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Searching for up to 100 curated homologs for WP_036259109.1 NCBI__GCF_000746085.1:WP_036259109.1 (214 a.a.)

Found high-coverage hits (≥70%) to 63 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SO1671 Maleylacetoacetate isomerase (EC 5.2.1.2) from Shewanella oneidensis MR-1
    54% identity, 98% coverage of query (219 bits)

Psest_3511 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas stutzeri RCH2
    51% identity, 99% coverage of query (199 bits)

MAAI2_DROME / Q9VHD2 Probable maleylacetoacetate isomerase 2; MAAI 2; Glutathione S-transferase zeta 2; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    46% identity, 99% coverage of query (183 bits)

Q5K5T6 glutathione transferase subunit (EC 2.5.1.18) from Escherichia coli (see 8 papers)
    47% identity, 97% coverage of query (181 bits)

GSTZ1 / O43708 maleylacetoacetate isomerase/glutathione transferase ζ monomer (EC 2.5.1.18; EC 5.2.1.2) from Homo sapiens (see 11 papers)
MAAI_HUMAN / O43708 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Homo sapiens (Human) (see 3 papers)
O43708 glutathione transferase (EC 2.5.1.18); maleylacetoacetate isomerase (EC 5.2.1.2) from Homo sapiens (see 8 papers)
    45% identity, 99% coverage of query (175 bits)

2cz2A / Q9WVL0 Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from mus musculus (form-1 crystal)
    44% identity, 99% coverage of query (174 bits)

Q9WVL0 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Mus musculus (Mouse)
    44% identity, 99% coverage of query (174 bits)

MAAI_RAT / P57113 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Rattus norvegicus (Rat) (see paper)
    45% identity, 99% coverage of query (173 bits)

1fw1A / O43708 Glutathione transferase zeta/maleylacetoacetate isomerase (see paper)
    44% identity, 99% coverage of query (173 bits)

2v6kA / O86043 Structure of maleyl pyruvate isomerase, a bacterial glutathione-s- transferase in zeta class, in complex with substrate analogue dicarboxyethyl glutathione (see paper)
    48% identity, 97% coverage of query (170 bits)

MAAI1_DROME / Q9VHD3 Probable maleylacetoacetate isomerase 1; MAAI 1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    41% identity, 99% coverage of query (170 bits)

nagL / O86043 glutathion-dependent maleylpyruvate isomerase (EC 5.2.1.4) from Ralstonia sp. (see paper)
NAGL_RALSP / O86043 Maleylpyruvate isomerase; MPI; Naphthalene degradation protein L; EC 5.2.1.4 from Ralstonia sp. (see 2 papers)
    48% identity, 97% coverage of query (170 bits)

2jl4A Holo structure of maleyl pyruvate isomerase, a bacterial glutathione- s-transferase in zeta class
    48% identity, 97% coverage of query (170 bits)

Ac3H11_2306 Maleylacetoacetate isomerase (EC 5.2.1.2) from Acidovorax sp. GW101-3H11
    43% identity, 98% coverage of query (163 bits)

GSTZ1_ARATH / Q9ZVQ3 Glutathione S-transferase Z1; AtGSTZ1; GST class-zeta member 1; Glutathione S-transferase 18; Maleylacetone isomerase; MAI; EC 2.5.1.18; EC 5.2.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    42% identity, 97% coverage of query (150 bits)

Pf6N2E2_5292 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E2
    42% identity, 97% coverage of query (147 bits)

MAIA_ASPFU / Q4WHT7 Maleylacetoacetate isomerase maiA; EC 5.2.1.2 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
    39% identity, 99% coverage of query (142 bits)

AO356_16835 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2C3
    41% identity, 97% coverage of query (142 bits)

AO353_15560 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E3
    39% identity, 97% coverage of query (139 bits)

maiA / O43123 maleylacetoacetate isomerase (EC 5.2.1.2) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (see paper)
MAAI_EMENI / O43123 Maleylacetoacetate isomerase; MAAI; EC 5.2.1.2 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
O43123 maleylacetoacetate isomerase (EC 5.2.1.2) from Aspergillus nidulans (see paper)
GI|2832725 maleylacetoacetate isomerase; EC 5.2.1.2 from Emericella nidulans (see paper)
maiA / CAA05041.1 maleylacetoacetate isomerase from Aspergillus nidulans (see paper)
maiA / CAA05044.1 maleylacetoacetate isomerase from Aspergillus nidulans (see paper)
    40% identity, 91% coverage of query (138 bits)

4pxoA / C5ATQ9 Crystal structure of maleylacetoacetate isomerase from methylobacteriu extorquens am1 with bound malonate and gsh (target efi-507068)
    41% identity, 97% coverage of query (138 bits)

4kdyA / B8J605 Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound gsh in the active site
    43% identity, 97% coverage of query (133 bits)

3n5oA / D2YW48 Crystal structure of putative glutathione transferase from coccidioides immitis bound to glutathione (see paper)
    40% identity, 85% coverage of query (133 bits)

D2YW48 Probable glutathione S-transferase; EC 2.5.1.18 from Coccidioides immitis (strain RS) (Valley fever fungus)
    40% identity, 85% coverage of query (133 bits)

4kaeA Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound dicarboxyethyl glutathione and citrate in the active site
    43% identity, 97% coverage of query (133 bits)

O04437 glutathione transferase (EC 2.5.1.18) from Triticum aestivum (see paper)
    35% identity, 99% coverage of query (127 bits)

Build an alignment

Build an alignment for WP_036259109.1 and 26 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

3m3mA / Q4K8I0 Crystal structure of glutathione s-transferase from pseudomonas fluorescens [pf-5]
    27% identity, 87% coverage of query (65.1 bits)

3qawA / B9VX79 Crystal structure of a glutathione-s-transferase from antarctic clam laternula elliptica in a complex with glutathione (see paper)
    26% identity, 86% coverage of query (62.4 bits)

GSTD3_DROME / Q9VG97 Inactive glutathione S-transferase D3 from Drosophila melanogaster (Fruit fly) (see paper)
    25% identity, 73% coverage of query (55.8 bits)

GSTO1_PIG / Q9N1F5 Glutathione S-transferase omega-1; GSTO-1; Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R; EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2 from Sus scrofa (Pig) (see paper)
    23% identity, 89% coverage of query (53.9 bits)

HPM2_HYPSB / B3FWR8 Glutathione S-transferase hmp2; Hypothemycin biosynthesis cluster protein hpm2; EC 2.5.1.18 from Hypomyces subiculosus (Nectria subiculosa) (see 10 papers)
    30% identity, 86% coverage of query (53.5 bits)

3vlnA Human glutathione transferase o1-1 c32s mutant in complex with ascorbic acid
    23% identity, 93% coverage of query (52.4 bits)

6mhcA / P78417 Glutathione s-transferase omega 1 bound to covalent inhibitor 37 (see paper)
    23% identity, 89% coverage of query (51.6 bits)

GSTO1 / P78417 glutathione transferase, Ω class subunit (EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2) from Homo sapiens (see 2 papers)
GSTO1_HUMAN / P78417 Glutathione S-transferase omega-1; GSTO-1; Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R; EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2 from Homo sapiens (Human) (see 5 papers)
P78417 methylarsonate reductase (EC 1.20.4.2); glutathione dehydrogenase (ascorbate) (EC 1.8.5.1); glutathione transferase (EC 2.5.1.18) from Homo sapiens (see 7 papers)
    23% identity, 89% coverage of query (51.6 bits)

6mhdA Glutathione s-transferase omega 1 bound to covalent inhibitor 44
    23% identity, 89% coverage of query (51.6 bits)

6pnoA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3-(n- isopropylsulfamoyl)phenyl)acetamide
    23% identity, 89% coverage of query (51.6 bits)

6pnmA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3- (morpholinosulfonyl)phenyl)acetamide
    23% identity, 89% coverage of query (51.6 bits)

5v3qA Human gsto1-1 complexed with ml175
    23% identity, 89% coverage of query (51.6 bits)

5uehA Structure of gsto1 covalently conjugated to quinolinic acid fluorosulfate
    23% identity, 89% coverage of query (51.6 bits)

6pnnA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3-(n-(2- methoxyethyl)-n-methylsulfamoyl)phenyl)acetamide
    23% identity, 89% coverage of query (51.6 bits)

4is0A Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of the non-catalytic ligandin site.
    23% identity, 89% coverage of query (51.6 bits)

4yqvA Glutathione s-transferase omega 1 bound to covalent inhibitor c4-10
    23% identity, 89% coverage of query (51.6 bits)

4yqmA Glutathione s-transferase omega 1 bound to covalent inhibitor c1-27
    23% identity, 89% coverage of query (51.6 bits)

1eemA Glutathione transferase from homo sapiens
    23% identity, 89% coverage of query (51.6 bits)

A1ZB72 glutathione transferase (EC 2.5.1.18) from Drosophila melanogaster (see paper)
4pngB / A1ZB72 Glutathione s-transferase from drosophila melanogaster - isozyme e7 (see paper)
    29% identity, 89% coverage of query (51.2 bits)

GSTF7_ARATH / Q9SRY5 Glutathione S-transferase F7; AtGSTF8; GST class-phi member 7; Glutathione S-transferase 11; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    27% identity, 79% coverage of query (50.8 bits)

GSTF6 / P42760 indole-3-acetonitrile glutathione transferase (EC 2.5.1.18) from Arabidopsis thaliana (see paper)
GSTF6_ARATH / P42760 Glutathione S-transferase F6; AtGSTF6; AtGSTF3; GST class-phi member 6; Glutathione S-transferase 1; AtGST1; Protein EARLY RESPONSE TO DEHYDRATION 11; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
    27% identity, 79% coverage of query (50.8 bits)

SSPA_COXBU / Q83AY0 Stringent starvation protein A homolog from Coxiella burnetii (strain RSA 493 / Nine Mile phase I) (see paper)
    26% identity, 73% coverage of query (50.8 bits)

L7QI27 glutathione transferase (EC 2.5.1.18) from Oncorhynchus kisutch (see paper)
    25% identity, 92% coverage of query (50.8 bits)

4yquA Glutathione s-transferase omega 1 bound to covalent inhibitor c1-31
    24% identity, 89% coverage of query (49.3 bits)

6mhbA Glutathione s-transferase omega 1 bound to covalent inhibitor 18
    24% identity, 89% coverage of query (49.3 bits)

4gf0A Crystal structure of glutahtione transferase homolog from sulfitobacter, target efi-501084, with bound glutathione
    26% identity, 74% coverage of query (48.1 bits)

Q5ISV1 glutathione transferase (EC 2.5.1.18) from Sarcoptes scabiei (see 2 papers)
    29% identity, 88% coverage of query (47.0 bits)

4chsA Crystal structure of a tau class glutathione transferase 10 from glycine max
    30% identity, 79% coverage of query (46.6 bits)

4hi7A / B4KM86 Crystal structure of glutathione transferase homolog from drosophilia mojavensis, target efi-501819, with bound glutathione
    25% identity, 88% coverage of query (45.1 bits)

3wd6A / A8R5V3 Crystal structure of bombyx mori omega-class glutathione transferase in complex with gsh (see paper)
    26% identity, 79% coverage of query (44.7 bits)

5a5kA Atgstf2 from arabidopsis thaliana in complex with camalexin
    26% identity, 79% coverage of query (43.9 bits)

1gnwA Structure of glutathione s-transferase
    26% identity, 79% coverage of query (43.9 bits)

1bx9A Glutathione s-transferase in complex with herbicide
    26% identity, 79% coverage of query (43.9 bits)

5a4wA Atgstf2 from arabidopsis thaliana in complex with quercetrin
    26% identity, 79% coverage of query (43.9 bits)

5a4vA Atgstf2 from arabidopsis thaliana in complex with quercetin
    26% identity, 79% coverage of query (43.9 bits)

5a4uA / P46422 Atgstf2 from arabidopsis thaliana in complex with indole-3-aldehyde (see paper)
    26% identity, 79% coverage of query (43.9 bits)

4iw9B Crystal structure of glutathione s-transferase mha_0454 (target efi- 507015) from mannheimia haemolytica, gsh complex
    26% identity, 75% coverage of query (43.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory