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Searching for up to 100 curated homologs for WP_057508382.1 NCBI__GCF_001431535.1:WP_057508382.1 (456 a.a.)

Found high-coverage hits (≥70%) to 29 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

uptG / AAK53485.1 cystathionine beta-lyase from Xanthomonas campestris pv. campestris (see 4 papers)
    88% identity, 100% coverage of query (837 bits)

Q9EYM7 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Streptomyces venezuelae (see paper)
    37% identity, 99% coverage of query (282 bits)

4pcuA Crystal structure of delta516-525 e201s human cystathionine beta- synthase with adomet
    34% identity, 98% coverage of query (262 bits)

7qgtB Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with aoaa.
    34% identity, 98% coverage of query (261 bits)

8s5hA / P35520 Full-length human cystathionine beta-synthase with c-terminal 6xhis- tag, basal state, helical reconstruction (see paper)
    33% identity, 98% coverage of query (257 bits)

Cbs / P32232 cystathionine β-synthase subunit (EC 4.2.1.22) from Rattus norvegicus (see 2 papers)
CBS_RAT / P32232 Cystathionine beta-synthase; Beta-thionase; Hemoprotein H-450; Serine sulfhydrase; EC 4.2.1.22 from Rattus norvegicus (Rat) (see 3 papers)
    34% identity, 99% coverage of query (256 bits)

CBS / P35520 cystathionine β-synthase monomer (EC 4.2.1.22) from Homo sapiens (see 12 papers)
CBS_HUMAN / P35520 Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Homo sapiens (Human) (see 43 papers)
P35520 cystathionine beta-synthase (EC 4.2.1.22) from Homo sapiens (see 18 papers)
    33% identity, 98% coverage of query (256 bits)

CYS4 / P32582 Cys4 (EC 4.2.1.22) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
CBS_YEAST / P32582 Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; Sulfur transfer protein 4; EC 4.2.1.22 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P32582 cystathionine beta-synthase (EC 4.2.1.22) from Saccharomyces cerevisiae (see 3 papers)
    34% identity, 98% coverage of query (252 bits)

Y1077_MYCTU / P9WP51 Probable cystathionine beta-synthase Rv1077; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    37% identity, 99% coverage of query (245 bits)

7xnzB / P9WP51 Native cystathionine beta-synthase of mycobacterium tuberculosis. (see paper)
    37% identity, 98% coverage of query (244 bits)

7xoyA Cystathionine beta-synthase of mycobacterium tuberculosis in the presence of s-adenosylmethionine and serine.
    37% identity, 98% coverage of query (244 bits)

mecA cystathionine beta-synthase; EC 4.2.1.22 from Emericella nidulans (see 2 papers)
    38% identity, 88% coverage of query (243 bits)

CBS / A0A563XPB1 cystathionine β-synthase (EC 4.2.1.22) from Gallus gallus (see 7 papers)
    34% identity, 95% coverage of query (241 bits)

6xwlC / A0A125YSJ9 Cystathionine beta-synthase from toxoplasma gondii (see paper)
    35% identity, 98% coverage of query (241 bits)

5ohxA / Q2V0C9 Structure of active cystathionine b-synthase from apis mellifera (see paper)
    33% identity, 99% coverage of query (240 bits)

CBS_APIME / Q2V0C9 Cystathionine beta-synthase; EC 4.2.1.22 from Apis mellifera (Honeybee) (see paper)
Q2V0C9 cystathionine beta-synthase (EC 4.2.1.22) from Apis mellifera (see paper)
    33% identity, 99% coverage of query (238 bits)

6xylA Crystal structure of delta466-491 cystathionine beta-synthase from toxoplasma gondii with l-serine
    35% identity, 98% coverage of query (238 bits)

6vjuB / Q5ZRD1 Crystal structure of cystathionine beta synthase from legionella pneumophila with llp, plp, and homocysteine
    42% identity, 70% coverage of query (235 bits)

3pc3A / Q9VRD9 Full length structure of cystathionine beta-synthase from drosophila in complex with aminoacrylate (see paper)
    33% identity, 98% coverage of query (225 bits)

Q9VRD9 cystathionine beta-synthase (EC 4.2.1.22) from Drosophila melanogaster (see paper)
    33% identity, 98% coverage of query (225 bits)

3pc2A Full length structure of cystathionine beta-synthase from drosophila
    35% identity, 90% coverage of query (225 bits)

3pc4A Full length structure of cystathionine beta-synthase from drosophila in complex with serine
    33% identity, 98% coverage of query (225 bits)

CYSK_EMENI / P50867 Cysteine synthase 1; CS 1; O-acetylserine (thiol)-lyase 1; OAS-TL 1; O-acetylserine sulfhydrylase 1; O-succinylserine sulfhydrylase; EC 2.5.1.-; EC 2.5.1.47 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
cysB / GB|AAC06128.1 cysteine synthase; EC 2.5.1.47 from Emericella nidulans (see 3 papers)
    37% identity, 72% coverage of query (192 bits)

cysB / AAC06128.1 cysteine synthase from Aspergillus nidulans (see paper)
    37% identity, 72% coverage of query (192 bits)

CYSK_NEUCR / Q7RYW6 Cysteine synthase 1; CS 1; O-acetylserine (thiol)-lyase 1; OAS-TL 1; O-acetylserine sulfhydrylase 1; O-succinylserine sulfhydrylase; EC 2.5.1.-; EC 2.5.1.47 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see paper)
    38% identity, 72% coverage of query (187 bits)

CYSK1_CAEEL / Q93244 Cysteine synthase 1; O-acetylserine (thiol)-lyase 1; OAS-TL; EC 2.5.1.47 from Caenorhabditis elegans (see 3 papers)
Q93244 cysteine synthase (EC 2.5.1.47) from Caenorhabditis elegans (see 2 papers)
    37% identity, 72% coverage of query (174 bits)

dcsD / D2Z027 O-ureido-L-serine synthase (EC 2.5.1.47; EC 2.6.99.3) from Streptomyces lavendulae (see 2 papers)
DCSD_STRLA / D2Z027 O-ureido-L-serine synthase; Cysteine synthase homolog DscD; O-acetylserine sulfhydrylase; EC 2.6.99.3; EC 2.5.1.47 from Streptomyces lavendulae (see 3 papers)
D2Z027 cysteine synthase (EC 2.5.1.47); O-ureido-L-serine synthase (EC 2.6.99.3) from Streptomyces lavendulae (see 4 papers)
    34% identity, 70% coverage of query (158 bits)

3x44A / D2Z027 Crystal structure of o-ureido-l-serine-bound k43a mutant of o-ureido- l-serine synthase (see paper)
    33% identity, 70% coverage of query (154 bits)

Build an alignment

Build an alignment for WP_057508382.1 and 28 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

cysK2 / Q79FV4 3-phospho-L-serine-dependent S-sulfo-L-cysteine synthase (EC 2.8.5.1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
CYSK2_MYCTU / Q79FV4 S-sulfocysteine synthase; O-phospho-L-serine-dependent S-sulfocysteine synthase; OPS-dependent S-sulfocysteine synthase; O-phosphoserine sulfhydrylase; EC 2.8.5.1; EC 2.5.1.65 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
Q79FV4 cysteine synthase (EC 2.5.1.47); O-phosphoserine sulfhydrylase (EC 2.5.1.65) from Mycobacterium tuberculosis (see 2 papers)
    27% identity, 76% coverage of query (107 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory