Searching for up to 100 curated homologs for WP_029151749.1 NCBI__GCF_000384075.1:WP_029151749.1 (450 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
GSHRP_PEA / P27456 Glutathione reductase, chloroplastic/mitochondrial; GR; GRase; GOR1; EC 1.8.1.7 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
51% identity, 99% coverage of query (462 bits)
P42770 glutathione-disulfide reductase (EC 1.8.1.7) from Arabidopsis thaliana (see 2 papers)
51% identity, 99% coverage of query (456 bits)
GB|AAC43334 glutathione reductase; EC 1.8.1.7 from Burkholderia cepacia (see paper)
49% identity, 99% coverage of query (451 bits)
P48642 glutathione-disulfide reductase (EC 1.8.1.7) from Oryza sativa (see 2 papers)
51% identity, 99% coverage of query (447 bits)
A8CCK8 glutathione-disulfide reductase (EC 1.8.1.7) from Hordeum vulgare (see paper)
50% identity, 99% coverage of query (447 bits)
A8CCK2 glutathione-disulfide reductase (EC 1.8.1.7) from Hordeum vulgare (see paper)
49% identity, 99% coverage of query (444 bits)
A0A068EUE1 glutathione-disulfide reductase (EC 1.8.1.7) from Cenchrus americanus (see paper)
50% identity, 98% coverage of query (435 bits)
3o0hB / A0A0H3LWY9 Crystal structure of glutathione reductase from bartonella henselae
48% identity, 99% coverage of query (429 bits)
4dnaA / Q92PC0 Crystal structure of putative glutathione reductase from sinorhizobium meliloti 1021
52% identity, 99% coverage of query (427 bits)
GSHRC_BRARP / O04955 Glutathione reductase, cytosolic; GR; GRase; EC 1.8.1.7 from Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis) (see paper)
49% identity, 99% coverage of query (424 bits)
D5LPR3 glutathione-disulfide reductase (EC 1.8.1.7) from Hevea brasiliensis (see paper)
48% identity, 99% coverage of query (417 bits)
GASHR_MARGR / D0VWY5 Glutathione amide reductase; GAR; EC 1.8.1.16 from Marichromatium gracile (Chromatium gracile) (see 2 papers)
44% identity, 100% coverage of query (384 bits)
2rabA Structure of glutathione amide reductase from chromatium gracile in complex with NAD
44% identity, 99% coverage of query (382 bits)
2r9zB / D0VWY5 Glutathione amide reductase from chromatium gracile (see paper)
44% identity, 99% coverage of query (379 bits)
Q7XEM9 glutathione-disulfide reductase (EC 1.8.1.7) from Oryza sativa (see paper)
48% identity, 81% coverage of query (350 bits)
Q389T8 trypanothione-disulfide reductase (EC 1.8.1.12) from Trypanosoma brucei brucei (see paper)
6btlA / Q389T8 Crystal structure of trypanothione reductase from trypanosoma brucei in complex with inhibitor rd117 1-[2-(piperazin-1-yl)ethyl]-5-{5-[1- (pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl}-1h-indole (see paper)
41% identity, 98% coverage of query (350 bits)
2wpcA Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (ddd00073357)
41% identity, 98% coverage of query (350 bits)
2wbaA Properties of trypanothione reductase from t. Brucei
41% identity, 98% coverage of query (350 bits)
6bu7A Crystal structure of trypanothione reductase from trypanosoma brucei in complex with inhibitor rd130 1-[2-(piperidin-4-yl)ethyl]-5-{5-[1- (pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl}-1h-indole
41% identity, 98% coverage of query (350 bits)
5sa3B Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z2856434874
41% identity, 98% coverage of query (350 bits)
5sa2B Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z1148747945
41% identity, 98% coverage of query (350 bits)
6oezA Crystal structure of trypanothione reductase from trypanosoma brucei in complex with inhibitor (+)-n-(cyclobutylmethyl)-3-{5-[1- (pyrrolidin-1-yl)cyclohexyl]-2-(1-{[(2s)-pyrro-lidin-2-yl]methyl}-1h- indol-5-yl)-1,3-thiazol-4-yl}prop-2-yn-1-amine
41% identity, 98% coverage of query (350 bits)
6oeyA Crystal structure of trypanothione reductase from trypanosoma brucei in complex with inhibitor (+)-5-{5-[1-(pyrrolidin-1-yl)cyclohexyl]-1, 3-thiazol-2-yl}-1-{[(2s)-pyrrolidin-2-yl]methyl}-1h-indole
41% identity, 98% coverage of query (350 bits)
6oexA Crystal structure of trypanothione reductase from trypanosoma brucei in complex with inhibitor 3-(2-{1-[2-(piperidin-4-yl)ethyl]-1h-indol- 5-yl}-5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3- thiazol-4-yl)-n-(2,2,2- trifluoroethyl)prop-2-yn-1-amine
41% identity, 98% coverage of query (350 bits)
5sa0A Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z1506050651
41% identity, 98% coverage of query (350 bits)
4nevA Crystal structure of trypanothione reductase from trypanosoma brucei in complex with inhibitor ep127 (5-{5-[1-(pyrrolidin-1-yl) cyclohexyl]-1,3-thiazol-2-yl}-1h-indole)
41% identity, 98% coverage of query (350 bits)
8pf4A Crystal structure of trypanosoma brucei trypanothione reductase in complex with 4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl) (4-fluorophenyl)carbamoyl)-1-methyl-1-(3-phenylpropyl)piperazin-1-ium
41% identity, 98% coverage of query (350 bits)
2wpfA Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (ddd00085762)
41% identity, 98% coverage of query (350 bits)
2wpeA Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (ddd00073359)
41% identity, 98% coverage of query (350 bits)
2wp6A Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (ddd00071494)
41% identity, 98% coverage of query (350 bits)
2wowA Trypanosoma brucei trypanothione reductase with NADP and trypanothione bound
41% identity, 98% coverage of query (350 bits)
7nvpAAA N(1),N(8)-bis(glutathionyl)spermidine reductase
41% identity, 98% coverage of query (349 bits)
6rb5A Trypanothione reductase in complex with 4-(((3-(8-(2-((1r,2s,5r)-6,6- dimethylbicyclo[3.1.1]heptan-2-yl)ethyl)-4-oxo-1-phenyl-1,3,8- triazaspiro[4.5]decan-3-yl)propyl)(methyl)amino)methyl)-4- hydroxypiperidine-1-carboximidamide
41% identity, 98% coverage of query (349 bits)
5sa1A Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z2856434944
41% identity, 98% coverage of query (349 bits)
5s9zA Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z2856434884
41% identity, 98% coverage of query (349 bits)
5s9yA Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z24758179
41% identity, 98% coverage of query (349 bits)
5s9xA Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z1899842917
41% identity, 98% coverage of query (349 bits)
5s9wA Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z26769872
41% identity, 98% coverage of query (349 bits)
5s9vA Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z2856434826
41% identity, 98% coverage of query (349 bits)
5s9uA Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z32327641
41% identity, 98% coverage of query (349 bits)
5s9tA Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z1614545742
41% identity, 98% coverage of query (349 bits)
5s9sA Pandda analysis group deposition -- crystal structure of trypanosoma brucei trypanothione reductase in complex with z2856434898
41% identity, 98% coverage of query (349 bits)
8pf5A Crystal structure of trypanosoma brucei trypanothione reductase in complex with 1-(3,4-dichlorobenzyl)-4-(((5-((4-fluorophenethyl) carbamoyl)furan-2-yl)methyl)carbamoyl)-1-(3-phenylpropyl)piperazin-1- ium
41% identity, 98% coverage of query (349 bits)
2wp5A Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (ddd00065414)
41% identity, 98% coverage of query (349 bits)
8pf3A Crystal structure of trypanosoma brucei trypanothione reductase in complex with 1-(3,4-dichlorobenzyl)-4-(((5-((4-fluorophenethyl) carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-(3- phenylpropyl)piperazin-1-ium
41% identity, 98% coverage of query (349 bits)
P39051 trypanothione-disulfide reductase (EC 1.8.1.12) from Trypanosoma brucei (see 2 papers)
41% identity, 98% coverage of query (347 bits)
6du7A / A0A0U0ARX4 Glutathione reductase from streptococcus pneumoniae (see paper)
44% identity, 94% coverage of query (342 bits)
A4HSF7 trypanothione-disulfide reductase (EC 1.8.1.12) from Leishmania infantum (see 4 papers)
41% identity, 98% coverage of query (339 bits)
6i7nA / A4HSF7 Trypanothione reductase from leismania infantum in complex with trl156 (see paper)
41% identity, 98% coverage of query (339 bits)
P28593 trypanothione-disulfide reductase (EC 1.8.1.12) from Trypanosoma cruzi (see 8 papers)
40% identity, 100% coverage of query (339 bits)
5ebkA Trypanothione reductase in complex with 6-(sec-butoxy)-2-((3- chlorophenyl)thio)pyrimidin-4-amine
41% identity, 98% coverage of query (339 bits)
2x50A Crystal structure of trypanothione reductase from leishmania infantum in complex with NADPH and silver
41% identity, 98% coverage of query (339 bits)
2w0hA X ray structure of leishmania infantum trypanothione reductase in complex with antimony and NADPH
41% identity, 98% coverage of query (339 bits)
6i7nB Trypanothione reductase from leismania infantum in complex with trl156
41% identity, 98% coverage of query (339 bits)
6er5A X-ray structure of trypanothione reductase from leishmania infantum in complex with 2-(diethylamino)ethyl 4-((3-(4-nitrophenyl)-3- oxopropyl)amino)benzoate
41% identity, 98% coverage of query (339 bits)
4apnA Structure of tr from leishmania infantum in complex with a diarylpirrole-based inhibitor
41% identity, 98% coverage of query (339 bits)
4adwA Crystal structure of leishmania infantum trypanothione reductase in complex with NADPH and trypanothione
41% identity, 98% coverage of query (339 bits)
2yauA X-ray structure of the leishmania infantum tryopanothione reductase in complex with auranofin
41% identity, 98% coverage of query (339 bits)
5grtA Human glutathione reductase a34e, r37w mutant, glutathionylspermidine complex
40% identity, 99% coverage of query (339 bits)
4grtA Human glutathione reductase a34e, r37w mutant, mixed disulfide between trypanothione and the enzyme
40% identity, 99% coverage of query (339 bits)
3grtA Human glutathione reductase a34e, r37w mutant, oxidized trypanothione complex
40% identity, 99% coverage of query (339 bits)
2grtA Human glutathione reductase a34e, r37w mutant, oxidized glutathione complex
40% identity, 99% coverage of query (339 bits)
6t98A Trypanothione reductase from leishmania infantum in complex with 9a
41% identity, 98% coverage of query (339 bits)
6t97A Trypanothione reductase from leismania infantum in complex with trl190
41% identity, 98% coverage of query (339 bits)
6t95A Trypanothione reductase from leismania infantum in complex with 4a
41% identity, 98% coverage of query (339 bits)
P28593 Trypanothione reductase; TR; N(1),N(8)-bis(glutathionyl)spermidine reductase; EC 1.8.1.12 from Trypanosoma cruzi
40% identity, 100% coverage of query (339 bits)
V5AJG2 trypanothione-disulfide reductase (EC 1.8.1.12) from Trypanosoma cruzi (see paper)
40% identity, 98% coverage of query (336 bits)
CAA78360.1 trypanothione reductase from Trypanosoma cruzi (see paper)
40% identity, 100% coverage of query (336 bits)
1bzlA / P28593 Crystal structure of trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors (see paper)
40% identity, 98% coverage of query (335 bits)
1feaA / P39040 Unliganded crithidia fasciculata trypanothione reductase at 2.2 angstrom resolution
40% identity, 98% coverage of query (335 bits)
4newA Crystal structure of trypanothione reductase from trypanosoma cruzi in complex with inhibitor ep127 (5-{5-[1-(pyrrolidin-1-yl)cyclohexyl]-1, 3-thiazol-2-yl}-1h-indole)
40% identity, 98% coverage of query (335 bits)
1gxfA Crystal structure of trypanosoma cruzi trypanothione reductase in complex with the inhibitor quinacrine mustard
40% identity, 98% coverage of query (335 bits)
TPR / P39040 trypanothione reductase subunit (EC 1.8.1.12) from Crithidia fasciculata (see 5 papers)
CAA78264.1 trypanothione reductase from Crithidia fasciculata (see 2 papers)
40% identity, 98% coverage of query (333 bits)
1typA Substrate interactions between trypanothione reductase and n1- glutathionylspermidine disulphide at 0.28-nm resolution
40% identity, 98% coverage of query (333 bits)
P39040 Trypanothione reductase; TR; N(1),N(8)-bis(glutathionyl)spermidine reductase; EC 1.8.1.12 from Crithidia fasciculata
40% identity, 98% coverage of query (333 bits)
6n7fA / Q9A0E2 1.90 angstrom resolution crystal structure of glutathione reductase from streptococcus pyogenes in complex with fad.
41% identity, 98% coverage of query (332 bits)
3djjA / P00390 Catalytic cycle of human glutathione reductase near 1 a resolution (see paper)
41% identity, 99% coverage of query (330 bits)
5vdnA / Q8CZL0 1.55 angstrom resolution crystal structure of glutathione reductase from yersinia pestis in complex with fad
43% identity, 94% coverage of query (330 bits)
GSR / P00390 glutathione reductase subunit (EC 1.8.1.7) from Homo sapiens (see 6 papers)
GSHR_HUMAN / P00390 Glutathione reductase, mitochondrial; GR; GRase; EC 1.8.1.7 from Homo sapiens (Human) (see 2 papers)
41% identity, 99% coverage of query (330 bits)
4gr1A The binding of the retro-analogue of glutathione disulfide to glutathione reductase
41% identity, 99% coverage of query (330 bits)
3sqpA Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity
41% identity, 99% coverage of query (330 bits)
2gh5A Crystal structure of human glutathione reductase complexed with a fluoro-analogue of the menadione derivative m5
41% identity, 99% coverage of query (330 bits)
2aaqA Crystal structure analysis of the human glutahione reductase, complexed with gopi
41% identity, 99% coverage of query (330 bits)
1xanA Human glutathione reductase in complex with a xanthene inhibitor
41% identity, 99% coverage of query (330 bits)
1grbA Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 angstroms resolution
41% identity, 99% coverage of query (330 bits)
1dncA Human glutathione reductase modified by diglutathione-dinitroso-iron
41% identity, 99% coverage of query (330 bits)
1bwcA Structure of human glutathione reductase complexed with ajoene inhibitor and subversive substrate
41% identity, 99% coverage of query (330 bits)
CAA80668.1 trypanothione reductase from Leishmania donovani (see paper)
41% identity, 98% coverage of query (328 bits)
E9AKE1 trypanothione-disulfide reductase (EC 1.8.1.12) from Leishmania mexicana (see paper)
40% identity, 98% coverage of query (327 bits)
1gerB / P06715 The structure of glutathione reductase from escherichia coli at 1.86 angstroms resolution: comparison with the enzyme from human erythrocytes (see paper)
42% identity, 94% coverage of query (326 bits)
1getA Anatomy of an engineered NAD-binding site
42% identity, 94% coverage of query (326 bits)
GorA / b3500 glutathione reductase (NADPH) (EC 1.8.1.7) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
gor / P06715 glutathione reductase (NADPH) (EC 1.8.1.7) from Escherichia coli (strain K12) (see 31 papers)
gor / GB|AAC76525.1 glutathione reductase; EC 1.8.1.7 from Escherichia coli K12 (see 6 papers)
42% identity, 94% coverage of query (325 bits)
Q9NL96 glutathione-disulfide reductase (EC 1.8.1.7) from Physarum polycephalum (see paper)
41% identity, 94% coverage of query (325 bits)
P06715 Glutathione reductase; GR; GRase; EC 1.8.1.7 from Escherichia coli (strain K12)
42% identity, 94% coverage of query (325 bits)
GSHR_DICDI / Q8T137 Glutathione reductase; GR; GRase; GSR; EC 1.8.1.7 from Dictyostelium discoideum (Social amoeba) (see paper)
40% identity, 99% coverage of query (318 bits)
1geuA Anatomy of an engineered NAD-binding site
42% identity, 94% coverage of query (318 bits)
6b4oA / Q82Z09 1.73 angstrom resolution crystal structure of glutathione reductase from enterococcus faecalis in complex with fad
41% identity, 99% coverage of query (317 bits)
5u1oB / Q87TK1 2.3 angstrom resolution crystal structure of glutathione reductase from vibrio parahaemolyticus in complex with fad.
41% identity, 94% coverage of query (313 bits)
5v36A / Q8DUR5 1.88 angstrom resolution crystal structure of glutathione reductase from streptococcus mutans ua159 in complex with fad
40% identity, 94% coverage of query (313 bits)
F1LRE1 glutathione-disulfide reductase (EC 1.8.1.7) from Rattus norvegicus (see paper)
40% identity, 90% coverage of query (309 bits)
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Lawrence Berkeley National Laboratory