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Searching for up to 100 curated homologs for WP_066328198.1 NCBI__GCF_900100165.1:WP_066328198.1 (812 a.a.)

Found high-coverage hits (≥70%) to 50 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

BGH2A_BACO1 / A7LXS9 Beta-galactosidase BoGH2A; Beta-gal; Glycosyl hydrolase family protein 2A; BoGH2A; EC 3.2.1.23 from Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC 11153) (see paper)
    49% identity, 99% coverage of query (823 bits)

7cwdA / A0A6M5K904 Crystal structure of beta-galactosidase ii from bacillus circulans in complex with beta-d-galactopyranosyl disaccharide (see paper)
    44% identity, 95% coverage of query (655 bits)

E5RWQ2 beta-glucosidase (EC 3.2.1.21) from Niallia circulans (see paper)
BAJ61032.1 β-galactosidase A / B / C / D / 91 (Bga;BgaD;β-Gal-A;β-Gal-B;β-Gal-C;β-Gal-D;β-Glα-91) (EC 3.2.1.23) (see protein)
    42% identity, 95% coverage of query (629 bits)

5t99A / A0A2D0TCC8 Crystal structure of bugh2awt in complex with galactoisofagomine (see paper)
    40% identity, 95% coverage of query (568 bits)

AAP86765.1 β-galactosidase (Gal02II;GalB) (EC 3.2.1.23) (see protein)
    38% identity, 94% coverage of query (523 bits)

AAM43337.1 β-galactosidase (XCC4116) (EC 3.2.1.23) (see protein)
    38% identity, 94% coverage of query (521 bits)

AAK99369.1 β-galactosidase (BgaA;spr0565) (EC 3.2.1.23) (see protein)
ABJ53768.1 β-galactosidase (BgaA;SPD0562;SPD_0562) (EC 3.2.1.23) (see protein)
    38% identity, 94% coverage of query (514 bits)

AAF97242.1 β-galactosidase (BgaA) (EC 3.2.1.23) (see protein)
AAK74795.1 β-1,4-galactosidase A (BgaA;SP0648;SP_0648) (EC 3.2.1.23) (see protein)
    38% identity, 94% coverage of query (513 bits)

4cu7A / A0A0H2UP19 Unravelling the multiple functions of the architecturally intricate streptococcus pneumoniae beta-galactosidase, bgaa (see paper)
    38% identity, 94% coverage of query (511 bits)

4cu8A Unravelling the multiple functions of the architecturally intricate streptococcus pneumoniae beta-galactosidase, bgaa
    38% identity, 94% coverage of query (511 bits)

4cucA Unravelling the multiple functions of the architecturally intricate streptococcus pneumoniae beta-galactosidase, bgaa.
    38% identity, 94% coverage of query (509 bits)

BAI94821.1 lacto-N-neotetraose β-galactosidase (BbgIII) (EC 3.2.1.23) (see protein)
bbgIII / BAI94821.1 beta-galactosidase from Bifidobacterium bifidum (see paper)
    35% identity, 96% coverage of query (491 bits)

ABE27152.1 β-galactosidase S1 (BbgIII) (EC 3.2.1.23) (see protein)
    35% identity, 96% coverage of query (489 bits)

7nitD / A0A415C3Q2 X-ray structure of a multidomain bbgiii from bifidobacterium bifidum (see paper)
    35% identity, 96% coverage of query (489 bits)

CAC14566.2 β-galactosidase (BIF3) (EC 3.2.1.23) (see protein)
    35% identity, 96% coverage of query (488 bits)

5dmyA Beta-galactosidase - construct 33-930
    35% identity, 96% coverage of query (488 bits)

6qubA Truncated beta-galactosidase iii from bifidobacterium bifidum in complex with galactose
    35% identity, 95% coverage of query (486 bits)

6qudA / Q9F4D5 2-deoxy-galactose reaction intermediate of a truncated beta- galactosidase iii from bifidobacterium bifidum
    35% identity, 95% coverage of query (480 bits)

5t9gC / A0A2D0TCC9 Crystal structure of bugh2cwt in complex with galactoisofagomine (see paper)
    34% identity, 96% coverage of query (467 bits)

AAM40554.1 β-galactosidase (BgA;XCC1256) (EC 3.2.1.23) (see protein)
AAP86764.1 β-galactosidase (Gal02I;GalA) (EC 3.2.1.23) (see protein)
AAY50033.1 XC_2985 (EC 3.2.1.23) (see protein)
    34% identity, 96% coverage of query (448 bits)

PLH16_FORAG / T2KM09 Putative beta-glucuronidase; Glycosyl hydrolase 2 family protein P16; P16_GH2; Polysaccharide utilization locus H protein P16; PUL H protein P16; EC 3.2.1.31 from Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) (see paper)
    35% identity, 98% coverage of query (422 bits)

CAC50569.1 β-galactosidase (Lac) (EC 3.2.1.23) (see protein)
    35% identity, 92% coverage of query (419 bits)

Build an alignment

Build an alignment for WP_066328198.1 and 22 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

AFC90218.1 β-glycosidase (Bgp2) (EC 3.2.1.-) (see protein)
    28% identity, 91% coverage of query (318 bits)

PLH17_FORAG / T2KN75 Beta-glucuronidase; Glycosyl hydrolase 2 family protein P17; P17_GH2; Polysaccharide utilization locus H protein P17; PUL H protein P17; EC 3.2.1.31 from Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) (see paper)
    28% identity, 89% coverage of query (246 bits)

6hpdA / T2KN75 The structure of a beta-glucuronidase from glycoside hydrolase family 2 (see paper)
    28% identity, 89% coverage of query (246 bits)

CAC50570.1 β-galactosidase (Lac) (EC 3.2.1.23) (see protein)
    25% identity, 96% coverage of query (228 bits)

6d50B / A0A078SUX9 Bacteroides uniforms beta-glucuronidase 2 bound to d-glucaro-1,5- lactone (see paper)
    28% identity, 79% coverage of query (223 bits)

6nzgA Bacteroides uniformis beta-glucuronidase 2 covalently bound to cyclophellitol-6-carboxylate aziridine
    28% identity, 79% coverage of query (223 bits)

CAA69850.1 β-galactosidase (LacA;Teth39_0611) (EC 3.2.1.23) (see protein)
    25% identity, 96% coverage of query (217 bits)

5z1aA / Q5LIC7 The crystal structure of bacteroides fragilis beta-glucuronidase in complex with uronic isofagomine
    27% identity, 78% coverage of query (208 bits)

BGLR_BACFN / Q5LIC7 Beta-glucuronidase; GUS; BfGUS; EC 3.2.1.31 from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / LMG 10263 / NCTC 9343 / Onslow / VPI 2553 / EN-2) (see paper)
    27% identity, 78% coverage of query (207 bits)

8dhlB / G8UKC1 Tannerella forsythia beta-glucuronidase (l2) (see paper)
    29% identity, 73% coverage of query (190 bits)

8dhlA Tannerella forsythia beta-glucuronidase (l2)
    29% identity, 73% coverage of query (188 bits)

CBJ55484.1 β-glucuronidase (H11G11-BG) (EC 3.2.1.31) (see protein)
    26% identity, 84% coverage of query (183 bits)

CBJ55485.1 β-glucuronidase (C7D2-BG) (EC 3.2.1.31) (see protein)
    26% identity, 77% coverage of query (171 bits)

Q9AHJ8 beta-glucuronidase (EC 3.2.1.31) from Lactobacillus gasseri (see 2 papers)
AAK07836.1 β-glucuronidase (GusA) (EC 3.2.1.31) (see protein)
    25% identity, 74% coverage of query (154 bits)

7kgyA Beta-glucuronidase from faecalibacterium prausnitzii bound to the inhibitor unc10201652-glucuronide (see paper)
    25% identity, 72% coverage of query (152 bits)

6d7jA / K5ZWV5 The crystal structure of parabacteroides merdae beta-glucuronidase (gus) with glycerol in active-site (see paper)
    25% identity, 90% coverage of query (149 bits)

8getA R. Hominis 2 beta-glucuronidase bound to norquetiapine-glucuronide
    26% identity, 82% coverage of query (148 bits)

6mvgA Crystal structure of fmn-binding beta-glucuronidase from ruminococcus gnavus (see paper)
    26% identity, 74% coverage of query (146 bits)

SM_b21655 Beta-galactosidase (EC 3.2.1.23) from Sinorhizobium meliloti 1021
    23% identity, 89% coverage of query (146 bits)

6mvfA / D4K3H3 Crystal structure of fmn-binding beta-glucuronidase from facaelibacterium prausnitzii l2-6 (see paper)
    25% identity, 73% coverage of query (144 bits)

7kgzB / A0A395V874 Fmn-binding beta-glucuronidase from roseburia hominis (see paper)
    25% identity, 77% coverage of query (144 bits)

6mvhA Crystal structure of fmn-binding beta-glucuronidase from roseburia hominis
    25% identity, 82% coverage of query (144 bits)

6ed2A / C7H4D2 Faecalibacterium prausnitzii beta-glucuronidase (see paper)
    25% identity, 71% coverage of query (142 bits)

8gesA R. Hominis 2 beta-glucuronidase bound to unc10201652-glucuronide
    25% identity, 82% coverage of query (142 bits)

8getC / A0A395V8I7 R. Hominis 2 beta-glucuronidase bound to norquetiapine-glucuronide (see paper)
    25% identity, 82% coverage of query (137 bits)

BGAL_THETU / P26257 Beta-galactosidase; Beta-gal; EC 3.2.1.23 from Thermoanaerobacterium thermosulfurigenes (Clostridium thermosulfurogenes) (see paper)
AAA23249.1 β-galactosidase (LacZ;LacA) (EC 3.2.1.23) (see protein)
    24% identity, 89% coverage of query (134 bits)

Q2PBR7 beta-glucuronidase (EC 3.2.1.31) from Streptococcus equi subsp. zooepidemicus (see paper)
gusA / CAI72019.1 beta-glucuronidase from Streptococcus equi subsp. zooepidemicus (see paper)
    24% identity, 74% coverage of query (134 bits)

ACY69080.1 β-galactosidase (BgaL;(Par?DG) (EC 3.2.1.23) (see protein)
5ldrA / D1LZK0 Crystal structure of a cold-adapted dimeric beta-d-galactosidase from paracoccus sp. 32d strain in complex with galactose (see paper)
    23% identity, 94% coverage of query (114 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory