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Searching for up to 100 curated homologs for WP_025273527.1 NCBI__GCF_000527155.1:WP_025273527.1 (421 a.a.)

Found high-coverage hits (≥70%) to 43 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AK_MYCTU / P9WPX3 Aspartokinase; Aspartate kinase; ASK; EC 2.7.2.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P9WPX3 aspartate kinase (EC 2.7.2.4) from Mycobacterium tuberculosis (see paper)
    68% identity, 100% coverage of query (595 bits)

lysCα / P26512 aspartokinase α subunit (EC 2.7.2.4) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
lysCβ / P26512 aspartokinase β subunit (EC 2.7.2.4) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
AK_CORGL / P26512 Aspartokinase; Aspartate kinase; EC 2.7.2.4 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see 2 papers)
P26512 aspartate kinase (EC 2.7.2.4) from Corynebacterium glutamicum (see 2 papers)
lysC aspartate kinase 2; EC 2.7.2.4 from Corynebacterium glutamicum (see 3 papers)
    69% identity, 100% coverage of query (574 bits)

AK_CORFL / P41398 Aspartokinase; Aspartate kinase; EC 2.7.2.4 from Corynebacterium flavescens (see paper)
lysC / GB|AAA23293.1 aspartate kinase; EC 2.7.2.4 from Corynebacterium flavescens (see paper)
    69% identity, 100% coverage of query (572 bits)

3aawC / P26512 Crystal structure of aspartate kinase from corynebacterium glutamicum in complex with lysine and threonine (see paper)
    66% identity, 97% coverage of query (516 bits)

3ab4A / P26512 Crystal structure of feedback inhibition resistant mutant of aspartate kinase from corynebacterium glutamicum in complex with lysine and threonine (see paper)
    62% identity, 97% coverage of query (471 bits)

AK_PSEPK / Q88EI9 Aspartate kinase; Aspartokinase; EC 2.7.2.4 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    48% identity, 97% coverage of query (386 bits)

O69077 aspartate kinase (EC 2.7.2.4) from Pseudomonas aeruginosa (see paper)
    48% identity, 97% coverage of query (386 bits)

AKLYS_STUS1 / A4VJB4 Aspartate kinase Ask_LysC; Aspartokinase; EC 2.7.2.4 from Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri) (see paper)
    49% identity, 97% coverage of query (385 bits)

AK_PSEFS / C3JXY0 Aspartate kinase; Aspartokinase; EC 2.7.2.4 from Pseudomonas fluorescens (strain SBW25) (see 2 papers)
    48% identity, 97% coverage of query (375 bits)

5yeiC / O69077 Mechanistic insight into the regulation of pseudomonas aeruginosa aspartate kinase (see paper)
    47% identity, 96% coverage of query (372 bits)

AK_THETH / P61489 Aspartokinase; Aspartate kinase; AK; ASK; Threonine-sensitive AK; ThrA; EC 2.7.2.4 from Thermus thermophilus (see 4 papers)
P61489 aspartate kinase (EC 2.7.2.4) from Thermus thermophilus (see 3 papers)
    46% identity, 97% coverage of query (357 bits)

AK_THET2 / P61488 Aspartokinase; Aspartate kinase; ASK; EC 2.7.2.4 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see paper)
    46% identity, 97% coverage of query (356 bits)

P74569 aspartate kinase (EC 2.7.2.4) from Synechocystis sp. (see paper)
    47% identity, 96% coverage of query (346 bits)

3l76A / P74569 Crystal structure of aspartate kinase from synechocystis (see paper)
    45% identity, 96% coverage of query (328 bits)

Q9WZ17 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Thermotoga maritima (see paper)
    40% identity, 97% coverage of query (325 bits)

lysCα / P08495 aspartate kinase II α subunit (EC 2.7.2.4) from Bacillus subtilis (strain 168) (see 4 papers)
lysCβ / P08495 aspartate kinase II β subunit (EC 2.7.2.4) from Bacillus subtilis (strain 168) (see 4 papers)
AK2_BACSU / P08495 Aspartokinase 2; Aspartate kinase 2; Aspartokinase II; EC 2.7.2.4 from Bacillus subtilis (strain 168) (see 2 papers)
P08495 aspartate kinase (EC 2.7.2.4) from Bacillus subtilis (see paper)
lysC / GB|CAA99580.1 aspartate kinase 2; EC 2.7.2.4 from Bacillus subtilis (see paper)
    44% identity, 98% coverage of query (322 bits)

dapG / Q04795 aspartokinase I (alpha and beta subunits) (EC 2.7.2.4) from Bacillus subtilis (strain 168) (see 6 papers)
    37% identity, 97% coverage of query (214 bits)

dapG aspartate kinase 1; EC 2.7.2.4 from Bacillus subtilis (see paper)
    37% identity, 97% coverage of query (214 bits)

3c1mC / Q57991 Cyrstal structure of threonine-sensitive aspartokinase from methanococcus jannaschii with mgamp-pnp and l-aspartate (see paper)
    34% identity, 81% coverage of query (194 bits)

2hmfA Structure of a threonine sensitive aspartokinase from methanococcus jannaschii complexed with mg-adp and aspartate
    34% identity, 81% coverage of query (194 bits)

Q57991 aspartate kinase (EC 2.7.2.4) from Methanocaldococcus jannaschii (see 2 papers)
    33% identity, 81% coverage of query (192 bits)

3c1nA Crystal structure of allosteric inhibition threonine-sensitive aspartokinase from methanococcus jannaschii with l-threonine
    34% identity, 81% coverage of query (191 bits)

Q5JK18 aspartate kinase (EC 2.7.2.4) from Oryza sativa Japonica Group (see paper)
    30% identity, 95% coverage of query (164 bits)

Q9RUL9 aspartate kinase (EC 2.7.2.4) from Deinococcus radiodurans (see paper)
    36% identity, 82% coverage of query (163 bits)

Build an alignment

Build an alignment for WP_025273527.1 and 24 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

AK2_ARATH / O23653 Aspartokinase 2, chloroplastic; Aspartate kinase 2; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O23653 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see 2 papers)
    28% identity, 95% coverage of query (154 bits)

AK3 / Q9S702 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see paper)
AK3_ARATH / Q9S702 Aspartokinase 3, chloroplastic; Aspartate kinase 3; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9S702 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see 2 papers)
    28% identity, 99% coverage of query (150 bits)

2cdqA / Q9LYU8 Crystal structure of arabidopsis thaliana aspartate kinase complexed with lysine and s- adenosylmethionine (see paper)
    29% identity, 96% coverage of query (147 bits)

AK1_ARATH / Q9LYU8 Aspartokinase 1, chloroplastic; Aspartate kinase 1; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9LYU8 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see 2 papers)
    28% identity, 96% coverage of query (144 bits)

ThrD / b0002 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
thrA / P00561 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 33 papers)
P00561 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Escherichia coli (see paper)
    30% identity, 80% coverage of query (139 bits)

AAA16972.1 aspartokinase-homoserine dehydrogenase, partial from Daucus carota (see paper)
    30% identity, 99% coverage of query (137 bits)

AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    28% identity, 99% coverage of query (135 bits)

AKH1_ARATH / Q9SA18 Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic; AK-HD 1; AK-HSDH 1; Beta-aspartyl phosphate homoserine 1; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    28% identity, 96% coverage of query (133 bits)

CA265_RS23475 aspartate kinase; homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Pedobacter sp. GW460-11-11-14-LB5
    28% identity, 95% coverage of query (133 bits)

O63067 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max (see paper)
    30% identity, 81% coverage of query (131 bits)

AK_YEAST / P10869 Aspartokinase; Aspartate kinase; EC 2.7.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P10869 aspartate kinase (EC 2.7.2.4) from Saccharomyces cerevisiae (see paper)
    28% identity, 81% coverage of query (126 bits)

yclM / P94417 aspartate kinase III (EC 2.7.2.4) from Bacillus subtilis (strain 168) (see 4 papers)
AK3_BACSU / P94417 Aspartokinase 3; Aspartate kinase 3; Aspartokinase III; EC 2.7.2.4 from Bacillus subtilis (strain 168) (see paper)
    26% identity, 89% coverage of query (120 bits)

Echvi_2000 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Echinicola vietnamensis KMM 6221, DSM 17526
    26% identity, 95% coverage of query (117 bits)

BT2403 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Bacteroides thetaiotaomicron VPI-5482
    26% identity, 95% coverage of query (111 bits)

FUB3_GIBM7 / W7MS01 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4 from Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) (see 10 papers)
    27% identity, 80% coverage of query (102 bits)

O60163 Probable aspartokinase; Aspartate kinase; EC 2.7.2.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    27% identity, 81% coverage of query (101 bits)

Q97MC0 aspartate kinase (EC 2.7.2.4) from Clostridium acetobutylicum (see paper)
    24% identity, 96% coverage of query (97.1 bits)

ABZR86_RS19560 aspartate kinase / diaminopimelate decarboxylase (EC 4.1.1.20; EC 2.7.2.4) from Dyella japonica UNC79MFTsu3.2
    25% identity, 95% coverage of query (89.7 bits)

MetM / b3940 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
metL / P00562 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 9 papers)
    27% identity, 95% coverage of query (74.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory