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Searching for up to 100 curated homologs for WP_038018174.1 NCBI__GCF_000757425.2:WP_038018174.1 (459 a.a.)

Found high-coverage hits (≥70%) to 62 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

rfbK / BAA07746.1 phosphomannomutase from Escherichia coli (see 2 papers)
    71% identity, 99% coverage of query (684 bits)

RfbK / b2048 phosphomannomutase (EC 5.4.2.8) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
cpsG / P24175 phosphomannomutase (EC 5.4.2.8) from Escherichia coli (strain K12) (see 6 papers)
manB / GB|AAC75109.1 phosphomannomutase; EC 5.4.2.8 from Escherichia coli K12 (see paper)
    68% identity, 99% coverage of query (660 bits)

manB / AAC27539.1 ManB from Escherichia coli (see 6 papers)
    67% identity, 98% coverage of query (644 bits)

Q8PGN7 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Xanthomonas citri pv. citri (see paper)
    52% identity, 100% coverage of query (498 bits)

5bmpA Crystal structure of phosphoglucomutase from xanthomonas citri complexed with glucose-1-phosphate (see paper)
    52% identity, 99% coverage of query (496 bits)

6mlwA Crystal structure of x. Citri phosphoglucomutase in complex with 2- fluoro mannosyl-1-methyl-phosphonic acid
    52% identity, 99% coverage of query (496 bits)

6nqhA Xanthomonas citri dephospho-pgm in complex with xylose-1-phosphate
    52% identity, 99% coverage of query (496 bits)

6np8A Xanthomonas citri phospho-pgm in complex with mannose-6-phosphate
    52% identity, 99% coverage of query (496 bits)

6nolA Xanthomonas citri dephospho-pgm in complex with mannose-1-phosphate
    52% identity, 99% coverage of query (496 bits)

6nnpA Xanthomonas citri dephospho-pgm in complex with glucose-6-phosphate
    52% identity, 99% coverage of query (496 bits)

6nn2A Xanthomonas citri pgm apo-phospho
    52% identity, 99% coverage of query (496 bits)

6n1eA Crystal structure of x. Citri phosphoglucomutase in complex with 1- methyl-glucose 6-phosphate
    52% identity, 99% coverage of query (496 bits)

6mnvA Crystal structure of x. Citri phosphoglucomutase in complex with ch2fg1p
    52% identity, 99% coverage of query (496 bits)

6mlhA Crystal structure of x. Citri phosphoglucomutase in complex with glucopyranosyl-1-methyl-phosphonic acid
    52% identity, 99% coverage of query (496 bits)

6mlfA Crystal structure of x. Citri phosphoglucomutase in complex with 6- fluoro glucose 1-phosphate
    52% identity, 99% coverage of query (496 bits)

5kl0A Crystal structure of phosphoglucomutase from xanthomonas citri citri complexed with glucose-1,6-biphosphate
    52% identity, 99% coverage of query (496 bits)

xanA / AAA27610.1 phosphomannomutase/phosphoglucomutase from Xanthomonas campestris pv. campestris (see 4 papers)
    52% identity, 99% coverage of query (493 bits)

B6Z254 phosphomannomutase (EC 5.4.2.8) from Streptomyces nodosus (see paper)
    38% identity, 100% coverage of query (292 bits)

Q9KZL6 phosphomannomutase (EC 5.4.2.8) from Streptomyces coelicolor (see paper)
    36% identity, 100% coverage of query (273 bits)

MANB_METJA / Q57842 Phosphomannomutase; PMM; Phosphoglucomutase; EC 5.4.2.8 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
    34% identity, 99% coverage of query (239 bits)

algC / P26276 phosphomannomutase (EC 5.4.2.2; EC 5.4.2.8) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
ALGC_PSEAE / P26276 Phosphomannomutase/phosphoglucomutase; PMM / PGM; EC 5.4.2.2; EC 5.4.2.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 12 papers)
    34% identity, 97% coverage of query (209 bits)

2h5aX Complex of the enzyme pmm/pgm with xylose 1-phosphate
    34% identity, 97% coverage of query (209 bits)

2h4lX Complex of pmm/pgm with ribose 1-phosphate
    34% identity, 97% coverage of query (209 bits)

2fkfA Phosphomannomutase/phosphoglucomutase from pseudomonas aeruginosa with alpha-d-glucose 1,6-bisphosphate bound
    34% identity, 97% coverage of query (209 bits)

1pcmX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    34% identity, 97% coverage of query (209 bits)

1p5gX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    34% identity, 97% coverage of query (209 bits)

1p5dX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    34% identity, 97% coverage of query (209 bits)

Q02E40 Phosphomannomutase/phosphoglucomutase; PMM / PGM; EC 5.4.2.2; EC 5.4.2.8 from Pseudomonas aeruginosa (strain UCBPP-PA14)
    34% identity, 97% coverage of query (209 bits)

1pcjX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    34% identity, 97% coverage of query (209 bits)

1k2yX Crystal structure of phosphomannomutase/phosphoglucomutase s108a mutant from p. Aeruginosa
    34% identity, 97% coverage of query (208 bits)

4il8A / P26276 Crystal structure of an h329a mutant of p. Aeruginosa pmm/pgm (see paper)
    34% identity, 97% coverage of query (206 bits)

3uw2A / Q2SYG4 X-ray crystal structure of phosphoglucomutase/phosphomannomutase family protein (bth_i1489)from burkholderia thailandensis (see paper)
    36% identity, 97% coverage of query (201 bits)

pgm / AAA20399.1 phosphoglucomutase from Neisseria gonorrhoeae (see paper)
pgm / AAA20588.1 phosphoglucomutase from Neisseria gonorrhoeae (see paper)
    31% identity, 97% coverage of query (195 bits)

M1T754 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2); phosphomannomutase (EC 5.4.2.8) from Sphingomonas sanxanigenens (see paper)
    31% identity, 98% coverage of query (180 bits)

pgm / AAA20589.1 phosphoglucomutase from Neisseria meningitidis (see paper)
    30% identity, 98% coverage of query (177 bits)

3rsmA Crystal structure of s108c mutant of pmm/pgm
    32% identity, 93% coverage of query (174 bits)

Build an alignment

Build an alignment for WP_038018174.1 and 36 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

PGMMM_THEKO / Q68BJ6 Phosphoglucomutase/phosphomannomutase; PGM/PMM; EC 5.4.2.2; EC 5.4.2.8 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    28% identity, 99% coverage of query (172 bits)

PH0923 / O58651 phosphomannose mutase (EC 5.4.2.8) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
1wqaA / O58651 Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
    27% identity, 98% coverage of query (162 bits)

Q5X1A3 phosphoglucosamine mutase (EC 5.4.2.10) from Legionella pneumophila (see paper)
    29% identity, 97% coverage of query (129 bits)

pgmL / Q0P8K7 phosphoglucosamine mutase (EC 5.4.2.10) from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
    30% identity, 96% coverage of query (129 bits)

B3WD16 phosphoglucosamine mutase (EC 5.4.2.10) from Lacticaseibacillus casei (see paper)
    27% identity, 98% coverage of query (125 bits)

ST0242 / Q976E4 hexose-6-phosphate mutase/isomerase (EC 5.3.1.8; EC 5.3.1.9; EC 5.4.2.10; EC 5.4.2.13) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (see paper)
PGMUT_SULTO / Q976E4 Phosphoglucosamine/phosphogalactosamine mutase; PGlcNM; EC 5.4.2.10; EC 5.4.2.13 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
Q976E4 phosphogalactosamine mutase (EC 5.4.2.13) from Sulfurisphaera tokodaii (see paper)
    27% identity, 94% coverage of query (124 bits)

GLMM_METMP / Q6LYB4 Phosphoglucosamine mutase; EC 5.4.2.10 from Methanococcus maripaludis (strain DSM 14266 / JCM 13030 / NBRC 101832 / S2 / LL) (see paper)
Q6LYB4 phosphoglucosamine mutase (EC 5.4.2.10) from Methanococcus maripaludis (see paper)
    27% identity, 95% coverage of query (122 bits)

GLMM_HELPY / P25177 Phosphoglucosamine mutase; EC 5.4.2.10 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see 2 papers)
    26% identity, 98% coverage of query (112 bits)

A9CQM6 phosphoglucosamine mutase (EC 5.4.2.10) from Streptococcus gordonii (see paper)
    26% identity, 94% coverage of query (112 bits)

GLMM_BACSU / O34824 Phosphoglucosamine mutase; EC 5.4.2.10 from Bacillus subtilis (strain 168) (see 2 papers)
    25% identity, 98% coverage of query (112 bits)

7ojrA / O34824 Bacillus subtilis phosphoglucomutase glmm (phosphate bound) (see paper)
    25% identity, 98% coverage of query (112 bits)

3i3wA / Q5NII8 Structure of a phosphoglucosamine mutase from francisella tularensis
    27% identity, 97% coverage of query (112 bits)

7omlA Bacillus subtilis phosphoglucomutase glmm (metal bound)
    25% identity, 98% coverage of query (112 bits)

GLMM_STAA8 / P0C0V7 Phosphoglucosamine mutase; EC 5.4.2.10 from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
GLMM_STAAC / Q5HE43 Phosphoglucosamine mutase; EC 5.4.2.10 from Staphylococcus aureus (strain COL) (see 3 papers)
    25% identity, 98% coverage of query (111 bits)

Q8DTC6 phosphoglucosamine mutase (EC 5.4.2.10) from Streptococcus mutans (see paper)
    25% identity, 94% coverage of query (110 bits)

GLMM_STRR6 / Q8DP16 Phosphoglucosamine mutase; EC 5.4.2.10 from Streptococcus pneumoniae (strain ATCC BAA-255 / R6) (see paper)
    26% identity, 94% coverage of query (106 bits)

Q81VN7 phosphoglucosamine mutase (EC 5.4.2.10) from Bacillus anthracis (see paper)
    25% identity, 94% coverage of query (106 bits)

Q980S1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2); phosphomannomutase (EC 5.4.2.8) from Saccharolobus solfataricus (see paper)
    26% identity, 97% coverage of query (105 bits)

GLMM_METJA / Q58500 Phosphoglucosamine mutase; EC 5.4.2.10 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
    25% identity, 88% coverage of query (97.8 bits)

YhbF / b3176 phosphoglucosamine mutase (EC 5.4.2.10) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
glmM / P31120 phosphoglucosamine mutase (EC 5.4.2.10) from Escherichia coli (strain K12) (see 9 papers)
GLMM_ECOLI / P31120 Phosphoglucosamine mutase; EC 5.4.2.10 from Escherichia coli (strain K12) (see 2 papers)
glmM phosphoglucosamine mutase; EC 5.4.2.10 from Escherichia coli K12 (see 6 papers)
    25% identity, 98% coverage of query (96.7 bits)

pgcA / P18159 α-phosphoglucomutase (EC 5.4.2.2) from Bacillus subtilis (strain 168) (see paper)
PGCA_BACSU / P18159 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
    26% identity, 70% coverage of query (59.3 bits)

PGM1 / P36871 phosphoglucomutase-1 (EC 5.4.2.2) from Homo sapiens (see 3 papers)
PGM1_HUMAN / P36871 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Homo sapiens (Human) (see 8 papers)
P36871 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Homo sapiens (see 4 papers)
    22% identity, 73% coverage of query (46.6 bits)

7s0wB / P36871 Crystal structure of the t337m variant of human pgm-1 (see paper)
    22% identity, 73% coverage of query (46.2 bits)

6snoA / P36871 Crystal structures of human pgm1 isoform 2 (see paper)
    22% identity, 73% coverage of query (45.4 bits)

5jn5A Crystal structure of the d263y missense variant of human pgm1
    22% identity, 73% coverage of query (45.4 bits)

6snqA Crystal structures of human pgm1 isoform 2
    22% identity, 73% coverage of query (45.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory