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Searching for up to 100 curated homologs for WP_027178500.1 NCBI__GCF_000429985.1:WP_027178500.1 (394 a.a.)

Found high-coverage hits (≥70%) to 76 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4dq6A / Q183G9 Crystal structure of plp-bound putative aminotransferase from clostridium difficile 630
    45% identity, 99% coverage of query (350 bits)

CBL_BACSU / Q08432 Cystathionine beta-lyase PatB; CBL; Beta-cystathionase PatB; Cysteine lyase PatB; Cysteine-S-conjugate beta-lyase PatB; EC 4.4.1.13 from Bacillus subtilis (strain 168) (see paper)
6qp3A / Q08432 Crystal structure of the plp-bound c-s lyase from bacillus subtilis (strain 168) (see paper)
    39% identity, 99% coverage of query (325 bits)

8jujB / Q816F3 Crystal structures of cystathionine beta lyase from bacillus cereus atcc 14579
    39% identity, 98% coverage of query (300 bits)

1c7nA / Q56257 Crystal structure of cystalysin from treponema denticola contains a pyridoxal 5'-phosphate cofactor (see paper)
    40% identity, 100% coverage of query (296 bits)

hly hemolysin from Treponema denticola (see paper)
hly / AAA85439.1 hemolysin from Treponema denticola (see paper)
    41% identity, 100% coverage of query (296 bits)

1c7oA Crystal structure of cystalysin from treponema denticola contains a pyridoxal 5'-phosphate-l-aminoethoxyvinylglycine complex
    40% identity, 100% coverage of query (296 bits)

B9X1L2 L-cysteine desulfidase (EC 4.4.1.28) from Prevotella intermedia (see paper)
    38% identity, 98% coverage of query (293 bits)

lcd / Q8L0M8 cysteine-S-conjugate β-lyase (EC 4.4.1.13) from Streptococcus anginosus (see paper)
    39% identity, 98% coverage of query (292 bits)

3l8aB / Q8DST5 Crystal structure of metc from streptococcus mutans
    39% identity, 98% coverage of query (286 bits)

3b1cA / A6BMJ3 Crystal structure of betac-s lyase from streptococcus anginosus: internal aldimine form (see paper)
    37% identity, 98% coverage of query (285 bits)

3b1eA Crystal structure of betac-s lyase from streptococcus anginosus in complex with l-serine: alpha-aminoacrylate form
    37% identity, 98% coverage of query (285 bits)

3b1dA Crystal structure of betac-s lyase from streptococcus anginosus in complex with l-serine: external aldimine form
    37% identity, 98% coverage of query (285 bits)

7qugA Crystal structure of carbon-sulfur lyase fnapatb1 from fusobacterium nucleatum subspecies animalis in complex with allyl-cysteine (see paper)
    36% identity, 99% coverage of query (255 bits)

A6YH85 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei (see paper)
    35% identity, 97% coverage of query (248 bits)

A0A0U5KG73 L-cysteine desulfidase (EC 4.4.1.28) from Lactobacillus delbrueckii subsp. bulgaricus (see paper)
    34% identity, 91% coverage of query (237 bits)

6qp1B Crystal structure of the plp-bound c-s lyase in the external aldimine form from staphylococcus hominis complexed with an inhibitor, l- cycloserine. (see paper)
    33% identity, 99% coverage of query (231 bits)

5z0qC / B2VJB8 Crystal structure of ovob (see paper)
    33% identity, 99% coverage of query (228 bits)

MalY / b1622 negative regulator of MalT activity/cystathionine β-lyase (EC 4.4.1.13; EC 4.4.1.1; EC 4.4.1.28; EC 5.1.1.1) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
malY / P23256 negative regulator of MalT activity/cystathionine β-lyase (EC 4.4.1.13; EC 4.4.1.1; EC 5.1.1.10) from Escherichia coli (strain K12) (see 18 papers)
MALY_ECOLI / P23256 Protein MalY; EC 4.4.1.13 from Escherichia coli (strain K12) (see 2 papers)
8bobA / P23256 Structural basis for negative regulation of the maltose system (see paper)
malY maltose regulon modulator MalY; EC 4.4.1.8 from Escherichia coli K12 (see 6 papers)
    32% identity, 99% coverage of query (227 bits)

6qp2A Crystal structure of the plp-bound c-s lyase from staphylococcus hominis
    32% identity, 99% coverage of query (226 bits)

A0A223K4L6 cysteine-S-conjugate beta-lyase (EC 4.4.1.13); amino-acid racemase (EC 5.1.1.10) from Latilactobacillus sakei (see paper)
    32% identity, 99% coverage of query (208 bits)

CBL_THET8 / Q5SHW0 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    32% identity, 92% coverage of query (187 bits)

Build an alignment

Build an alignment for WP_027178500.1 and 21 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

CBL_CORGT / Q93QC6 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Corynebacterium glutamicum (Brevibacterium saccharolyticum) (see paper)
    29% identity, 98% coverage of query (155 bits)

Q46061 L-cysteine desulfidase (EC 4.4.1.28) from Corynebacterium glutamicum (see paper)
    28% identity, 86% coverage of query (133 bits)

metC / Q64HC5 cysteine-S-conjugate β-lyase (EC 4.4.1.13) from Corynebacterium striatum (see paper)
CBL_CORST / Q64HC5 Cysteine-S-conjugate beta-lyase; C-S lyase; Cystathionine beta-lyase; CBL; EC 4.4.1.13 from Corynebacterium striatum (see 2 papers)
    25% identity, 99% coverage of query (109 bits)

Q9RAT0 aromatic-amino-acid transaminase (EC 2.6.1.57) from Lactococcus lactis (see paper)
    25% identity, 94% coverage of query (105 bits)

A0A6F8T0V6 aspartate transaminase (EC 2.6.1.1) from Geobacillus sp. MAS1 (see paper)
    26% identity, 92% coverage of query (100 bits)

NOAT_STRMU / Q8DTM1 Asparagine--oxo-acid transaminase; Asparagine:2-oxoglutarate aminotransferase; EC 2.6.1.14 from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see paper)
Q8DTM1 asparagine-oxo-acid transaminase (EC 2.6.1.14) from Streptococcus mutans serotype c (see paper)
    24% identity, 92% coverage of query (99.8 bits)

aspB / GB|CAB14153.1 aspartate transaminase; EC 2.6.1.1 from Bacillus subtilis (see paper)
aspB / AAB38454.1 aspartate aminotransferase from Bacillus subtilis (see paper)
    24% identity, 92% coverage of query (99.0 bits)

1gd9A / O59096 Crystall structure of pyrococcus protein-a1 (see paper)
    22% identity, 92% coverage of query (94.0 bits)

O59096 aromatic-amino-acid transaminase (EC 2.6.1.57) from Pyrococcus horikoshii (see paper)
    22% identity, 92% coverage of query (94.0 bits)

1gdeA Crystal structure of pyrococcus protein a-1 e-form
    22% identity, 92% coverage of query (94.0 bits)

1xi9C / Q9P9M8 Alanine aminotransferase from pyrococcus furiosus pfu-1397077-001
    24% identity, 88% coverage of query (93.6 bits)

aat / Q9P9M8 alanine aminotransferase subunit (EC 2.6.1.2) from Pyrococcus furiosus (see paper)
Q9P9M8 alanine transaminase (EC 2.6.1.2) from Pyrococcus furiosus (see 3 papers)
    24% identity, 88% coverage of query (93.6 bits)

aspC / GB|CAA63799.1 aspartate transaminase; EC 2.6.1.1 from Geobacillus stearothermophilus (see paper)
    24% identity, 93% coverage of query (92.0 bits)

ARAT2_THELN / H3ZPU1 Aromatic-amino-acid aminotransferase 2; ARAT-II; AROAT; EC 2.6.1.57 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
    22% identity, 95% coverage of query (88.6 bits)

PAT_PETHY / E9L7A5 Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase; PhPPA-AT; EC 2.6.1.1; EC 2.6.1.78; EC 2.6.1.79 from Petunia hybrida (Petunia) (see 2 papers)
    25% identity, 86% coverage of query (86.3 bits)

5wmhA Arabidopsis thaliana prephenate aminotransferase
    25% identity, 82% coverage of query (85.9 bits)

PAT_ARATH / Q9SIE1 Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase; AtAAT; AtPPA-AT; Protein MATERNAL EFFECT EMBRYO ARREST 17; EC 2.6.1.1; EC 2.6.1.78; EC 2.6.1.79 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q9SIE1 aspartate transaminase (EC 2.6.1.1); aspartate-prephenate aminotransferase (EC 2.6.1.78); glutamate-prephenate aminotransferase (EC 2.6.1.79) from Arabidopsis thaliana (see 4 papers)
    25% identity, 82% coverage of query (85.5 bits)

101251438 / A0A3Q7IS73 2-oxo-4-methylthiobutanoate-glutamine aminotransferase monomer (EC 2.6.1.117) from Solanum lycopersicum (see paper)
    24% identity, 76% coverage of query (85.5 bits)

5wmiA Arabidopsis thaliana prephenate aminotransferase mutant- t84v
    25% identity, 82% coverage of query (85.5 bits)

A0A1D6I5Q5 L-glutamine-4-(methylsulfanyl)-2-oxobutanoate aminotransferase (EC 2.6.1.117) from Zea mays (see paper)
    26% identity, 76% coverage of query (84.7 bits)

patA / P16524 N-acetyl-L,L-diaminopimelate aminotransferase from Bacillus subtilis (strain 168) (see 3 papers)
DAPX_BACSU / P16524 Probable N-acetyl-LL-diaminopimelate aminotransferase; Putative aminotransferase A; EC 2.6.1.- from Bacillus subtilis (strain 168) (see paper)
    23% identity, 91% coverage of query (84.7 bits)

5wmlA / Q9SIE1 Arabidopsis thaliana prephenate aminotransferase mutant- k306a (see paper)
    24% identity, 82% coverage of query (83.6 bits)

aruH / Q9HUI9 L-arginine:pyruvate transaminase subunit (EC 2.6.1.84) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
ARUH_PSEAE / Q9HUI9 Arginine--pyruvate transaminase AruH; EC 2.6.1.84 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HUI9 arginine-pyruvate transaminase (EC 2.6.1.84) from Pseudomonas aeruginosa (see paper)
    23% identity, 92% coverage of query (80.5 bits)

ATTY_CAEEL / Q93703 Tyrosine aminotransferase; TAT; L-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5 from Caenorhabditis elegans (see 3 papers)
    22% identity, 80% coverage of query (80.5 bits)

Tat / P04694 tyrosine aminotransferase subunit (EC 2.6.1.1) from Rattus norvegicus (see 10 papers)
ATTY_RAT / P04694 Tyrosine aminotransferase; TAT; L-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5 from Rattus norvegicus (Rat) (see 2 papers)
    23% identity, 79% coverage of query (79.7 bits)

Q8YMS6 aspartate transaminase (EC 2.6.1.1) from Nostoc sp. (see paper)
    23% identity, 84% coverage of query (79.3 bits)

8wkjA / A0A130QXX8 The crystal structure of aspartate aminotransferases lpg0070 from legionella pneumophila (see paper)
    22% identity, 91% coverage of query (79.0 bits)

TAT / P17735 Tyrosine aminotransferase (EC 2.6.1.1) from Homo sapiens (see 2 papers)
ATTY_HUMAN / P17735 Tyrosine aminotransferase; TAT; L-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5 from Homo sapiens (Human) (see 3 papers)
    21% identity, 78% coverage of query (79.0 bits)

3dydA / P17735 Human tyrosine aminotransferase
    21% identity, 78% coverage of query (78.6 bits)

ATTY_MOUSE / Q8QZR1 Tyrosine aminotransferase; TAT; L-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5 from Mus musculus (Mouse) (see paper)
Q8QZR1 tyrosine transaminase (EC 2.6.1.5) from Mus musculus (see paper)
    23% identity, 78% coverage of query (76.3 bits)

AAT_MUSP7 / C6C2Z3 Aspartate aminotransferase; AAT; AspAT; EC 2.6.1.1 from Musicola paradisiaca (strain Ech703) (Dickeya paradisiaca) (Dickeya dadantii) (see paper)
    22% identity, 93% coverage of query (74.3 bits)

YbdL / b0600 methionine transaminase (EC 2.6.1.88) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ybdL / P77806 methionine transaminase (EC 2.6.1.88) from Escherichia coli (strain K12) (see 3 papers)
YBDL_ECOLI / P77806 Methionine aminotransferase; Methionine-oxo-acid transaminase; EC 2.6.1.88 from Escherichia coli (strain K12) (see paper)
P77806 methionine transaminase (EC 2.6.1.88) from Escherichia coli (see paper)
ybdL / MB|P77806 aminotransferase ybdL; EC 2.6.1.- from Escherichia coli K12 (see 5 papers)
    22% identity, 78% coverage of query (73.9 bits)

1u08A / P77806 Crystal structure and reactivity of ybdl from escherichia coli identify a methionine aminotransferase function. (see paper)
    22% identity, 78% coverage of query (73.9 bits)

mfnC / Q58097 2-furaldehyde phosphate aminotransferase (EC 2.6.1.108) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
MFNC_METJA / Q58097 (5-formylfuran-3-yl)methyl phosphate transaminase; 4-HFC-P:alanine aminotransferase; EC 2.6.1.108 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 2 papers)
Q58097 (5-formylfuran-3-yl)methyl phosphate transaminase (EC 2.6.1.108) from Methanocaldococcus jannaschii (see paper)
    24% identity, 91% coverage of query (72.4 bits)

6f77A / Q02635 Crystal structure of the prephenate aminotransferase from rhizobium meliloti (see paper)
    22% identity, 91% coverage of query (65.9 bits)

AAPAT_RHIME / Q02635 Aspartate/prephenate aminotransferase; AspAT / PAT; Transaminase A; EC 2.6.1.1; EC 2.6.1.79 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see 4 papers)
Q02635 aspartate transaminase (EC 2.6.1.1); aspartate-prephenate aminotransferase (EC 2.6.1.78); glutamate-prephenate aminotransferase (EC 2.6.1.79) from Sinorhizobium meliloti (see 2 papers)
aatA / AAA26245.1 aspartate aminotransferase from Sinorhizobium meliloti (see paper)
    22% identity, 91% coverage of query (65.9 bits)

5yhvB Crystal structure of an aminotransferase from mycobacterium tuberculosis
    21% identity, 92% coverage of query (65.9 bits)

5yhvA / P96847 Crystal structure of an aminotransferase from mycobacterium tuberculosis
    21% identity, 81% coverage of query (65.5 bits)

AVTA_MYCTU / P96847 Valine--pyruvate aminotransferase; Alanine--valine transaminase; EC 2.6.1.66 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    21% identity, 81% coverage of query (65.5 bits)

2o1bA / Q2FV61 Structure of aminotransferase from staphylococcus aureus
    22% identity, 93% coverage of query (63.2 bits)

1o4sB / Q9X0Y2 Crystal structure of aspartate aminotransferase (tm1255) from thermotoga maritima at 1.90 a resolution (see paper)
    23% identity, 93% coverage of query (62.4 bits)

6l1oB Product bound bacf structure from bacillus subtillis
    23% identity, 80% coverage of query (61.2 bits)

6l1lB / P39643 Apo-bacf structure from bacillus subtillis (see paper)
    23% identity, 80% coverage of query (61.2 bits)

6l1nA Substrate bound bacf structure from bacillus subtillis
    23% identity, 80% coverage of query (61.2 bits)

SMc04386 2-aminoadipate:2-oxoglutarate aminotransferase (EC 2.6.1.39) from Sinorhizobium meliloti 1021
AAT_RHIME / P58350 Aspartate aminotransferase; AAT; AspAT; Putative 2-aminoadipate transaminase; Transaminase A; EC 2.6.1.1; EC 2.6.1.39 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see 2 papers)
    21% identity, 91% coverage of query (59.7 bits)

8ffuA Structure of gntc, a plp-dependent enzyme catalyzing l-enduracididine biosynthesis from (s)-4-hydroxy-l-arginine, with the substrate bound (see paper)
    22% identity, 78% coverage of query (59.3 bits)

6f35A / P58350 Crystal structure of the aspartate aminotranferase from rhizobium meliloti (see paper)
    21% identity, 91% coverage of query (58.5 bits)

3cbfA Crystal structure of lysn, alpha-aminoadipate aminotransferase, from thermus thermophilus hb27
    22% identity, 77% coverage of query (54.7 bits)

2z1yA Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with n-(5'-phosphopyridoxyl)-l-leucine), from thermus thermophilus hb27
    22% identity, 77% coverage of query (54.7 bits)

2egyA Crystal structure of lysn, alpha-aminoadipate aminotransferase (substrate free form), from thermus thermophilus hb27
    22% identity, 77% coverage of query (54.7 bits)

2x5dD / Q9HV83 Crystal structure of a probable aminotransferase from pseudomonas aeruginosa (see paper)
    22% identity, 80% coverage of query (54.3 bits)

LYSN_THET2 / Q72LL6 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT; EC 2.6.1.39 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 3 papers)
Q72LL6 2-aminoadipate transaminase (EC 2.6.1.39) from Thermus thermophilus (see paper)
2zyjA / Q72LL6 Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with n-(5'-phosphopyridoxyl)-l-glutamate), from thermus thermophilus hb27 (see paper)
    22% identity, 77% coverage of query (54.3 bits)

DAPAT_CHLTR / O84395 LL-diaminopimelate aminotransferase; DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase; EC 2.6.1.83 from Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx) (see 2 papers)
O84395 LL-diaminopimelate aminotransferase (EC 2.6.1.83) from Chlamydia trachomatis (see 2 papers)
    22% identity, 74% coverage of query (52.8 bits)

6hnuB / C4YJ02 Crystal structure of the aminotransferase aro8 from c. Albicans with ligands (see paper)
    22% identity, 76% coverage of query (49.7 bits)

1A16_ARATH / Q9SAR0 1-aminocyclopropane-1-carboxylate synthase 6; ACC synthase 6; S-adenosyl-L-methionine methylthioadenosine-lyase 6; EC 4.4.1.14 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q9SAR0 1-aminocyclopropane-1-carboxylate synthase (EC 4.4.1.14) from Arabidopsis thaliana (see 2 papers)
    24% identity, 77% coverage of query (49.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory