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Searching for up to 100 curated homologs for WP_058930133.1 NCBI__GCF_001484605.1:WP_058930133.1 (550 a.a.)

Found high-coverage hits (≥70%) to 29 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q9ZH77 malate synthase (EC 2.3.3.9) from Streptomyces clavuligerus (see paper)
    63% identity, 95% coverage of query (649 bits)

CH_124037 putative malate synthase [Candida tropicalis] from Magnaporthe grisea 70-15 (see paper)
    53% identity, 95% coverage of query (558 bits)

BPHYT_RS12305 Malate synthase (EC 2.3.3.9) from Burkholderia phytofirmans PsJN
    54% identity, 95% coverage of query (557 bits)

Q5YLB8 malate synthase (EC 2.3.3.9) from Paracoccidioides brasiliensis (see 2 papers)
    53% identity, 92% coverage of query (550 bits)

acuE malate synthase; EC 2.3.3.9 from Emericella nidulans (see 5 papers)
    54% identity, 92% coverage of query (546 bits)

3cuxA / A0A6L8PPD0 Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design (see paper)
    54% identity, 92% coverage of query (541 bits)

MLS1 / P30952 malate synthase (EC 2.3.3.7; EC 2.3.3.9) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
MLS1_YEAST / P30952 Malate synthase 1; EC 2.3.3.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    50% identity, 95% coverage of query (531 bits)

MLS1 malate synthase; EC 2.3.3.9 from Candida albicans (see paper)
    50% identity, 96% coverage of query (523 bits)

MASY_DICDI / Q8T2K9 Malate synthase; EC 2.3.3.9 from Dictyostelium discoideum (Social amoeba) (see paper)
    49% identity, 95% coverage of query (520 bits)

DAL7 / P21826 malate synthase 2 (EC 2.3.3.7; EC 2.3.3.9) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
MLS2_YEAST / P21826 Malate synthase 2; Degradation of allantoin protein 7; EC 2.3.3.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
    50% identity, 92% coverage of query (519 bits)

GCP_CAEEL / Q10663 Bifunctional glyoxylate cycle protein; Gex-3-interacting protein 7; EC 4.1.3.1; EC 2.3.3.9 from Caenorhabditis elegans (see 2 papers)
    48% identity, 96% coverage of query (504 bits)

3cv2A Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design
    48% identity, 93% coverage of query (483 bits)

3cuzA / P08997 Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design (see paper)
    47% identity, 93% coverage of query (482 bits)

Mas / b4014 malate synthase A (EC 2.3.3.9) from Escherichia coli K-12 substr. MG1655 (see 14 papers)
aceB / P08997 malate synthase A (EC 2.3.3.9) from Escherichia coli (strain K12) (see 15 papers)
    47% identity, 93% coverage of query (482 bits)

3cv1A Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design
    47% identity, 93% coverage of query (482 bits)

SO1483 Malate synthase (EC 2.3.3.9) from Shewanella oneidensis MR-1
    45% identity, 97% coverage of query (462 bits)

MASY_ORYSJ / Q7XUG1 Malate synthase; EC 2.3.3.9 from Oryza sativa subsp. japonica (Rice) (see paper)
    47% identity, 92% coverage of query (450 bits)

MLS / Q9LZC3 malate synthase (EC 2.3.3.9) from Arabidopsis thaliana (see paper)
MASY_ARATH / Q9LZC3 Malate synthase; EC 2.3.3.9 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    45% identity, 92% coverage of query (447 bits)

CAA40262.1 malate synthase from Cucurbita hybrid cultivar (see paper)
    46% identity, 92% coverage of query (439 bits)

Build an alignment

Build an alignment for WP_058930133.1 and 19 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

3sadA Crystal structure of mycobacterium tuberculosis malate synthase in complex with 4-(2-mehtylphenyl)-2,4-dioxobutanoic acid inhibitor
    24% identity, 75% coverage of query (64.3 bits)

6c7bA Crystal structure of mycobacterium tuberculosis malate synthase in complex with methoxynaphthyldiketoacid
    24% identity, 75% coverage of query (63.9 bits)

3sazA Crystal structure of mycobacterium tuberculosis malate synthase in complex with 4-(3-bromophenyl)-2,4-dioxobutanoic acid inhibitor
    24% identity, 75% coverage of query (63.5 bits)

5cewA Crystal structure of mycobacterium tuberculosis malate synthase in complex with 2-(pyridin-4-yl)thiazolidine-4-carboxylic acid
    24% identity, 75% coverage of query (63.2 bits)

6axeA / B2HSY2 Crystal structure of a malate synthase g from mycobacterium marinum bound to acetyl coa
    24% identity, 77% coverage of query (60.8 bits)

6as6A Crystal structure of mycobacterium tuberculosis malate synthase in complex with 3-prop-6-me-phenyldiketoacid
    24% identity, 75% coverage of query (60.8 bits)

MASZ_MYCLB / B8ZSN3 Malate synthase G; EC 2.3.3.9 from Mycobacterium leprae (strain Br4923)
    23% identity, 76% coverage of query (55.1 bits)

4ex4B / B8ZSN3 The structure of glcb from mycobacterium leprae
    24% identity, 76% coverage of query (53.1 bits)

5oasA / Q9I636 Crystal structure of malate synthase g from pseudomonas aeruginosa in apo form. (see paper)
    23% identity, 73% coverage of query (44.3 bits)

5vfbA 1.36 angstrom resolution crystal structure of malate synthase g from pseudomonas aeruginosa in complex with glycolic acid.
    23% identity, 73% coverage of query (44.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory