78% coverage of query (385 bits)
K0B622 formate dehydrogenase (NAD+, ferredoxin) (subunit 2/4) (EC 1.17.1.11) from Gottschalkia acidurici (see paper)
43% identity, 91% coverage of query (384 bits)
7p8nB / O52682 Tmhydabc- t. Maritima hydrogenase with bridge closed (see paper)
43% identity, 98% coverage of query (380 bits)
TC 3.D.1.5.1 / Q74GA3 NuoF aka GSU0343, component of Proton-translocating NADH dehydrogenase I from Geobacter sulfurreducens (see paper)
40% identity, 98% coverage of query (380 bits)
hydB / Q8RBC9 NADH-dependent hydrogenase β subunit (EC 1.12.1.2) from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (see 2 papers)
45% identity, 95% coverage of query (379 bits)
hydB / O52682 hydrogenase β subunit (EC 1.12.1.4) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
HYDB_THEMA / O52682 Bifurcating [FeFe] hydrogenase beta subunit; Hydrogenase (NAD(+), ferredoxin) beta subunit; Iron-hydrogenase beta subunit; EC 1.12.1.4 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
43% identity, 98% coverage of query (378 bits)
7t2rB / I4BYB5 Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn-free apo state (see paper)
47% identity, 79% coverage of query (372 bits)
7t30B Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn/NAD(h) bound state
47% identity, 79% coverage of query (372 bits)
hymB / GI|14250934 protein HymB from Eubacterium acidaminophilum (see paper)
40% identity, 97% coverage of query (367 bits)
hytB / S5YUD3 hydrogenase (NADP+,ferredoxin) β subunit from Clostridium autoethanogenum DSM 10061 (see paper)
43% identity, 83% coverage of query (360 bits)
7q4vF Electron bifurcating hydrogenase - hydabc from a. Woodii
47% identity, 77% coverage of query (357 bits)
8a5eB Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from acetobacterium woodii in the reduced state
48% identity, 71% coverage of query (340 bits)
8qh7B Crystal structure of respiratory complex i subunits nuoef from aquifex aeolicus bound to reduced 3-acetylpyridine adenine dinucleotide (without reducing agent)
42% identity, 80% coverage of query (317 bits)
8qg1B Crystal structure of oxidized respiratory complex i subunits nuoef from aquifex aeolicus bound to adp-ribose
42% identity, 80% coverage of query (317 bits)
6hl3B Wild-type nuoef from aquifex aeolicus - oxidized form bound to NAD+
43% identity, 79% coverage of query (317 bits)
6hl2B Wild-type nuoef from aquifex aeolicus - oxidized form
43% identity, 79% coverage of query (317 bits)
6saqB Wild-type nuoef from aquifex aeolicus bound to nadh-oh
42% identity, 81% coverage of query (317 bits)
6q9cB Crystal structure of aquifex aeolicus nadh-quinone oxidoreductase subunits nuoe and nuof bound to nadh under anaerobic conditions
42% identity, 80% coverage of query (317 bits)
8qgwB Crystal structure of oxidized respiratory complex i subunits nuoef from aquifex aeolicus bound to oxidized 3-acetylpyridine adenine dinucleotide
42% identity, 80% coverage of query (317 bits)
4hea1 / Q56222 Crystal structure of the entire respiratory complex i from thermus thermophilus (see paper)
42% identity, 80% coverage of query (313 bits)
NQO1_THET8 / Q56222 NADH-quinone oxidoreductase subunit 1; NADH dehydrogenase I chain 1; NDH-1 subunit 1; EC 7.1.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 2 papers)
TC 3.D.1.3.1 / Q56222 Nqo1, component of NADH Dehydrogenase, NDH (Baradaran et al. 2013). The x-ray structures of various complexes have been solved, and a coupling mechanism involving long range conformational changes has been proposed from Thermus thermophilus (see 3 papers)
42% identity, 80% coverage of query (313 bits)
2ybb1 Fitted model for bovine mitochondrial supercomplex i1iii2iv1 by single particle cryo-em (emd-1876)
42% identity, 80% coverage of query (313 bits)
9fdvB / O66841 Crystal structure of reduced nuoef variant r66g(nuof) from aquifex aeolicus (see paper)
42% identity, 80% coverage of query (303 bits)
7p61F / P31979 Complex i from e. Coli, ddm-purified, with nadh, resting state (see paper)
42% identity, 76% coverage of query (298 bits)
NuoF / b2284 NADH:quinone oxidoreductase subunit F from Escherichia coli K-12 substr. MG1655 (see 15 papers)
nuoF / P31979 NADH:quinone oxidoreductase subunit F from Escherichia coli (strain K12) (see 15 papers)
TC 3.D.1.1.1 / P31979 NUOF aka B2284, component of NADH dehydrogenase I, NuoA-N from Escherichia coli (see 7 papers)
42% identity, 76% coverage of query (298 bits)
nuoF / CAA71232.1 complex I 51kDa subunit from Rhodobacter capsulatus (see paper)
39% identity, 76% coverage of query (278 bits)
hoxF / P22317 α subunit from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
P22317 hydrogen dehydrogenase (EC 1.12.1.2) from Cupriavidus necator (see paper)
39% identity, 75% coverage of query (274 bits)
8iufV1 8iufV1 (see paper)
38% identity, 76% coverage of query (272 bits)
8j9iV1 ndufv1
38% identity, 76% coverage of query (272 bits)
8e9hF / A0QU31 Mycobacterial respiratory complex i, fully-inserted quinone (see paper)
40% identity, 76% coverage of query (270 bits)
TC 3.D.1.2.1 / P29913 NQO1, component of NADH dehydrogenase I from Paracoccus denitrificans (see 3 papers)
AAA25585.1 NADH dehydrogenase from Paracoccus denitrificans (see paper)
38% identity, 80% coverage of query (270 bits)
nuoF / Q88FH3 NADH-quinone oxidoreductase subunit F (EC 7.1.1.2) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
40% identity, 76% coverage of query (263 bits)
TC 3.D.1.6.4 / Q6V9B2 50 (NuoF), component of The green algal H+ translocating NADH dehydrogenase (NDH) complex (42 subunits; 33 included here) from Chlamydomonas reinhardtii
39% identity, 75% coverage of query (263 bits)
7v2cA / A0A4X1SZP7 Active state complex i from q10 dataset (see paper)
38% identity, 74% coverage of query (262 bits)
NDUV1_MOUSE / Q91YT0 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Mus musculus (Mouse) (see 2 papers)
39% identity, 74% coverage of query (261 bits)
nubm / CAB65520.1 NUBM protein from Yarrowia lipolytica (see paper)
38% identity, 76% coverage of query (261 bits)
7b0nF / Q9UUU2 3.7-angstrom structure of Yarrowia lipolytica complex I with an R121M mutation in NUCM. (see paper)
38% identity, 76% coverage of query (260 bits)
7o6yB Cryo-em structure of respiratory complex i under turnover
38% identity, 76% coverage of query (260 bits)
NDUV1_BOVIN / P25708 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Bos taurus (Bovine) (see 4 papers)
TC 3.D.1.6.1 / P25708 51 (NuoF), component of The vertebrate H+-translocating NADH dehydrogenase (NDH) complex (45 subunits) from Bos taurus (Bovine) (see 2 papers)
38% identity, 75% coverage of query (259 bits)
NDUFV1 / P49821 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial from Homo sapiens (see 4 papers)
NDUV1_HUMAN / P49821 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Homo sapiens (Human) (see 5 papers)
38% identity, 74% coverage of query (259 bits)
TC 3.D.1.6.2 / P24917 51 (NuoF), component of The fungal H+ translocating NADH dehydrogenase (NDH) complex (38 subunits; 35 included here) from Neurospora crassa (see 3 papers)
37% identity, 77% coverage of query (259 bits)
6zk91 Peripheral domain of open complex i during turnover
39% identity, 74% coverage of query (259 bits)
5lnk1 Entire ovine respiratory complex i
38% identity, 74% coverage of query (259 bits)
7dgq8 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
37% identity, 77% coverage of query (259 bits)
8b9zF / Q9VMI3 Drosophila melanogaster complex i in the active state (dm1) (see paper)
38% identity, 74% coverage of query (258 bits)
at5g08530 / Q9FNN5 NADH-ubiquinone oxidoreductase 51 kDa subunit (EC 7.1.1.2) from Arabidopsis thaliana (see paper)
TC 3.D.1.6.3 / Q9FNN5 53.5 (NuoF), component of The higher plant H+ translocating NADH dehydrogenase (NDH) complex (41 subunits; 23 included here) from Arabidopsis thaliana (Mouse-ear cress) (see paper)
38% identity, 76% coverage of query (257 bits)
7arcF / A0A7S0V3A3 Cryo-em structure of polytomella complex-i (peripheral arm) (see paper)
37% identity, 76% coverage of query (257 bits)
NDH51 NADH-quinone oxidoreductase chain F from Candida albicans (see 4 papers)
37% identity, 75% coverage of query (257 bits)
7aqrF / Q9FNN5 Cryo-em structure of arabidopsis thaliana complex-i (peripheral arm) (see paper)
38% identity, 76% coverage of query (257 bits)
8eswV1 NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform A
38% identity, 74% coverage of query (257 bits)
7zm7B / G0SA46 Cryoem structure of mitochondrial complex i from chaetomium thermophilum (inhibited by ddm) (see paper)
37% identity, 77% coverage of query (251 bits)
8gymv1 / Q23KE4 8gymv1 (see paper)
35% identity, 75% coverage of query (243 bits)
fdh1B / Q8KTI8 NAD-dependent formate dehydrogenase β subunit (EC 1.17.1.9) from Methylorubrum extorquens (see 2 papers)
Q8KTI8 formate dehydrogenase (EC 1.17.1.9) from Methylorubrum extorquens (see paper)
38% identity, 76% coverage of query (231 bits)
7vw6B / C5ATT6 Cryo-em structure of formate dehydrogenase 1 from methylorubrum extorquens am1 (see paper)
38% identity, 75% coverage of query (231 bits)
5xf9A Crystal structure of NAD+-reducing [nife]-hydrogenase in the air- oxidized state
38% identity, 73% coverage of query (219 bits)
5xfaA / A0A077L6X8 Crystal structure of NAD+-reducing [nife]-hydrogenase in the h2- reduced state (see paper)
38% identity, 73% coverage of query (218 bits)
Build an alignment for WP_020174657.1 and 63 homologs with ≥ 30% identity
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NDUV1_SCHPO / O94500 NADH-ubiquinone oxidoreductase 51 kDa subunit homolog SPBC18E5.10, mitochondrial; EC 1.6.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
29% identity, 76% coverage of query (184 bits)
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Lawrence Berkeley National Laboratory