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Searching for up to 100 curated homologs for WP_049991158.1 NCBI__GCF_000784335.1:WP_049991158.1 (325 a.a.)

Found high-coverage hits (≥70%) to 59 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

GLK_PYRCJ / A3MUZ0 Glucokinase; ATP-dependent glucokinase; ATP-GLK; Glucose kinase; EC 2.7.1.2 from Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) (see paper)
A3MUZ0 glucokinase (EC 2.7.1.2) from Pyrobaculum calidifontis (see paper)
    32% identity, 96% coverage of query (137 bits)

Q7ZAH1 hexokinase (EC 2.7.1.1) from Thermoproteus tenax (see paper)
hxk / CAD52839.1 hexokinase from Thermoproteus tenax (see paper)
    34% identity, 94% coverage of query (131 bits)

Q8R8N4 ADP-specific glucose/glucosamine kinase (EC 2.7.1.147) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
    33% identity, 93% coverage of query (129 bits)

Q8RDE9 glucokinase (EC 2.7.1.2) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
    31% identity, 96% coverage of query (122 bits)

Build an alignment

Build an alignment for WP_049991158.1 and 4 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

rokA / Q5GBH5 glucokinase / N-acetylglucosamine kinase / mannokinase (EC 2.7.1.7; EC 2.7.1.1; EC 2.7.1.59) from Bacteroides fragilis (see 2 papers)
    29% identity, 95% coverage of query (97.8 bits)

2qm1B / Q830J4 Crystal structure of glucokinase from enterococcus faecalis
    27% identity, 95% coverage of query (95.5 bits)

glkA / CAA62003.1 glucokinase from Renibacterium salmoninarum (see 2 papers)
    31% identity, 85% coverage of query (93.6 bits)

O31392 glucokinase (EC 2.7.1.2) from Priestia megaterium (see paper)
glk glucokinase; EC 2.7.1.2 from Bacillus megaterium (see paper)
glk / CAA03848.1 glucose kinase from Bacillus megaterium (see paper)
    29% identity, 92% coverage of query (93.2 bits)

XylR / VIMSS854293 XylR regulator of Xylose utilization, effector Xylose (repressor) from Geobacillus kaustophilus HTA426
    28% identity, 95% coverage of query (92.8 bits)

XylR / VIMSS38296 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus subtilis subsp. subtilis str. 168
    25% identity, 92% coverage of query (92.0 bits)

glk / Q9X1I0 glucokinase subunit (EC 2.7.1.1) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
GLK_THEMA / Q9X1I0 Glucokinase; ATP-dependent glucokinase; ATP-GLK; Glucose kinase; EC 2.7.1.2 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    33% identity, 96% coverage of query (89.4 bits)

GLK_AERPE / Q9YA47 Glucokinase; ATP-dependent glucokinase; ATP-GLK; Glucose kinase; EC 2.7.1.2 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) (see 2 papers)
    33% identity, 96% coverage of query (89.0 bits)

XylR / P16557 Transcription factor XylR (repressor) from Bacillus subtilis 168 (see 2 papers)
    25% identity, 92% coverage of query (87.8 bits)

3vgkB / B1VZT1 Crystal structure of a rok family glucokinase from streptomyces griseus (see paper)
    32% identity, 87% coverage of query (85.9 bits)

B1VZT1 glucokinase (EC 2.7.1.2) from Streptomyces griseus (see 2 papers)
    32% identity, 87% coverage of query (85.9 bits)

3vglA Crystal structure of a rok family glucokinase from streptomyces griseus in complex with glucose and amppnp
    32% identity, 87% coverage of query (85.9 bits)

glk / Q8DVE8 glucokinase subunit (EC 2.7.1.1) from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see paper)
    26% identity, 94% coverage of query (82.0 bits)

glcK / GI|1303865 glucokinase; EC 2.7.1.2 from Bacillus subtilis (see paper)
    28% identity, 93% coverage of query (80.9 bits)

glcK / P54495 glucokinase (EC 2.7.1.1) from Bacillus subtilis (strain 168) (see paper)
GLK_BACSU / P54495 Glucokinase; Glucose kinase; EC 2.7.1.2 from Bacillus subtilis (strain 168) (see paper)
P54495 glucokinase (EC 2.7.1.2) from Bacillus subtilis (see paper)
    27% identity, 93% coverage of query (80.9 bits)

Q5RLG0 hexokinase (EC 2.7.1.1) from Thermus caldophilus (see paper)
    31% identity, 78% coverage of query (79.7 bits)

Q5SLJ4 hexokinase (EC 2.7.1.1) from Thermus thermophilus (see paper)
    31% identity, 78% coverage of query (79.7 bits)

XylR / VIMSS6926953 XylR regulator of Xylose utilization, effector Xylose (repressor) from Paenibacillus sp. JDR-2
    27% identity, 82% coverage of query (79.0 bits)

3vovB / Q5SLJ4 Crystal structure of rok hexokinase from thermus thermophilus (see paper)
    32% identity, 78% coverage of query (78.6 bits)

2yhwA / Q9Y223 High-resolution crystal structures of n-acetylmannosamine kinase: insights about substrate specificity, activity and inhibitor modelling. (see paper)
    27% identity, 85% coverage of query (78.2 bits)

NanR / VIMSS6110394 NanR regulator of Sialic acid utilization; N-acetylglucosamine utilization, effector N-acetylglucosamine; N-acetylneuraminic acid (repressor) from Bacteroides plebeius DSM 17135
    25% identity, 90% coverage of query (78.2 bits)

GLCNE_MOUSE / Q91WG8 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; EC 3.2.1.183; EC 2.7.1.60 from Mus musculus (Mouse) (see 4 papers)
Q91WG8 UDP-N-acetylglucosamine 2-epimerase (hydrolysing) (EC 3.2.1.183) from Mus musculus (see paper)
    27% identity, 85% coverage of query (77.0 bits)

6jdbA / Q4QP43 Crystal structure of n-acetyl mannosmaine kinase in complex with mannac-6p and adp from haemophilus influenzae
    27% identity, 93% coverage of query (77.0 bits)

Gne / O35826 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase subunit (EC 2.7.1.60; EC 3.2.1.183) from Rattus norvegicus (see paper)
GLCNE_RAT / O35826 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; EC 3.2.1.183; EC 2.7.1.60 from Rattus norvegicus (Rat) (see 5 papers)
    27% identity, 85% coverage of query (77.0 bits)

XylR / VIMSS354812 XylR regulator of Xylose utilization, effector Xylose (repressor) from Enterococcus faecalis V583
    28% identity, 80% coverage of query (76.6 bits)

2yi1A Crystal structure of n-acetylmannosamine kinase in complex with n- acetyl mannosamine 6-phosphate and adp.
    27% identity, 85% coverage of query (76.6 bits)

2yhyA Structure of n-acetylmannosamine kinase in complex with n- acetylmannosamine and adp
    27% identity, 85% coverage of query (76.6 bits)

GLCNE_HUMAN / Q9Y223 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; EC 3.2.1.183; EC 2.7.1.60 from Homo sapiens (Human) (see 31 papers)
Q9Y223 N-acylmannosamine kinase (EC 2.7.1.60); UDP-N-acetylglucosamine 2-epimerase (hydrolysing) (EC 3.2.1.183); UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) (EC 5.1.3.14) from Homo sapiens (see 18 papers)
    27% identity, 85% coverage of query (75.9 bits)

GLCNE_CRIGR / Q7TQ49 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; EC 3.2.1.183; EC 2.7.1.60 from Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (see paper)
    27% identity, 85% coverage of query (75.1 bits)

XylR / VIMSS10362834 XylR regulator of Xylose utilization, effector Xylose; Glucose (repressor) from Thermotoga naphthophila RKU-10
    27% identity, 73% coverage of query (74.7 bits)

XylR / VIMSS3426742 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus pumilus SAFR-032
    26% identity, 88% coverage of query (74.7 bits)

5f7qE / Q8YAF1 Rok repressor lmo0178 from listeria monocytogenes bound to operator (see paper)
    24% identity, 88% coverage of query (73.9 bits)

NanR / VIMSS3720738 NanR regulator of Sialic acid utilization; N-acetylglucosamine utilization, effector N-acetylglucosamine; N-acetylneuraminic acid (repressor) from Bacteroides vulgatus ATCC 8482
    23% identity, 82% coverage of query (73.6 bits)

5f7rA Rok repressor lmo0178 from listeria monocytogenes bound to inducer
    24% identity, 88% coverage of query (71.6 bits)

XylR / Q9WXW5_THEMA Transcription factor XylR (repressor) from Thermotoga maritima MSB8
    24% identity, 82% coverage of query (70.1 bits)

H6UH58 glucokinase (EC 2.7.1.2) from Staphylococcus aureus (see paper)
    25% identity, 83% coverage of query (69.3 bits)

CA265_RS11300 N-acetylglucosamine kinase (EC 2.7.1.59) from Pedobacter sp. GW460-11-11-14-LB5
    24% identity, 96% coverage of query (68.9 bits)

GLK_STRCO / P0A4E1 Glucokinase; Glucose kinase; ORF 3; EC 2.7.1.2 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
P0A4E1 glucokinase (EC 2.7.1.2) from Streptomyces coelicolor (see paper)
glkA glucokinase; EC 2.7.1.2 from Streptomyces coelicolor (see 2 papers)
    27% identity, 93% coverage of query (68.6 bits)

6jdhA Crystal structure of n-acetyl mannosmaine kinase from pasteurella multocida
    28% identity, 81% coverage of query (65.9 bits)

6jdoA Crystal structure of n-acetyl mannosmaine kinase with amp-pnp from pasteurella multocida
    28% identity, 81% coverage of query (65.9 bits)

NagC / VIMSS4630820 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Moritella sp. PE36
    25% identity, 81% coverage of query (63.5 bits)

4db3A / Q8D9M7 1.95 angstrom resolution crystal structure of n-acetyl-d-glucosamine kinase from vibrio vulnificus.
    25% identity, 94% coverage of query (62.8 bits)

3eo3A / Q9Y223 Crystal structure of the n-acetylmannosamine kinase domain of human gne protein (see paper)
    26% identity, 85% coverage of query (62.0 bits)

nanK / Q8ZLQ8 N-acetylmannosamine kinase subunit (EC 2.7.1.60) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
    32% identity, 81% coverage of query (60.1 bits)

XylR / VIMSS279908 XylR regulator of Xylose utilization, effector Xylose (repressor) from Oceanobacillus iheyensis HTE831
    25% identity, 82% coverage of query (58.9 bits)

NanR / VIMSS6257414 NanR regulator of Sialic acid utilization; N-acetylglucosamine utilization, effector N-acetylglucosamine; N-acetylneuraminic acid (repressor) from Bacteroides eggerthii DSM 20697
    23% identity, 95% coverage of query (57.8 bits)

YhcI / b3222 N-acetylmannosamine kinase (EC 2.7.1.60) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
nanK / P45425 N-acetylmannosamine kinase (EC 2.7.1.60) from Escherichia coli (strain K12) (see 5 papers)
NANK_ECOLI / P45425 N-acetylmannosamine kinase; ManNAc kinase; N-acetyl-D-mannosamine kinase; EC 2.7.1.60 from Escherichia coli (strain K12) (see 3 papers)
    30% identity, 81% coverage of query (57.4 bits)

2aa4A / P45425 Crystal structure of escherichia coli putative n-acetylmannosamine kinase, new york structural genomics consortium
    30% identity, 81% coverage of query (57.4 bits)

A0SZU9 hexokinase (EC 2.7.1.1); glucokinase (EC 2.7.1.2) from Lysinibacillus sphaericus (see paper)
    21% identity, 87% coverage of query (57.0 bits)

GluR / VIMSS7271596 GluR regulator of Glucose utilization; Trehalose utilization, effector Glucose (repressor) from Thermotoga sp. RQ2
    27% identity, 86% coverage of query (56.2 bits)

ManR / Q9X0V1_THEMA Transcription factor ManR (repressor) from Thermotoga maritima MSB8
    23% identity, 96% coverage of query (56.2 bits)

NagC / VIMSS1972937 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Psychromonas ingrahamii 37
    23% identity, 78% coverage of query (54.3 bits)

7p7wBBB / Q12306,R8APY9 7p7wBBB
    23% identity, 92% coverage of query (49.3 bits)

7p9lAAA Ubiquitin-like protein SMT3,N-acetyl-D-glucosamine kinase
    23% identity, 92% coverage of query (49.3 bits)

7p9pAAA Ubiquitin-like protein SMT3,N-acetyl-D-glucosamine kinase
    23% identity, 92% coverage of query (49.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory