Searching for up to 100 curated homologs for WP_020175105.1 NCBI__GCF_000385335.1:WP_020175105.1 (319 a.a.)
Found high-coverage hits (≥70%) to 94 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
LTHAD_YEAST / P36007 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; EC 4.3.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
32% identity, 97% coverage of query (140 bits)
B1N2N4 L-serine ammonia-lyase (EC 4.3.1.17) from Entamoeba histolytica (see paper)
33% identity, 87% coverage of query (139 bits)
ILV1 putative uncharacterized protein ILV1 from Candida albicans (see paper)
31% identity, 87% coverage of query (135 bits)
TSAL_GEOSL / Q74FW6 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine/serine ammonia-lyase; EC 4.3.1.19; EC 4.3.1.17 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
Q74FW6 threonine ammonia-lyase (EC 4.3.1.19) from Geobacter sulfurreducens (see paper)
34% identity, 87% coverage of query (132 bits)
thadh / A4F2N8 L-threo-3-hydroxy aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. (see 2 papers)
LTHAD_PSESP / A4F2N8 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; L-THA DH; EC 4.3.1.16 from Pseudomonas sp. (see 2 papers)
A4F2N8 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. T62 (see paper)
32% identity, 93% coverage of query (130 bits)
Ga0059261_3694 threonine deaminase (EC 4.3.1.19) from Sphingomonas koreensis DSMZ 15582
33% identity, 98% coverage of query (129 bits)
F7ZG00 serine racemase (EC 5.1.1.18) from Roseobacter litoralis (see paper)
32% identity, 86% coverage of query (127 bits)
L0N5C4 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. N99 (see paper)
32% identity, 93% coverage of query (126 bits)
BHCB_PARDP / A1B8Z2 beta-hydroxyaspartate dehydratase; EC 4.2.1.- from Paracoccus denitrificans (strain Pd 1222) (see paper)
31% identity, 90% coverage of query (126 bits)
CCNA_03750 threonine deaminase (EC 4.3.1.19) from Caulobacter crescentus NA1000
34% identity, 98% coverage of query (124 bits)
8y1jA / Q9I6G0 Structure of the pyridoxal 5'-phosphate-dependent (plp) threonine deaminase ilva1 from pseudomonas aeruginosa pao1 (see paper)
31% identity, 92% coverage of query (123 bits)
Ile / b3772 threonine deaminase (EC 4.3.1.19) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ilvA / P04968 threonine deaminase (EC 4.3.1.19) from Escherichia coli (strain K12) (see 21 papers)
ILVA_ECOLI / P04968 L-threonine dehydratase biosynthetic IlvA; Threonine deaminase; EC 4.3.1.19 from Escherichia coli (strain K12) (see 4 papers)
P04968 threonine ammonia-lyase (EC 4.3.1.19) from Escherichia coli (see paper)
30% identity, 90% coverage of query (122 bits)
1tdjA / P04968 Threonine deaminase (biosynthetic) from e. Coli (see paper)
30% identity, 90% coverage of query (122 bits)
Build an alignment for WP_020175105.1 and 13 homologs with ≥ 30% identity
Or download the sequences
2zpuA / O59791 Crystal structure of modified serine racemase from s.Pombe. (see paper)
29% identity, 97% coverage of query (119 bits)
SRR_SCHPO / O59791 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
O59791 serine racemase (EC 5.1.1.18) from Schizosaccharomyces pombe (see 2 papers)
29% identity, 97% coverage of query (119 bits)
2zr8A Crystal structure of modified serine racemase complexed with serine
29% identity, 97% coverage of query (119 bits)
1wtcA Crystal structure of s.Pombe serine racemase complex with amppcp
29% identity, 97% coverage of query (119 bits)
1v71A Crystal structure of s.Pombe serine racemase
29% identity, 97% coverage of query (119 bits)
FSDH_RALPI / Q10725 Phenylserine dehydratase; EC 4.2.1.- from Ralstonia pickettii (Burkholderia pickettii) (see 2 papers)
31% identity, 97% coverage of query (117 bits)
A0A0U5AKI6 serine racemase (EC 5.1.1.18) from Crassostrea gigas (see paper)
30% identity, 90% coverage of query (116 bits)
TD_NICAT / Q9AXU4 Threonine dehydratase; Threonine deaminase; EC 4.3.1.19 from Nicotiana attenuata (Coyote tobacco) (see 2 papers)
Q9AXU4 threonine ammonia-lyase (EC 4.3.1.19) from Nicotiana attenuata (see paper)
28% identity, 94% coverage of query (115 bits)
TSAL_THEMA / Q9WYJ1 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine dehydratase; EC 4.3.1.19; EC 4.3.1.17 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
31% identity, 96% coverage of query (110 bits)
3l6bA X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor
27% identity, 90% coverage of query (109 bits)
7nbgDDD structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
27% identity, 90% coverage of query (109 bits)
7nbcAAA / Q9GZT4 structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
27% identity, 90% coverage of query (108 bits)
7nbfAAA structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen
27% identity, 90% coverage of query (108 bits)
7nbdAAA structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen
27% identity, 90% coverage of query (108 bits)
7nbcCCC structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen
27% identity, 90% coverage of query (108 bits)
7nbgAAA structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
27% identity, 90% coverage of query (108 bits)
7nbhAAA structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen
27% identity, 90% coverage of query (108 bits)
SRR / Q9GZT4 Serine racemase (EC 5.1.1.10) from Homo sapiens (see 4 papers)
SRR_HUMAN / Q9GZT4 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Homo sapiens (Human) (see 8 papers)
27% identity, 90% coverage of query (107 bits)
TD2_SOLLC / P25306 Threonine dehydratase 2 biosynthetic, chloroplastic; SlTD2; Threonine deaminase 2; EC 4.3.1.17; EC 4.3.1.19 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see 5 papers)
27% identity, 87% coverage of query (105 bits)
6zspAAA serine racemase bound to atp and malonate.
26% identity, 90% coverage of query (105 bits)
THDH_YEAST / P00927 Threonine dehydratase, mitochondrial; Threonine deaminase; EC 4.3.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
28% identity, 87% coverage of query (104 bits)
Tdc / b3117 catabolic threonine dehydratase (EC 4.3.1.17; EC 4.3.1.19) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
tdcB / P0AGF6 catabolic threonine dehydratase (EC 4.3.1.17; EC 4.3.1.19) from Escherichia coli (strain K12) (see 25 papers)
TDCB_ECOLI / P0AGF6 L-threonine dehydratase catabolic TdcB; L-serine dehydratase; Threonine deaminase; EC 4.3.1.19; EC 4.3.1.17 from Escherichia coli (strain K12) (see 4 papers)
tdcB / RF|NP_417587 threonine ammonia-lyase; EC 4.3.1.19 from Escherichia coli K12 (see 7 papers)
28% identity, 96% coverage of query (103 bits)
V6QU65 threonine ammonia-lyase (EC 4.3.1.19) from Fusarium graminearum (see paper)
28% identity, 87% coverage of query (103 bits)
Q54HH2 D-Serine ammonia-lyase (EC 4.3.1.18) from Dictyostelium discoideum (see paper)
25% identity, 98% coverage of query (103 bits)
TDCB_SALTY / P11954 L-threonine dehydratase catabolic TdcB; L-serine dehydratase; Threonine deaminase; EC 4.3.1.19; EC 4.3.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
27% identity, 96% coverage of query (103 bits)
2gn2A / P11954 Crystal structure of tetrameric biodegradative threonine deaminase (tdcb) from salmonella typhimurium in complex with cmp at 2.5a resolution (hexagonal form) (see paper)
27% identity, 96% coverage of query (102 bits)
CH_124219 threonine deaminase [Arxula adeninivorans] from Magnaporthe grisea 70-15 (see paper)
28% identity, 87% coverage of query (102 bits)
CA265_RS15860 threonine deaminase (EC 4.3.1.19) from Pedobacter sp. GW460-11-11-14-LB5
26% identity, 94% coverage of query (100 bits)
THDH_SCHPO / O94634 Threonine dehydratase, mitochondrial; Threonine deaminase; EC 4.3.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
26% identity, 92% coverage of query (100 bits)
SRR_ORYSJ / Q7XSN8 Serine racemase; D-serine dehydratase; D-serine ammonia-lyase; L-serine dehydratase; L-serine ammonia-lyase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
Q7XSN8 serine racemase (EC 5.1.1.18) from Oryza sativa (see paper)
28% identity, 96% coverage of query (100 bits)
ILV / CAA10977.1 threonine deaminase from Blastobotrys adeninivorans (see paper)
28% identity, 92% coverage of query (99.0 bits)
sr / Q2PGG3 serine racemase/D-serine ammonia-lyase (EC 5.1.1.10) from Arabidopsis thaliana (see paper)
SRR_ARATH / Q2PGG3 Serine racemase; AtSR; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q2PGG3 serine racemase (EC 5.1.1.18) from Arabidopsis thaliana (see paper)
27% identity, 96% coverage of query (98.6 bits)
K1QH67 aspartate racemase (EC 5.1.1.13) from Crassostrea gigas (see paper)
27% identity, 94% coverage of query (95.9 bits)
1ve5A / Q5SLL4 Crystal structure of t.Th. Hb8 threonine deaminase
31% identity, 83% coverage of query (95.5 bits)
SRR_RAT / Q76EQ0 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Rattus norvegicus (Rat) (see 3 papers)
Q76EQ0 serine racemase (EC 5.1.1.18) from Rattus norvegicus (see 6 papers)
27% identity, 90% coverage of query (94.7 bits)
TD1_SOLLC / A0FKE6 Threonine dehydratase 1 biosynthetic, chloroplastic; SlTD1; Threonine deaminase 1; EC 4.3.1.19 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see 2 papers)
28% identity, 93% coverage of query (94.4 bits)
Asr / BAE78960.1 aspartate racemase from Scapharca broughtonii (see paper)
29% identity, 90% coverage of query (94.4 bits)
3hmkA Crystal structure of serine racemase
27% identity, 90% coverage of query (94.4 bits)
SRR_MOUSE / Q9QZX7 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Mus musculus (Mouse) (see 6 papers)
27% identity, 90% coverage of query (93.2 bits)
A0A0U4MRI4 serine racemase (EC 5.1.1.18) from Penaeus monodon (see paper)
29% identity, 95% coverage of query (92.8 bits)
sr / A5HUN0 serine racemase/D-serine ammonia-lyase (EC 5.1.1.10) from Hordeum vulgare (see paper)
A5HUN0 serine racemase (EC 5.1.1.18) from Hordeum vulgare (see paper)
27% identity, 96% coverage of query (90.9 bits)
AKS11_ALTAL / V5Y0V0 Threonine dehydratase-like protein AKTS1-1; AK-toxin biosynthesis protein S1-1; EC 4.3.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 4 papers)
27% identity, 92% coverage of query (88.2 bits)
Q04513 threonine ammonia-lyase (EC 4.3.1.19) from Corynebacterium glutamicum (see paper)
28% identity, 97% coverage of query (87.4 bits)
Q2V0H1 serine racemase (EC 5.1.1.18) from Pyrobaculum islandicum (see paper)
30% identity, 93% coverage of query (87.0 bits)
5cvcA / F5CAQ9 Structure of maize serine racemase (see paper)
25% identity, 96% coverage of query (86.3 bits)
F5CAQ9 serine racemase (EC 5.1.1.18) from Zea mays (see paper)
25% identity, 96% coverage of query (86.3 bits)
Q93968 serine racemase (EC 5.1.1.18) from Caenorhabditis elegans (see paper)
25% identity, 86% coverage of query (85.1 bits)
A0QY48 L-serine ammonia-lyase (EC 4.3.1.17) from Mycolicibacterium smegmatis (see paper)
34% identity, 91% coverage of query (83.6 bits)
thrC / CAA82669.1 threonine synthase from Bacillus sp. (see paper)
29% identity, 87% coverage of query (82.4 bits)
ilvA / AAA96639.1 threonine dehydratase from Bacillus subtilis (see 3 papers)
26% identity, 92% coverage of query (80.5 bits)
A0A0U5A554 aspartate racemase (EC 5.1.1.13) from Penaeus monodon (see paper)
26% identity, 96% coverage of query (78.6 bits)
SDSL_MOUSE / Q8R238 Serine dehydratase-like; Glutamate racemase; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; SDH; EC 5.1.1.3; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse) (see paper)
29% identity, 85% coverage of query (78.2 bits)
4d9nA / P66899 Crystal structure of diaminopropionate ammonia lyase from escherichia coli in complex with d-serine (see paper)
28% identity, 77% coverage of query (77.0 bits)
YgeX / b2871 2,3-diaminopropionate ammonia-lyase (EC 4.3.1.15) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
ygeX / P66899 2,3-diaminopropionate ammonia-lyase (EC 4.3.1.15) from Escherichia coli (strain K12) (see 5 papers)
DPAL_ECOLI / P66899 Diaminopropionate ammonia-lyase; DAPAL; 2,3-diaminopropionate ammonia-lyase; Alpha,beta-diaminopropionate ammonia-lyase; Diaminopropionatase; EC 4.3.1.15 from Escherichia coli (strain K12) (see 4 papers)
P66899 Diaminopropionate ammonia-lyase (EC 4.3.1.15) from Escherichia coli (see 3 papers)
28% identity, 77% coverage of query (75.9 bits)
4d9mA Crystal structure of diaminopropionate ammonia lyase from escherichia coli in complex with aminoacrylate-plp azomethine reaction intermediate
29% identity, 77% coverage of query (75.5 bits)
A0A0X1KHE6 L-serine ammonia-lyase (EC 4.3.1.17) from Rhizomucor miehei (see paper)
25% identity, 88% coverage of query (69.7 bits)
1ve5D / Q5SLL4 Crystal structure of t.Th. Hb8 threonine deaminase
28% identity, 83% coverage of query (68.6 bits)
5ygrB / P40817 Crystal structure of plp bound diaminopropionate ammonia lyase from salmonella typhimurium (see paper)
26% identity, 77% coverage of query (68.2 bits)
2rkbA / Q96GA7 Serine dehydratase like-1 from human cancer cells (see paper)
28% identity, 85% coverage of query (68.2 bits)
5c3uA / A0A0X1KHE6 Crystal structure of a fungal l-serine ammonia-lyase from rhizomucor miehei (see paper)
25% identity, 82% coverage of query (67.8 bits)
A0QX60 threonine ammonia-lyase (EC 4.3.1.19) from Mycolicibacterium smegmatis (see paper)
26% identity, 97% coverage of query (67.8 bits)
SDSL / Q96GA7 Serine dehydratase-like (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens (see paper)
SDSL_HUMAN / Q96GA7 Serine dehydratase-like; Cancerous serine dehydratase; cSDH; Glutamate racemase; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; SDHL; L-threonine dehydratase; TDH; Serine dehydratase 2; SDH 2; EC 5.1.1.3; EC 4.3.1.17; EC 4.3.1.19 from Homo sapiens (Human) (see 2 papers)
Q96GA7 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens (see paper)
28% identity, 85% coverage of query (67.8 bits)
THRC_METAC / Q8TQD4 Threonine synthase; TS; EC 4.2.3.1 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
GB|AAM05023.1 threonine synthase; EC 4.2.3.1 from Methanosarcina acetivorans C2A (see paper)
27% identity, 83% coverage of query (65.1 bits)
4d9kA / P66899 Crystal structure of escherichia coli diaminopropionate ammonia lyase in apo form (see paper)
25% identity, 77% coverage of query (64.3 bits)
6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
25% identity, 89% coverage of query (63.5 bits)
6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
25% identity, 89% coverage of query (63.5 bits)
6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
25% identity, 89% coverage of query (62.0 bits)
THRC_MYCTU / P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG59 threonine synthase (EC 4.2.3.1) from Mycobacterium tuberculosis (see 2 papers)
27% identity, 89% coverage of query (55.1 bits)
2d1fA / P9WG59 Structure of mycobacterium tuberculosis threonine synthase (see paper)
27% identity, 89% coverage of query (54.7 bits)
Q8VBT2 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse)
26% identity, 81% coverage of query (54.3 bits)
1pwhA / P09367 Rat liver l-serine dehydratase- complex with pyridoxyl-(o-methyl- serine)-5-monophosphate (see paper)
26% identity, 81% coverage of query (53.9 bits)
A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
26% identity, 93% coverage of query (53.9 bits)
O66740 threonine synthase (EC 4.2.3.1) from Aquifex aeolicus (see paper)
25% identity, 83% coverage of query (52.8 bits)
2zsjA / O66740 Crystal structure of threonine synthase from aquifex aeolicus vf5
25% identity, 83% coverage of query (52.4 bits)
P83823 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see paper)
Q5SL02 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see 2 papers)
3aexA / Q5SL02 Catalytic intermediate analogue of threonine synthase from thermus thermophilus hb8 (see paper)
28% identity, 87% coverage of query (52.4 bits)
3aeyA Apo form of threonine synthase from thermus thermophilus hb8
28% identity, 87% coverage of query (52.4 bits)
1uimA Crystal structure of threonine synthase from thermus thermophilus hb8, orthorhombic crystal form
28% identity, 87% coverage of query (52.4 bits)
1v7cA Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue
28% identity, 87% coverage of query (52.4 bits)
4pcuA Crystal structure of delta516-525 e201s human cystathionine beta- synthase with adomet
25% identity, 82% coverage of query (48.1 bits)
7qgtB Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with aoaa.
25% identity, 83% coverage of query (44.7 bits)
8s5hA / P35520 Full-length human cystathionine beta-synthase with c-terminal 6xhis- tag, basal state, helical reconstruction (see paper)
25% identity, 83% coverage of query (44.7 bits)
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