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Searching for up to 100 curated homologs for WP_051402369.1 NCBI__GCF_000496075.1:WP_051402369.1 (340 a.a.)

Found high-coverage hits (≥70%) to 94 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

LTHAD_YEAST / P36007 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; EC 4.3.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    44% identity, 95% coverage of query (231 bits)

thadh / A4F2N8 L-threo-3-hydroxy aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. (see 2 papers)
LTHAD_PSESP / A4F2N8 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; L-THA DH; EC 4.3.1.16 from Pseudomonas sp. (see 2 papers)
A4F2N8 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. T62 (see paper)
    45% identity, 95% coverage of query (230 bits)

sr / Q2PGG3 serine racemase/D-serine ammonia-lyase (EC 5.1.1.10) from Arabidopsis thaliana (see paper)
SRR_ARATH / Q2PGG3 Serine racemase; AtSR; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q2PGG3 serine racemase (EC 5.1.1.18) from Arabidopsis thaliana (see paper)
    41% identity, 89% coverage of query (214 bits)

SRR_ORYSJ / Q7XSN8 Serine racemase; D-serine dehydratase; D-serine ammonia-lyase; L-serine dehydratase; L-serine ammonia-lyase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
Q7XSN8 serine racemase (EC 5.1.1.18) from Oryza sativa (see paper)
    41% identity, 89% coverage of query (209 bits)

Q54HH2 D-Serine ammonia-lyase (EC 4.3.1.18) from Dictyostelium discoideum (see paper)
    34% identity, 95% coverage of query (208 bits)

L0N5C4 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. N99 (see paper)
    43% identity, 91% coverage of query (206 bits)

A0QY48 L-serine ammonia-lyase (EC 4.3.1.17) from Mycolicibacterium smegmatis (see paper)
    46% identity, 95% coverage of query (206 bits)

sr / A5HUN0 serine racemase/D-serine ammonia-lyase (EC 5.1.1.10) from Hordeum vulgare (see paper)
A5HUN0 serine racemase (EC 5.1.1.18) from Hordeum vulgare (see paper)
    41% identity, 90% coverage of query (197 bits)

SRR_SCHPO / O59791 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
O59791 serine racemase (EC 5.1.1.18) from Schizosaccharomyces pombe (see 2 papers)
    39% identity, 94% coverage of query (197 bits)

2zpuA / O59791 Crystal structure of modified serine racemase from s.Pombe. (see paper)
    39% identity, 94% coverage of query (197 bits)

1wtcA Crystal structure of s.Pombe serine racemase complex with amppcp
    39% identity, 94% coverage of query (197 bits)

1v71A Crystal structure of s.Pombe serine racemase
    39% identity, 94% coverage of query (197 bits)

2zr8A Crystal structure of modified serine racemase complexed with serine
    39% identity, 94% coverage of query (197 bits)

Tdc / b3117 catabolic threonine dehydratase (EC 4.3.1.17; EC 4.3.1.19) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
tdcB / P0AGF6 catabolic threonine dehydratase (EC 4.3.1.17; EC 4.3.1.19) from Escherichia coli (strain K12) (see 25 papers)
TDCB_ECOLI / P0AGF6 L-threonine dehydratase catabolic TdcB; L-serine dehydratase; Threonine deaminase; EC 4.3.1.19; EC 4.3.1.17 from Escherichia coli (strain K12) (see 4 papers)
tdcB / RF|NP_417587 threonine ammonia-lyase; EC 4.3.1.19 from Escherichia coli K12 (see 7 papers)
    41% identity, 96% coverage of query (194 bits)

TSAL_THEMA / Q9WYJ1 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine dehydratase; EC 4.3.1.19; EC 4.3.1.17 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    42% identity, 91% coverage of query (193 bits)

F5CAQ9 serine racemase (EC 5.1.1.18) from Zea mays (see paper)
    40% identity, 90% coverage of query (192 bits)

5cvcA / F5CAQ9 Structure of maize serine racemase (see paper)
    40% identity, 90% coverage of query (192 bits)

A0A0U5AKI6 serine racemase (EC 5.1.1.18) from Crassostrea gigas (see paper)
    38% identity, 91% coverage of query (191 bits)

BHCB_PARDP / A1B8Z2 beta-hydroxyaspartate dehydratase; EC 4.2.1.- from Paracoccus denitrificans (strain Pd 1222) (see paper)
    38% identity, 91% coverage of query (191 bits)

SRR / Q9GZT4 Serine racemase (EC 5.1.1.10) from Homo sapiens (see 4 papers)
SRR_HUMAN / Q9GZT4 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Homo sapiens (Human) (see 8 papers)
    38% identity, 91% coverage of query (189 bits)

7nbcAAA / Q9GZT4 structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
    38% identity, 91% coverage of query (189 bits)

7nbfAAA structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen
    38% identity, 91% coverage of query (189 bits)

7nbdAAA structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen
    38% identity, 91% coverage of query (189 bits)

7nbcCCC structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen
    38% identity, 91% coverage of query (189 bits)

7nbhAAA structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen
    38% identity, 91% coverage of query (189 bits)

7nbgAAA structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
    38% identity, 91% coverage of query (189 bits)

TDCB_SALTY / P11954 L-threonine dehydratase catabolic TdcB; L-serine dehydratase; Threonine deaminase; EC 4.3.1.19; EC 4.3.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    39% identity, 96% coverage of query (187 bits)

2gn2A / P11954 Crystal structure of tetrameric biodegradative threonine deaminase (tdcb) from salmonella typhimurium in complex with cmp at 2.5a resolution (hexagonal form) (see paper)
    39% identity, 96% coverage of query (186 bits)

6zspAAA serine racemase bound to atp and malonate.
    37% identity, 91% coverage of query (186 bits)

7nbgDDD structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
    37% identity, 91% coverage of query (185 bits)

3l6bA X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor
    37% identity, 91% coverage of query (185 bits)

8y1jA / Q9I6G0 Structure of the pyridoxal 5'-phosphate-dependent (plp) threonine deaminase ilva1 from pseudomonas aeruginosa pao1 (see paper)
    39% identity, 88% coverage of query (176 bits)

SRR_RAT / Q76EQ0 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Rattus norvegicus (Rat) (see 3 papers)
Q76EQ0 serine racemase (EC 5.1.1.18) from Rattus norvegicus (see 6 papers)
    38% identity, 91% coverage of query (174 bits)

1ve5A / Q5SLL4 Crystal structure of t.Th. Hb8 threonine deaminase
    45% identity, 91% coverage of query (174 bits)

3hmkA Crystal structure of serine racemase
    38% identity, 91% coverage of query (174 bits)

FSDH_RALPI / Q10725 Phenylserine dehydratase; EC 4.2.1.- from Ralstonia pickettii (Burkholderia pickettii) (see 2 papers)
    37% identity, 95% coverage of query (172 bits)

A0A0U4MRI4 serine racemase (EC 5.1.1.18) from Penaeus monodon (see paper)
    37% identity, 90% coverage of query (172 bits)

SRR_MOUSE / Q9QZX7 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Mus musculus (Mouse) (see 6 papers)
    38% identity, 91% coverage of query (170 bits)

B1N2N4 L-serine ammonia-lyase (EC 4.3.1.17) from Entamoeba histolytica (see paper)
    36% identity, 95% coverage of query (169 bits)

A0A0U5A554 aspartate racemase (EC 5.1.1.13) from Penaeus monodon (see paper)
    36% identity, 92% coverage of query (164 bits)

F7ZG00 serine racemase (EC 5.1.1.18) from Roseobacter litoralis (see paper)
    35% identity, 93% coverage of query (164 bits)

CA265_RS15860 threonine deaminase (EC 4.3.1.19) from Pedobacter sp. GW460-11-11-14-LB5
    35% identity, 92% coverage of query (162 bits)

TSAL_GEOSL / Q74FW6 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine/serine ammonia-lyase; EC 4.3.1.19; EC 4.3.1.17 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
Q74FW6 threonine ammonia-lyase (EC 4.3.1.19) from Geobacter sulfurreducens (see paper)
    40% identity, 90% coverage of query (161 bits)

ILV1 putative uncharacterized protein ILV1 from Candida albicans (see paper)
    36% identity, 86% coverage of query (159 bits)

K1QH67 aspartate racemase (EC 5.1.1.13) from Crassostrea gigas (see paper)
    35% identity, 91% coverage of query (157 bits)

THDH_SCHPO / O94634 Threonine dehydratase, mitochondrial; Threonine deaminase; EC 4.3.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    38% identity, 85% coverage of query (155 bits)

TD_NICAT / Q9AXU4 Threonine dehydratase; Threonine deaminase; EC 4.3.1.19 from Nicotiana attenuata (Coyote tobacco) (see 2 papers)
Q9AXU4 threonine ammonia-lyase (EC 4.3.1.19) from Nicotiana attenuata (see paper)
    33% identity, 88% coverage of query (154 bits)

1ve5D / Q5SLL4 Crystal structure of t.Th. Hb8 threonine deaminase
    42% identity, 91% coverage of query (153 bits)

Ga0059261_3694 threonine deaminase (EC 4.3.1.19) from Sphingomonas koreensis DSMZ 15582
    36% identity, 93% coverage of query (147 bits)

Asr / BAE78960.1 aspartate racemase from Scapharca broughtonii (see paper)
    33% identity, 93% coverage of query (146 bits)

TD2_SOLLC / P25306 Threonine dehydratase 2 biosynthetic, chloroplastic; SlTD2; Threonine deaminase 2; EC 4.3.1.17; EC 4.3.1.19 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see 5 papers)
    33% identity, 77% coverage of query (145 bits)

V6QU65 threonine ammonia-lyase (EC 4.3.1.19) from Fusarium graminearum (see paper)
    36% identity, 92% coverage of query (145 bits)

CCNA_03750 threonine deaminase (EC 4.3.1.19) from Caulobacter crescentus NA1000
    38% identity, 72% coverage of query (145 bits)

THDH_YEAST / P00927 Threonine dehydratase, mitochondrial; Threonine deaminase; EC 4.3.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
    37% identity, 86% coverage of query (145 bits)

ILV / CAA10977.1 threonine deaminase from Blastobotrys adeninivorans (see paper)
    35% identity, 85% coverage of query (144 bits)

A0QX60 threonine ammonia-lyase (EC 4.3.1.19) from Mycolicibacterium smegmatis (see paper)
    35% identity, 93% coverage of query (143 bits)

Q2V0H1 serine racemase (EC 5.1.1.18) from Pyrobaculum islandicum (see paper)
    37% identity, 87% coverage of query (141 bits)

CH_124219 threonine deaminase [Arxula adeninivorans] from Magnaporthe grisea 70-15 (see paper)
    36% identity, 85% coverage of query (135 bits)

Q93968 serine racemase (EC 5.1.1.18) from Caenorhabditis elegans (see paper)
    30% identity, 91% coverage of query (133 bits)

TD1_SOLLC / A0FKE6 Threonine dehydratase 1 biosynthetic, chloroplastic; SlTD1; Threonine deaminase 1; EC 4.3.1.19 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see 2 papers)
    37% identity, 80% coverage of query (131 bits)

Ile / b3772 threonine deaminase (EC 4.3.1.19) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ilvA / P04968 threonine deaminase (EC 4.3.1.19) from Escherichia coli (strain K12) (see 21 papers)
ILVA_ECOLI / P04968 L-threonine dehydratase biosynthetic IlvA; Threonine deaminase; EC 4.3.1.19 from Escherichia coli (strain K12) (see 4 papers)
P04968 threonine ammonia-lyase (EC 4.3.1.19) from Escherichia coli (see paper)
    34% identity, 79% coverage of query (126 bits)

1tdjA / P04968 Threonine deaminase (biosynthetic) from e. Coli (see paper)
    34% identity, 79% coverage of query (126 bits)

AKS11_ALTAL / V5Y0V0 Threonine dehydratase-like protein AKTS1-1; AK-toxin biosynthesis protein S1-1; EC 4.3.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 4 papers)
    31% identity, 88% coverage of query (126 bits)

ilvA / AAA96639.1 threonine dehydratase from Bacillus subtilis (see 3 papers)
    31% identity, 91% coverage of query (124 bits)

Q04513 threonine ammonia-lyase (EC 4.3.1.19) from Corynebacterium glutamicum (see paper)
    32% identity, 92% coverage of query (118 bits)

1pwhA / P09367 Rat liver l-serine dehydratase- complex with pyridoxyl-(o-methyl- serine)-5-monophosphate (see paper)
    30% identity, 89% coverage of query (93.6 bits)

Build an alignment

Build an alignment for WP_051402369.1 and 66 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

Q8VBT2 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse)
    28% identity, 89% coverage of query (90.5 bits)

SDHL_RAT / P09367 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Rattus norvegicus (Rat) (see 7 papers)
P09367 L-serine ammonia-lyase (EC 4.3.1.17) from Rattus norvegicus (see 3 papers)
    28% identity, 89% coverage of query (76.3 bits)

SDS / P20132 L-serine dehydratase (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens (see 2 papers)
SDHL_HUMAN / P20132 L-serine dehydratase/L-threonine deaminase; SDH; Hepatic serine dehydratase; hSDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Homo sapiens (Human) (see 5 papers)
P20132 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens (see 3 papers)
    30% identity, 87% coverage of query (75.5 bits)

SDSL_MOUSE / Q8R238 Serine dehydratase-like; Glutamate racemase; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; SDH; EC 5.1.1.3; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse) (see paper)
    29% identity, 85% coverage of query (73.2 bits)

1p5jA / P20132 Crystal structure analysis of human serine dehydratase (see paper)
    28% identity, 86% coverage of query (72.8 bits)

2rkbA / Q96GA7 Serine dehydratase like-1 from human cancer cells (see paper)
    30% identity, 86% coverage of query (69.7 bits)

SDSL / Q96GA7 Serine dehydratase-like (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens (see paper)
SDSL_HUMAN / Q96GA7 Serine dehydratase-like; Cancerous serine dehydratase; cSDH; Glutamate racemase; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; SDHL; L-threonine dehydratase; TDH; Serine dehydratase 2; SDH 2; EC 5.1.1.3; EC 4.3.1.17; EC 4.3.1.19 from Homo sapiens (Human) (see 2 papers)
Q96GA7 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens (see paper)
    30% identity, 86% coverage of query (69.3 bits)

A0A0X1KHE6 L-serine ammonia-lyase (EC 4.3.1.17) from Rhizomucor miehei (see paper)
    28% identity, 90% coverage of query (68.9 bits)

5c3uA / A0A0X1KHE6 Crystal structure of a fungal l-serine ammonia-lyase from rhizomucor miehei (see paper)
    28% identity, 86% coverage of query (68.6 bits)

SDSL_RAT / A0A6N3IN21 Serine dehydratase-like; Glutamate racemase; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; EC 5.1.1.3; EC 4.3.1.17; EC 4.3.1.19 from Rattus norvegicus (Rat) (see paper)
    29% identity, 87% coverage of query (65.9 bits)

STDH_YEAST / P25379 Catabolic L-serine/threonine dehydratase; EC 4.3.1.17; EC 4.3.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    24% identity, 79% coverage of query (60.8 bits)

6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
    25% identity, 87% coverage of query (55.5 bits)

6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    25% identity, 87% coverage of query (55.5 bits)

6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    25% identity, 87% coverage of query (54.3 bits)

THRC_MYCTU / P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG59 threonine synthase (EC 4.2.3.1) from Mycobacterium tuberculosis (see 2 papers)
    26% identity, 82% coverage of query (53.1 bits)

2d1fA / P9WG59 Structure of mycobacterium tuberculosis threonine synthase (see paper)
    26% identity, 82% coverage of query (53.1 bits)

thrC / CAA82669.1 threonine synthase from Bacillus sp. (see paper)
    26% identity, 85% coverage of query (52.4 bits)

1jbqA Structure of human cystathionine beta-synthase: a unique pyridoxal 5'- phosphate dependent hemeprotein
    26% identity, 84% coverage of query (49.7 bits)

CBS / P35520 cystathionine β-synthase monomer (EC 4.2.1.22) from Homo sapiens (see 12 papers)
CBS_HUMAN / P35520 Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Homo sapiens (Human) (see 43 papers)
P35520 cystathionine beta-synthase (EC 4.2.1.22) from Homo sapiens (see 18 papers)
    27% identity, 84% coverage of query (48.9 bits)

8s5hA / P35520 Full-length human cystathionine beta-synthase with c-terminal 6xhis- tag, basal state, helical reconstruction (see paper)
    27% identity, 84% coverage of query (48.5 bits)

7qgtB Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with aoaa.
    27% identity, 84% coverage of query (48.5 bits)

5ygrD / P40817 Crystal structure of plp bound diaminopropionate ammonia lyase from salmonella typhimurium (see paper)
    22% identity, 73% coverage of query (48.1 bits)

DPAL_SALTY / P40817 Diaminopropionate ammonia-lyase; DAPAL; 2,3-diaminopropionate ammonia-lyase; Alpha,beta-diaminopropionate ammonia-lyase; Diaminopropionatase; EC 4.3.1.15 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
P40817 Diaminopropionate ammonia-lyase (EC 4.3.1.15) from Salmonella enterica subsp. enterica serovar Typhimurium (see 2 papers)
    21% identity, 73% coverage of query (47.8 bits)

P83823 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see paper)
Q5SL02 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see 2 papers)
3aexA / Q5SL02 Catalytic intermediate analogue of threonine synthase from thermus thermophilus hb8 (see paper)
    28% identity, 83% coverage of query (46.6 bits)

3aeyA Apo form of threonine synthase from thermus thermophilus hb8
    28% identity, 83% coverage of query (46.6 bits)

1uimA Crystal structure of threonine synthase from thermus thermophilus hb8, orthorhombic crystal form
    28% identity, 83% coverage of query (46.6 bits)

1v7cA Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue
    28% identity, 83% coverage of query (46.6 bits)

4pcuA Crystal structure of delta516-525 e201s human cystathionine beta- synthase with adomet
    27% identity, 84% coverage of query (46.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory