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Searching for up to 100 curated homologs for WP_028584415.1 NCBI__GCF_000429965.1:WP_028584415.1 (317 a.a.)

Found high-coverage hits (≥70%) to 35 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

GsiC / b0831 glutathione ABC transporter membrane subunit GsiC (EC 7.4.2.10) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
gsiC / P75798 glutathione ABC transporter membrane subunit GsiC (EC 7.4.2.10) from Escherichia coli (strain K12) (see paper)
GSIC_ECOLI / P75798 Glutathione transport system permease protein GsiC from Escherichia coli (strain K12) (see 2 papers)
P75798 ABC-type glutathione transporter (EC 7.4.2.10) from Escherichia coli (see paper)
TC 3.A.1.5.11 / P75798 Inner membrane ABC transporter permease protein yliC, component of Glutathione porter, YliABCD or GsiABCD from Escherichia coli (see 5 papers)
gsiC / GB|ABE06320.1 glutathione ABC transporter, permease protein GsiC from Escherichia coli K12 (see paper)
    34% identity, 99% coverage of query (205 bits)

DPPB_PSEAB / A0A0H2ZGW7 Di/tripeptide transport system permease protein DppB from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
TC 3.A.1.5.39 / W0WN20 Dipeptide transport system permease protein dppB, component of Di- and tri-peptide transporter, DppBCDF with periplasmic substrate binding receptors, A1, A3, A5, A7 and A9, each with differing specificities for peptides from Pseudomonas aeruginosa MH38
    34% identity, 99% coverage of query (185 bits)

NikB / b3477 Ni(2+) ABC transporter membrane subunit NikB from Escherichia coli K-12 substr. MG1655 (see 3 papers)
nikB / P33591 nickel ABC transporter membrane subunit NikB from Escherichia coli (strain K12) (see paper)
TC 3.A.1.5.3 / P33591 NikB aka B3477, component of Nickel porter from Escherichia coli (see 5 papers)
    37% identity, 97% coverage of query (184 bits)

b3543 dipeptide ABC transporter, membrane subunit (DppB) from Escherichia coli BW25113
DppB / b3543 dipeptide ABC transporter membrane subunit DppB (EC 7.4.2.9) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
dppB / P0AEF8 dipeptide ABC transporter membrane subunit DppB (EC 7.4.2.9) from Escherichia coli (strain K12) (see paper)
DPPB_ECOLI / P0AEF8 Dipeptide transport system permease protein DppB from Escherichia coli (strain K12) (see 4 papers)
dppB / GB|AAC76568.1 dipeptide ABC transporter, permease protein DppB from Escherichia coli (see 7 papers)
    33% identity, 98% coverage of query (183 bits)

TC 3.A.1.5.20 / P42062 AppB, component of 5-6 amino acyl oligopeptide transporter AppA-F from Bacillus subtilis (see 3 papers)
    33% identity, 94% coverage of query (177 bits)

TC 3.A.1.5.27 / P45096 Dipeptide transport system permease protein dppB, component of The glutathione uptake porter, DppBCDF with the glutathione binding protein, DppA (GbpA; HbpA). Takes up reduced (GSH) and oxidized (GSSG) but not bulky glutathione S conjugates or glutathione derivatives with C-terminal modifications from Haemophilus influenzae (see 2 papers)
    34% identity, 98% coverage of query (176 bits)

appB / GB|CAB12996.1 oligopeptide ABC transporter, permease protein AppB from Bacillus subtilis (see 2 papers)
    34% identity, 94% coverage of query (175 bits)

PS417_04060 dipeptide ABC transporter, permease component from Pseudomonas simiae WCS417
    33% identity, 98% coverage of query (172 bits)

TC 3.A.1.5.19 / Q2FZR7 OppB, component of The major oligopeptide uptake porter, Opp-3 (of four paralogues, this is the only one that mediates nitrogen nutrition from Staphylococcus aureus (strain NCTC 8325)
    30% identity, 98% coverage of query (168 bits)

TC 3.A.1.5.36 / Q93IU1 BldKC, putative ABC transport system integral membrane protein, component of Peptide transporter encoded adjacent to the putative transport system with TC#3.A.1.5.35 (Akanuma et al. 2011). Induced by exogenous S-adenosylmethionine (SAM) at a concentration of 2muM which also enhanced antibiotic production and inhibited morphological development (Park et al. 2005). SAM can be imported into cells. Mutants in the bldK genes confer resistance to the toxic tripeptide, bialaphos from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    30% identity, 99% coverage of query (160 bits)

OPPB_SALTY / P08005 Oligopeptide transport system permease protein OppB from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
TC 3.A.1.5.1 / P08005 OppB aka STM1745, component of Oligopeptide porter (also takes up amino glycoside antibiotics such as kanamycin, streptomycin and neomycin as well as cell wall-derived peptides such as murein tripeptide). It transports substrate peptides of 2-5 amino acids with highest affinity for tripeptides. Also transports δ-aminolevulinic acid (ALA). [May be regulated by PTS Enzyme INtr-aspartokinase.] ATP-binding to OppDF may result in donation of peptide to OppBC and simultaneous release of OppA from Salmonella typhimurium (see 3 papers)
    33% identity, 98% coverage of query (159 bits)

TC 3.A.1.5.40 / Q7VJ34 Nickel transport system permease protein NikB, component of Nickel uptake porter, NikAB(CD)E from Helicobacter hepaticus (strain ATCC 51449 / 3B1)
    32% identity, 89% coverage of query (156 bits)

TC 3.A.1.5.15 / Q9X269 TM1747, component of Probable mannose/mannoside porter. Induced by beta-mannan (Conners et al., 2005). Regulated by mannose-responsive regulator manR (see paper)
    32% identity, 95% coverage of query (155 bits)

Build an alignment

Build an alignment for WP_028584415.1 and 13 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

TC 3.A.1.5.33 / I0C488 NikB, component of The Nickel (Ni2+) uptake porter, NikABCDE from Staphylococcus aureus subsp. aureus 71193
    28% identity, 99% coverage of query (155 bits)

OppB / b1244 murein tripeptide ABC transporter / oligopeptide ABC transporter inner membrane subunit OppB (EC 7.4.2.6) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
oppB / P0AFH2 murein tripeptide ABC transporter / oligopeptide ABC transporter inner membrane subunit OppB (EC 7.4.2.6) from Escherichia coli (strain K12) (see 3 papers)
OPPB_ECOLI / P0AFH2 Oligopeptide transport system permease protein OppB from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.5.41 / P0AFH2 Oligopeptide transport system permease protein OppB, component of Oligopeptide transporter, OppABCDF/MppA/YgiS from Escherichia coli (strain K12)
oppB / ECOCYC|OPPB-MONOMER oligopeptide transport system permease protein oppB from Escherichia coli K12 (see 6 papers)
    32% identity, 98% coverage of query (154 bits)

NIKB_STAA8 / Q2FYQ5 Nickel import system permease protein NikB from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
    28% identity, 99% coverage of query (153 bits)

Q5V9S1 ABC-type oligopeptide transporter (EC 7.4.2.6) from Vibrio fluvialis (see paper)
TC 3.A.1.5.22 / Q5V9S1 OppB, component of The peptide transporter OppA,B,C,D,F (influences biofilm formation; Lee et al., 2004). Similar to 3.A.1.5.1, OppA is similar to the Vibrio furnissii OppA that provides several functions: hemolysis, antibiotic resistance, and virulence from Vibrio fluvialis (see paper)
    29% identity, 98% coverage of query (153 bits)

TC 3.A.1.5.25 / Q9CIL1 Oligopeptide ABC trasporter permease protein, component of The ABC peptide/signalling peptide transporter. OptA binds peptides of 3-6 aas; OptS binds dipeptides. OptB,C,D are most similar to 3.A.1.5.19 from Lactococcus lactis subsp. lactis (see paper)
    30% identity, 91% coverage of query (150 bits)

SM_b21646 ABC transporter for D-Raffinose, permease component 2 from Sinorhizobium meliloti 1021
    31% identity, 98% coverage of query (150 bits)

OPPB_LACLA / P0A4N7 Oligopeptide transport system permease protein OppB from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) (see paper)
TC 3.A.1.5.10 / P0A4N7 OppB, component of Oligopeptide porter (transports peptides of 4-35) amino acyl residues; di- and tripeptides are not transported; hydrophobic basic peptides are preferred). OppA determines the specificity of the system (Doeven et al., 2004). A large cavity in OppA binds proline-rich peptides preferentially (Berntsson et al., 2009). Two crystal structures of OppA with different nonapeptides show binding in different registers from Lactococcus lactis subsp. lactis (Streptococcus lactis) (see 2 papers)
    30% identity, 98% coverage of query (149 bits)

DPPB_LACLM / A2RI75 Dipeptide transport system permease protein DppB from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
    30% identity, 91% coverage of query (147 bits)

TC 3.A.1.5.4 / O30543 AccD, component of Agrocinopine (an opine)/Agrocin 84 (an antibiotic) porter from Agrobacterium radiobacter (see 3 papers)
    31% identity, 92% coverage of query (144 bits)

TC 3.A.1.5.37 / B1W1M1 Putative peptide ABC transporter permease protein, component of The ABC BldKA-E (SGR_2418-2414) oligopeptide transport system. It controls aerial mycelium formation on glucose media. Probably involved in extracellular peptide signalling (Akanuma et al. 2011).  Probably orthologous to 3.A.1.5.35 from Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
    29% identity, 98% coverage of query (142 bits)

TC 3.A.1.5.2 / P26903 DppB aka DCIAB, component of Dipeptide porter. Also transports δ-aminolevulinic acid (ALA) and heme from Bacillus subtilis (see 2 papers)
    29% identity, 95% coverage of query (142 bits)

TC 3.A.1.5.32 / F0TFS8 Oligopeptide transport protein, component of ABC α-galactoside uptake porter from Lactobacillus acidophilus (strain 30SC)
    27% identity, 98% coverage of query (141 bits)

TC 3.A.1.5.17 / Q92NF0 PrbB, component of The proline betaine uptake porter from Rhizobium meliloti (Sinorhizobium meliloti) (see paper)
    30% identity, 93% coverage of query (141 bits)

TC 3.A.1.5.26 / P66966 Putative peptide transport permease protein Rv1283c/MT1320, component of The glutathione transporter, OppA (Dasgupta et al., 2010). OppA binds glutathione and the nanopeptide, bradykinin. Also regulates cytokine release, apoptosis and the innate immune response of macrophages infected with M. tuberculosis from Mycobacterium tuberculosis (see 2 papers)
    32% identity, 86% coverage of query (134 bits)

Q9ZAS5 ABC-type dipeptide transporter (EC 7.4.2.9) from Streptococcus pyogenes (see paper)
    27% identity, 95% coverage of query (134 bits)

TC 3.A.1.5.12 / Q9X0F6 TM1066, component of Probable rhamnose oligosaccharide porter. Induced by rhamnose (see paper)
    27% identity, 98% coverage of query (130 bits)

CNTB_STAAM / A0A0H3K104 Metal-staphylopine import system permease protein CntB from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
    27% identity, 98% coverage of query (129 bits)

DdpB / b1486 putative D,D-dipeptide ABC transporter membrane subunit DdpB from Escherichia coli K-12 substr. MG1655 (see 3 papers)
DDPB_ECOLI / P77308 Probable D,D-dipeptide transport system permease protein DdpB from Escherichia coli (strain K12) (see paper)
    33% identity, 97% coverage of query (129 bits)

CNTB_STAA8 / Q2FVE8 Metal-staphylopine import system permease protein CntB from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 2 papers)
TC 3.A.1.5.43 / Q2FVE8 Peptide ABC transporter, permease protein, putative, component of The metal-staphylopine (nicotianamine-like metalophore) complex uptake system, CntABCDF from Staphylococcus aureus (strain NCTC 8325)
    27% identity, 98% coverage of query (128 bits)

OPPB_BACSU / P24138 Oligopeptide transport system permease protein OppB; Stage 0 sporulation protein KB from Bacillus subtilis (strain 168) (see 4 papers)
    28% identity, 99% coverage of query (127 bits)

TC 3.A.1.5.16 / Q9WXN7 TM0030, component of β-glucoside porter (Conners et al., 2005). Binds cellobiose, laminaribiose (Nanavati et al. 2006). Regulated by cellobiose-responsive repressor BglR (see paper)
    30% identity, 98% coverage of query (127 bits)

TC 3.A.1.5.23 / Q9F9T6 EppB, component of The Ethylene diamine tetraacetate (EDTA) uptake porter, EppABCD (see 2 papers)
    33% identity, 86% coverage of query (124 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory