Searching for up to 100 curated homologs for WP_028584457.1 NCBI__GCF_000429965.1:WP_028584457.1 (235 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
1ji0A / Q9X0M3 Crystal structure analysis of the abc transporter from thermotoga maritima
58% identity, 100% coverage of query (272 bits)
braG / CAB75552.1 ATPase from Rhizobium leguminosarum bv. viciae (see 2 papers)
55% identity, 99% coverage of query (262 bits)
AZOBR_RS08250 L-proline and D-alanine ABC transporter, ATPase component 2 from Azospirillum brasilense Sp245
56% identity, 99% coverage of query (261 bits)
TC 3.A.1.4.10 / Q8DQH7 ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
53% identity, 100% coverage of query (257 bits)
LivF / b3454 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
LivF / P22731 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.4.1 / P22731 LivF aka B3454, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 4 papers)
livF / GB|AAC76479.2 high-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivF from Escherichia coli K12 (see 5 papers)
53% identity, 100% coverage of query (249 bits)
HSERO_RS00900 L-proline ABC transporter, ATPase component 2 from Herbaspirillum seropedicae SmR1
50% identity, 100% coverage of query (236 bits)
TC 3.A.1.4.8 / P21630 High-affinity branched-chain amino acid transport ATP-binding protein BraG, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
56% identity, 100% coverage of query (235 bits)
Ac3H11_1692 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, ATPase component 2 from Acidovorax sp. GW101-3H11
48% identity, 100% coverage of query (230 bits)
Pf6N2E2_2926 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, ATPase component 2 LivF from Pseudomonas fluorescens FW300-N2E2
53% identity, 100% coverage of query (226 bits)
TC 3.A.1.4.6 / Q8YT15 NatE, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
48% identity, 100% coverage of query (211 bits)
TC 3.A.1.4.11 / Q6N8W2 Branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
44% identity, 100% coverage of query (196 bits)
TC 3.A.1.4.2 / P73650 NatE aka LivF aka SLR1881, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
49% identity, 96% coverage of query (179 bits)
TC 3.A.1.4.9 / Q0S720 ABC branched-chain amino acid transporter, ATP-binding component, component of Uptake transporter, CamABCD of cholate (steroid) metabolites, 1β(2'-propanoate)-3aα-H-4α(3"(R)-hydroxy-3"-propanoate)-7aβ-methylhexahydro-5-indanone and a desaturated analog from Rhodococcus sp. (strain RHA1)
39% identity, 100% coverage of query (177 bits)
TC 3.A.1.4.7 / Q92TN4 Putative branched-chain amino acid uptake ABC transporter ATP-binding protein, component of The protocatechuate (3,4-dihydroxybenzoate) uptake porter, PcaMNVWX from Rhizobium meliloti (strain 1021)
35% identity, 100% coverage of query (141 bits)
TC 3.A.1.4.5 / Q8NRV7 UrtE, component of The high affinity urea/thiourea/hydroxyurea porter from Corynebacterium glutamicum (see paper)
37% identity, 97% coverage of query (139 bits)
TC 3.A.1.4.10 / Q8DQH8 ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
33% identity, 100% coverage of query (132 bits)
lptB / O25417 lipopolysaccharide transport system ATP-binding protein LptB (EC 7.5.2.5) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
35% identity, 94% coverage of query (131 bits)
Pf6N2E2_2925 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, ATPase component 1 LivG from Pseudomonas fluorescens FW300-N2E2
31% identity, 100% coverage of query (129 bits)
TC 3.A.1.4.11 / Q6N8W1 Putative branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
33% identity, 100% coverage of query (127 bits)
TC 3.A.1.4.8 / P21629 High-affinity branched-chain amino acid transport ATP-binding protein BraF, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
30% identity, 100% coverage of query (126 bits)
TC 3.A.1.4.4 / Q9L3S2 UrtE, component of The high-affinity (<1 μM) urea porter (see paper)
37% identity, 93% coverage of query (126 bits)
lptB / Q7CPN9 LPS export ABC transporter ATP-binding protein (EC 7.5.2.5) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 9 papers)
33% identity, 99% coverage of query (124 bits)
PGA1_c12640 D-lactate transporter, ATP-binding component from Phaeobacter inhibens BS107
31% identity, 100% coverage of query (124 bits)
Build an alignment for WP_028584457.1 and 23 homologs with ≥ 30% identity
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LivG / b3455 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivG (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
LivG / P0A9S7 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivG (EC 7.4.2.2) from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.4.1 / P0A9S7 High-affinity branched-chain amino acid transport ATP-binding protein LivG aka B3455, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 4 papers)
29% identity, 100% coverage of query (124 bits)
TC 3.A.1.3.16 / A3ZI83 PEB1C, component of Uptake system for glutamate and aspartate from Campylobacter jejuni subsp. jejuni 84-25
29% identity, 99% coverage of query (122 bits)
lptB / Q2YP14 lipopolysaccharide transport system ATP-binding protein (EC 7.5.2.5) from Brucella abortus (strain 2308) (see paper)
30% identity, 99% coverage of query (122 bits)
E6MYT4 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Neisseria meningitidis serogroup B / serotype 15 (see 2 papers)
31% identity, 99% coverage of query (121 bits)
TC 3.A.1.4.3 / Q8VM83 BraF aka Bra2F, component of General L- (and D-)amino acid uptake porter (transports acidic, basic, polar, semipolar and hydrophobic amino acids). The amino and carboxyl groups do not need to be α since γ-aminobutyric acid (GABA) is a substrate. The system may function with additional binding proteins since L-alanine uptake is not dependent on BraC from Rhizobium leguminosarum (biovar viciae) (see paper)
29% identity, 100% coverage of query (120 bits)
TC 3.A.1.2.24 / O50504 Probable ABC-transport system ATP binding protein, component of XylFGH downstream of characterized transcriptional regulator, ROK7B7 (Sco6008); XylF (Sco6009); XylG (Sco6010); XylH (Sco6011)) from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
33% identity, 90% coverage of query (120 bits)
LptB / b3201 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
LptB / P0A9V1 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli (strain K12) (see 10 papers)
LPTB_ECOLI / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB; EC 7.5.2.- from Escherichia coli (strain K12) (see 5 papers)
P0A9V1 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Escherichia coli (see 3 papers)
TC 1.B.42.1.2 / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB, component of LPS export porin complex, LptBCFG-A-DE, consists of LptD (Omp; OmpA; 784 aas)-LptE (RlpB; 193 aas; O.M. lipoprotein)-LptA (KdsD; YhbN; OstA small; 185 aas periplasmic chaparone protein)-LptB (KdsC; YhbG; 241 aas cytoplasmic ABC-type ATPase)-LptC (YrbK, 199aas;1 N-terminal TMS)- LptFG, part of the ABC transporter. LptDE (1:1 stoichiometry) comprise a two-protein β-barrel-lipoprotein complex in the outer membrane that assembles and exports LPS from Escherichia coli (strain K12)
lptB lipopolysaccharide ABC transporter, ATP-binding protein LptB; EC 3.6.3.- from Escherichia coli K12 (see 9 papers)
32% identity, 99% coverage of query (118 bits)
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
32% identity, 99% coverage of query (118 bits)
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
32% identity, 99% coverage of query (118 bits)
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
32% identity, 99% coverage of query (118 bits)
Ac3H11_1693 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, ATPase component 1 from Acidovorax sp. GW101-3H11
31% identity, 100% coverage of query (117 bits)
6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
32% identity, 100% coverage of query (117 bits)
6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
32% identity, 99% coverage of query (117 bits)
6b89A E. Coli lptb in complex with adp and novobiocin
32% identity, 99% coverage of query (116 bits)
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
32% identity, 99% coverage of query (116 bits)
6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
32% identity, 98% coverage of query (114 bits)
LolD / b1117 lipoprotein release complex - ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 2 papers)
LolD / P75957 lipoprotein release complex - ATP binding subunit from Escherichia coli (strain K12) (see paper)
LOLD_ECOLI / P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
TC 3.A.1.125.1 / P75957 LolD aka B1117, component of Lipoprotein translocation system (translocates lipoproteins from the inner membrane to periplasmic chaperone, LolA, which transfers the lipoproteins to an outer membrane receptor, LolB, which anchors the lipoprotein to the outer membrane of the Gram-negative bacterial cell envelope) (see 1.B.46; Narita et al., 2003; Ito et al., 2006; Watanabe et al., 2007). The structure of ligand-bound LolCDE has been solved (Ito et al., 2006). LolC and LolE each have 4 TMSs (1+3). Unlike most ATP binding cassette transporters mediating the transmembrane flux of substrates, the LolCDE complex catalyzes the extrusion of lipoproteins anchored to the outer leaflet of the inner membrane. The LolCDE complex is unusual in that it can be purified as a liganded form, which is an intermediate of the lipoprotein release reaction (Taniguchi and Tokuda, 2008). LolCDE has been reconstituted from separated subunits from Escherichia coli (see 5 papers)
lolD / GB|BAA35937.2 lipoprotein releasing system, ATP-binding protein; EC 3.6.3.- from Escherichia coli K12 (see 5 papers)
32% identity, 91% coverage of query (107 bits)
7arlD Lolcde in complex with lipoprotein and adp
32% identity, 91% coverage of query (107 bits)
7mdyC Lolcde nucleotide-bound
32% identity, 91% coverage of query (107 bits)
7v8iD / P75957 Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
31% identity, 91% coverage of query (105 bits)
1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
27% identity, 100% coverage of query (104 bits)
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
27% identity, 100% coverage of query (102 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
30% identity, 96% coverage of query (99.8 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
29% identity, 89% coverage of query (99.0 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
30% identity, 91% coverage of query (99.0 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
29% identity, 96% coverage of query (98.6 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
29% identity, 96% coverage of query (98.6 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
29% identity, 96% coverage of query (98.6 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
28% identity, 96% coverage of query (97.4 bits)
FTSE_STRP2 / A0A0H2ZM82 Cell division ATP-binding protein FtsE from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) (see 3 papers)
FTSE_STRR6 / Q8DQH4 Cell division ATP-binding protein FtsE from Streptococcus pneumoniae (strain ATCC BAA-255 / R6) (see paper)
6z4wA / Q8DQH4 Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
32% identity, 91% coverage of query (96.7 bits)
6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution
32% identity, 91% coverage of query (96.7 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
29% identity, 91% coverage of query (96.7 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
27% identity, 95% coverage of query (95.9 bits)
2pclA / O66646 Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
34% identity, 91% coverage of query (95.5 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
32% identity, 91% coverage of query (95.1 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
27% identity, 95% coverage of query (93.6 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
27% identity, 95% coverage of query (93.6 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
27% identity, 95% coverage of query (93.6 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
27% identity, 95% coverage of query (93.2 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
27% identity, 95% coverage of query (93.2 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
27% identity, 95% coverage of query (93.2 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
27% identity, 95% coverage of query (93.2 bits)
8wm7C / Q8YZ76 Cryo-em structure of cyanobacterial nitrate/nitrite transporter nrtbcd in complex with signalling protein pii (see paper)
32% identity, 90% coverage of query (92.0 bits)
8wm7D / Q8YZ75 Cryo-em structure of cyanobacterial nitrate/nitrite transporter nrtbcd in complex with signalling protein pii (see paper)
32% identity, 85% coverage of query (92.0 bits)
8w6iD / P0A9R7 Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
32% identity, 87% coverage of query (91.7 bits)
FtsE / b3463 cell division protein FtsE from Escherichia coli K-12 substr. MG1655 (see 9 papers)
FTSE_ECOLI / P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see 4 papers)
ftsE cell division ATP-binding protein ftsE from Escherichia coli K12 (see 3 papers)
32% identity, 87% coverage of query (91.3 bits)
8w9mC Cryo-em structure of the cyanobacterial nitrate transporter nrtbcd in complex with atp
31% identity, 90% coverage of query (91.3 bits)
8w9mD Cryo-em structure of the cyanobacterial nitrate transporter nrtbcd in complex with atp
32% identity, 85% coverage of query (90.9 bits)
8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
32% identity, 87% coverage of query (90.1 bits)
1f3oA / Q58206 Crystal structure of mj0796 atp-binding cassette (see paper)
28% identity, 93% coverage of query (90.1 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
28% identity, 90% coverage of query (89.7 bits)
1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette
28% identity, 93% coverage of query (89.0 bits)
8tzjA / Q9KVJ5 Cryo-em structure of vibrio cholerae ftse/ftsx complex (see paper)
33% identity, 80% coverage of query (87.0 bits)
6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm)
31% identity, 92% coverage of query (87.0 bits)
ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
30% identity, 84% coverage of query (85.9 bits)
8i6rB / Q9I6C0 Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
30% identity, 94% coverage of query (85.9 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
27% identity, 91% coverage of query (85.9 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
27% identity, 95% coverage of query (85.5 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
29% identity, 84% coverage of query (85.1 bits)
7lkpA Structure of atp-free human abca4
27% identity, 86% coverage of query (85.1 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
28% identity, 84% coverage of query (84.3 bits)
7zdkC If(apo/asym) conformation of cyddc in amp-pnp(cydc)/amp-pnp(cydd) bound state (dataset-8)
33% identity, 96% coverage of query (84.3 bits)
7zdfC If(heme/confined) conformation of cyddc in amp-pnp(cydd) bound state (dataset-4)
33% identity, 96% coverage of query (84.3 bits)
4q9iA P-glycoprotein cocrystallised with qz-ala
31% identity, 92% coverage of query (84.3 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
27% identity, 90% coverage of query (84.3 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
27% identity, 90% coverage of query (84.3 bits)
2olkA Abc protein artp in complex with adp-beta-s
27% identity, 90% coverage of query (84.3 bits)
2oljA Abc protein artp in complex with adp/mg2+
27% identity, 90% coverage of query (84.3 bits)
4xwkA P-glycoprotein co-crystallized with bde-100
31% identity, 92% coverage of query (84.3 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
31% identity, 92% coverage of query (84.3 bits)
7zdaC If(apo/asym) conformation of cyddc in adp+pi(cydc)/atp(cydd) bound state (dataset-2)
33% identity, 96% coverage of query (84.3 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
28% identity, 84% coverage of query (84.3 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
28% identity, 84% coverage of query (84.3 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
31% identity, 92% coverage of query (84.3 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
31% identity, 92% coverage of query (84.3 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
31% identity, 92% coverage of query (84.3 bits)
7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
31% identity, 92% coverage of query (84.0 bits)
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Lawrence Berkeley National Laboratory