Searching for up to 100 curated homologs for WP_046104561.1 NCBI__GCF_000969445.1:WP_046104561.1 (403 a.a.)
Found high-coverage hits (≥70%) to 91 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
idhA / AAC43640.1 isocitrate dehydrogenase from Sphingobium yanoikuyae (see paper)
74% identity, 100% coverage of query (640 bits)
B7GQR3 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Bifidobacterium longum subsp. infantis (see paper)
70% identity, 100% coverage of query (604 bits)
icd1 / P9WKL1 isocitrate dehydrogenase subunit (EC 1.1.1.42) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
A5U813 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mycobacterium tuberculosis (see paper)
P9WKL1 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mycobacterium tuberculosis (see paper)
69% identity, 100% coverage of query (586 bits)
4hcxA / P9WKL1 Structure of icdh-1 from m.Tuberculosis complexed with NADPH & mn2+ (see paper)
70% identity, 99% coverage of query (583 bits)
IDHP_PIG / P33198 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Sus scrofa (Pig) (see 2 papers)
67% identity, 100% coverage of query (574 bits)
IDHP_MOUSE / P54071 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Mus musculus (Mouse) (see 2 papers)
P54071 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mus musculus (see 5 papers)
66% identity, 100% coverage of query (571 bits)
Q4E4L7 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Trypanosoma cruzi (see paper)
66% identity, 100% coverage of query (570 bits)
IDH1 / O75874 cytosolic NADP(+)-dependent isocitrate dehydrogenase monomer (EC 1.1.1.42) from Homo sapiens (see 13 papers)
IDHC_HUMAN / O75874 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Homo sapiens (Human) (see 5 papers)
O75874 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Homo sapiens (see 8 papers)
66% identity, 100% coverage of query (569 bits)
IDH2 / P48735 mitochondrial isocitrate dehydrogenase monomer (EC 1.1.1.42) from Homo sapiens (see 14 papers)
IDHP_HUMAN / P48735 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Homo sapiens (Human) (see 5 papers)
P48735 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Homo sapiens (see 9 papers)
66% identity, 100% coverage of query (569 bits)
1t09A Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex NADP
66% identity, 100% coverage of query (569 bits)
5h3eB Crystal structure of mouse isocitrate dehydrogenases 2 k256q mutant complexed with isocitrate
66% identity, 100% coverage of query (569 bits)
6ajcA / Q4E4L7 Crystal structure of trypanosoma cruzi cytosolic isocitrate dehydrogenase in complex with NADP+, isocitrate and ca2+
66% identity, 99% coverage of query (568 bits)
8vhaA Crystal structure of human idh1 r132q in complex with NADPH and alpha- ketoglutarate
66% identity, 100% coverage of query (568 bits)
8vheB / O75874 8vheB (see paper)
66% identity, 100% coverage of query (567 bits)
IDHP_RAT / P56574 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Rattus norvegicus (Rat)
P56574 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Rattus norvegicus (see 2 papers)
66% identity, 100% coverage of query (567 bits)
5svoA Structure of idh2 mutant r140q
66% identity, 100% coverage of query (567 bits)
6bl2A Novel modes of inhibition of wild-type idh1: direct covalent modification of his315 with cmpd15
67% identity, 98% coverage of query (567 bits)
6bl1A Novel modes of inhibition of wild-type idh1: direct covalent modification of his315 with cmpd13
67% identity, 98% coverage of query (567 bits)
6bl0A Novel modes of inhibition of wild-type idh1:direct covalent modification of his315 with cmpd11
67% identity, 98% coverage of query (567 bits)
6bkyA Novel binding modes of inhibition of wild-type idh1: allosteric inhibition with cmpd2
67% identity, 98% coverage of query (567 bits)
5i95A Crystal structure of human mitochondrial isocitrate dehydrogenase r140q mutant homodimer bound to NADPH and alpha-ketoglutaric acid
66% identity, 100% coverage of query (567 bits)
6adiA / P48735 Crystal structures of idh2 r140q in complex with ag-881 (see paper)
66% identity, 100% coverage of query (566 bits)
6bkxA Novel modes of inhibition of wild-type idh1: direct covalent modification of his315 with cmpd1
67% identity, 98% coverage of query (566 bits)
5i96A Crystal structure of human mitochondrial isocitrate dehydrogenase (idh2) r140q mutant homodimer in complex with ag-221 (enasidenib) inhibitor.
66% identity, 100% coverage of query (566 bits)
5yfmA Human isocitrate dehydrogenase 1 bound with NADP
67% identity, 98% coverage of query (566 bits)
4ja8A Complex of mitochondrial isocitrate dehydrogenase r140q mutant with agi-6780 inhibitor
66% identity, 100% coverage of query (566 bits)
6bkzA Novel modes of inhibition of wild-type idh1: non-equivalent allosteric inhibition with cmpd3
67% identity, 98% coverage of query (566 bits)
6vg0A Crystal structure of human cytosolic isocitrate dehydrogenase (idh1) r132h mutant in complex with NADPH and agi-15056
66% identity, 100% coverage of query (565 bits)
6u4jA Crystal structure of idh1 r132h mutant in complex with ft-2102
67% identity, 98% coverage of query (565 bits)
Q6C2Y4 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Yarrowia lipolytica (see 2 papers)
67% identity, 100% coverage of query (564 bits)
6veiA Crystal structure of human cytosolic isocitrate dehydrogenase (idh1) r132h mutant in complex with NADPH and ag-881 (vorasidenib) inhibitor
67% identity, 98% coverage of query (564 bits)
8bayA Crystal structure of idh1 variant r132c s280f in complex with NADPH, ca2+ and 3-butyl-2-oxoglutarate
67% identity, 98% coverage of query (564 bits)
6adgA Crystal structures of idh1 r132h in complex with ag-881
67% identity, 98% coverage of query (564 bits)
4umxA Idh1 r132h in complex with cpd 1
67% identity, 98% coverage of query (564 bits)
6o2yA Crystal structure of idh1 r132h mutant in complex with compound 24
67% identity, 98% coverage of query (564 bits)
3inmA Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase r132h mutant in complex with NADPH, alpha-ketoglutarate and calcium(2+)
67% identity, 98% coverage of query (564 bits)
IDHC_RAT / P41562 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Rattus norvegicus (Rat) (see 2 papers)
P41562 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Rattus norvegicus (see 2 papers)
66% identity, 100% coverage of query (563 bits)
cICDH / Q9SRZ6 NADP+-dependent isocitrate dehydrogenase (EC 1.1.1.42) from Arabidopsis thaliana (see paper)
ICDHC_ARATH / Q9SRZ6 Cytosolic isocitrate dehydrogenase [NADP]; EC 1.1.1.42 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SRZ6 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Arabidopsis thaliana (see paper)
66% identity, 99% coverage of query (561 bits)
ICDHP_ARATH / Q8LPJ5 Isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial; EC 1.1.1.42 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
66% identity, 99% coverage of query (558 bits)
O65853 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Nicotiana tabacum (see paper)
65% identity, 100% coverage of query (558 bits)
5lgeA Crystal structure of human idh1 mutant (r132h) in complex with NADP+ and an inhibitor related to bay 1436032
66% identity, 98% coverage of query (558 bits)
A0A4X1UZU9 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Sus scrofa (see paper)
65% identity, 100% coverage of query (557 bits)
IDHC_MOUSE / O88844 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Mus musculus (Mouse) (see 2 papers)
O88844 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mus musculus (see 3 papers)
65% identity, 100% coverage of query (557 bits)
5l57A Crystal structure of iso-citrate dehydrogenase r132h in complex with a novel inhibitor (compound 13a)
66% identity, 98% coverage of query (557 bits)
6o2zA Crystal structure of idh1 r132h mutant in complex with compound 32
67% identity, 98% coverage of query (556 bits)
5yziA Crystal structure of mouse cytosolic isocitrate dehydrogenase complexed with cadmium
66% identity, 98% coverage of query (556 bits)
IDHC_BOVIN / Q9XSG3 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Bos taurus (Bovine) (see paper)
64% identity, 100% coverage of query (555 bits)
IDHP_SCHPO / O14254 Probable isocitrate dehydrogenase [NADP], mitochondrial; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
64% identity, 98% coverage of query (553 bits)
A0A2G2Y555 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Capsicum annuum (see paper)
66% identity, 99% coverage of query (552 bits)
Q6R6M7 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Pisum sativum (see 2 papers)
65% identity, 100% coverage of query (552 bits)
IDHC_SOYBN / Q06197 Isocitrate dehydrogenase [NADP]; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Glycine max (Soybean) (Glycine hispida) (see paper)
65% identity, 100% coverage of query (551 bits)
J9Q6L4 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Capsicum annuum (see paper)
66% identity, 97% coverage of query (551 bits)
7pjnA Crystal structure of ivosidenib-resistant idh1 variant r132c s280f in complex with NADPH and inhibitor ds-1001b
66% identity, 98% coverage of query (551 bits)
idpA mitochondrial NADP-dependent isocitrate dehydrogenase; EC 1.1.1.42 from Emericella nidulans (see paper)
63% identity, 99% coverage of query (550 bits)
A0AR16 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Pinus pinaster (see paper)
66% identity, 99% coverage of query (549 bits)
P21954 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Saccharomyces cerevisiae (see 2 papers)
65% identity, 100% coverage of query (547 bits)
2qfyA / P21954 Crystal structure of saccharomyces cerevesiae mitochondrial NADP(+)- dependent isocitrate dehydrogenase in complex with a-ketoglutarate (see paper)
65% identity, 100% coverage of query (546 bits)
ICDHX_ARATH / Q9SLK0 Peroxisomal isocitrate dehydrogenase [NADP]; EC 1.1.1.42 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SLK0 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Arabidopsis thaliana (see paper)
65% identity, 99% coverage of query (546 bits)
2qfxA Crystal structure of saccharomyces cerevesiae mitochondrial NADP(+)- dependent isocitrate dehydrogenase in complex with NADPH, a- ketoglutarate and ca(2+)
65% identity, 100% coverage of query (546 bits)
2qfvA Crystal structure of saccharomyces cerevesiae mitochondrial NADP(+)- dependent isocitrate dehydrogenase in complex with NADP(+)
65% identity, 100% coverage of query (546 bits)
6aj6A / Q387G0 Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+
62% identity, 100% coverage of query (539 bits)
6ajbA Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with nadh, alpha-ketoglutarate and ca2+
62% identity, 100% coverage of query (539 bits)
6aj8B Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+, alpha-ketoglutarate and ca2+
62% identity, 100% coverage of query (539 bits)
6aj8A Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+, alpha-ketoglutarate and ca2+
62% identity, 100% coverage of query (539 bits)
IDP2 / P41939 NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 4 papers)
IDHC_YEAST / P41939 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P41939 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Saccharomyces cerevisiae (see paper)
63% identity, 99% coverage of query (538 bits)
6q6fA Crystal structure of idh1 r132h in complex with hms101
63% identity, 100% coverage of query (537 bits)
5tqhA Idh1 r132h mutant in complex with idh889
65% identity, 98% coverage of query (534 bits)
8hb9AAA Isocitrate dehydrogenase [NADP] cytoplasmic
65% identity, 98% coverage of query (531 bits)
Q4DG65 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Trypanosoma cruzi (see paper)
67% identity, 94% coverage of query (530 bits)
5svfA Idh1 r132h in complex with idh125
64% identity, 98% coverage of query (528 bits)
6b0zA Idh1 r132h mutant in complex with idh305
64% identity, 98% coverage of query (528 bits)
6io0A Human idh1 r132c mutant complexed with compound a.
64% identity, 98% coverage of query (528 bits)
5de1A Crystal structure of human idh1 in complex with gsk321a
64% identity, 98% coverage of query (525 bits)
6adgC / O75874 Crystal structures of idh1 r132h in complex with ag-881 (see paper)
62% identity, 98% coverage of query (511 bits)
4xrxA Crystal structure of a metabolic reductase with (e)-5-((1-methyl-5- oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1h)-one
62% identity, 98% coverage of query (509 bits)
3marA / O75874 Crystal structure of homodimeric r132h mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP (see paper)
62% identity, 100% coverage of query (508 bits)
5sunA Idh1 r132h in complex with idh146
62% identity, 98% coverage of query (503 bits)
4xs3A Crystal structure of a metabolic reductase with (e)-1-benzyl-5-((1- methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1h)-one
61% identity, 98% coverage of query (494 bits)
5l58A / O75874 Crystal structure of iso-citrate dehydrogenase 1 [idh1 (r132h)] in complex with a novel inhibitor (compound 2) (see paper)
61% identity, 98% coverage of query (490 bits)
4i3kA / O75874 Crystal structure of a metabolic reductase with 1-hydroxy-6-(4- hydroxybenzyl)-4-methylpyridin-2(1h)-one (see paper)
59% identity, 98% coverage of query (466 bits)
4aouA / A3DC45 Ctidh bound to NADP. The complex structures of isocitrate dehydrogenase from clostridium thermocellum and desulfotalea psychrophila, support a new active site locking mechanism (see paper)
56% identity, 99% coverage of query (463 bits)
4aovA Dpidh-NADP. The complex structures of isocitrate dehydrogenase from clostridium thermocellum and desulfotalea psychrophila, support a new active site locking mechanism
49% identity, 99% coverage of query (400 bits)
Q6AQ66 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Desulfotalea psychrophila (see paper)
2uxqA / Q6AQ66 Isocitrate dehydrogenase from the psychrophilic bacterium desulfotalea psychrophila: biochemical properties and crystal structure analysis (see paper)
49% identity, 99% coverage of query (399 bits)
IDH1_PHATC / B7G620 Isocitrate dehydrogenase [NAD(+)] 1, mitochondrial; PtIDH1; EC 1.1.1.41 from Phaeodactylum tricornutum (strain CCAP 1055/1) (see paper)
33% identity, 99% coverage of query (170 bits)
IDH_OSTTA / A0A096P8D3 Isocitrate dehydrogenase (NAD(+)), mitochondrial; OtIDH; EC 1.1.1.41 from Ostreococcus tauri (see paper)
31% identity, 99% coverage of query (159 bits)
6ixnA / A0A096P8D3 Crystal structure of isocitrate dehydrogenase from ostreococcus tauri in complex with NAD+ and citrate (see paper)
31% identity, 99% coverage of query (159 bits)
6ixtA Crystal structure of isocitrate dehydrogenase from ostreococcus tauri in complex with NAD+ and mg2+
31% identity, 99% coverage of query (159 bits)
C1E5X2 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Micromonas commoda (see paper)
32% identity, 97% coverage of query (157 bits)
A4SBK5 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Ostreococcus sp. 'lucimarinus' (see paper)
33% identity, 99% coverage of query (157 bits)
Build an alignment for WP_046104561.1 and 89 homologs with ≥ 30% identity
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Q4J6C9 isocitrate-homoisocitrate dehydrogenase (EC 1.1.1.286) from Sulfolobus acidocaldarius (see paper)
21% identity, 81% coverage of query (47.0 bits)
Q9HLV8 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Thermoplasma acidophilum (see paper)
23% identity, 82% coverage of query (46.2 bits)
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