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Searching for up to 100 curated homologs for WP_041456752.1 NCBI__GCF_000204075.1:WP_041456752.1 (298 a.a.)

Found high-coverage hits (≥70%) to 77 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q8R8N4 ADP-specific glucose/glucosamine kinase (EC 2.7.1.147) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
    34% identity, 96% coverage of query (167 bits)

CA265_RS11300 N-acetylglucosamine kinase (EC 2.7.1.59) from Pedobacter sp. GW460-11-11-14-LB5
    32% identity, 99% coverage of query (157 bits)

glk / Q9X1I0 glucokinase subunit (EC 2.7.1.1) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
GLK_THEMA / Q9X1I0 Glucokinase; ATP-dependent glucokinase; ATP-GLK; Glucose kinase; EC 2.7.1.2 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    32% identity, 99% coverage of query (157 bits)

Q8RDE9 glucokinase (EC 2.7.1.2) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
    32% identity, 96% coverage of query (150 bits)

XylR / VIMSS38296 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus subtilis subsp. subtilis str. 168
    30% identity, 97% coverage of query (142 bits)

XylR / P16557 Transcription factor XylR (repressor) from Bacillus subtilis 168 (see 2 papers)
    30% identity, 97% coverage of query (141 bits)

2qm1B / Q830J4 Crystal structure of glucokinase from enterococcus faecalis
    34% identity, 98% coverage of query (141 bits)

rokA / Q5GBH5 glucokinase / N-acetylglucosamine kinase / mannokinase (EC 2.7.1.7; EC 2.7.1.1; EC 2.7.1.59) from Bacteroides fragilis (see 2 papers)
    34% identity, 98% coverage of query (140 bits)

GLK_STRCO / P0A4E1 Glucokinase; Glucose kinase; ORF 3; EC 2.7.1.2 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
P0A4E1 glucokinase (EC 2.7.1.2) from Streptomyces coelicolor (see paper)
glkA glucokinase; EC 2.7.1.2 from Streptomyces coelicolor (see 2 papers)
    34% identity, 96% coverage of query (137 bits)

glkA / CAA62003.1 glucokinase from Renibacterium salmoninarum (see 2 papers)
    32% identity, 100% coverage of query (135 bits)

B1VZT1 glucokinase (EC 2.7.1.2) from Streptomyces griseus (see 2 papers)
    34% identity, 96% coverage of query (132 bits)

3vgkB / B1VZT1 Crystal structure of a rok family glucokinase from streptomyces griseus (see paper)
    34% identity, 96% coverage of query (132 bits)

O31392 glucokinase (EC 2.7.1.2) from Priestia megaterium (see paper)
glk glucokinase; EC 2.7.1.2 from Bacillus megaterium (see paper)
glk / CAA03848.1 glucose kinase from Bacillus megaterium (see paper)
    33% identity, 99% coverage of query (132 bits)

3vglA Crystal structure of a rok family glucokinase from streptomyces griseus in complex with glucose and amppnp
    34% identity, 96% coverage of query (132 bits)

Q8RDN7 N-acylmannosamine kinase (EC 2.7.1.60) from Fusobacterium nucleatum subsp. nucleatum (see paper)
    34% identity, 97% coverage of query (131 bits)

XylR / VIMSS854293 XylR regulator of Xylose utilization, effector Xylose (repressor) from Geobacillus kaustophilus HTA426
    30% identity, 77% coverage of query (126 bits)

glk / Q8DVE8 glucokinase subunit (EC 2.7.1.1) from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see paper)
    32% identity, 97% coverage of query (125 bits)

XylR / VIMSS3426742 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus pumilus SAFR-032
    30% identity, 97% coverage of query (124 bits)

glcK / GI|1303865 glucokinase; EC 2.7.1.2 from Bacillus subtilis (see paper)
    34% identity, 97% coverage of query (120 bits)

glcK / P54495 glucokinase (EC 2.7.1.1) from Bacillus subtilis (strain 168) (see paper)
GLK_BACSU / P54495 Glucokinase; Glucose kinase; EC 2.7.1.2 from Bacillus subtilis (strain 168) (see paper)
P54495 glucokinase (EC 2.7.1.2) from Bacillus subtilis (see paper)
    34% identity, 97% coverage of query (119 bits)

XylR / VIMSS822024 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus clausii KSM-K16
    32% identity, 79% coverage of query (119 bits)

BGLK_KLEPN / Q93LQ8 Beta-glucoside kinase; EC 2.7.1.85 from Klebsiella pneumoniae (see paper)
    30% identity, 95% coverage of query (119 bits)

Build an alignment

Build an alignment for WP_041456752.1 and 22 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

XylR / VIMSS730014 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus licheniformis DSM 13
    29% identity, 97% coverage of query (117 bits)

XylR / P70928_BACLI Transcription factor XylR (repressor) from Bacillus licheniformis Gibson 46 (see paper)
    28% identity, 97% coverage of query (117 bits)

4db3A / Q8D9M7 1.95 angstrom resolution crystal structure of n-acetyl-d-glucosamine kinase from vibrio vulnificus.
    30% identity, 98% coverage of query (115 bits)

Q5SLJ4 hexokinase (EC 2.7.1.1) from Thermus thermophilus (see paper)
    34% identity, 99% coverage of query (112 bits)

Q5RLG0 hexokinase (EC 2.7.1.1) from Thermus caldophilus (see paper)
    33% identity, 99% coverage of query (111 bits)

7p7wBBB / Q12306,R8APY9 7p7wBBB
    29% identity, 96% coverage of query (110 bits)

7p9pAAA Ubiquitin-like protein SMT3,N-acetyl-D-glucosamine kinase
    29% identity, 96% coverage of query (110 bits)

7p9lAAA Ubiquitin-like protein SMT3,N-acetyl-D-glucosamine kinase
    29% identity, 96% coverage of query (110 bits)

XylR / VIMSS6926953 XylR regulator of Xylose utilization, effector Xylose (repressor) from Paenibacillus sp. JDR-2
    31% identity, 79% coverage of query (109 bits)

XylR / VIMSS3676564 XylR regulator of Xylose utilization, effector Xylose; Glucose (repressor) from Thermotoga lettingae TMO
    29% identity, 97% coverage of query (108 bits)

3vovB / Q5SLJ4 Crystal structure of rok hexokinase from thermus thermophilus (see paper)
    34% identity, 99% coverage of query (107 bits)

XylR / Q9WXW5_THEMA Transcription factor XylR (repressor) from Thermotoga maritima MSB8
    29% identity, 97% coverage of query (107 bits)

XylR / VIMSS10362834 XylR regulator of Xylose utilization, effector Xylose; Glucose (repressor) from Thermotoga naphthophila RKU-10
    30% identity, 97% coverage of query (107 bits)

BGLK_LISMO / Q8Y3R9 Beta-glucoside kinase; EC 2.7.1.85 from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) (see paper)
    30% identity, 95% coverage of query (106 bits)

BGLK_LISIN / Q926Y3 Beta-glucoside kinase; EC 2.7.1.85 from Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) (see paper)
    30% identity, 95% coverage of query (102 bits)

XylR / VIMSS279908 XylR regulator of Xylose utilization, effector Xylose (repressor) from Oceanobacillus iheyensis HTE831
    28% identity, 97% coverage of query (102 bits)

1z05A / Q9KQJ1 Crystal structure of the rok family transcriptional regulator, homolog of e.Coli mlc protein.
    27% identity, 79% coverage of query (100 bits)

NagC / VIMSS3566654 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Aeromonas salmonicida subsp. salmonicida A449
    26% identity, 95% coverage of query (100 bits)

5f7qE / Q8YAF1 Rok repressor lmo0178 from listeria monocytogenes bound to operator (see paper)
    26% identity, 94% coverage of query (100 bits)

5f7rA Rok repressor lmo0178 from listeria monocytogenes bound to inducer
    28% identity, 78% coverage of query (99.8 bits)

YcfX / b1119 N-acetyl-D-glucosamine kinase (EC 2.7.1.59) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
nagK / P75959 N-acetyl-D-glucosamine kinase (EC 2.7.1.59) from Escherichia coli (strain K12) (see 6 papers)
NAGK_ECOLI / P75959 N-acetyl-D-glucosamine kinase; GlcNAc kinase; EC 2.7.1.59 from Escherichia coli (strain K12) (see 2 papers)
nagK / GB|ABB62126.1 N-acetyl-D-glucosamine kinase; EC 2.7.1.59 from Escherichia coli K12 (see 5 papers)
    28% identity, 95% coverage of query (96.7 bits)

NagC / VIMSS7700176 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Tolumonas auensis DSM 9187
    30% identity, 76% coverage of query (96.7 bits)

NagC / VIMSS339340 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (activator/repressor) from Vibrio parahaemolyticus RIMD 2210633
    26% identity, 97% coverage of query (95.9 bits)

NagC / VIMSS4630820 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Moritella sp. PE36
    28% identity, 79% coverage of query (95.9 bits)

NagC / VIMSS548778 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (activator/repressor) from Photorhabdus luminescens TTO1
    27% identity, 99% coverage of query (95.1 bits)

NanR / VIMSS6110394 NanR regulator of Sialic acid utilization; N-acetylglucosamine utilization, effector N-acetylglucosamine; N-acetylneuraminic acid (repressor) from Bacteroides plebeius DSM 17135
    24% identity, 98% coverage of query (94.7 bits)

NagC / b0676 DNA-binding transcriptional dual regulator NagC from Escherichia coli K-12 substr. MG1655 (see 14 papers)
NAGC_ECOLI / P0AF20 N-acetylglucosamine repressor from Escherichia coli (strain K12) (see paper)
NagC / P0AF20 Transcription factor NagC (activator/repressor) from Escherichia coli K12 MG1655 (see 3 papers)
nagC / SP|P0AF20 N-acetylglucosamine repressor from Escherichia coli K12 (see paper)
    27% identity, 99% coverage of query (94.0 bits)

2yi1A Crystal structure of n-acetylmannosamine kinase in complex with n- acetyl mannosamine 6-phosphate and adp.
    29% identity, 88% coverage of query (93.2 bits)

2yhyA Structure of n-acetylmannosamine kinase in complex with n- acetylmannosamine and adp
    29% identity, 88% coverage of query (93.2 bits)

A0A160PRJ4 polyphosphate-glucose phosphotransferase (EC 2.7.1.63) from Corynebacterium glutamicum (see paper)
    30% identity, 95% coverage of query (92.8 bits)

GLCNE_CRIGR / Q7TQ49 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; EC 3.2.1.183; EC 2.7.1.60 from Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (see paper)
    29% identity, 86% coverage of query (92.0 bits)

GLCNE_MOUSE / Q91WG8 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; EC 3.2.1.183; EC 2.7.1.60 from Mus musculus (Mouse) (see 3 papers)
Q91WG8 UDP-N-acetylglucosamine 2-epimerase (hydrolysing) (EC 3.2.1.183) from Mus musculus (see paper)
    28% identity, 87% coverage of query (92.0 bits)

H6UH58 glucokinase (EC 2.7.1.2) from Staphylococcus aureus (see paper)
    27% identity, 96% coverage of query (91.3 bits)

XylR / VIMSS65339 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus halodurans C-125
    28% identity, 79% coverage of query (91.3 bits)

2yhwA / Q9Y223 High-resolution crystal structures of n-acetylmannosamine kinase: insights about substrate specificity, activity and inhibitor modelling. (see paper)
    28% identity, 88% coverage of query (91.3 bits)

Gne / O35826 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase subunit (EC 2.7.1.60; EC 3.2.1.183) from Rattus norvegicus (see paper)
GLCNE_RAT / O35826 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; EC 3.2.1.183; EC 2.7.1.60 from Rattus norvegicus (Rat) (see 5 papers)
    28% identity, 87% coverage of query (91.3 bits)

GLCNE_HUMAN / Q9Y223 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; EC 3.2.1.183; EC 2.7.1.60 from Homo sapiens (Human) (see 24 papers)
Q9Y223 N-acylmannosamine kinase (EC 2.7.1.60); UDP-N-acetylglucosamine 2-epimerase (hydrolysing) (EC 3.2.1.183); UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) (EC 5.1.3.14) from Homo sapiens (see 18 papers)
    28% identity, 87% coverage of query (89.4 bits)

Mlc / b1594 DNA-binding transcriptional repressor Mlc from Escherichia coli K-12 substr. MG1655 (see 15 papers)
MLC_ECOLI / P50456 DNA-binding transcriptional repressor Mlc; Making large colonies protein; Membrane linked control from Escherichia coli (strain K12) (see 15 papers)
Mlc / P50456 Transcription factor Mlc (repressor) from Escherichia coli K12 MG1655 (see 4 papers)
mlc / RF|NP_416111.1 protein mlc from Escherichia coli K12 (see 7 papers)
    26% identity, 76% coverage of query (87.8 bits)

YjcT / b4084 D-allose kinase (EC 2.7.1.55) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
alsK / P32718 D-allose kinase (EC 2.7.1.55) from Escherichia coli (strain K12) (see 4 papers)
ALSK_ECOLI / P32718 D-allose kinase; Allokinase; EC 2.7.1.55 from Escherichia coli (strain K12) (see 2 papers)
alsK / RF|NP_418508 D-allose kinase; EC 2.7.1.55 from Escherichia coli K12 (see 6 papers)
    27% identity, 97% coverage of query (87.8 bits)

SMc03109 Mannokinase (EC 2.7.1.7) from Sinorhizobium meliloti 1021
    28% identity, 96% coverage of query (87.8 bits)

1z6rA / P50456 Crystal structure of mlc from escherichia coli (see paper)
    26% identity, 76% coverage of query (87.4 bits)

A0A3G4RHV5 polyphosphate-glucose phosphotransferase (EC 2.7.1.63) from Methylomonas methanica (see paper)
    30% identity, 98% coverage of query (86.7 bits)

6jdhA Crystal structure of n-acetyl mannosmaine kinase from pasteurella multocida
    27% identity, 95% coverage of query (85.9 bits)

6jdoA Crystal structure of n-acetyl mannosmaine kinase with amp-pnp from pasteurella multocida
    27% identity, 95% coverage of query (85.9 bits)

6jdbA / Q4QP43 Crystal structure of n-acetyl mannosmaine kinase in complex with mannac-6p and adp from haemophilus influenzae
    26% identity, 97% coverage of query (83.2 bits)

1woqA / Q7WT42 Crystal structure of inorganic polyphosphate/atp-glucomannokinase from arthrobacter sp. Strain km at 1.8 a resolution (see paper)
    31% identity, 87% coverage of query (82.8 bits)

2gupA / A0A0H2USG4 Structural genomics, the crystal structure of a rok family protein from streptococcus pneumoniae tigr4 in complex with sucrose
    27% identity, 84% coverage of query (81.6 bits)

2ap1A / Q8ZPZ9 Crystal structure of the putative regulatory protein
    29% identity, 97% coverage of query (80.1 bits)

3eo3A / Q9Y223 Crystal structure of the n-acetylmannosamine kinase domain of human gne protein (see paper)
    29% identity, 87% coverage of query (79.3 bits)

6jdcA / Q4QP43 Crystal structure of n-acetyl mannosmaine kinase in complex with mannac from haemophilus influenzae
    26% identity, 97% coverage of query (78.2 bits)

NAGK_SALTY / Q8ZPZ9 N-acetyl-D-glucosamine kinase; GlcNAc kinase; EC 2.7.1.59 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    30% identity, 95% coverage of query (77.8 bits)

3lm9A Crystal structure of fructokinase with adp and fructose bound in the active site
    26% identity, 95% coverage of query (77.0 bits)

1xc3A / O05510 Structure of a putative fructokinase from bacillus subtilis (see paper)
    26% identity, 95% coverage of query (76.6 bits)

YhcI / b3222 N-acetylmannosamine kinase (EC 2.7.1.60) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
nanK / P45425 N-acetylmannosamine kinase (EC 2.7.1.60) from Escherichia coli (strain K12) (see 5 papers)
NANK_ECOLI / P45425 N-acetylmannosamine kinase; ManNAc kinase; N-acetyl-D-mannosamine kinase; EC 2.7.1.60 from Escherichia coli (strain K12) (see 3 papers)
    28% identity, 80% coverage of query (63.9 bits)

2aa4A / P45425 Crystal structure of escherichia coli putative n-acetylmannosamine kinase, new york structural genomics consortium
    28% identity, 80% coverage of query (63.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory