Searching for up to 100 curated homologs for WP_058930225.1 NCBI__GCF_001484605.1:WP_058930225.1 (304 a.a.)
Found high-coverage hits (≥70%) to 53 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
5y8iA / P9WNY5 Mycobacterium tuberculosis 3-hydroxyisobutyrate dehydrogenase (mthibadh) + (s)-3-hydroxyisobutyrate (s-hiba) (see paper)
54% identity, 98% coverage of query (293 bits)
P9WNY5 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Mycobacterium tuberculosis (see paper)
54% identity, 99% coverage of query (293 bits)
5y8hA Mycobacterium tuberculosis 3-hydroxyisobutyrate dehydrogenase (mthibadh) + NAD+
54% identity, 98% coverage of query (292 bits)
5y8lB Mycobacterium tuberculosis 3-hydroxyisobutyrate dehydrogenase (mthibadh) + NAD +(s)-3-hydroxyisobutyrate (s-hiba)
55% identity, 97% coverage of query (292 bits)
5y8kA Mycobacterium tuberculosis 3-hydroxyisobutyrate dehydrogenase (mthibadh) + l-serine
55% identity, 97% coverage of query (292 bits)
3HIDH_HUMAN / P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial; HIBADH; EC 1.1.1.31 from Homo sapiens (Human) (see paper)
43% identity, 98% coverage of query (238 bits)
2i9pB / P31937 Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+
43% identity, 97% coverage of query (236 bits)
P29266 3-hydroxyisobutyrate dehydrogenase, mitochondrial; HIBADH; EC 1.1.1.31 from Rattus norvegicus (Rat)
41% identity, 99% coverage of query (232 bits)
Q9SUC0 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Arabidopsis thaliana (see paper)
43% identity, 95% coverage of query (231 bits)
mmsB / Q76KL5 3-hydroxyisobutyrate dehydrogenase subunit (EC 1.1.1.31) from Pseudomonas putida (see 5 papers)
Q76KL5 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas putida (see paper)
46% identity, 97% coverage of query (229 bits)
MMSB_PSEAE / P28811 3-hydroxyisobutyrate dehydrogenase; HIBADH; EC 1.1.1.31 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
mmsB / AAA25892.1 3-hydroxyisobutyrate dehydrogenase from Pseudomonas aeruginosa (see paper)
45% identity, 98% coverage of query (227 bits)
Psest_2438 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas stutzeri RCH2
44% identity, 97% coverage of query (224 bits)
AO353_05985 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas fluorescens FW300-N2E3
44% identity, 97% coverage of query (211 bits)
SERDH_PSEAE / Q9I5I6 NAD-dependent L-serine dehydrogenase; L-serine 3-dehydrogenase (NAD(+)); EC 1.1.1.387 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I5I6 L-serine 3-dehydrogenase (NAD+) (EC 1.1.1.387) from Pseudomonas aeruginosa (see paper)
46% identity, 98% coverage of query (211 bits)
PfGW456L13_5145 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas fluorescens GW456-L13
44% identity, 97% coverage of query (210 bits)
3q3cA Crystal structure of a serine dehydrogenase from pseudomonas aeruginosa pao1 in complex with NAD
46% identity, 98% coverage of query (209 bits)
3obbA / Q9I5I6 Crystal structure of a possible 3-hydroxyisobutyrate dehydrogenase from pseudomonas aeruginosa pao1 (see paper)
46% identity, 98% coverage of query (204 bits)
hgd / Q0QLF5 2-(hydroxymethyl)glutarate dehydrogenase subunit (EC 1.1.1.291) from Eubacterium barkeri (see paper)
HMGD_EUBBA / Q0QLF5 2-(hydroxymethyl)glutarate dehydrogenase; EC 1.1.1.291 from Eubacterium barkeri (Clostridium barkeri) (see 2 papers)
36% identity, 97% coverage of query (162 bits)
HPD1 / A0A1D8PQ07 3-hydroxypropanonate dehydrogenase (EC 1.1.1.59) from Candida albicans (strain SC5314 / ATCC MYA-2876) (see paper)
A0A1D8PQ07 3-hydroxypropionate dehydrogenase (EC 1.1.1.59) from Candida albicans (see paper)
32% identity, 99% coverage of query (142 bits)
5je8B / Q81DR6 The crystal structure of bacillus cereus 3-hydroxyisobutyrate dehydrogenase in complex with NAD (see paper)
31% identity, 97% coverage of query (140 bits)
Q8ZLV8 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
36% identity, 95% coverage of query (139 bits)
YbbQ / b0509 tartronate semialdehyde reductase 2 from Escherichia coli K-12 substr. MG1655 (see 5 papers)
glxR / P77161 tartronate semialdehyde reductase 2 (EC 1.1.1.60) from Escherichia coli (strain K12) (see 3 papers)
32% identity, 97% coverage of query (138 bits)
YhaE / b3125 tartronate semialdehyde reductase (EC 1.1.1.60) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
garR / P0ABQ2 tartronate semialdehyde reductase (EC 1.1.1.60) from Escherichia coli (strain K12) (see 2 papers)
GARR_ECOLI / P0ABQ2 2-hydroxy-3-oxopropionate reductase; Tartronate semialdehyde reductase; TSAR; EC 1.1.1.60 from Escherichia coli (strain K12) (see 2 papers)
36% identity, 91% coverage of query (137 bits)
YKWC_BACSU / O34948 Uncharacterized oxidoreductase YkwC; EC 1.1.-.- from Bacillus subtilis (strain 168) (see paper)
31% identity, 93% coverage of query (136 bits)
3w6zA / A3MU08 Crystal structure of NADP bound l-serine 3-dehydrogenase (k170m) from hyperthermophilic archaeon pyrobaculum calidifontis (see paper)
32% identity, 93% coverage of query (131 bits)
3ws7A The 1.18 a resolution structure of l-serine 3-dehydrogenase complexed with NADP+ and sulfate ion from the hyperthermophilic archaeon pyrobaculum calidifontis
33% identity, 93% coverage of query (130 bits)
A0A1C8M593 glyoxylate reductase (NADP+) (EC 1.1.1.79) from Malus domestica (see paper)
31% identity, 98% coverage of query (129 bits)
Q5SLQ6 3-hydroxypropionate dehydrogenase (NADP+) (EC 1.1.1.298) from Thermus thermophilus (see paper)
2cvzC / Q5SLQ6 Structure of hydroxyisobutyrate dehydrogenase from thermus thermophilus hb8 (see paper)
35% identity, 93% coverage of query (127 bits)
1wp4A Structure of tt368 protein from thermus thermophilus hb8
35% identity, 93% coverage of query (127 bits)
GLYR2_ARATH / F4I907 Glyoxylate/succinic semialdehyde reductase 2, chloroplastic; AtGLYR2; AtGR2; SSA reductase 2; EC 1.1.1.79; EC 1.1.1.n11 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
F4I907 glyoxylate reductase (NADP+) (EC 1.1.1.79) from Arabidopsis thaliana (see 3 papers)
30% identity, 97% coverage of query (123 bits)
SquU / b3882 3-sulfolactaldehyde reductase (EC 1.1.1.373; EC 1.1.1.61) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yihU / P0A9V8 3-sulfolactaldehyde reductase (EC 1.1.1.373; EC 1.1.1.61) from Escherichia coli (strain K12) (see 3 papers)
SQUU_ECOLI / P0A9V8 3-sulfolactaldehyde reductase; SLA reductase; 4-hydroxybutyrate dehydrogenase; Gamma-hydroxybutyrate dehydrogenase; GHBDH; Succinic semialdehyde reductase; SSA reductase; EC 1.1.1.373; EC 1.1.1.61 from Escherichia coli (strain K12) (see 2 papers)
P0A9V8 sulfolactaldehyde 3-reductase (EC 1.1.1.373); 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61) from Escherichia coli (see 2 papers)
32% identity, 96% coverage of query (119 bits)
6smzC / P0A9V8 Crystal structure of sla reductase yihu from e. Coli in complex with nadh
32% identity, 96% coverage of query (119 bits)
6smyA Crystal structure of sla reductase yihu from e. Coli with nadh and product dhps
32% identity, 96% coverage of query (119 bits)
Build an alignment for WP_058930225.1 and 33 homologs with ≥ 30% identity
Or download the sequences
GLYR1 / Q9LSV0 succinate semialdehyde reductase (NADPH) from Arabidopsis thaliana (see paper)
GLYR1_ARATH / Q9LSV0 Glyoxylate/succinic semialdehyde reductase 1; AtGLYR1; AtGR1; SSA reductase 1; Gamma-hydroxybutyrate dehydrogenase; AtGHBDH; EC 1.1.1.79; EC 1.1.1.n11 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
Q9LSV0 glyoxylate reductase (EC 1.1.1.26); 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61); glyoxylate reductase (NADP+) (EC 1.1.1.79) from Arabidopsis thaliana (see 6 papers)
29% identity, 96% coverage of query (115 bits)
3pduA / Q74DE4 Crystal structure of gamma-hydroxybutyrate dehydrogenase from geobacter sulfurreducens in complex with NADP+ (see paper)
32% identity, 96% coverage of query (113 bits)
3pefA / Q39R98 Crystal structure of gamma-hydroxybutyrate dehydrogenase from geobacter metallireducens in complex with NADP+ (see paper)
30% identity, 95% coverage of query (111 bits)
A0A1C8M582 glyoxylate reductase (NADP+) (EC 1.1.1.79) from Malus domestica (see paper)
28% identity, 96% coverage of query (107 bits)
B9JKN9 L-threonate 2-dehydrogenase (EC 1.1.1.411) from Agrobacterium tumefaciens (see paper)
32% identity, 95% coverage of query (107 bits)
LTND_CUPNH / Q0KBC7 L-threonate dehydrogenase; EC 1.1.1.411 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
Q0KBC7 L-threonate 2-dehydrogenase (EC 1.1.1.411) from Cupriavidus necator (see 2 papers)
30% identity, 96% coverage of query (103 bits)
SSR1 / B1Q3F6 NAD-dependent succinate semialdehyde dehydrogenase (EC 1.2.1.24) from Solanum lycopersicum (see paper)
29% identity, 95% coverage of query (102 bits)
2uyyA / Q49A26 Structure of the cytokine-like nuclear factor n-pac
24% identity, 96% coverage of query (96.7 bits)
GLYR1_HUMAN / Q49A26 Cytokine-like nuclear factor N-PAC; NPAC; 3-hydroxyisobutyrate dehydrogenase-like protein; Glyoxylate reductase 1 homolog; Nuclear protein NP60; Nuclear protein of 60 kDa; Nucleosome-destabilizing factor; hNDF; Putative oxidoreductase GLYR1 from Homo sapiens (Human) (see 7 papers)
24% identity, 96% coverage of query (95.9 bits)
GLYR1_MOUSE / Q922P9 Cytokine-like nuclear factor N-PAC; NPAC; Glyoxylate reductase 1 homolog; Nuclear protein NP60; Putative oxidoreductase GLYR1 from Mus musculus (Mouse) (see 2 papers)
24% identity, 96% coverage of query (93.2 bits)
LTND_PECAS / Q6CZ26 L-threonate dehydrogenase; EC 1.1.1.411 from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) (see paper)
Q6CZ26 L-threonate 2-dehydrogenase (EC 1.1.1.411) from Pectobacterium atrosepticum (see paper)
31% identity, 95% coverage of query (91.3 bits)
Q1QSN6 L-threonate 2-dehydrogenase (EC 1.1.1.411) from Chromohalobacter salexigens (see paper)
29% identity, 96% coverage of query (89.7 bits)
LTND_ECOL6 / A0A0H2VA68 L-threonate dehydrogenase; EC 1.1.1.411 from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see paper)
31% identity, 95% coverage of query (88.2 bits)
ltnD / P44979 L-threonate 2-dehydrogenase (EC 1.1.1.411) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
LTND_HAEIN / P44979 L-threonate dehydrogenase; EC 1.1.1.411 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
30% identity, 96% coverage of query (88.2 bits)
YgbJ / b2736 putative L-threonate dehydrogenase from Escherichia coli K-12 substr. MG1655 (see 2 papers)
30% identity, 95% coverage of query (85.5 bits)
B9J8U1 L-threonate 2-dehydrogenase (EC 1.1.1.411) from Agrobacterium tumefaciens (see paper)
33% identity, 97% coverage of query (81.6 bits)
GLYR1_DROME / Q8T079 Cytokine-like nuclear factor N-PAC; NPAC; Glyoxylate reductase 1 homolog; Nuclear protein NP60 homolog; Nucleosome-destabilizing factor; Putative oxidoreductase GLYR1 homolog from Drosophila melanogaster (Fruit fly) (see 2 papers)
22% identity, 98% coverage of query (79.0 bits)
5u5gA / I6R485 Psf3 in complex with NADP+ and 2-opp (see paper)
30% identity, 70% coverage of query (74.7 bits)
7puaFM / C9ZJW2 7puaFM (see paper)
24% identity, 78% coverage of query (68.2 bits)
6PGD_AGGAC / P70718 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) (see paper)
23% identity, 76% coverage of query (46.6 bits)
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Lawrence Berkeley National Laboratory