Searching for up to 100 curated homologs for WP_041099023.1 NCBI__GCF_000828635.1:WP_041099023.1 (237 a.a.)
Found high-coverage hits (≥70%) to 71 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
5xf9B / A0A077L885 Crystal structure of NAD+-reducing [nife]-hydrogenase in the air- oxidized state (see paper)
56% identity, 95% coverage of query (269 bits)
hoxU / P22318 γ subunit from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
P22318 hydrogen dehydrogenase (EC 1.12.1.2) from Frankia sp. R43 (see paper)
41% identity, 95% coverage of query (176 bits)
7t30A / I4BYB4 Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn/NAD(h) bound state (see paper)
37% identity, 85% coverage of query (134 bits)
Build an alignment for WP_041099023.1 and 3 homologs with ≥ 30% identity
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fdhB-I / CAC39233.1 FdhB-I protein from Peptoclostridium acidaminophilum (see paper)
29% identity, 89% coverage of query (115 bits)
7p8na / O52683 Tmhydabc- t. Maritima hydrogenase with bridge closed (see paper)
27% identity, 85% coverage of query (110 bits)
hydA / O52683 hydrogenase α subunit (EC 1.12.1.4) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
HYDA_THEMA / O52683 Bifurcating [FeFe] hydrogenase alpha subunit; Hydrogenase (NAD(+), ferredoxin) alpha subunit; Iron-hydrogenase alpha subunit; EC 1.12.1.4 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
27% identity, 85% coverage of query (110 bits)
fdhA / P77908 NADP-dependent formate dehydrogenase α subunit (EC 1.17.1.10) from Moorella thermoacetica (see 3 papers)
30% identity, 85% coverage of query (107 bits)
fdhB-II / CAC39238.1 FdhB-II protein from Peptoclostridium acidaminophilum (see paper)
32% identity, 87% coverage of query (106 bits)
8a5eA / H6LFG3 Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from acetobacterium woodii in the reduced state (see paper)
29% identity, 86% coverage of query (102 bits)
hydA / Q8RBC8 NADH-dependent hydrogenase α subunit (EC 1.12.1.2) from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (see paper)
30% identity, 85% coverage of query (99.0 bits)
Q84FW1 formate dehydrogenase (EC 1.17.1.9) from Methylorubrum extorquens (see paper)
33% identity, 73% coverage of query (98.2 bits)
NDUS1_CANAL / A0A1D8PU51 NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial; EC 7.1.1.2 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
30% identity, 87% coverage of query (96.3 bits)
8a6tA / A0A097ATG3 Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from thermoanaerobacter kivui in the reduced state (see paper)
31% identity, 85% coverage of query (95.9 bits)
TC 3.D.1.5.1 / Q746S9 NuoG aka GSU3439, component of Proton-translocating NADH dehydrogenase I from Geobacter sulfurreducens (see paper)
31% identity, 87% coverage of query (95.9 bits)
fdhA-II / CAC39239.1 FdhA-II protein from Peptoclostridium acidaminophilum (see paper)
29% identity, 86% coverage of query (95.5 bits)
7q5yA / O66748 Structure of nadh:ubichinon oxidoreductase (complex i) of the hyperthermophilic eubacterium aquifex aeolicus
31% identity, 86% coverage of query (94.4 bits)
SFRA_GEOSK / D7AF63 NADPH-Fe(3+) oxidoreductase subunit alpha; Soluble Fe(3+) reductase alpha subunit; EC 1.-.-.- from Geobacter sulfurreducens (strain DL-1 / KN400) (see paper)
SFRA_GEOSL / Q74FU6 NADPH-Fe(3+) oxidoreductase subunit alpha; Soluble Fe(3+) reductase alpha subunit; EC 1.-.-.- from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see 2 papers)
26% identity, 86% coverage of query (94.0 bits)
fdsA / CAA11235.1 NAD-dependent formate dehydrogenase alpha subunit from Cupriavidus necator (see paper)
31% identity, 76% coverage of query (93.6 bits)
6tg9A / D5AQH0 Cryo-em structure of nadh reduced form of NAD+-dependent formate dehydrogenase from rhodobacter capsulatus (see paper)
29% identity, 85% coverage of query (92.4 bits)
fdhA-I / CAC39234.1 FdhA-I protein from Peptoclostridium acidaminophilum (see paper)
29% identity, 86% coverage of query (91.7 bits)
fdhF2 / K0B3A3 formate dehydrogenase H (EC 1.17.1.11) from Gottschalkia acidurici (strain ATCC 7906 / DSM 604 / BCRC 14475 / CIP 104303 / KCTC 5404 / NCIMB 10678 / 9a) (see 4 papers)
K0B3A3 formate dehydrogenase (NAD+, ferredoxin) (subunit 4/4) (EC 1.17.1.11) from Gottschalkia acidurici (see paper)
30% identity, 85% coverage of query (90.5 bits)
NUOG_MYCTU / P9WIV9 NADH-quinone oxidoreductase subunit G; NADH dehydrogenase I subunit G; NDH-1 subunit G; EC 7.1.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
31% identity, 85% coverage of query (90.1 bits)
7arcG Cryo-em structure of polytomella complex-i (peripheral arm) (see paper)
28% identity, 87% coverage of query (89.0 bits)
7zm7A / G0RYA1 Cryoem structure of mitochondrial complex i from chaetomium thermophilum (inhibited by ddm) (see paper)
28% identity, 87% coverage of query (88.6 bits)
TC 3.D.1.6.2 / P24918 78 (NuoG), component of The fungal H+ translocating NADH dehydrogenase (NDH) complex (38 subunits; 35 included here) from Neurospora crassa (see 3 papers)
28% identity, 87% coverage of query (88.2 bits)
7awtG / P33602 E. Coli nadh quinone oxidoreductase hydrophilic arm (see paper)
29% identity, 86% coverage of query (88.2 bits)
NuoG / b2283 NADH:quinone oxidoreductase subunit G from Escherichia coli K-12 substr. MG1655 (see 15 papers)
nuoG / P33602 NADH:quinone oxidoreductase subunit G from Escherichia coli (strain K12) (see 14 papers)
NUOG_ECOLI / P33602 NADH-quinone oxidoreductase subunit G; NADH dehydrogenase I subunit G; NDH-1 subunit G; NUO7; EC 7.1.1.- from Escherichia coli (strain K12) (see paper)
TC 3.D.1.1.1 / P33602 NUOG aka B2283, component of NADH dehydrogenase I, NuoA-N from Escherichia coli (see 7 papers)
29% identity, 86% coverage of query (88.2 bits)
7nyrG Respiratory complex i from escherichia coli - conformation 1
29% identity, 86% coverage of query (88.2 bits)
NUOG_PSEFL / Q9KGW3 NADH-quinone oxidoreductase subunit G; NADH dehydrogenase I subunit G; NDH-1 subunit G; EC 7.1.1.- from Pseudomonas fluorescens (see paper)
30% identity, 86% coverage of query (87.8 bits)
fdh1A / Q8KTI7 NAD-dependent formate dehydrogenase α subunit (EC 1.17.1.9) from Methylorubrum extorquens (see 2 papers)
Q8KTI7 formate dehydrogenase (EC 1.17.1.9) from Methylorubrum extorquens (see paper)
28% identity, 87% coverage of query (85.9 bits)
TC 3.D.1.6.4 / Q6UKY6 75 (NuoG), component of The green algal H+ translocating NADH dehydrogenase (NDH) complex (42 subunits; 33 included here) from Chlamydomonas reinhardtii
27% identity, 87% coverage of query (84.7 bits)
7vw6A / C5ATT7 Cryo-em structure of formate dehydrogenase 1 from methylorubrum extorquens am1 (see paper)
28% identity, 86% coverage of query (84.3 bits)
7b0nG / Q9UUU3 3.7-angstrom structure of Yarrowia lipolytica complex I with an R121M mutation in NUCM. (see paper)
26% identity, 87% coverage of query (84.0 bits)
nuam / CAB65519.1 NUAM protein from Yarrowia lipolytica (see paper)
26% identity, 87% coverage of query (84.0 bits)
8e9hG / A0QU30 Mycobacterial respiratory complex i, fully-inserted quinone (see paper)
29% identity, 85% coverage of query (82.4 bits)
6x89S1 / A0A1S3TQ85 radiata mitochondrial complex I* (see paper)
28% identity, 87% coverage of query (82.4 bits)
7a23C / Q9FGI6 Plant mitochondrial respiratory complex i (see paper)
27% identity, 87% coverage of query (80.5 bits)
8gyms1 / Q23KA9 8gyms1 (see paper)
25% identity, 87% coverage of query (80.5 bits)
at5g37510 / Q9FGI6 NADH-ubiquinone oxidoreductase 75 kDa subunit (EC 7.1.1.2) from Arabidopsis thaliana (see paper)
TC 3.D.1.6.3 / Q9FGI6 81.5 (NuoG), component of The higher plant H+ translocating NADH dehydrogenase (NDH) complex (41 subunits; 23 included here) from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
27% identity, 87% coverage of query (80.5 bits)
8bedG Cryo-em structure of the arabidopsis thaliana i+iii2 supercomplex (ci peripheral tip)
27% identity, 87% coverage of query (80.5 bits)
NDUS1_BOVIN / P15690 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Complex I-75kD; CI-75kD; EC 7.1.1.2 from Bos taurus (Bovine) (see 3 papers)
TC 3.D.1.6.1 / P15690 75 (NuoG), component of The vertebrate H+-translocating NADH dehydrogenase (NDH) complex (45 subunits) from Bos taurus (Bovine) (see paper)
25% identity, 87% coverage of query (80.1 bits)
7qsoG / P15690 Bovine complex i in lipid nanodisc, state 3 (slack) (see paper)
25% identity, 87% coverage of query (80.1 bits)
HNDD_SOLFR / Q46508 NADP-reducing hydrogenase subunit HndD; Hydrogen dehydrogenase (NADP(+)); EC 1.12.1.3 from Solidesulfovibrio fructosivorans (Desulfovibrio fructosivorans) (see 2 papers)
29% identity, 86% coverage of query (79.7 bits)
NDUS1_MOUSE / Q91VD9 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Complex I-75kD; CI-75kD; EC 7.1.1.2 from Mus musculus (Mouse) (see 2 papers)
25% identity, 87% coverage of query (79.3 bits)
NDUFS1 / P28331 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial from Homo sapiens (see 3 papers)
NDUS1_HUMAN / P28331 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Complex I-75kD; CI-75kD; EC 7.1.1.2 from Homo sapiens (Human) (see 4 papers)
25% identity, 87% coverage of query (79.3 bits)
8eszS1 / Q94511 8eszS1 (see paper)
27% identity, 87% coverage of query (79.3 bits)
7v2cM Active state complex i from q10 dataset
25% identity, 87% coverage of query (79.3 bits)
5gupG structure of mammalian respiratory supercomplex I1III2IV1
25% identity, 87% coverage of query (79.3 bits)
5lc5G / P15690 Structure of mammalian respiratory complex i, class2 (see paper)
25% identity, 84% coverage of query (77.8 bits)
TC 3.D.1.7.1 / Q0P855 NuoG, component of The NADH: ubiquinone oxidoreductase homologue using flavodoxin rather than NADH as electron donor (Weerakoon and Olson, 2008), from Campylobacter jejuni (see paper)
25% identity, 91% coverage of query (77.4 bits)
3i9vC Crystal structure of the hydrophilic domain of respiratory complex i from thermus thermophilus, oxidized, 2 mol/asu
27% identity, 83% coverage of query (75.9 bits)
3i9v3 Crystal structure of the hydrophilic domain of respiratory complex i from thermus thermophilus, oxidized, 2 mol/asu
27% identity, 83% coverage of query (75.9 bits)
2ybb3 Fitted model for bovine mitochondrial supercomplex i1iii2iv1 by single particle cryo-em (emd-1876)
27% identity, 83% coverage of query (75.9 bits)
4hea3 / Q56223 Crystal structure of the entire respiratory complex i from thermus thermophilus (see paper)
26% identity, 83% coverage of query (75.1 bits)
NQO3_PARDE / P29915 NADH-quinone oxidoreductase chain 3; NADH dehydrogenase I, chain 3; NDH-1, chain 3; EC 7.1.1.- from Paracoccus denitrificans (see 2 papers)
TC 3.D.1.2.1 / P29915 NQO3, component of NADH dehydrogenase I from Paracoccus denitrificans (see 4 papers)
NQO3 / AAA25587.1 NADH dehydrogenase from Paracoccus denitrificans (see paper)
25% identity, 90% coverage of query (74.3 bits)
8iuf1A 8iuf1A (see paper)
25% identity, 82% coverage of query (68.2 bits)
NQO3_THET8 / Q56223 NADH-quinone oxidoreductase subunit 3; NADH dehydrogenase I chain 3; NDH-1 subunit 3; EC 7.1.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 2 papers)
TC 3.D.1.3.1 / Q56223 Nqo3, component of NADH Dehydrogenase, NDH (Baradaran et al. 2013). The x-ray structures of various complexes have been solved, and a coupling mechanism involving long range conformational changes has been proposed from Thermus thermophilus (see 4 papers)
24% identity, 83% coverage of query (67.0 bits)
5byrA Semisynthetic [fefe]-hydrogenase cpi with propane-dithiolato-bridged [2fe] cofactor
21% identity, 86% coverage of query (46.6 bits)
8aioA Co-bound [fefe]-hydrogenase i from clostridium pasteurianum (cpi)
21% identity, 86% coverage of query (46.6 bits)
5oefA Active semisynthetic [fefe]-hydrogenase cpi with aza-diselenato- bridged [2fe] cofactor
21% identity, 86% coverage of query (46.2 bits)
3c8yA 1.39 angstrom crystal structure of fe-only hydrogenase
21% identity, 86% coverage of query (46.2 bits)
1c4cA Binding of exogenously added carbon monoxide at the active site of the fe-only hydrogenase (cpi) from clostridium pasteurianum
21% identity, 86% coverage of query (46.2 bits)
1c4aA Binding of exogenously added carbon monoxide at the active site of the fe-only hydrogenase (cpi) from clostridium pasteurianum
21% identity, 86% coverage of query (46.2 bits)
PHF1_CLOPA / P29166 Iron hydrogenase 1; CpI; Fe-only hydrogenase; [Fe] hydrogenase; EC 1.12.7.2 from Clostridium pasteurianum (see 2 papers)
GI|144836 ferredoxin hydrogenase; EC 1.12.7.2 from Clostridium pasteurianum (see 3 papers)
21% identity, 86% coverage of query (46.2 bits)
8aj6A Cyanide-bound [fefe]-hydrogenase i from clostridium pasteurianum (cpi)
21% identity, 86% coverage of query (46.2 bits)
6h63A Semisynthetic [fefe]-hydrogenase cpi with ethanedithiolate [2fe] cofactor
21% identity, 86% coverage of query (46.2 bits)
5bysA Semisynthetic [fefe]-hydrogenase cpi with sulfur-dithiolato-bridged [2fe] cofactor
21% identity, 86% coverage of query (46.2 bits)
8pvmA Formaldehyde-inhibited [fefe]-hydrogenase cpi from clostridium pasteurianum, variant c299d
21% identity, 86% coverage of query (46.2 bits)
4xddA / P29166 Apo [fefe]-hydrogenase cpi (see paper)
21% identity, 86% coverage of query (46.2 bits)
4xdcA Active semisynthetic [fefe]-hydrogenase cpi with aza-dithiolato- bridged [2fe] cofactor
21% identity, 86% coverage of query (46.2 bits)
5byqA Semisynthetic [fefe]-hydrogenase cpi with oxodithiolato-bridged [2fe] cofactor
21% identity, 86% coverage of query (46.2 bits)
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Lawrence Berkeley National Laboratory