Searching for up to 100 curated homologs for WP_042118977.1 NCBI__GCF_000092045.1:WP_042118977.1 (389 a.a.)
Found high-coverage hits (≥70%) to 37 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
pobA / AAA73519.1 4-hydroxybenzoate hydroxylase from Rhizobium leguminosarum (see paper)
90% identity, 100% coverage of query (727 bits)
pobA / P00438 p-hydroxybenzoate hydroxylase (EC 1.14.13.2) from Pseudomonas fluorescens (see 2 papers)
PHHY_PSEFL / P00438 p-hydroxybenzoate hydroxylase; PHBH; PHBHase; 4-hydroxybenzoate 3-monooxygenase; EC 1.14.13.2 from Pseudomonas fluorescens (see 13 papers)
65% identity, 100% coverage of query (533 bits)
2phhA The coenzyme analogue adenosine 5-diphosphoribose displaces fad in the active site of p-hydroxybenzoate hydroxylase. An x-ray crystallographic investigation
65% identity, 100% coverage of query (533 bits)
1pdhA Crystal structure of p-hydroxybenzoate hydroxylase reconstituted with the modified fad present in alcohol oxidase from methylotrophic yeasts: evidence for an arabinoflavin
65% identity, 100% coverage of query (533 bits)
PHHY_PSEAE / P20586 p-hydroxybenzoate hydroxylase; PHBH; 4-hydroxybenzoate 3-monooxygenase; EC 1.14.13.2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 7 papers)
1d7lA / P20586 Structure-function correlations of the reaction of reduced nicotinamide analogs with p-hydroxybenzoate hydroxylase substituted with a series of 8-substituted flavins (see paper)
65% identity, 100% coverage of query (532 bits)
1iusA P-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate at ph 5.0
65% identity, 100% coverage of query (532 bits)
1dodA The mobil flavin of 4-oh benzoate hydroxylase: motion of a prosthetic group regulates catalysis
65% identity, 100% coverage of query (532 bits)
1k0lA Pseudomonas aeruginosa phbh r220q free of p-ohb
65% identity, 100% coverage of query (531 bits)
1k0jA Pseudomonas aeruginosa phbh r220q in complex with NADPH and free of p- ohb
65% identity, 100% coverage of query (531 bits)
1pbcA Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate, 2,4-dihydroxybenzoate and 2-hydroxy- 4-aminobenzoate and of the try222ala mutant, complexed with 2- hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring
65% identity, 100% coverage of query (530 bits)
1bf3A P-hydroxybenzoate hydroxylase (phbh) mutant with cys 116 replaced by ser (c116s) and arg 42 replaced by lys (r42k), in complex with fad and 4-hydroxybenzoic acid
65% identity, 100% coverage of query (528 bits)
8y2sA 4-hydroxybenzoate 3-monooxygenase
64% identity, 100% coverage of query (527 bits)
1ykjB A45g p-hydroxybenzoate hydroxylase with p-hydroxybenzoate bound
64% identity, 100% coverage of query (524 bits)
6dllB / Q88H28 2.2 angstrom resolution crystal structure of p-hydroxybenzoate hydroxylase from pseudomonas putida in complex with fad. (see paper)
62% identity, 100% coverage of query (504 bits)
Pf6N2E2_2914 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Pseudomonas fluorescens FW300-N2E2
62% identity, 100% coverage of query (504 bits)
pobA / Q9R9T1 p-hydroxybenzoate hydroxylase (EC 1.14.13.2) from Pseudomonas putida (see paper)
Q9R9T1 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Pseudomonas putida (see paper)
62% identity, 100% coverage of query (503 bits)
RR42_RS21940 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Cupriavidus basilensis FW507-4G11
66% identity, 100% coverage of query (502 bits)
pobA / F2JUE7 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1) (see paper)
58% identity, 100% coverage of query (470 bits)
7on9A / C4TP09 Crystal structure of para-hydroxybenzoate-3-hydroxylase prai (see paper)
53% identity, 100% coverage of query (402 bits)
PRAI_PAESP / C4TP09 4-hydroxybenzoate 3-monooxygenase (NAD(P)H); 4-hydroxybenzoate 3-hydroxylase; 4HB 3-hydroxylase; EC 1.14.13.33 from Paenibacillus sp. (see paper)
praI / BAH79107.1 4-hydroxybenzoate 3-hydroxylase from Paenibacillus sp. JJ-1b (see paper)
53% identity, 100% coverage of query (402 bits)
8jqoA Protocatecuate hydroxylase from xylophilus ampelinus complexed with imidazole (see paper)
45% identity, 100% coverage of query (362 bits)
8weqC / A0A4P7SP66 P-hydroxybenzoate 3-monooxygenase
46% identity, 100% coverage of query (332 bits)
8jqoD Protocatecuate hydroxylase from xylophilus ampelinus complexed with imidazole (see paper)
40% identity, 99% coverage of query (271 bits)
Build an alignment for WP_042118977.1 and 23 homologs with ≥ 30% identity
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oxyS / L8EUQ6 anhydrotetracycline monooxygenase monomer (EC 1.14.13.234; EC 1.14.13.38) from Streptomyces rimosus subsp. rimosus (strain ATCC 10970 / DSM 40260 / JCM 4667 / NRRL 2234) (see 6 papers)
OXYS_STRR1 / L8EUQ6 12-dehydrotetracycline 5-monooxygenase/anhydrotetracycline 6-monooxygenase; EC 1.14.13.234; EC 1.14.13.38 from Streptomyces rimosus subsp. rimosus (strain ATCC 10970 / DSM 40260 / JCM 4667 / NRRL 2234) (see paper)
L8EUQ6 5a,11a-dehydrotetracycline 5-monooxygenase (EC 1.14.13.234) from Streptomyces rimosus subsp. rimosus (see paper)
26% identity, 78% coverage of query (53.5 bits)
4k2xB / L8EUQ6 Oxys anhydrotetracycline hydroxylase from streptomyces rimosus (see paper)
27% identity, 78% coverage of query (53.5 bits)
OTCC_STRRM / Q58PK7 Anhydrotetracycline monooxygenase; EC 1.14.13.38 from Streptomyces rimosus (see paper)
Q58PK7 anhydrotetracycline 6-monooxygenase (EC 1.14.13.38) from Streptomyces rimosus (see paper)
26% identity, 78% coverage of query (51.6 bits)
7oujAAA / Q8KY42 7oujAAA (see paper)
26% identity, 75% coverage of query (50.8 bits)
rif19 / Q9AE02 rifamycin ring hydroxylase from Amycolatopsis mediterranei (see 4 papers)
24% identity, 79% coverage of query (49.7 bits)
7yj0D Structural basis of oxepinone formation by a flavin-monooxygenase vibo (see paper)
23% identity, 79% coverage of query (49.3 bits)
5kowA / Q5YTV5 Structure of rifampicin monooxygenase (see paper)
28% identity, 78% coverage of query (49.3 bits)
6c7sA Structure of rifampicin monooxygenase with product bound
28% identity, 78% coverage of query (49.3 bits)
5koxA Structure of rifampicin monooxygenase complexed with rifampicin
28% identity, 78% coverage of query (49.3 bits)
ROX_NOCFA / Q5YTV5 Rifampicin monooxygenase; RIFMO; EC 1.14.13.211 from Nocardia farcinica (strain IFM 10152) (see 3 papers)
Q5YTV5 rifampicin monooxygenase (EC 1.14.13.211) from Nocardia farcinica (see paper)
28% identity, 78% coverage of query (49.3 bits)
elmG / Q9L4Y1 tetracenomycin B2 oxygenase (EC 1.14.13.200) from Streptomyces olivaceus (see 6 papers)
ELMG_STROV / Q9L4Y1 Tetracenomycin B2 monooxygenase-dioxygenase; Tetracenomycin B2 oxygenase; Tcm B2 oxygenase; EC 1.14.13.200 from Streptomyces olivaceus (see 2 papers)
Q9L4Y1 tetracenomycin A2 monooxygenase-dioxygenase (EC 1.14.13.200) from Streptomyces olivaceus (see 2 papers)
24% identity, 84% coverage of query (48.5 bits)
PYRE3_STRRG / K7QRJ5 Dialkyldecalin synthase; FAD-dependent [4+2] cyclase; EC 5.5.1.- from Streptomyces rugosporus (see 2 papers)
26% identity, 79% coverage of query (45.4 bits)
5xgvA / K7QRJ5 The structure of diels-alderase pyre3 in the biosynthetic pathway of pyrroindomycins (see paper)
26% identity, 78% coverage of query (44.3 bits)
8fhjC Crystal structure of a fad monooxygenease from methylocystis sp. Strain sb2 (see paper)
26% identity, 79% coverage of query (43.9 bits)
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