Searching for up to 100 curated homologs for WP_052666358.1 NCBI__GCF_000969705.1:WP_052666358.1 (303 a.a.)
Found high-coverage hits (≥70%) to 36 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ddh / Q2VEQ7 (D)-2-hydroxyacid dehydrogenase (NADP+) monomer (EC 1.1.1.272) from Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (see paper)
DDH_HALMT / Q2VEQ7 D-2-hydroxyacid dehydrogenase; D2-HDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.- from Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei) (see paper)
Q2VEQ7 D-2-hydroxyacid dehydrogenase (NADP+) (EC 1.1.1.272) from Haloferax mediterranei (see 3 papers)
5mh5A / Q2VEQ7 D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with 2-keto-hexanoic acid and NADP+ (1.4 a resolution)
37% identity, 72% coverage of query (125 bits)
5mh6A D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with 2-ketohexanoic acid and NAD+ (1.35 a resolution)
37% identity, 72% coverage of query (125 bits)
5mhaB D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 a resolution)
37% identity, 72% coverage of query (125 bits)
5mhaA D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 a resolution)
37% identity, 72% coverage of query (125 bits)
3bazA / Q65CJ7 Structure of hydroxyphenylpyruvate reductase from coleus blumei in complex with NADP+ (see paper)
33% identity, 82% coverage of query (106 bits)
HPPR / Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see paper)
HPPR_PLESU / Q65CJ7 Hydroxyphenylpyruvate reductase; HPPR; EC 1.1.1.237 from Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides) (see paper)
Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see 2 papers)
hppr / CAD47810.2 hydroxyphenylpyruvate reductase (HPPR) from Plectranthus scutellarioides (see paper)
33% identity, 82% coverage of query (106 bits)
BPHYT_RS11290 2-ketogluconate 6-phosphate reductase (EC 1.1.1.43) from Burkholderia phytofirmans PsJN
32% identity, 85% coverage of query (105 bits)
A0A0A7RFJ3 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Salvia miltiorrhiza (see paper)
35% identity, 72% coverage of query (103 bits)
Build an alignment for WP_052666358.1 and 8 homologs with ≥ 30% identity
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O58256 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pyrococcus horikoshii (see paper)
28% identity, 96% coverage of query (102 bits)
Sama_3039 Phosphoglycerate dehydrogenase (EC 1.1.1.95) from Shewanella amazonensis SB2B
29% identity, 81% coverage of query (102 bits)
8oq2A Binding of NADP to a formate dehydrogenase from starkeya novella.
32% identity, 72% coverage of query (101 bits)
A0A178WMD4 hydroxyphenylpyruvate reductase (EC 1.1.1.237); glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 2 papers)
33% identity, 73% coverage of query (100 bits)
3wr5A / Q76EB7 Structural basis on the efficient co2 reduction of acidophilic formate dehydrogenase
32% identity, 72% coverage of query (98.6 bits)
Q76EB7 formate dehydrogenase (EC 1.17.1.9) from Thiobacillus sp. (see paper)
32% identity, 72% coverage of query (98.6 bits)
4zqbB / Q3IWN8 Crystal structure of NADP-dependent dehydrogenase from rhodobactersphaeroides in complex with NADP and sulfate
32% identity, 90% coverage of query (98.2 bits)
HPR3 / Q9LE33 glyoxylate reductase (NADP+) (EC 1.1.1.79; EC 1.1.1.81) from Arabidopsis thaliana (see 8 papers)
HPR3_ARATH / Q9LE33 Glyoxylate/hydroxypyruvate reductase HPR3; NAD(P)H-dependent hydroxypyruvate reductase 3; AtHPR3; HPR 3; EC 1.1.1.79; EC 1.1.1.81 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9LE33 hydroxyphenylpyruvate reductase (EC 1.1.1.237); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 3 papers)
33% identity, 71% coverage of query (97.8 bits)
fdh / BAB69476.1 formate dehydrogenase from Mycolicibacterium vaccae (see paper)
31% identity, 72% coverage of query (97.1 bits)
FDH_PSESR / P33160 Formate dehydrogenase; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Pseudomonas sp. (strain 101) (Achromobacter parvulus T1) (see 2 papers)
P33160 formate dehydrogenase (EC 1.17.1.9) from Pseudomonas sp. 101 (see paper)
31% identity, 72% coverage of query (97.1 bits)
2nadA High resolution structures of holo and apo formate dehydrogenase
31% identity, 72% coverage of query (97.1 bits)
5vg6B / A7IIH0 Crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase from xanthobacter autotrophicus py2 in complex with NADPH and mes.
31% identity, 86% coverage of query (94.7 bits)
7jqhA / A0A140NAE3 Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with phosphate and NADP+
30% identity, 71% coverage of query (94.0 bits)
2KGR_GLUOX / Q5FTU6 2-ketogluconate reductase; 2KGR; Gluconate 2-dehydrogenase; EC 1.1.1.215 from Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) (see paper)
Q5FTU6 gluconate 2-dehydrogenase (EC 1.1.1.215) from Gluconobacter oxydans (see 2 papers)
30% identity, 82% coverage of query (93.6 bits)
7jqiA Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with alpha-ketoglutarate and NADP+
30% identity, 71% coverage of query (93.6 bits)
6p35A 2.5 angstrom structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with 2-keto arginine and NADP
30% identity, 71% coverage of query (93.6 bits)
GhrA / b1033 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ghrA / P75913 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli (strain K12) (see 4 papers)
GHRA_ECOLI / P75913 Glyoxylate/hydroxypyruvate reductase A; 2-ketoacid reductase; EC 1.1.1.79; EC 1.1.1.81 from Escherichia coli (strain K12) (see paper)
30% identity, 71% coverage of query (93.2 bits)
6jujA Crystal structure of formate dehydrogenase mutant v198i/c256i/p260s/e261p/s381n/s383f from pseudomonas sp. 101in complex with non-natural cofactor nicotinamide cytosine dinucleotide
30% identity, 72% coverage of query (92.8 bits)
Q845T0 formate dehydrogenase (EC 1.17.1.9) from Ancylobacter aquaticus (see paper)
32% identity, 72% coverage of query (92.0 bits)
5bqfA / Q2KDT2 Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADP, hepes and l(+)-tartaric acid
35% identity, 70% coverage of query (92.0 bits)
4xcvA Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH
35% identity, 70% coverage of query (92.0 bits)
5tsdA Crystal structure of NADPH-dependent 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH and oxalate
35% identity, 70% coverage of query (92.0 bits)
HPR_BLAHS / C0CMQ8 Hydroxypyruvate reductase; EC 1.1.1.81 from Blautia hydrogenotrophica (strain DSM 10507 / JCM 14656 / S5a33) (Ruminococcus hydrogenotrophicus) (see paper)
27% identity, 96% coverage of query (91.3 bits)
TkrA / b3553 glyoxylate reductase (EC 1.1.1.79; EC 1.1.1.215) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ghrB / P37666 glyoxylate reductase (EC 1.1.1.79; EC 1.1.1.215) from Escherichia coli (strain K12) (see 4 papers)
GHRB_ECOLI / P37666 Glyoxylate/hydroxypyruvate reductase B; 2-ketoaldonate reductase; 2-ketogluconate reductase; 2KR; EC 1.1.1.79; EC 1.1.1.81; EC 1.1.1.215 from Escherichia coli (strain K12) (see 2 papers)
ghrB / GB|AAC76577.2 glyoxylate/hydroxypyruvate reductase B; EC 1.1.1.215; EC 1.1.1.79; EC 1.1.1.81 from Escherichia coli K12 (see 6 papers)
32% identity, 71% coverage of query (86.7 bits)
kguD / Q5TM04 2-dehydro-6-phosphogluconate reductase (EC 1.1.1.43) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see 2 papers)
30% identity, 78% coverage of query (82.0 bits)
AO353_26885 phosphogluconate 2-dehydrogenase KguD (EC 1.1.1.43) from Pseudomonas fluorescens FW300-N2E3
30% identity, 78% coverage of query (79.3 bits)
EFUE_HORCR / A0A2Z4HPZ6 Dehydrogenase efuE; Enfumafungin biosynthesis cluster protein E; EC 1.-.-.- from Hormonema carpetanum (see paper)
28% identity, 85% coverage of query (79.0 bits)
SERA_YEAST / P40054 D-3-phosphoglycerate dehydrogenase 1; 3-PGDH 1; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
28% identity, 75% coverage of query (77.0 bits)
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