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Searching for up to 100 curated homologs for WP_041642796.1 NCBI__GCF_000061505.1:WP_041642796.1 (195 a.a.)

Found high-coverage hits (≥70%) to 40 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

hisB / BAC65272.1 imidazoleglycerol-phosphate dehydratase from Burkholderia multivorans (see paper)
    79% identity, 100% coverage of query (313 bits)

BPHYT_RS17700 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) from Burkholderia phytofirmans PsJN
    77% identity, 100% coverage of query (309 bits)

HIS5B_ARATH / O23346 Imidazoleglycerol-phosphate dehydratase 2, chloroplastic; IGPD 2; Protein HISTIDINE BIOSYNTHESIS 5B; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O23346 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) from Arabidopsis thaliana (see paper)
    55% identity, 99% coverage of query (216 bits)

5el9A / O23346 A. Thaliana igpd2 in complex with the triazole-phosphonate inhibitor, (s)-c348, to 1.1a resolution (see paper)
    55% identity, 99% coverage of query (214 bits)

HISN5A / P34047 imidazoleglycerolphosphate dehydratase (EC 4.2.1.19) from Arabidopsis thaliana (see 2 papers)
HIS5A_ARATH / P34047 Imidazoleglycerol-phosphate dehydratase 1, chloroplastic; IGPD 1; Protein HISTIDINE BIOSYNTHESIS 5A; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    53% identity, 99% coverage of query (212 bits)

5ekwA A. Thaliana igpd2 in complex with the racemate of the triazole- phosphonate inhibitor, c348
    55% identity, 98% coverage of query (212 bits)

4qnkA The structure of wt a. Thaliana igpd2 in complex with mn2+ and phosphate
    54% identity, 93% coverage of query (199 bits)

4mu1A The structure of wt a. Thaliana igpd2 in complex with mn2+, imidazole, and sulfate at 1.5 a resolution
    54% identity, 93% coverage of query (199 bits)

4mu0A The structure of wt a. Thaliana igpd2 in complex with mn2+ and 1,2,4- triazole at 1.3 a resolution
    54% identity, 93% coverage of query (199 bits)

4mu3A The form a structure of an e21q catalytic mutant of a. Thaliana igpd2 in complex with mn2+ and a mixture of its substrate, 2r3s-igp, and an inhibitor, 2s3s-igp, to 1.12 a resolution
    54% identity, 93% coverage of query (198 bits)

2f1dA X-ray structure of imidazoleglycerol-phosphate dehydratase
    53% identity, 93% coverage of query (196 bits)

8qawA / A0A072VQG6 Medicago truncatula hisn5 (igpd) in complex with mn, imd, edo, fmt, gol and trs (see paper)
    52% identity, 93% coverage of query (194 bits)

8qavA Medicago truncatula hisn5 (igpd) in complex with mn and ig2
    52% identity, 93% coverage of query (194 bits)

6fwhA / L8H477 Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
    51% identity, 99% coverage of query (192 bits)

6fwhL Acanthamoeba igpd in complex with r-c348 to 1.7a resolution
    51% identity, 99% coverage of query (192 bits)

HIS7_SPILD / D2QPE6 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896 / Claus 1) (see paper)
    48% identity, 99% coverage of query (190 bits)

HIS7_CRYNJ / P0CO22 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) (see paper)
    48% identity, 99% coverage of query (190 bits)

HIS7_ECO57 / Q9S5G5 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Escherichia coli O157:H7 (see paper)
    49% identity, 99% coverage of query (186 bits)

HisB / b2022 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (EC 4.2.1.19; EC 3.1.3.15) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
hisB / P06987 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (EC 4.2.1.19; EC 3.1.3.15) from Escherichia coli (strain K12) (see 11 papers)
    49% identity, 99% coverage of query (186 bits)

HIS7_BACTN / Q8ABA7 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) (see paper)
    44% identity, 99% coverage of query (172 bits)

1rhyB / P0CO22 Crystal structure of imidazole glycerol phosphate dehydratase (see paper)
    45% identity, 92% coverage of query (166 bits)

HIS3 imidazoleglycerol-phosphate dehydratase; EC 4.2.1.19 from Candida albicans (see paper)
    41% identity, 99% coverage of query (161 bits)

hisB / CAQ00039.1 imidazoleglycerol-phosphate dehydratase from Rhodococcus erythropolis (see paper)
    46% identity, 99% coverage of query (161 bits)

HIS7_MYCTU / P9WML9 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    45% identity, 94% coverage of query (157 bits)

6ezmU / P06633 Imidazoleglycerol-phosphate dehydratase from saccharomyces cerevisiae (see paper)
    41% identity, 99% coverage of query (155 bits)

H9C4A4 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) from Kazachstania humilis (see paper)
    42% identity, 99% coverage of query (155 bits)

HIS7_YEAST / P06633 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    40% identity, 99% coverage of query (154 bits)

his5 / GI|3116116 imidazoleglycerol-phosphate dehydratase His5; EC 4.2.1.19 from Schizosaccharomyces pombe (see 2 papers)
his5 / AAA92791.1 imidazoleglycerol-phosphate dehydratase from Schizosaccharomyces pombe (see paper)
    41% identity, 100% coverage of query (153 bits)

P40374 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    41% identity, 100% coverage of query (153 bits)

2ae8B / P64373 Crystal structure of imidazoleglycerol-phosphate dehydratase from staphylococcus aureus subsp. Aureus n315
    44% identity, 88% coverage of query (150 bits)

hisB imidazoleglycerol-phosphate dehydratase; EC 4.2.1.19 from Emericella nidulans (see 2 papers)
    36% identity, 98% coverage of query (145 bits)

4gquA / P9WML9 Crystal structure of hisb from mycobacterium tuberculosis
    43% identity, 89% coverage of query (143 bits)

5xdsA Crystal structure of mycobacterium tuberculosis hisb bound with an inhibitor
    43% identity, 89% coverage of query (143 bits)

4lomA Crystal structure of mycobacterium tuberculosis hisb in complex with its substrate
    43% identity, 89% coverage of query (143 bits)

7fcyA Crystal structure of m.Tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
    43% identity, 88% coverage of query (143 bits)

7dnqA Crystal structure of m.Tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
    43% identity, 88% coverage of query (143 bits)

7ddvA Crystal structure of m.Tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
    43% identity, 88% coverage of query (143 bits)

4lpfA Crystal structure of mycobacterium tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
    43% identity, 88% coverage of query (143 bits)

5dnlA / P58880 Crystal structure of igpd from pyrococcus furiosus in complex with (s)-c348 (see paper)
    40% identity, 96% coverage of query (107 bits)

5dnxA Crystal structure of igpd from pyrococcus furiosus in complex with (r)-c348
    40% identity, 96% coverage of query (107 bits)

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Build an alignment for WP_041642796.1 and 40 homologs with ≥ 30% identity

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory