Sites on a Tree

 

Searching for up to 100 curated homologs for WP_050656343.1 NCBI__GCF_002893965.1:WP_050656343.1 (261 a.a.)

Found high-coverage hits (≥70%) to 96 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TPIS_MYCTU / P9WG43 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
P9WG43 triose-phosphate isomerase (EC 5.3.1.1) from Mycobacterium tuberculosis (see 2 papers)
    75% identity, 100% coverage of query (399 bits)

3taoA / P9WG43 Structure of mycobacterium tuberculosis triosephosphate isomerase bound to phosphoglycolohydroxamate (see paper)
    75% identity, 98% coverage of query (387 bits)

TPIS_STRCO / Q9Z520 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    65% identity, 95% coverage of query (341 bits)

P27876 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Bacillus subtilis (strain 168)
    48% identity, 96% coverage of query (234 bits)

tpiA / O32757 triosephosphate isomerase subunit (EC 5.3.1.1) from Lactobacillus delbrueckii subsp. bulgaricus (see paper)
    46% identity, 96% coverage of query (233 bits)

TPIS_BACCE / Q4MQ55 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Bacillus cereus (see paper)
    48% identity, 96% coverage of query (225 bits)

P35144 triose-phosphate isomerase (EC 5.3.1.1) from Priestia megaterium (see paper)
    48% identity, 96% coverage of query (223 bits)

TPIS_THET8 / Q5SJR1 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
    45% identity, 97% coverage of query (221 bits)

3uwvA / Q6GIL6 Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with 2-phosphoglyceric acid (see paper)
    46% identity, 96% coverage of query (219 bits)

TPIS_STAAR / Q6GIL6 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Staphylococcus aureus (strain MRSA252) (see 3 papers)
Q6GIL6 triose-phosphate isomerase (EC 5.3.1.1) from Staphylococcus aureus (see paper)
    46% identity, 96% coverage of query (219 bits)

3uwzA Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with glycerol-2-phosphate
    46% identity, 96% coverage of query (219 bits)

3uwwA Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with 3-phosphoglyceric acid
    46% identity, 96% coverage of query (219 bits)

3uwuA Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with glycerol-3-phosphate
    46% identity, 96% coverage of query (219 bits)

pgk / P36204 Pgk (EC 2.7.2.3; EC 5.3.1.1) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 4 papers)
PGKT_THEMA / P36204 Bifunctional PGK/TIM; EC 2.7.2.3; EC 5.3.1.1 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 3 papers)
P36204 triose-phosphate isomerase (EC 5.3.1.1) from Thermotoga maritima (see 2 papers)
    46% identity, 98% coverage of query (214 bits)

TPIS_CLOPE / Q8XKU1 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Clostridium perfringens (strain 13 / Type A) (see paper)
    46% identity, 96% coverage of query (213 bits)

TPIS_GEOSE / P00943 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 3 papers)
P00943 triose-phosphate isomerase (EC 5.3.1.1) from Geobacillus stearothermophilus (see paper)
    45% identity, 96% coverage of query (213 bits)

1btmA / P00943 Triosephosphate isomerase (tim) complexed with 2-phosphoglycolic acid (see paper)
    46% identity, 95% coverage of query (213 bits)

tpiA / P50918 triosephosphate isomerase subunit (EC 5.3.1.1) from Lactococcus lactis subsp. lactis (strain IL1403) (see paper)
    45% identity, 96% coverage of query (209 bits)

3uwzB Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with glycerol-2-phosphate
    45% identity, 96% coverage of query (208 bits)

tpi / AAC43268.1 triosephosphate isomerase from Lactococcus lactis subsp. lactis (see paper)
    44% identity, 96% coverage of query (207 bits)

4y90A / Q9RUP5 Crystal structure of triosephosphate isomerase from deinococcus radiodurans (see paper)
    49% identity, 96% coverage of query (206 bits)

TPIS_DEIRA / Q9RUP5 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see paper)
    49% identity, 95% coverage of query (204 bits)

8w06B Crystal structure of the reconstruction of the ancestral triosephosphate isomerase of the last opisthokont common ancestor obtained by maximum likelihood with pgh (see paper)
    48% identity, 94% coverage of query (204 bits)

4y96A / A0A0M3KL18 Crystal structure of triosephosphate isomerase from gemmata obscuriglobus (see paper)
    46% identity, 94% coverage of query (202 bits)

6neeB Crystal structure of a reconstructed ancestor of triosephosphate isomerase from eukaryotes (see paper)
    46% identity, 95% coverage of query (193 bits)

6bveA / Q59994 Triosephosphate isomerase of synechocystis in complex with 2- phosphoglycolic acid (see paper)
    44% identity, 96% coverage of query (188 bits)

Q0H294 triose-phosphate isomerase (EC 5.3.1.1) from Pteris vittata (see paper)
    45% identity, 94% coverage of query (186 bits)

TPIS_MORMI / P50921 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Moritella marina (Vibrio marinus) (see paper)
P50921 triose-phosphate isomerase (EC 5.3.1.1) from Moritella marina (see 2 papers)
tpiA / PDB|1AW1_A triose-phosphate isomerase; EC 5.3.1.1 from Moritella marina (see paper)
    43% identity, 93% coverage of query (183 bits)

1aw1A / P50921 Triosephosphate isomerase of vibrio marinus complexed with 2- phosphoglycolate (see paper)
    43% identity, 92% coverage of query (182 bits)

Tpi / b3919 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
tpiA / P0A858 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli (strain K12) (see 32 papers)
TPIS_ECODH / B1XB85 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Escherichia coli (strain K12 / DH10B) (see paper)
TPIS_ECOLI / P0A858 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Escherichia coli (strain K12) (see 8 papers)
P0A858 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli (see paper)
4mvaA 1.43 angstrom resolution crystal structure of triosephosphate isomerase (tpia) from escherichia coli in complex with acetyl phosphate. (see paper)
tpiA / RF|NP_418354 triose-phosphate isomerase from Escherichia coli K12 (see 4 papers)
    42% identity, 96% coverage of query (182 bits)

tpi1 / CAD98875.1 triose phosphate isomerase from Klebsiella pneumoniae (see paper)
    42% identity, 96% coverage of query (181 bits)

Q5S7Y5 triose-phosphate isomerase (EC 5.3.1.1) from Chlamydomonas reinhardtii (see paper)
    45% identity, 98% coverage of query (179 bits)

5zfxB / A0A074Z863 Crystal structure of triosephosphate isomerase from opisthorchis viverrini (see paper)
    43% identity, 93% coverage of query (178 bits)

CTIMC / P48491 cytosolic triose-phosphate isomerase (EC 5.3.1.1) from Arabidopsis thaliana (see paper)
TPIS_ARATH / P48491 Triosephosphate isomerase, cytosolic; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
P48491 triose-phosphate isomerase (EC 5.3.1.1) from Arabidopsis thaliana (see 2 papers)
    44% identity, 94% coverage of query (178 bits)

6ooiC / P48501 Crystal structure of triosephosphate isomerase from schistosoma mansoni in complex with 2pg (see paper)
    40% identity, 93% coverage of query (177 bits)

A2FT29 triose-phosphate isomerase (EC 5.3.1.1) from Trichomonas vaginalis (see 2 papers)
    41% identity, 93% coverage of query (176 bits)

6oogA / Q9GTX8 Crystal structure of triosephosphate isomerase from taenia solium in complex with 2pg (see paper)
    42% identity, 97% coverage of query (175 bits)

TPIS_PARBA / Q96VN5 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis) (see paper)
    43% identity, 93% coverage of query (174 bits)

Q0ZAG6 triose-phosphate isomerase (EC 5.3.1.1) from Leishmania donovani (see paper)
    43% identity, 93% coverage of query (174 bits)

TPIS_CAEEL / Q10657 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Caenorhabditis elegans (see paper)
Q10657 triose-phosphate isomerase (EC 5.3.1.1) from Caenorhabditis elegans (see paper)
    42% identity, 97% coverage of query (174 bits)

A2EGX9 triose-phosphate isomerase (EC 5.3.1.1) from Trichomonas vaginalis (see 3 papers)
    41% identity, 93% coverage of query (174 bits)

P52270 triose-phosphate isomerase (EC 5.3.1.1) from Trypanosoma cruzi (see 7 papers)
    43% identity, 93% coverage of query (172 bits)

1ci1B / P52270 Crystal structure of triosephosphate isomerase from trypanosoma cruzi in hexane (see paper)
    43% identity, 93% coverage of query (172 bits)

2y63A Crystal structure of leishmanial e65q-tim complexed with bromohydroxyacetone phosphate
    42% identity, 93% coverage of query (172 bits)

2y61A Crystal structure of leishmanial e65q-tim complexed with s-glycidol phosphate
    42% identity, 93% coverage of query (172 bits)

2vxnA E65q-tim complexed with phosphoglycolohydroxamate at 0.82 a resolution
    42% identity, 93% coverage of query (172 bits)

1if2A X-ray structure of leishmania mexicana triosephosphate isomerase complexed with ipp
    42% identity, 93% coverage of query (172 bits)

TPIS_LEIME / P48499 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Leishmania mexicana (see 2 papers)
P48499 triose-phosphate isomerase (EC 5.3.1.1) from Leishmania mexicana (see 3 papers)
    42% identity, 93% coverage of query (171 bits)

Q8MPF2 triose-phosphate isomerase (EC 5.3.1.1) from Tenebrio molitor (see 2 papers)
    41% identity, 96% coverage of query (171 bits)

1amkA / P48499 Leishmania mexicana triose phosphate isomerase (see paper)
    42% identity, 93% coverage of query (171 bits)

TPIS_BARHE / Q8L1Z5 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Bartonella henselae (strain ATCC 49882 / DSM 28221 / CCUG 30454 / Houston 1) (Rochalimaea henselae)
Q8L1Z5 triose-phosphate isomerase (EC 5.3.1.1) from Bartonella henselae (see paper)
    40% identity, 96% coverage of query (169 bits)

TPIS_ENTH1 / O02611 Triosephosphate isomerase; EhTIM; Triose-phosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM) (see 2 papers)
O02611 triose-phosphate isomerase (EC 5.3.1.1) from Entamoeba histolytica (see 2 papers)
    42% identity, 95% coverage of query (167 bits)

tpi1 triosephosphate isomerase; EC 5.3.1.1 from Schizosaccharomyces pombe (see 2 papers)
    43% identity, 94% coverage of query (167 bits)

Q5CSE7 triose-phosphate isomerase (EC 5.3.1.1) from Cryptosporidium parvum (see paper)
    40% identity, 93% coverage of query (167 bits)

P07669 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    43% identity, 94% coverage of query (167 bits)

TPIS_PLAFA / Q07412 Triosephosphate isomerase; PfTIM; Triose-phosphate isomerase; EC 5.3.1.1 from Plasmodium falciparum (see 7 papers)
Q07412 triose-phosphate isomerase (EC 5.3.1.1) from Plasmodium falciparum (see 13 papers)
tpi / AAA18799.1 triosephosphate isomerase from Plasmodium falciparum (see paper)
    37% identity, 93% coverage of query (165 bits)

5eywA / K0E682 Crystal structure of litopenaeus vannamei triosephosphate isomerase complexed with 2-phosphoglycolic acid (see paper)
    40% identity, 96% coverage of query (165 bits)

TPI / GI|2143243 triosephosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica (see paper)
    42% identity, 95% coverage of query (165 bits)

TIM / PDB|1M6J_A triosephosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica (see paper)
    42% identity, 95% coverage of query (165 bits)

Q7NAQ4 triose-phosphate isomerase (EC 5.3.1.1) from Mycoplasma gallisepticum (see paper)
    39% identity, 95% coverage of query (164 bits)

1o5xB Plasmodium falciparum tim complexed to 2-phosphoglycerate
    37% identity, 93% coverage of query (161 bits)

1o5xA Plasmodium falciparum tim complexed to 2-phosphoglycerate
    37% identity, 93% coverage of query (161 bits)

1m7pA Plasmodium falciparum triosephosphate isomerase (pftim) compled to substrate analog glycerol-3-phosphate (g3p).
    37% identity, 93% coverage of query (161 bits)

4bi7A / P36186 Crystal structure of a mutant (c202a) of triosephosphate isomerase from giardia lamblia complexed with 2-phosphoglycolic acid (see paper)
    41% identity, 95% coverage of query (160 bits)

3pf3A Crystal structure of a mutant (c202a) of triosephosphate isomerase from giardia lamblia derivatized with mmts
    41% identity, 95% coverage of query (160 bits)

TPIS_SCYPA / A0A1L5YRA2 Triosephosphate isomerase; TIM; Allergen Scy p 8; Methylglyoxal synthase; Triose-phosphate isomerase; Allergen Scy p 8.0101; EC 5.3.1.1; EC 4.2.3.3 from Scylla paramamosain (Mud crab) (see 2 papers)
    38% identity, 97% coverage of query (160 bits)

1wobA Structure of a loop6 hinge mutant of plasmodium falciparum triosephosphate isomerase, w168f, complexed to sulfate
    36% identity, 93% coverage of query (157 bits)

1woaA Structure of the loop6 hinge mutant of plasmodium falciparum triosephosphate isomerase, w168f, complexed with glycerol-2-phosphate
    36% identity, 93% coverage of query (157 bits)

P17751 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Mus musculus (Mouse)
    41% identity, 93% coverage of query (157 bits)

1r2rB Crystal structure of rabbit muscle triosephosphate isomerase
    41% identity, 93% coverage of query (157 bits)

4owgA Crystal structure of rabbit muscle triosephosphate isomerase-pep complex
    41% identity, 93% coverage of query (157 bits)

TPIS_RABIT / P00939 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Oryctolagus cuniculus (Rabbit) (see 3 papers)
P00939 triose-phosphate isomerase (EC 5.3.1.1) from Oryctolagus cuniculus (see 3 papers)
    41% identity, 93% coverage of query (157 bits)

1htiB / P60174 Crystal structure of recombinant human triosephosphate isomerase at 2.8 angstroms resolution. Triosephosphate isomerase related human genetic disorders and comparison with the trypanosomal enzyme (see paper)
    41% identity, 93% coverage of query (156 bits)

4pocB Structure of triosephosphate isomerase wild type human enzyme.
    41% identity, 93% coverage of query (156 bits)

TPI1 / P60174 Triosephosphate isomerase (EC 5.3.1.1) from Homo sapiens (see 9 papers)
TPIS_HUMAN / P60174 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Homo sapiens (Human) (see 6 papers)
P60174 triose-phosphate isomerase (EC 5.3.1.1) from Homo sapiens (see 2 papers)
    41% identity, 93% coverage of query (156 bits)

6timB The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes
    41% identity, 93% coverage of query (156 bits)

4timB Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate
    41% identity, 93% coverage of query (156 bits)

1trdB The influence of crystal packing on crystallographic binding studies: a new crystal form of trypanosomal tim
    41% identity, 93% coverage of query (156 bits)

1iigB Structure of trypanosoma brucei brucei triosephosphate isomerase complexed with 3-phosphonopropionate
    41% identity, 93% coverage of query (156 bits)

1ag1T / P04789 Monohydrogen phosphate binding to trypanosomal triosephosphate isomerase (see paper)
    41% identity, 93% coverage of query (156 bits)

5gzpA / Q07412 Y74cox mutant of plasmodium falciparum triosephosphate isomerase
    37% identity, 93% coverage of query (155 bits)

TPIS_YEAST / P00942 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P00942 triose-phosphate isomerase (EC 5.3.1.1) from Saccharomyces cerevisiae (see 8 papers)
    38% identity, 94% coverage of query (155 bits)

1tsiA Structure of the complex between trypanosomal triosephosphate isomerase and n-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop
    41% identity, 93% coverage of query (154 bits)

1kv5A Structure of trypanosoma brucei brucei tim with the salt-bridge- forming residue arg191 mutated to ser
    41% identity, 93% coverage of query (153 bits)

TPIS_CHICK / P00940 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Gallus gallus (Chicken) (see paper)
P00940 triose-phosphate isomerase (EC 5.3.1.1) from Gallus gallus (see 3 papers)
    40% identity, 93% coverage of query (151 bits)

3ypiA Electrophilic catalysis in triosephosphase isomerase: the role of histidine-95
    38% identity, 93% coverage of query (150 bits)

1tpb1 Offset of a catalytic lesion by a bound water soluble
    41% identity, 93% coverage of query (149 bits)

4ff7B Structure of c126s mutant of saccharomyces cerevisiae triosephosphate isomerase
    38% identity, 93% coverage of query (149 bits)

4ff7A / P00942 Structure of c126s mutant of saccharomyces cerevisiae triosephosphate isomerase (see paper)
    38% identity, 93% coverage of query (149 bits)

1ssgA / P00940 Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase (see paper)
    39% identity, 93% coverage of query (147 bits)

2wsrA Monotim mutant rmm0-1, monomeric form.
    39% identity, 93% coverage of query (142 bits)

7rdeB Human triose phosphate isomerase q181p
    40% identity, 93% coverage of query (142 bits)

2vemA Structure-based enzyme engineering efforts with an inactive monomeric tim variant: the importance of a single point mutation for generating an active site with suitable binding properties
    37% identity, 90% coverage of query (128 bits)

2x1rA Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase
    36% identity, 90% coverage of query (125 bits)

TPIS_HELPY / P56076 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
P56076 triose-phosphate isomerase (EC 5.3.1.1) from Helicobacter pylori (see 2 papers)
    31% identity, 93% coverage of query (115 bits)

2jgqA / P56076 Kinetics and structural properties of triosephosphate isomerase from helicobacter pylori (see paper)
    31% identity, 93% coverage of query (110 bits)

Build an alignment

Build an alignment for WP_050656343.1 and 96 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory