Searching for up to 100 curated homologs for WP_026125978.1 NCBI__GCF_002263495.1:WP_026125978.1 (350 a.a.)
Found high-coverage hits (≥70%) to 94 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YOAD_BACSU / O34815 Putative 2-hydroxyacid dehydrogenase YoaD; EC 1.1.1.- from Bacillus subtilis (strain 168) (see paper)
37% identity, 79% coverage of query (186 bits)
1wwkA / O50095 Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
36% identity, 81% coverage of query (170 bits)
HPR_THEMA / Q9X1C1 Hydroxypyruvate reductase; HPR; EC 1.1.1.81 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
39% identity, 75% coverage of query (166 bits)
serA / GB|AAC83943.1 phosphoglycerate dehydrogenase; EC 1.1.1.95 from Bacillus subtilis (see paper)
serA / AAC83943.1 phosphoglycerate dehydrogenase from Bacillus subtilis (see 3 papers)
36% identity, 77% coverage of query (162 bits)
HPR_BLAHS / C0CMQ8 Hydroxypyruvate reductase; EC 1.1.1.81 from Blautia hydrogenotrophica (strain DSM 10507 / JCM 14656 / S5a33) (Ruminococcus hydrogenotrophicus) (see paper)
31% identity, 79% coverage of query (161 bits)
PHGDH / O43175 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 3 papers)
SERA_HUMAN / O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 7 papers)
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 8 papers)
32% identity, 84% coverage of query (157 bits)
SERA_MOUSE / Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95 from Mus musculus (Mouse) (see paper)
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mus musculus (see 2 papers)
32% identity, 84% coverage of query (155 bits)
Q9Z564 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Streptomyces coelicolor (see paper)
36% identity, 83% coverage of query (155 bits)
Phgdh / O08651 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95) from Rattus norvegicus (see paper)
SERA_RAT / O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95 from Rattus norvegicus (Rat) (see paper)
O08651 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Rattus norvegicus (see paper)
33% identity, 84% coverage of query (154 bits)
H9JRZ9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Bombyx mori (see paper)
32% identity, 82% coverage of query (154 bits)
7dkmA / O43175 Phgdh covalently linked to oridonin (see paper)
33% identity, 79% coverage of query (153 bits)
6plfA Crystal structure of human phgdh complexed with compound 1
33% identity, 79% coverage of query (153 bits)
6rj2A Crystal structure of phgdh in complex with compound 40
33% identity, 79% coverage of query (153 bits)
6plgA Crystal structure of human phgdh complexed with compound 15
33% identity, 79% coverage of query (153 bits)
6rj5A Crystal structure of phgdh in complex with compound 39
33% identity, 79% coverage of query (153 bits)
7ewhA Crystal structure of human phgdh in complex with homoharringtonine
33% identity, 79% coverage of query (153 bits)
6rihA Crystal structure of phgdh in complex with compound 9
33% identity, 79% coverage of query (153 bits)
6rj3A Crystal structure of phgdh in complex with compound 15
33% identity, 79% coverage of query (153 bits)
6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution
33% identity, 79% coverage of query (153 bits)
3ddnB Crystal structure of hydroxypyruvic acid phosphate bound d-3- phosphoglycerate dehydrogenase in mycobacterium tuberculosis
40% identity, 77% coverage of query (151 bits)
5aovA / Q8U3Y2 Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
34% identity, 82% coverage of query (150 bits)
3dc2A / P9WNX3 Crystal structure of serine bound d-3-phosphoglycerate dehydrogenase from mycobacterium tuberculosis (see paper)
40% identity, 77% coverage of query (150 bits)
Q8U3Y2 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus furiosus (see paper)
34% identity, 82% coverage of query (150 bits)
P9WNX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mycobacterium tuberculosis (see 5 papers)
40% identity, 77% coverage of query (150 bits)
hprA / Q59516 hydroxypyruvate reductase subunit (EC 1.1.1.81) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see 2 papers)
35% identity, 76% coverage of query (149 bits)
A0A2R6X868 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Marchantia polymorpha (see paper)
39% identity, 71% coverage of query (147 bits)
6plfB Crystal structure of human phgdh complexed with compound 1
33% identity, 76% coverage of query (147 bits)
6biiA / F8AEA4 Crystal structure of pyrococcus yayanosii glyoxylate hydroxypyruvate reductase in complex with NADP and malonate (re-refinement of 5aow) (see paper)
36% identity, 82% coverage of query (142 bits)
F8AEA4 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus yayanosii (see paper)
36% identity, 82% coverage of query (142 bits)
GYAR_THELN / Q9C4M5 Glyoxylate reductase; EC 1.1.1.26 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
Q9C4M5 glyoxylate reductase (EC 1.1.1.26) from Thermococcus litoralis (see paper)
33% identity, 81% coverage of query (141 bits)
A0A1Z4EAX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris (see paper)
35% identity, 74% coverage of query (137 bits)
hprA / P73821 glycerate dehydrogenase (EC 1.1.1.29) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
33% identity, 81% coverage of query (137 bits)
SERA1_ARATH / O49485 D-3-phosphoglycerate dehydrogenase 1, chloroplastic; Protein EMBRYO SAC DEVELOPMENT ARREST 9; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O49485 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 4 papers)
38% identity, 70% coverage of query (137 bits)
SERA2_ARATH / O04130 D-3-phosphoglycerate dehydrogenase 2, chloroplastic; PGDH; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O04130 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 3 papers)
33% identity, 81% coverage of query (137 bits)
Build an alignment for WP_026125978.1 and 34 homologs with ≥ 30% identity
Or download the sequences
2eklA / Q972A9 Structure of st1218 protein from sulfolobus tokodaii
29% identity, 76% coverage of query (137 bits)
Q972A9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Sulfurisphaera tokodaii (see paper)
29% identity, 76% coverage of query (137 bits)
O66939 D-lactate dehydrogenase (EC 1.1.1.28) from Aquifex aeolicus (see paper)
3kb6B / O66939 Crystal structure of d-lactate dehydrogenase from aquifex aeolicus complexed with NAD and lactic acid (see paper)
31% identity, 71% coverage of query (135 bits)
SERA_YEAST / P40054 D-3-phosphoglycerate dehydrogenase 1; 3-PGDH 1; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
30% identity, 83% coverage of query (133 bits)
SER33_YEAST / P40510 D-3-phosphoglycerate dehydrogenase 2; 3-PGDH 2; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
30% identity, 84% coverage of query (132 bits)
O58256 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pyrococcus horikoshii (see paper)
31% identity, 79% coverage of query (132 bits)
Echvi_2777 fused D-3-phosphoglycerate dehydrogenase / phosphoserine phosphatase (EC 1.1.1.95; EC 3.1.3.3) from Echinicola vietnamensis KMM 6221, DSM 17526
28% identity, 78% coverage of query (129 bits)
U3RH61 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Acanthamoeba castellanii (see paper)
31% identity, 80% coverage of query (129 bits)
P87228 Putative D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
29% identity, 83% coverage of query (128 bits)
BPHYT_RS11290 2-ketogluconate 6-phosphate reductase (EC 1.1.1.43) from Burkholderia phytofirmans PsJN
32% identity, 76% coverage of query (125 bits)
1psdA The allosteric ligand site in the vmax-type cooperative enzyme phosphoglycerate dehydrogenase
31% identity, 82% coverage of query (125 bits)
1ybaA The active form of phosphoglycerate dehydrogenase
31% identity, 82% coverage of query (125 bits)
SerA / b2913 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli K-12 substr. MG1655 (see 36 papers)
serA / P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli (strain K12) (see 36 papers)
SERA_ECOLI / P0A9T0 D-3-phosphoglycerate dehydrogenase; PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Escherichia coli (strain K12) (see paper)
C3SVM7 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli (see paper)
P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli (see 7 papers)
serA / RF|NP_417388 D-3-phosphoglycerate dehydrogenase; EC 1.1.1.95 from Escherichia coli K12 (see 5 papers)
31% identity, 82% coverage of query (124 bits)
2p9eA / P0A9T0 Crystal structure of g336v mutant of e.Coli phosphoglycerate dehydrogenase (see paper)
31% identity, 82% coverage of query (124 bits)
4cukA / Q8Z780 Structure of salmonella d-lactate dehydrogenase in complex with nadh
31% identity, 71% coverage of query (121 bits)
7arzA / A9SQZ2 Ternary complex of NAD-dependent formate dehydrogenase from physcomitrium patens
31% identity, 88% coverage of query (120 bits)
4e5kA Thermostable phosphite dehydrogenase in complex with NAD and sulfite
32% identity, 76% coverage of query (116 bits)
O58320 Glyoxylate reductase; EC 1.1.1.26 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
33% identity, 82% coverage of query (114 bits)
2dbqA / O58320 Crystal structure of glyoxylate reductase (ph0597) from pyrococcus horikoshii ot3, complexed with NADP (i41) (see paper)
33% identity, 82% coverage of query (114 bits)
4e5mA Thermostable phosphite dehydrogenase e175a/a176r in complex with NADP
32% identity, 76% coverage of query (114 bits)
4e5pA / O69054 Thermostable phosphite dehydrogenase a176r variant in complex with nad (see paper)
32% identity, 76% coverage of query (114 bits)
6ttbA / A0A0H3JSR9 Crystal structure of NAD-dependent formate dehydrogenase from staphylococcus aureus in complex with NAD
31% identity, 74% coverage of query (114 bits)
6t8zAAA Formate dehydrogenase
34% identity, 88% coverage of query (114 bits)
6t8yBBB / G0SGU4 6t8yBBB (see paper)
34% identity, 85% coverage of query (113 bits)
2gsdA / O08375 NAD-dependent formate dehydrogenase from bacterium moraxella sp.C2 in complex with NAD and azide (see paper)
33% identity, 86% coverage of query (112 bits)
FDH1_YEASC / N1P3Y5 Formate dehydrogenase 1; FDH 1; NAD-dependent formate dehydrogenase 1; EC 1.17.1.9 from Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) (see paper)
FDH1_YEAST / Q08911 Formate dehydrogenase 1; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
31% identity, 76% coverage of query (112 bits)
4prlA Crystal structure of d-lactate dehydrogenase with NAD+ from lactobacillus jensenii (see paper)
31% identity, 73% coverage of query (103 bits)
8j3oB Formate dehydrogenase wild-type enzyme from candida dubliniensis complexed with nadh
28% identity, 77% coverage of query (103 bits)
8bxxAA Formate dehydrogenase
30% identity, 86% coverage of query (103 bits)
8j3oA Formate dehydrogenase wild-type enzyme from candida dubliniensis complexed with nadh
28% identity, 77% coverage of query (103 bits)
FDH_PSESR / P33160 Formate dehydrogenase; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Pseudomonas sp. (strain 101) (Achromobacter parvulus T1) (see 2 papers)
P33160 formate dehydrogenase (EC 1.17.1.9) from Pseudomonas sp. 101 (see paper)
31% identity, 86% coverage of query (103 bits)
2nadA High resolution structures of holo and apo formate dehydrogenase
31% identity, 86% coverage of query (102 bits)
8j3pA / B9WHT3 Formate dehydrogenase mutant from from candida dubliniensis m4 complexed with NADP+ (see paper)
29% identity, 77% coverage of query (102 bits)
3wr5A / Q76EB7 Structural basis on the efficient co2 reduction of acidophilic formate dehydrogenase
31% identity, 86% coverage of query (102 bits)
4xyeA Granulicella m. Formate dehydrogenase (fdh) in complex with NAD(+)
31% identity, 82% coverage of query (102 bits)
4xybA / G8NVB5 Granulicella m. Formate dehydrogenase (fdh) in complex with NADP(+) and nan3 (see paper)
31% identity, 82% coverage of query (102 bits)
GRHPR / Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.81; EC 1.1.1.79) from Homo sapiens (see 2 papers)
GRHPR_HUMAN / Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase; EC 1.1.1.79; EC 1.1.1.81 from Homo sapiens (Human) (see 4 papers)
Q9UBQ7 glyoxylate reductase (EC 1.1.1.26); glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Homo sapiens (see 2 papers)
30% identity, 72% coverage of query (102 bits)
2gcgA / Q9UBQ7 Ternary crystal structure of human glyoxylate reductase/hydroxypyruvate reductase (see paper)
30% identity, 72% coverage of query (102 bits)
6jujA Crystal structure of formate dehydrogenase mutant v198i/c256i/p260s/e261p/s381n/s383f from pseudomonas sp. 101in complex with non-natural cofactor nicotinamide cytosine dinucleotide
31% identity, 86% coverage of query (101 bits)
6d4bA / A0A0A1EQY0 Crystal structure of candida boidinii formate dehydrogenase v123a mutant complexed with NAD+ and azide
30% identity, 77% coverage of query (100 bits)
FDH1 / O13437 formate dehydrogenase (EC 1.17.1.9) from Candida boidinii (see 3 papers)
FDH_CANBO / O13437 Formate dehydrogenase; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Candida boidinii (Yeast) (see 6 papers)
O13437 formate dehydrogenase (EC 1.17.1.9) from [Candida] boidinii (see 12 papers)
fdh3 / CAB54834.1 formate dehydrogenase from [Candida] boidinii (see paper)
30% identity, 77% coverage of query (100 bits)
8oq2A Binding of NADP to a formate dehydrogenase from starkeya novella.
31% identity, 86% coverage of query (100 bits)
4njmA / Q76KF5 Crystal structure of phosphoglycerate bound 3-phosphoglycerate dehydrogenase in entamoeba histolytica (see paper)
26% identity, 78% coverage of query (99.8 bits)
1sc6D / P0A9T0 Crystal structure of w139g d-3-phosphoglycerate dehydrogenase complexed with NAD+ (see paper)
29% identity, 82% coverage of query (99.8 bits)
4njoA Crystal structure of cofactor(NAD+) bound 3-phosphoglycerate dehydrogenase in entamoeba histolytica
26% identity, 78% coverage of query (99.4 bits)
6t9wB / G8NTI5 Crystal structure of formate dehydrogenase fdh2 d222a/q223r enzyme from granulicella mallensis mp5actx8 in complex with NADP and azide.
29% identity, 86% coverage of query (99.4 bits)
5dt9A / Q9KQ92 Crystal structure of a putative d-erythronate-4-phosphate dehydrogenase from vibrio cholerae
30% identity, 88% coverage of query (97.8 bits)
PDXB_PSEAE / Q9I3W9 Erythronate-4-phosphate dehydrogenase; EC 1.1.1.290 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9I3W9 4-phosphoerythronate dehydrogenase (EC 1.1.1.290) from Pseudomonas aeruginosa (see paper)
2o4cA / Q9I3W9 Crystal structure of d-erythronate-4-phosphate dehydrogenase complexed with NAD (see paper)
36% identity, 77% coverage of query (94.0 bits)
3bazA / Q65CJ7 Structure of hydroxyphenylpyruvate reductase from coleus blumei in complex with NADP+ (see paper)
30% identity, 73% coverage of query (92.0 bits)
HPPR / Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see paper)
HPPR_PLESU / Q65CJ7 Hydroxyphenylpyruvate reductase; HPPR; EC 1.1.1.237 from Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides) (see paper)
Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see 2 papers)
hppr / CAD47810.2 hydroxyphenylpyruvate reductase (HPPR) from Plectranthus scutellarioides (see paper)
30% identity, 73% coverage of query (92.0 bits)
6ih6A / G4XDR8 Phosphite dehydrogenase mutant i151r/p176r/m207a from ralstonia sp. 4506 in complex with non-natural cofactor nicotinamide cytosine dinucleotide
30% identity, 72% coverage of query (90.1 bits)
2yq5C / Q1GAA2 Crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase from lactobacillus delbrueckii ssp. Bulgaricus: NAD complexed form (see paper)
28% identity, 74% coverage of query (88.2 bits)
2w2lA / Q7LLW9 Crystal structure of the holo forms of rhodotorula graminis d- mandelate dehydrogenase at 2.5a.
31% identity, 74% coverage of query (87.8 bits)
3oetH / P60802 D-erythronate-4-phosphate dehydrogenase complexed with NAD
27% identity, 85% coverage of query (85.1 bits)
5vg6B / A7IIH0 Crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase from xanthobacter autotrophicus py2 in complex with NADPH and mes.
32% identity, 74% coverage of query (75.5 bits)
5j23A Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with 2'-phospho-adp-ribose
32% identity, 72% coverage of query (74.3 bits)
5v7nA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADP and 2-keto-d-gluconic acid
32% identity, 72% coverage of query (74.3 bits)
5v7gA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADPH and oxalate
32% identity, 72% coverage of query (73.9 bits)
5v6qB / Q92LZ4 Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADP and malonate (see paper)
32% identity, 72% coverage of query (73.9 bits)
6p2iA Acyclic imino acid reductase (bsp5) in complex with NADPH and d-arg (see paper)
23% identity, 83% coverage of query (70.9 bits)
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