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Searching for up to 100 curated homologs for WP_046104561.1 NCBI__GCF_000969445.1:WP_046104561.1 (403 a.a.)

Found high-coverage hits (≥70%) to 91 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

idhA / AAC43640.1 isocitrate dehydrogenase from Sphingobium yanoikuyae (see paper)
    74% identity, 100% coverage of query (640 bits)

B7GQR3 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Bifidobacterium longum subsp. infantis (see paper)
    70% identity, 100% coverage of query (604 bits)

icd1 / P9WKL1 isocitrate dehydrogenase subunit (EC 1.1.1.42) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
A5U813 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mycobacterium tuberculosis (see paper)
P9WKL1 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mycobacterium tuberculosis (see paper)
    69% identity, 100% coverage of query (586 bits)

4hcxA / P9WKL1 Structure of icdh-1 from m.Tuberculosis complexed with NADPH & mn2+ (see paper)
    70% identity, 99% coverage of query (583 bits)

IDHP_PIG / P33198 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Sus scrofa (Pig) (see 2 papers)
    67% identity, 100% coverage of query (574 bits)

IDHP_MOUSE / P54071 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Mus musculus (Mouse) (see 2 papers)
P54071 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mus musculus (see 5 papers)
    66% identity, 100% coverage of query (571 bits)

Q4E4L7 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Trypanosoma cruzi (see paper)
    66% identity, 100% coverage of query (570 bits)

IDH1 / O75874 cytosolic NADP(+)-dependent isocitrate dehydrogenase monomer (EC 1.1.1.42) from Homo sapiens (see 13 papers)
IDHC_HUMAN / O75874 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Homo sapiens (Human) (see 5 papers)
O75874 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Homo sapiens (see 8 papers)
    66% identity, 100% coverage of query (569 bits)

IDH2 / P48735 mitochondrial isocitrate dehydrogenase monomer (EC 1.1.1.42) from Homo sapiens (see 14 papers)
IDHP_HUMAN / P48735 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Homo sapiens (Human) (see 5 papers)
P48735 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Homo sapiens (see 9 papers)
    66% identity, 100% coverage of query (569 bits)

1t09A Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex NADP
    66% identity, 100% coverage of query (569 bits)

5h3eB Crystal structure of mouse isocitrate dehydrogenases 2 k256q mutant complexed with isocitrate
    66% identity, 100% coverage of query (569 bits)

6ajcA / Q4E4L7 Crystal structure of trypanosoma cruzi cytosolic isocitrate dehydrogenase in complex with NADP+, isocitrate and ca2+
    66% identity, 99% coverage of query (568 bits)

8vhaA Crystal structure of human idh1 r132q in complex with NADPH and alpha- ketoglutarate
    66% identity, 100% coverage of query (568 bits)

8vheB / O75874 8vheB (see paper)
    66% identity, 100% coverage of query (567 bits)

IDHP_RAT / P56574 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Rattus norvegicus (Rat)
P56574 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Rattus norvegicus (see 2 papers)
    66% identity, 100% coverage of query (567 bits)

5svoA Structure of idh2 mutant r140q
    66% identity, 100% coverage of query (567 bits)

6bl2A Novel modes of inhibition of wild-type idh1: direct covalent modification of his315 with cmpd15
    67% identity, 98% coverage of query (567 bits)

6bl1A Novel modes of inhibition of wild-type idh1: direct covalent modification of his315 with cmpd13
    67% identity, 98% coverage of query (567 bits)

6bl0A Novel modes of inhibition of wild-type idh1:direct covalent modification of his315 with cmpd11
    67% identity, 98% coverage of query (567 bits)

6bkyA Novel binding modes of inhibition of wild-type idh1: allosteric inhibition with cmpd2
    67% identity, 98% coverage of query (567 bits)

5i95A Crystal structure of human mitochondrial isocitrate dehydrogenase r140q mutant homodimer bound to NADPH and alpha-ketoglutaric acid
    66% identity, 100% coverage of query (567 bits)

6adiA / P48735 Crystal structures of idh2 r140q in complex with ag-881 (see paper)
    66% identity, 100% coverage of query (566 bits)

6bkxA Novel modes of inhibition of wild-type idh1: direct covalent modification of his315 with cmpd1
    67% identity, 98% coverage of query (566 bits)

5i96A Crystal structure of human mitochondrial isocitrate dehydrogenase (idh2) r140q mutant homodimer in complex with ag-221 (enasidenib) inhibitor.
    66% identity, 100% coverage of query (566 bits)

5yfmA Human isocitrate dehydrogenase 1 bound with NADP
    67% identity, 98% coverage of query (566 bits)

4ja8A Complex of mitochondrial isocitrate dehydrogenase r140q mutant with agi-6780 inhibitor
    66% identity, 100% coverage of query (566 bits)

6bkzA Novel modes of inhibition of wild-type idh1: non-equivalent allosteric inhibition with cmpd3
    67% identity, 98% coverage of query (566 bits)

6vg0A Crystal structure of human cytosolic isocitrate dehydrogenase (idh1) r132h mutant in complex with NADPH and agi-15056
    66% identity, 100% coverage of query (565 bits)

6u4jA Crystal structure of idh1 r132h mutant in complex with ft-2102
    67% identity, 98% coverage of query (565 bits)

Q6C2Y4 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Yarrowia lipolytica (see 2 papers)
    67% identity, 100% coverage of query (564 bits)

6veiA Crystal structure of human cytosolic isocitrate dehydrogenase (idh1) r132h mutant in complex with NADPH and ag-881 (vorasidenib) inhibitor
    67% identity, 98% coverage of query (564 bits)

8bayA Crystal structure of idh1 variant r132c s280f in complex with NADPH, ca2+ and 3-butyl-2-oxoglutarate
    67% identity, 98% coverage of query (564 bits)

6adgA Crystal structures of idh1 r132h in complex with ag-881
    67% identity, 98% coverage of query (564 bits)

4umxA Idh1 r132h in complex with cpd 1
    67% identity, 98% coverage of query (564 bits)

6o2yA Crystal structure of idh1 r132h mutant in complex with compound 24
    67% identity, 98% coverage of query (564 bits)

3inmA Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase r132h mutant in complex with NADPH, alpha-ketoglutarate and calcium(2+)
    67% identity, 98% coverage of query (564 bits)

IDHC_RAT / P41562 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Rattus norvegicus (Rat) (see 2 papers)
P41562 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Rattus norvegicus (see 2 papers)
    66% identity, 100% coverage of query (563 bits)

cICDH / Q9SRZ6 NADP+-dependent isocitrate dehydrogenase (EC 1.1.1.42) from Arabidopsis thaliana (see paper)
ICDHC_ARATH / Q9SRZ6 Cytosolic isocitrate dehydrogenase [NADP]; EC 1.1.1.42 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SRZ6 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Arabidopsis thaliana (see paper)
    66% identity, 99% coverage of query (561 bits)

ICDHP_ARATH / Q8LPJ5 Isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial; EC 1.1.1.42 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    66% identity, 99% coverage of query (558 bits)

O65853 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Nicotiana tabacum (see paper)
    65% identity, 100% coverage of query (558 bits)

5lgeA Crystal structure of human idh1 mutant (r132h) in complex with NADP+ and an inhibitor related to bay 1436032
    66% identity, 98% coverage of query (558 bits)

A0A4X1UZU9 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Sus scrofa (see paper)
    65% identity, 100% coverage of query (557 bits)

IDHC_MOUSE / O88844 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Mus musculus (Mouse) (see 2 papers)
O88844 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mus musculus (see 3 papers)
    65% identity, 100% coverage of query (557 bits)

5l57A Crystal structure of iso-citrate dehydrogenase r132h in complex with a novel inhibitor (compound 13a)
    66% identity, 98% coverage of query (557 bits)

6o2zA Crystal structure of idh1 r132h mutant in complex with compound 32
    67% identity, 98% coverage of query (556 bits)

5yziA Crystal structure of mouse cytosolic isocitrate dehydrogenase complexed with cadmium
    66% identity, 98% coverage of query (556 bits)

IDHC_BOVIN / Q9XSG3 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Bos taurus (Bovine) (see paper)
    64% identity, 100% coverage of query (555 bits)

IDHP_SCHPO / O14254 Probable isocitrate dehydrogenase [NADP], mitochondrial; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    64% identity, 98% coverage of query (553 bits)

A0A2G2Y555 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Capsicum annuum (see paper)
    66% identity, 99% coverage of query (552 bits)

Q6R6M7 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Pisum sativum (see 2 papers)
    65% identity, 100% coverage of query (552 bits)

IDHC_SOYBN / Q06197 Isocitrate dehydrogenase [NADP]; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Glycine max (Soybean) (Glycine hispida) (see paper)
    65% identity, 100% coverage of query (551 bits)

J9Q6L4 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Capsicum annuum (see paper)
    66% identity, 97% coverage of query (551 bits)

7pjnA Crystal structure of ivosidenib-resistant idh1 variant r132c s280f in complex with NADPH and inhibitor ds-1001b
    66% identity, 98% coverage of query (551 bits)

idpA mitochondrial NADP-dependent isocitrate dehydrogenase; EC 1.1.1.42 from Emericella nidulans (see paper)
    63% identity, 99% coverage of query (550 bits)

A0AR16 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Pinus pinaster (see paper)
    66% identity, 99% coverage of query (549 bits)

P21954 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Saccharomyces cerevisiae (see 2 papers)
    65% identity, 100% coverage of query (547 bits)

2qfyA / P21954 Crystal structure of saccharomyces cerevesiae mitochondrial NADP(+)- dependent isocitrate dehydrogenase in complex with a-ketoglutarate (see paper)
    65% identity, 100% coverage of query (546 bits)

ICDHX_ARATH / Q9SLK0 Peroxisomal isocitrate dehydrogenase [NADP]; EC 1.1.1.42 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SLK0 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Arabidopsis thaliana (see paper)
    65% identity, 99% coverage of query (546 bits)

2qfxA Crystal structure of saccharomyces cerevesiae mitochondrial NADP(+)- dependent isocitrate dehydrogenase in complex with NADPH, a- ketoglutarate and ca(2+)
    65% identity, 100% coverage of query (546 bits)

2qfvA Crystal structure of saccharomyces cerevesiae mitochondrial NADP(+)- dependent isocitrate dehydrogenase in complex with NADP(+)
    65% identity, 100% coverage of query (546 bits)

6aj6A / Q387G0 Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+
    62% identity, 100% coverage of query (539 bits)

6ajbA Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with nadh, alpha-ketoglutarate and ca2+
    62% identity, 100% coverage of query (539 bits)

6aj8B Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+, alpha-ketoglutarate and ca2+
    62% identity, 100% coverage of query (539 bits)

6aj8A Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+, alpha-ketoglutarate and ca2+
    62% identity, 100% coverage of query (539 bits)

IDP2 / P41939 NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 4 papers)
IDHC_YEAST / P41939 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P41939 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Saccharomyces cerevisiae (see paper)
    63% identity, 99% coverage of query (538 bits)

6q6fA Crystal structure of idh1 r132h in complex with hms101
    63% identity, 100% coverage of query (537 bits)

5tqhA Idh1 r132h mutant in complex with idh889
    65% identity, 98% coverage of query (534 bits)

8hb9AAA Isocitrate dehydrogenase [NADP] cytoplasmic
    65% identity, 98% coverage of query (531 bits)

Q4DG65 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Trypanosoma cruzi (see paper)
    67% identity, 94% coverage of query (530 bits)

5svfA Idh1 r132h in complex with idh125
    64% identity, 98% coverage of query (528 bits)

6b0zA Idh1 r132h mutant in complex with idh305
    64% identity, 98% coverage of query (528 bits)

6io0A Human idh1 r132c mutant complexed with compound a.
    64% identity, 98% coverage of query (528 bits)

5de1A Crystal structure of human idh1 in complex with gsk321a
    64% identity, 98% coverage of query (525 bits)

6adgC / O75874 Crystal structures of idh1 r132h in complex with ag-881 (see paper)
    62% identity, 98% coverage of query (511 bits)

4xrxA Crystal structure of a metabolic reductase with (e)-5-((1-methyl-5- oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1h)-one
    62% identity, 98% coverage of query (509 bits)

3marA / O75874 Crystal structure of homodimeric r132h mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP (see paper)
    62% identity, 100% coverage of query (508 bits)

5sunA Idh1 r132h in complex with idh146
    62% identity, 98% coverage of query (503 bits)

4xs3A Crystal structure of a metabolic reductase with (e)-1-benzyl-5-((1- methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1h)-one
    61% identity, 98% coverage of query (494 bits)

5l58A / O75874 Crystal structure of iso-citrate dehydrogenase 1 [idh1 (r132h)] in complex with a novel inhibitor (compound 2) (see paper)
    61% identity, 98% coverage of query (490 bits)

4i3kA / O75874 Crystal structure of a metabolic reductase with 1-hydroxy-6-(4- hydroxybenzyl)-4-methylpyridin-2(1h)-one (see paper)
    59% identity, 98% coverage of query (466 bits)

4aouA / A3DC45 Ctidh bound to NADP. The complex structures of isocitrate dehydrogenase from clostridium thermocellum and desulfotalea psychrophila, support a new active site locking mechanism (see paper)
    56% identity, 99% coverage of query (463 bits)

4aovA Dpidh-NADP. The complex structures of isocitrate dehydrogenase from clostridium thermocellum and desulfotalea psychrophila, support a new active site locking mechanism
    49% identity, 99% coverage of query (400 bits)

Q6AQ66 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Desulfotalea psychrophila (see paper)
2uxqA / Q6AQ66 Isocitrate dehydrogenase from the psychrophilic bacterium desulfotalea psychrophila: biochemical properties and crystal structure analysis (see paper)
    49% identity, 99% coverage of query (399 bits)

IDH1_PHATC / B7G620 Isocitrate dehydrogenase [NAD(+)] 1, mitochondrial; PtIDH1; EC 1.1.1.41 from Phaeodactylum tricornutum (strain CCAP 1055/1) (see paper)
    33% identity, 99% coverage of query (170 bits)

IDH_OSTTA / A0A096P8D3 Isocitrate dehydrogenase (NAD(+)), mitochondrial; OtIDH; EC 1.1.1.41 from Ostreococcus tauri (see paper)
    31% identity, 99% coverage of query (159 bits)

6ixnA / A0A096P8D3 Crystal structure of isocitrate dehydrogenase from ostreococcus tauri in complex with NAD+ and citrate (see paper)
    31% identity, 99% coverage of query (159 bits)

6ixtA Crystal structure of isocitrate dehydrogenase from ostreococcus tauri in complex with NAD+ and mg2+
    31% identity, 99% coverage of query (159 bits)

C1E5X2 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Micromonas commoda (see paper)
    32% identity, 97% coverage of query (157 bits)

A4SBK5 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Ostreococcus sp. 'lucimarinus' (see paper)
    33% identity, 99% coverage of query (157 bits)

Build an alignment

Build an alignment for WP_046104561.1 and 89 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

Q4J6C9 isocitrate-homoisocitrate dehydrogenase (EC 1.1.1.286) from Sulfolobus acidocaldarius (see paper)
    21% identity, 81% coverage of query (47.0 bits)

Q9HLV8 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Thermoplasma acidophilum (see paper)
    23% identity, 82% coverage of query (46.2 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory