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Searching for up to 100 curated homologs for WP_047093910.1 NCBI__GCF_001013305.1:WP_047093910.1 (251 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

5yssB / A0A0D7LY80 Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
    53% identity, 99% coverage of query (261 bits)

A8R3J3 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Ralstonia pickettii (see paper)
    56% identity, 99% coverage of query (261 bits)

Q9AE70 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Pseudomonas putida (see 2 papers)
    54% identity, 100% coverage of query (254 bits)

2q2qD / Q9AE70 Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
    54% identity, 99% coverage of query (253 bits)

Q5KST5 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Pseudomonas fragi (see 3 papers)
1wmbA / Q5KST5 Crystal structure of NAD dependent d-3-hydroxybutylate dehydrogenase (see paper)
BAD86668.1 D(-)-3-hydroxybutyrate dehydrogenase from Pseudomonas fragi (see paper)
    51% identity, 100% coverage of query (248 bits)

Q2PEN2 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Ralstonia pickettii (see 2 papers)
    52% identity, 100% coverage of query (248 bits)

2ztlA Closed conformation of d-3-hydroxybutyrate dehydrogenase complexed with NAD+ and l-3-hydroxybutyrate
    51% identity, 100% coverage of query (248 bits)

5b4tA / D0VWQ0 Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
    51% identity, 100% coverage of query (241 bits)

3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
    51% identity, 100% coverage of query (241 bits)

3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+)
    51% identity, 100% coverage of query (241 bits)

3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate
    51% identity, 100% coverage of query (241 bits)

Q767A0 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Acidovorax sp. (see paper)
    50% identity, 98% coverage of query (240 bits)

1x1tA / Q5KST5 Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+ (see paper)
    48% identity, 100% coverage of query (223 bits)

A0A1E3M3N6 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Acinetobacter baumannii (see paper)
6zzsD / A0A1E3M3N6 Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
    42% identity, 100% coverage of query (196 bits)

6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate
    42% identity, 100% coverage of query (196 bits)

Q2PEN3 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Ralstonia pickettii (see 2 papers)
    39% identity, 99% coverage of query (154 bits)

Q4FRT2 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Psychrobacter arcticus (see paper)
    36% identity, 98% coverage of query (145 bits)

6zzoC / Q4FRT2 Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and acetoacetate (see paper)
    36% identity, 98% coverage of query (145 bits)

aknA / Q9L553 aclacinomycin polyketide synthase reductase from Streptomyces galilaeus (see paper)
    39% identity, 96% coverage of query (145 bits)

6zzpA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and 3-oxovalerate
    36% identity, 98% coverage of query (145 bits)

Q5ZT49 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Legionella pneumophila subsp. pneumophila (see paper)
    35% identity, 100% coverage of query (142 bits)

3sjuA / Q67G28 Hedamycin polyketide ketoreductase bound to NADPH (see paper)
    36% identity, 96% coverage of query (140 bits)

dpsE / Q54812 daunorubicin polyketide synthase reductase from Streptomyces peucetius (see paper)
    38% identity, 96% coverage of query (140 bits)

BPHYT_RS34215 2-keto-3-deoxy-L-fuconate 4-dehydrogenase FucDH from Burkholderia phytofirmans PsJN
    38% identity, 98% coverage of query (139 bits)

Ira5 / Q1NEI6 L-2-keto-3-deoxyrhamnonate 4-dehydrogenase subunit (EC 1.1.1.401) from Sphingomonas sp. (strain SKA58) (see paper)
KDRDH_SPHSS / Q1NEI6 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD(+)); 2-keto-3-deoxy-L-rhamnonate dehydrogenase; KDRDH; L-KDR dehydrogenase; L-KDR 4-dehydrogenase; EC 1.1.1.401 from Sphingomonas sp. (strain SKA58) (see paper)
Q1NEI6 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+) (EC 1.1.1.401) from Sphingomonas sp. (see paper)
    37% identity, 98% coverage of query (137 bits)

KDUD_BACSU / P50842 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase; 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase; EC 1.1.1.127 from Bacillus subtilis (strain 168) (see paper)
    35% identity, 99% coverage of query (137 bits)

6ixmC / X2D0L0 Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
    34% identity, 99% coverage of query (137 bits)

phaB / BAC45231.1 3-keto-acyl-CoA reductase from Bacillus sp. INT005 (see paper)
    36% identity, 98% coverage of query (137 bits)

5u9pB / B4EEX4 Crystal structure of a gluconate 5-dehydrogenase from burkholderia cenocepacia j2315 in complex with NADP and tartrate
    34% identity, 99% coverage of query (137 bits)

4k6fB / B4EAU4 X-ray crystal structure of a putative acetoacetyl-coa reductase from burkholderia cenocepacia bound to the co-factor NADP
    35% identity, 96% coverage of query (136 bits)

8dt1C / A0A1V2Y0M0 Crystal structure of a putative d-beta-hydroxybutyrate dehydrogenase from burkholderia cenocepacia j2315 in complex with NAD
    37% identity, 98% coverage of query (134 bits)

8y83A / A0A562MSV3 Crystal structure of a ketoreductase from sphingobacterium siyangense sy1 with co-enzyme
    35% identity, 99% coverage of query (134 bits)

snoaD / CAA12013.1 SnoaD from Streptomyces nogalater (see 3 papers)
    38% identity, 97% coverage of query (134 bits)

ACT3_STRCO / P16544 Putative ketoacyl reductase; EC 1.3.1.- from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
    38% identity, 96% coverage of query (134 bits)

2rh4B / P16544 Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin (see paper)
    38% identity, 96% coverage of query (134 bits)

1xr3A Actinorhodin polyketide ketoreductase with NADP and the inhibitor isoniazid bound
    38% identity, 96% coverage of query (134 bits)

2rh4A Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin
    38% identity, 96% coverage of query (134 bits)

1w4zA Structure of actinorhodin polyketide (actiii) reductase
    38% identity, 96% coverage of query (134 bits)

gno / P50199 D-gluconate 5-dehydrogenase monomer from Gluconobacter oxydans (strain 621H) (see paper)
GNO_GLUOX / P50199 Gluconate 5-dehydrogenase; D-gluconate 5-dehydrogenase (NADP); Gluconate:NADP 5-oxidoreductase; GNO; EC 1.1.1.- from Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) (see paper)
    35% identity, 98% coverage of query (133 bits)

jadE / Q56166 jadomycin biosynthesis oxidoreductase JadE from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see 2 papers)
    36% identity, 98% coverage of query (132 bits)

C7RM91 acetoacetyl-CoA reductase (EC 1.1.1.36) from Candidatus Accumulibacter phosphatis (see 2 papers)
    36% identity, 96% coverage of query (132 bits)

A0A5P1RES5 acetoacetyl-CoA reductase (subunit 1/2) (EC 1.1.1.36) from Neptunomonas concharum (see paper)
    33% identity, 96% coverage of query (132 bits)

9fe6B / A0A7C5VFX3 Short-chain dehydrogenase/reductase (sdr) from thermus caliditerrae
    36% identity, 98% coverage of query (132 bits)

9febA Short-chain dehydrogenase/reductase (sdr) from thermus caliditerrae in complex with NADP
    36% identity, 98% coverage of query (132 bits)

Q4UN54 acetoacetyl-CoA reductase (EC 1.1.1.36) from Rickettsia felis (see paper)
    33% identity, 96% coverage of query (130 bits)

HSERO_RS19365 2-keto-3-deoxy-L-fuconate 4-dehydrogenase FucDH from Herbaspirillum seropedicae SmR1
    36% identity, 98% coverage of query (129 bits)

A0JC04 octanol dehydrogenase (EC 1.1.1.73) from Ogataea wickerhamii (see paper)
    33% identity, 99% coverage of query (129 bits)

4nbuB Crystal structure of fabg from bacillus sp (see paper)
    34% identity, 98% coverage of query (128 bits)

FabG / b1093 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
fabG / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli (strain K12) (see 22 papers)
FABG_ECOLI / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 9 papers)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Escherichia coli (see 2 papers)
    34% identity, 99% coverage of query (128 bits)

4hp8B / A9CEQ9 Crystal structure of a putative 2-deoxy-d-gluconate 3-dehydrogenase from agrobacterium tumefaciens (target efi-506435) with bound NADP
    36% identity, 99% coverage of query (127 bits)

5vmlA / Q3JRS9 Crystal structure of acetoacetyl-coa reductase from burkholderia pseudomallei 1710b with bound NADP
    31% identity, 96% coverage of query (127 bits)

5vt6A / Q3JJT1 Crystal structure of acetoacetyl-coa reductase from burkholderia pseudomallei 1710b complexed with NADP
    32% identity, 96% coverage of query (127 bits)

7emgB Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
    33% identity, 98% coverage of query (127 bits)

C785_RS13675 / A0A4P7ABK7 2-dehydro-3-deoxy-D-pentonate/2-dehydro-3-deoxy-L-fuconate 4-dehydrogenase (EC 1.1.1.434) from Herbaspirillum huttiense (see paper)
    36% identity, 98% coverage of query (127 bits)

8y4jA SDR family oxidoreductase
    36% identity, 98% coverage of query (127 bits)

8y11A Crystal structure of l-2-keto-3-deoxyfuconate 4-dehydrogenase bound to NAD(h) and sulfate ion
    36% identity, 98% coverage of query (127 bits)

8y46B SDR family oxidoreductase
    36% identity, 98% coverage of query (127 bits)

1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+
    34% identity, 98% coverage of query (127 bits)

FABG_SALTY / P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    33% identity, 99% coverage of query (126 bits)

8y46A 8y46A (see paper)
    36% identity, 98% coverage of query (126 bits)

phbB / P23238 acetoacetyl-CoA reductase subunit (EC 1.1.1.36) from Shinella zoogloeoides (see 2 papers)
PHAB_SHIZO / P23238 Acetoacetyl-CoA reductase; EC 1.1.1.36 from Shinella zoogloeoides (Crabtreella saccharophila) (see paper)
    33% identity, 96% coverage of query (126 bits)

6t77A / W9B6I8 Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
    34% identity, 99% coverage of query (126 bits)

FABG_STAAM / P0A0H9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Staphylococcus aureus (strain Mu50 / ATCC 700699)
3osuA / P0A0H9 Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
    33% identity, 97% coverage of query (126 bits)

Q2FZ53 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Staphylococcus aureus (see paper)
    33% identity, 97% coverage of query (126 bits)

3o03A Quaternary complex structure of gluconate 5-dehydrogenase from streptococcus suis type 2 (see paper)
    34% identity, 99% coverage of query (125 bits)

phbB / AAA90983.1 acetoacetyl CoA reductase from Sinorhizobium meliloti (see 2 papers)
    34% identity, 96% coverage of query (125 bits)

fabG / P51831 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Bacillus subtilis (strain 168) (see 3 papers)
    32% identity, 98% coverage of query (125 bits)

1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment
    34% identity, 98% coverage of query (125 bits)

1vl8B / Q9WYS2 Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
    35% identity, 99% coverage of query (124 bits)

uxaD / Q9WYS2 fructuronate reductase from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    35% identity, 99% coverage of query (124 bits)

CHCB2_CORCT / P0DXE1 Cis-4-hydroxycyclohexanecarboxylate dehydrogenase; Cis-4-hydroxyCHCA dehydrogenase; EC 1.1.1.438 from Corynebacterium cyclohexanicum (Sinomonas cyclohexanicum) (see paper)
    34% identity, 98% coverage of query (123 bits)

dhuD / Q8E370 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase monomer (EC 1.1.1.127) from Streptococcus agalactiae serotype III (strain NEM316) (see paper)
    33% identity, 99% coverage of query (123 bits)

A0A068FPP9 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Bacillus sp. (in: Bacteria) (see paper)
    35% identity, 98% coverage of query (123 bits)

3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH
    33% identity, 97% coverage of query (123 bits)

chnA / Q5P8S7 cyclohexanol dehydrogenase from Aromatoleum aromaticum (strain EbN1) (see paper)
4ureB / Q5P8S7 Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1 (see paper)
    34% identity, 100% coverage of query (122 bits)

3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
    34% identity, 99% coverage of query (122 bits)

7tzpG / A0A332H2K8 Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
    36% identity, 98% coverage of query (122 bits)

4urfB Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1
    34% identity, 100% coverage of query (122 bits)

4urfA Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1
    34% identity, 100% coverage of query (122 bits)

Q1J2J0 L-iditol 2-dehydrogenase (EC 1.1.1.14) from Deinococcus geothermalis (see paper)
    34% identity, 98% coverage of query (121 bits)

RADH_LENKE / Q6WVP7 NADP-dependent (R)-specific alcohol dehydrogenase; (R)-specific ADH; Ketoreductase; KRED; EC 1.1.1.- from Lentilactobacillus kefiri (Lactobacillus kefiri)
    35% identity, 99% coverage of query (120 bits)

5itvA / P39640 Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
    32% identity, 100% coverage of query (120 bits)

4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH
    33% identity, 99% coverage of query (120 bits)

phbB / D3UAK7 hydroxyvaleryl-CoA reductase (EC 1.1.1.36) from Cupriavidus necator (see 2 papers)
PHAB_CUPNH / P14697 Acetoacetyl-CoA reductase; EC 1.1.1.36 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see 4 papers)
P14697 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); acetoacetyl-CoA reductase (EC 1.1.1.36) from Cupriavidus necator (see 3 papers)
    31% identity, 96% coverage of query (119 bits)

1zk4A Structure of r-specific alcohol dehydrogenase (wildtype) from lactobacillus brevis in complex with acetophenone and NADP
    33% identity, 99% coverage of query (119 bits)

6y0sAAA / Q84EX5 6y0sAAA (see paper)
    33% identity, 99% coverage of query (119 bits)

3vzsB / P14697 Crystal structure of phab from ralstonia eutropha in complex with acetoacetyl-coa and NADP (see paper)
    31% identity, 96% coverage of query (119 bits)

FABG_SYNY3 / P73574 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-acyl carrier protein reductase; EC 1.1.1.100 from Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa) (see paper)
    36% identity, 98% coverage of query (118 bits)

5t2uA / A0R723 Short chain dehydrogenase/reductase family protein (see paper)
    35% identity, 100% coverage of query (117 bits)

7ejiB Crystal structure of kred f147l/l153q/y190p/l199a/m205f/m206f variant and methyl methacrylate complex
    34% identity, 99% coverage of query (117 bits)

7ejhA / Q6WVP7 Crystal structure of kred mutant-f147l/l153q/y190p/l199a/m205f/m206f and 2-hydroxyisoindoline-1,3-dione complex
    34% identity, 99% coverage of query (117 bits)

1zk1A Structure of r-specific alcohol dehydrogenase (mutant g37d) from lactobacillus brevis in complex with phenylethanol and NAD
    33% identity, 99% coverage of query (117 bits)

1zjzA Structure of r-specific alcohol dehydrogenase (mutant g37d) from lactobacillus brevis in complex with phenylethanol and NAD
    33% identity, 99% coverage of query (117 bits)

1zjyA Structure of r-specific alcohol dehydrogenase (mutant g37d) from lactobacillus brevis in complex with phenylethanol and nadh
    33% identity, 99% coverage of query (117 bits)

4nbtA / A9NFJ2 Crystal structure of fabg from acholeplasma laidlawii (see paper)
    34% identity, 98% coverage of query (117 bits)

DHG_PRIMG / P40288 Glucose 1-dehydrogenase; EC 1.1.1.47 from Priestia megaterium (Bacillus megaterium) (see paper)
P40288 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Priestia megaterium (see 9 papers)
    32% identity, 98% coverage of query (117 bits)

4jroC / Q8Y690 Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
    33% identity, 99% coverage of query (116 bits)

5h5xC / Q9KYM4 Crystal structure of nadh bound carbonyl reductase from streptomyces coelicolor
    34% identity, 99% coverage of query (115 bits)

1g6kA / P40288 Crystal structure of glucose dehydrogenase mutant e96a complexed with NAD+
    32% identity, 98% coverage of query (115 bits)

3ay6B / P39485 Crystal structure of bacillus megaterium glucose dehydrogenase 4 a258f mutant in complex with nadh and d-glucose (see paper)
    32% identity, 98% coverage of query (115 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory