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Searching for up to 100 curated homologs for WP_028314019.1 NCBI__GCF_000429905.1:WP_028314019.1 (428 a.a.)

Found high-coverage hits (≥70%) to 91 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

THLA_SYNWW / Q0AVM3 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; EC 2.3.1.9 from Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) (see paper)
    52% identity, 100% coverage of query (422 bits)

thlA1 / A5N3I5 acetyl-CoA acetyltransferase (EC 2.3.1.16) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) (see 3 papers)
    50% identity, 100% coverage of query (419 bits)

thl / P45359 acetoacetyl-CoA thiolase monomer (EC 2.3.1.16) from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 3 papers)
THLA_CLOAB / P45359 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; CaTHL; EC 2.3.1.9 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W) (see 2 papers)
P45359 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Clostridium acetobutylicum (see paper)
    49% identity, 100% coverage of query (413 bits)

4xl4A / A0A0R4I970 Crystal structure of thiolase from clostridium acetobutylicum in complex with coa (see paper)
    49% identity, 100% coverage of query (409 bits)

PS417_10515 / A0A1N7U0F8 acetyl-CoA C-acetyltransferase (EC 2.3.1.16) from Pseudomonas simiae (see paper)
    48% identity, 100% coverage of query (388 bits)

AO356_21640 acetyl-CoA C-acetyltransferase [EC: 2.3.1.9] from Pseudomonas fluorescens FW300-N2C3
    48% identity, 100% coverage of query (387 bits)

8jg2A / A0A848BQU5 Crystal structure of a biosynthetic thiolase from megasphaera hexanoica soaked with hexanoyl-coa
    49% identity, 100% coverage of query (386 bits)

THIL_ALLVD / P45369 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D) (Chromatium vinosum) (see paper)
    47% identity, 99% coverage of query (380 bits)

THIL_THIVI / P45363 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Thiocystis violacea (see paper)
    47% identity, 99% coverage of query (375 bits)

phaA / Q3IZW1 acetyl-CoA acetyltransferase (EC 2.3.1.16) from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (see paper)
    47% identity, 100% coverage of query (374 bits)

phbA / P14611 acetyl-CoA acetyltransferase subunit (EC 2.3.1.16) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see 4 papers)
THIL_CUPNH / P14611 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see 4 papers)
P14611 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Cupriavidus necator (see paper)
    47% identity, 100% coverage of query (374 bits)

5f38D / P76461 X-ray crystal structure of a thiolase from escherichia coli at 1.8 a resolution (see paper)
    48% identity, 100% coverage of query (370 bits)

AtoB / b2224 acetyl-CoA acetyltransferase (EC 2.3.1.16; EC 2.3.1.9) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
atoB / P76461 acetyl-CoA acetyltransferase (EC 2.3.1.16) from Escherichia coli (strain K12) (see 7 papers)
P76461 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Escherichia coli (see 2 papers)
    48% identity, 100% coverage of query (369 bits)

4o9cC / P14611 Crystal structure of beta-ketothiolase (phaa) from ralstonia eutropha h16 (see paper)
    47% identity, 100% coverage of query (369 bits)

1ou6A / P07097 Biosynthetic thiolase from zoogloea ramigera in complex with acetyl-o- pantetheine-11-pivalate
    47% identity, 99% coverage of query (365 bits)

2vu1A Biosynthetic thiolase from z. Ramigera. Complex of with o-pantheteine- 11-pivalate.
    47% identity, 99% coverage of query (365 bits)

2vu2A Biosynthetic thiolase from z. Ramigera. Complex with s-pantetheine-11- pivalate.
    47% identity, 99% coverage of query (365 bits)

1dm3A Acetylated biosynthetic thiolase from zoogloea ramigera in complex with acetyl-coa
    47% identity, 99% coverage of query (365 bits)

1dlvA Biosynthetic thiolase from zoogloea ramigera in complex with coa
    47% identity, 99% coverage of query (365 bits)

PGA1_c03400 acetyl-CoA:acetyl-CoA C-acetyltransferase / acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase (EC 2.3.1.9; EC 2.3.1.16) from Phaeobacter inhibens BS107
    45% identity, 100% coverage of query (364 bits)

THIL_SHIZO / P07097 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Shinella zoogloeoides (Crabtreella saccharophila) (see 3 papers)
    46% identity, 99% coverage of query (363 bits)

2wkuA Biosynthetic thiolase from z. Ramigera. The n316h mutant.
    47% identity, 99% coverage of query (363 bits)

SMc03879 Acetyl-CoA acetyltransferase (EC 2.3.1.9) from Sinorhizobium meliloti 1021
THIL_RHIME / P50174 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
phbA / AAA90982.1 beta-ketothiolase from Sinorhizobium meliloti (see 2 papers)
    46% identity, 99% coverage of query (362 bits)

5f38B X-ray crystal structure of a thiolase from escherichia coli at 1.8 a resolution
    48% identity, 100% coverage of query (361 bits)

1m1oA Crystal structure of biosynthetic thiolase, c89a mutant, complexed with acetoacetyl-coa
    47% identity, 99% coverage of query (361 bits)

YqeF / b2844 putative acyltransferase from Escherichia coli K-12 substr. MG1655 (see 7 papers)
    44% identity, 100% coverage of query (353 bits)

PfGW456L13_2411 Acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Pseudomonas fluorescens GW456-L13
    44% identity, 100% coverage of query (352 bits)

ACAT2 / Q9BWD1 acetyl-CoA acetyltransferase (EC 2.3.1.16) from Homo sapiens (see 11 papers)
THIC_HUMAN / Q9BWD1 Acetyl-CoA acetyltransferase, cytosolic; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase; EC 2.3.1.9 from Homo sapiens (Human) (see 2 papers)
    44% identity, 99% coverage of query (347 bits)

1wl4A / Q9BWD1 Human cytosolic acetoacetyl-coa thiolase complexed with coa (see paper)
    44% identity, 99% coverage of query (346 bits)

bktB / Q0KBP1 β-ketothiolase (EC 2.3.1.16; EC 2.3.1.9) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
BKTB_CUPNH / Q0KBP1 Beta-ketothiolase BktB; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; EC 2.3.1.16; EC 2.3.1.9 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
Q0KBP1 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Cupriavidus necator (see paper)
bktB / AAC38322.1 beta-ketothiolase from Cupriavidus necator (see paper)
    44% identity, 100% coverage of query (343 bits)

THL_BACSU / P45855 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; EC 2.3.1.9 from Bacillus subtilis (strain 168) (see paper)
    44% identity, 100% coverage of query (333 bits)

7cw5B / Q814S6 Acetyl-coa acetyltransferase from bacillus cereus atcc 14579 (see paper)
    44% identity, 99% coverage of query (323 bits)

SO1677 3-ketoacyl-CoA thiolase [isoleucine degradation] (EC 2.3.1.16) from Shewanella oneidensis MR-1
    42% identity, 100% coverage of query (317 bits)

8gqnA / G3XD40 X-ray structure of thiolase with coa
    43% identity, 99% coverage of query (308 bits)

FADA_BACSU / O32177 3-ketoacyl-CoA thiolase; Acetyl-CoA acyltransferase; Beta-ketothiolase; EC 2.3.1.16 from Bacillus subtilis (strain 168) (see paper)
    43% identity, 100% coverage of query (307 bits)

PfGW456L13_2982 3-ketoacyl-CoA thiolase (EC 2.3.1.16) from Pseudomonas fluorescens GW456-L13
    42% identity, 99% coverage of query (306 bits)

BWI76_RS23710 3-keto-2-deoxy-D-ribonyl-CoA thiolase from Klebsiella michiganensis M5al
    40% identity, 99% coverage of query (303 bits)

Ac3H11_2994 3-ketoacyl-CoA thiolase (EC 2.3.1.16) from Acidovorax sp. GW101-3H11
    40% identity, 99% coverage of query (299 bits)

AO353_25685 acetyl-CoA:acetyl-CoA C-acetyltransferase / acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase (EC 2.3.1.9; EC 2.3.1.16) from Pseudomonas fluorescens FW300-N2E3
    40% identity, 99% coverage of query (295 bits)

mvaE / Q9FD70 acetyl-CoA acetyltransferase/HMG-CoA reductase (EC 1.1.1.34; EC 2.3.1.16) from Enterococcus faecalis (see 2 papers)
    41% identity, 100% coverage of query (294 bits)

ERG10_SCHPO / Q9UQW6 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Ergosterol biosynthesis protein 10; EC 2.3.1.9 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    39% identity, 100% coverage of query (293 bits)

6bn2A / A0A077EEP0 Crystal structure of acetyl-coa acetyltransferase from elizabethkingia anophelis nuhp1
    39% identity, 100% coverage of query (291 bits)

ACAT1 / P24752 acetyl-CoA acetyltransferase monomer (EC 2.3.1.16) from Homo sapiens (see 11 papers)
THIL_HUMAN / P24752 Acetyl-CoA acetyltransferase, mitochondrial; Acetoacetyl-CoA thiolase; T2; EC 2.3.1.9 from Homo sapiens (Human) (see 6 papers)
    41% identity, 100% coverage of query (291 bits)

2ib8D / P24752 Crystallographic and kinetic studies of human mitochondrial acetoacetyl-coa thiolase (t2): the importance of potassium and chloride for its structure and function (see paper)
    41% identity, 100% coverage of query (290 bits)

Q86AD9 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Dictyostelium discoideum (see paper)
    39% identity, 100% coverage of query (290 bits)

AACT1_ARATH / Q9FIK7 Acetyl-CoA acetyltransferase 1; Acetoacetyl-CoA thiolase 1; Thiolase 1; EC 2.3.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9FIK7 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Arabidopsis thaliana (see paper)
    40% identity, 100% coverage of query (288 bits)

7feaB / A0A7U5Y2I6 Py14 in complex with col-d (see paper)
    39% identity, 100% coverage of query (287 bits)

B7XEI5 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Ostrinia scapulalis (see paper)
    37% identity, 100% coverage of query (283 bits)

pcaF / Q0K4S3 3-oxoadipyl-CoA thiolase (EC 2.3.1.174) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
    39% identity, 100% coverage of query (283 bits)

2f2sA Human mitochondrial acetoacetyl-coa thiolase
    41% identity, 100% coverage of query (283 bits)

6aqpA Aspergillus fumigatus cytosolic thiolase: acetylated enzyme in complex with coa and potassium ions
    40% identity, 99% coverage of query (282 bits)

ER10B_GIBZE / I1RY81 Acetyl-CoA acetyltransferase ERG10, cytosolic; Acetoacetyl-CoA thiolase ERG10; ACAT; Cytosolic thiolase ERG10; CT; Ergosterol biosynthesis protein 10; EC 2.3.1.9 from Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum) (see paper)
    39% identity, 99% coverage of query (281 bits)

7ei4A Crystal structure of masl in complex with a novel covalent inhibitor, collimonin c
    38% identity, 100% coverage of query (280 bits)

ER10B_ASPFC / B0YA65 Acetyl-CoA acetyltransferase erg10B, cytosolic; Acetoacetyl-CoA thiolase erg10B; ACAT; Cytosolic thiolase erg10B; CT; Ergosterol biosynthesis protein 10B; EC 2.3.1.9 from Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10) (Neosartorya fumigata) (see 4 papers)
ER10B_ASPFU / Q4WCL5 Acetyl-CoA acetyltransferase erg10B, cytosolic; Acetoacetyl-CoA thiolase erg10B; ACAT; Cytosolic thiolase erg10B; CT; Ergosterol biosynthesis protein 10B; EC 2.3.1.9 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 2 papers)
    40% identity, 99% coverage of query (279 bits)

6aqpC / Q4WCL5 Aspergillus fumigatus cytosolic thiolase: acetylated enzyme in complex with coa and potassium ions
    40% identity, 99% coverage of query (279 bits)

ERG10 / P41338 Erg10 (EC 2.3.1.16) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
ERG10_YEAST / P41338 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Ergosterol biosynthesis protein 10; EC 2.3.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
P41338 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Saccharomyces cerevisiae (see paper)
    41% identity, 99% coverage of query (278 bits)

ER10A_ASPFC / B0XMC1 Acetyl-CoA acetyltransferase erg10A, mitochondrial; Acetoacetyl-CoA thiolase erg10A; Ergosterol biosynthesis protein 10A; EC 2.3.1.9 from Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10) (Neosartorya fumigata) (see paper)
ER10A_ASPFU / Q4WLA8 Acetyl-CoA acetyltransferase erg10A, mitochondrial; Acetoacetyl-CoA thiolase erg10A; Ergosterol biosynthesis protein 10A; EC 2.3.1.9 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
B0XMC1 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Aspergillus fumigatus (see paper)
    39% identity, 100% coverage of query (275 bits)

6l2cA / B0XMC1 Crystal structure of aspergillus fumigatus mitochondrial acetyl-coa acetyltransferase in complex with coa (see paper)
    39% identity, 100% coverage of query (274 bits)

A0R1Y7 Probable acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; EC 2.3.1.9 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    38% identity, 99% coverage of query (273 bits)

ACAA2 / P42765 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) from Homo sapiens (see paper)
THIM_HUMAN / P42765 3-ketoacyl-CoA thiolase, mitochondrial; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; Acyl-CoA hydrolase, mitochondrial; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase; T1; EC 2.3.1.16; EC 2.3.1.9; EC 3.1.2.-; EC 3.1.2.1; EC 3.1.2.2 from Homo sapiens (Human) (see 2 papers)
P42765 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Homo sapiens (see 2 papers)
    36% identity, 100% coverage of query (270 bits)

4c2jD / P42765 Crystal structure of human mitochondrial 3-ketoacyl-coa thiolase in complex with coa (see paper)
    36% identity, 100% coverage of query (270 bits)

5bz4K / A0QUH3 Crystal structure of a t1-like thiolase (coa-complex) from mycobacterium smegmatis (see paper)
    36% identity, 100% coverage of query (266 bits)

6pccA Crystal structure of beta-ketoadipyl-coa thiolase mutant (h356a) in complex hexanoyl coenzyme a
    37% identity, 100% coverage of query (263 bits)

6pcbA / Q88N39 Crystal structure of beta-ketoadipyl-coa thiolase mutant (h356a) in complex with coa (see paper)
    37% identity, 100% coverage of query (263 bits)

ACAA1 / P09110 3-ketoacyl-CoA thiolase, peroxisomal (EC 2.3.1.223; EC 2.3.1.16) from Homo sapiens (see 20 papers)
THIK_HUMAN / P09110 3-ketoacyl-CoA thiolase, peroxisomal; Acetyl-CoA C-myristoyltransferase; Acetyl-CoA acyltransferase; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolase; EC 2.3.1.16; EC 2.3.1.155; EC 2.3.1.9 from Homo sapiens (Human) (see 2 papers)
    38% identity, 99% coverage of query (261 bits)

THILH_CAEEL / Q22100 Acetyl-CoA acetyltransferase homolog, mitochondrial; 3-ketoacyl-CoA thiolase; EC 2.3.1.- from Caenorhabditis elegans (see 3 papers)
Q22100 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Caenorhabditis elegans (see paper)
    37% identity, 100% coverage of query (255 bits)

2d3tC / P28790 Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form v (see paper)
    42% identity, 85% coverage of query (253 bits)

6pcdA Crystal structure of beta-ketoadipyl-coa thiolase mutant (c90s-h356a) in complex octanoyl coenzyme a
    37% identity, 100% coverage of query (253 bits)

6bjbA / F1KYX0 Crystal structure of acat2-c91s thiolase from ascaris suum in complex with propionyl-coa and nitrate (see paper)
    36% identity, 100% coverage of query (249 bits)

PED1 / Q56WD9 3-ketoacyl-CoA thiolase 2, peroxisomal (EC 2.3.1.16) from Arabidopsis thaliana (see 2 papers)
THIK2_ARATH / Q56WD9 3-ketoacyl-CoA thiolase 2, peroxisomal; Acetyl-CoA acyltransferase 2; Beta-ketothiolase 2; Peroxisomal 3-oxoacyl-CoA thiolase 2; Peroxisome defective protein 1; EC 2.3.1.16 from Arabidopsis thaliana (Mouse-ear cress) (see 13 papers)
Q56WD9 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Arabidopsis thaliana (see 4 papers)
    40% identity, 82% coverage of query (249 bits)

6bjaA / F1L3N8 Crystal structure of acat5 thiolase from ascaris suum in complex with coenzyme a (see paper)
    36% identity, 100% coverage of query (242 bits)

8gqmA / Q9HZQ7 Crystal structure of thiolase complexed with acetyl coenzyme a
    38% identity, 88% coverage of query (221 bits)

8oqmD Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-10
    38% identity, 85% coverage of query (219 bits)

8opyD Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-b-dnq
    37% identity, 85% coverage of query (218 bits)

8oqoC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-49
    38% identity, 85% coverage of query (218 bits)

8oqlC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1
    38% identity, 85% coverage of query (218 bits)

8opuC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with sulfamethoxazole (fragment-b-e1)
    37% identity, 85% coverage of query (216 bits)

8pf8C Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72
    37% identity, 85% coverage of query (216 bits)

8oqsC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-83
    37% identity, 85% coverage of query (216 bits)

8oqpC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-76
    37% identity, 85% coverage of query (216 bits)

4b3iC Crystal structure of mycobacterium tuberculosis fatty acid beta- oxidation complex with coenzymea bound at the hydratase active sites
    37% identity, 85% coverage of query (216 bits)

Y0859_MYCTU / O53871 Putative acyltransferase Rv0859; EC 2.3.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
7o4tD / O53871 Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme with coenzyme a bound at the hydratase, thiolase active sites and possible additional binding site (coa(ech/had)) (see paper)
    37% identity, 85% coverage of query (215 bits)

8opxC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with trehalose (fragment-b-tre)
    37% identity, 85% coverage of query (215 bits)

4ubvA Structure of the 3-ketoacyl-coa thiolase fada5 from m. Tuberculosis with an partially acetylated cysteine in complex with acetyl-coa and coa
    37% identity, 81% coverage of query (189 bits)

fadA5 / I6XHI4 steroid 3-ketoacyl-CoA thiolase monomer (EC 2.3.1.16; EC 2.3.1.176) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
FADA5_MYCTU / I6XHI4 Steroid 3-ketoacyl-CoA thiolase; Acetyl-CoA acetyltransferase FadA5; Beta-ketoacyl-CoA thiolase; EC 2.3.1.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
    37% identity, 81% coverage of query (189 bits)

4ubtA / I6XHI4 Structure of the c93s variant of the 3-ketoacyl-coa thiolase fada5 from m. Tuberculosis in complex with a steroid and coa. (see paper)
    36% identity, 81% coverage of query (185 bits)

Build an alignment

Build an alignment for WP_028314019.1 and 86 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

mvaE / A0A384E138 acetyl-CoA C-acetyltransferase (EC 2.3.1.16) from Methanothermococcus thermolithotrophicus (see paper)
A0A384E138 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Methanothermococcus thermolithotrophicus (see paper)
6esqA / A0A384E138 Structure of the acetoacetyl-coa thiolase/hmg-coa synthase complex from methanothermococcus thermolithotrophicus soaked with acetyl-coa (see paper)
    24% identity, 88% coverage of query (56.6 bits)

NLTP2_CAEEL / G5EDP2 Non-specific lipid-transfer protein-like 2; NSL-TP2; 3-keto-acyl-CoA thiolase; Abnormal dauer formation protein 22; Propanoyl-CoA C-acyltransferase; Protein P-44; EC 2.3.1.176 from Caenorhabditis elegans (see 3 papers)
    22% identity, 80% coverage of query (50.1 bits)

5lotA Crystal structure of scp2 thiolase from leishmania mexicana. Complex of the c123a mutant with acetyl-coa.
    24% identity, 75% coverage of query (46.2 bits)

5lnqA / E9AW84 Crystal structure of scp2 thiolase from leishmania mexicana. Complex of the c123a mutant with acetoacetyl-coa. (see paper)
    24% identity, 75% coverage of query (46.2 bits)

3zbnA Crystal structure of scp2 thiolase from leishmania mexicana. Complex of the c123a mutant with coenzyme a.
    24% identity, 75% coverage of query (46.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory