Searching for up to 100 curated homologs for WP_020175535.1 NCBI__GCF_000385335.1:WP_020175535.1 (280 a.a.)

Found high-coverage hits (≥70%) to 29 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

6y88B / P20577 Igps (indole-3-glycerol phosphate synthase) from pseudomonas aeruginosa in complex with substrate inhibitor rcdrp (see paper)
    38% identity, 91% coverage of query (145 bits)

6y88G Igps (indole-3-glycerol phosphate synthase) from pseudomonas aeruginosa in complex with substrate inhibitor rcdrp
    41% identity, 77% coverage of query (133 bits)

TRPC_ARATH / P49572 Indole-3-glycerol phosphate synthase, chloroplastic; IGPS; EC 4.1.1.48 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    32% identity, 93% coverage of query (130 bits)

A1KJ27 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Mycobacterium tuberculosis variant bovis BCG (see paper)
A5U2W7 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Mycobacterium tuberculosis H37Ra (see paper)
P9WFX7 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Mycobacterium tuberculosis (see paper)
    36% identity, 93% coverage of query (127 bits)

trpC / AAB39010.1 indole-3-glycerol-phosphate synthase from Bradyrhizobium japonicum (see paper)
    35% identity, 80% coverage of query (125 bits)

3t44A / P9WFX7 Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with indole glycerol phosphate (igp) amd anthranilate
    36% identity, 90% coverage of query (125 bits)

3t55A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with phenoxymethyl benzoic acid (pmba)
    36% identity, 90% coverage of query (125 bits)

3t78A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with 5-fluoroanthranilate
    36% identity, 90% coverage of query (121 bits)

trpC / Q9YGB5 indole-3-glycerol phosphate synthase (EC 4.1.1.48) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
Q9YGB5 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Thermococcus kodakarensis (see paper)
    36% identity, 76% coverage of query (119 bits)

trpC anthranilate synthase component 2; EC 4.1.3.27 from Emericella nidulans (see 4 papers)
    35% identity, 77% coverage of query (117 bits)

trpC / AAD09119.1 indole-3-glycerol phosphate synthase from Rhodobacter sphaeroides (see paper)
    37% identity, 70% coverage of query (117 bits)

trpC / BAC65125.1 indole-3-glycerol phosphate synthase from Burkholderia multivorans (see paper)
    39% identity, 73% coverage of query (116 bits)

P84126 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Thermus thermophilus (see paper)
1vc4B / P84126 Crystal structure of indole-3-glycerol phosphate synthase (trpc) from thermus thermophilus at 1.8 a resolution (see paper)
    38% identity, 75% coverage of query (110 bits)

1lbfA Crystal structure of indole-3-glycerol phosphate syntase (igps)with reduced 1-(o-caboxyphenylamino)-1-deoxyribulose 5-phosphate (rcdrp)
    33% identity, 73% coverage of query (108 bits)

1jukA Indole-3-glycerolphosphate synthase from sulfolobus solfataricus in a trigonal crystal form
    33% identity, 73% coverage of query (108 bits)

1igsA Indole-3-glycerolphosphate synthase from sulfolobus solfataricus at 2.0 a resolution
    33% identity, 73% coverage of query (108 bits)

1a53A Complex of indole-3-glycerolphosphate synthase from sulfolobus solfataricus with indole-3-glycerolphosphate at 2.0 a resolution
    33% identity, 73% coverage of query (108 bits)

3t40A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) complex with n-2-carboxyphenyl glycine (cpg)
    34% identity, 93% coverage of query (108 bits)

TRPG_YEAST / P00937 Multifunctional tryptophan biosynthesis protein; EC 4.1.3.27; EC 4.1.1.48 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    32% identity, 73% coverage of query (107 bits)

TrpC / b1262 fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase (EC 4.1.1.48; EC 5.3.1.24) from Escherichia coli K-12 substr. MG1655 (see 17 papers)
trpC / P00909 fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase (EC 4.1.1.48; EC 5.3.1.24) from Escherichia coli (strain K12) (see 16 papers)
P00909 phosphoribosylanthranilate isomerase (EC 5.3.1.24) from Escherichia coli (see 2 papers)
    32% identity, 80% coverage of query (99.0 bits)

1piiA / P00909 Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from escherichia coli refined at 2.0 angstroms resolution (see paper)
    32% identity, 80% coverage of query (99.0 bits)

1jcmP Trpc stability mutant containing an engineered disulphide bridge and in complex with a cdrp-related substrate
    32% identity, 80% coverage of query (97.8 bits)

4iwwA Computational design of an unnatural amino acid metalloprotein with atomic level accuracy
    32% identity, 76% coverage of query (96.3 bits)

6nw4A Evolution of a computationally designed kemp eliminase
    31% identity, 73% coverage of query (92.4 bits)

7etxA / P06560 Crystal structure of bifunctional indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpc) from corynebacterium glutamicum (see paper)
    31% identity, 86% coverage of query (87.8 bits)

7etyA Crystal structure of bifunctional indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpc) from corynebacterium glutamicum in complex with reduced 1-(o-carboxyphenylamino)-1- deoxyribulose 5-phosphate (rcdrp)
    31% identity, 86% coverage of query (87.8 bits)

trpC / Q56319 indole-3-glycerol phosphate synthase (EC 4.1.1.48) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    31% identity, 72% coverage of query (84.3 bits)

5k7jA Structure of designed zinc binding protein ze2 bound to zn2+
    30% identity, 73% coverage of query (82.8 bits)

Build an alignment

Build an alignment for WP_020175535.1 and 28 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

5an7A Structure of the engineered retro-aldolase ra95.5-8f with a bound 1,3- diketone inhibitor
    29% identity, 75% coverage of query (79.3 bits)

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