Searching for up to 100 curated homologs for WP_067078821.1 NCBI__GCF_001602375.1:WP_067078821.1 (317 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
8rwlA / Q8TWG5 Crystal structure of methanopyrus kandleri malate dehydrogenase mutant 1
50% identity, 98% coverage of query (301 bits)
MDH_METTM / D9PVI7 Malate dehydrogenase; MdhII; EC 1.1.1.299 from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) (see paper)
48% identity, 99% coverage of query (288 bits)
mdh / O26290 NAD(P)-dependent malate dehydrogenase (EC 1.1.1.299) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see paper)
48% identity, 99% coverage of query (284 bits)
mdh / Q60176 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+] (EC 1.1.1.375; EC 1.1.1.299) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 3 papers)
MDH_METJA / Q60176 L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)); MdhII; EC 1.1.1.375 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 5 papers)
Q60176 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+] (EC 1.1.1.375) from Methanocaldococcus jannaschii (see 4 papers)
1hygA / Q60176 Crystal structure of mj0490 gene product, the family of lactate/malate dehydrogenase (see paper)
48% identity, 97% coverage of query (280 bits)
4ln1B / Q81EP4 Crystal structure of l-lactate dehydrogenase from bacillus cereus atcc 14579 complexed with calcium, nysgrc target 029452
37% identity, 96% coverage of query (182 bits)
B9MKZ8 L-lactate dehydrogenase (EC 1.1.1.27) from Caldicellulosiruptor bescii (see paper)
40% identity, 77% coverage of query (180 bits)
ldh / P00343 L-lactate dehydrogenase subunit (EC 1.1.1.27) from Lactobacillus casei (see 2 papers)
LDH_LACCA / P00343 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Lacticaseibacillus casei (Lactobacillus casei) (see 3 papers)
36% identity, 86% coverage of query (177 bits)
1llcA / P00343 Structure determination of the allosteric l-lactate dehydrogenase from lactobacillus casei at 3.0 angstroms resolution
36% identity, 86% coverage of query (177 bits)
A0A2U9AUU1 L-lactate dehydrogenase (EC 1.1.1.27) from Lacticaseibacillus casei (see paper)
36% identity, 86% coverage of query (176 bits)
6j9tB Complex structure of lactobacillus casei lactate dehydrogenase with fructose-1,6-bisphosphate
36% identity, 86% coverage of query (176 bits)
A0A1A6GB48 L-lactate dehydrogenase (EC 1.1.1.27) from Enterococcus mundtii (see paper)
37% identity, 85% coverage of query (174 bits)
ldh2 / E8ME30 L-lactate dehydrogenase subunit (EC 1.1.1.27) from Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b) (see 2 papers)
LDH2_BIFL2 / E8ME30 L-lactate dehydrogenase 2; L-LDH 2; FBP-dependent LDH; EC 1.1.1.27 from Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b) (see 2 papers)
40% identity, 74% coverage of query (172 bits)
1lldA / E8ME30 Molecular basis of allosteric activation of bacterial l-lactate dehydrogenase (see paper)
39% identity, 74% coverage of query (172 bits)
1lthR T and r states in the crystals of bacterial l-lactate dehydrogenase reveal the mechanism for allosteric control
39% identity, 74% coverage of query (172 bits)
LDH_BACSU / P13714 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Bacillus subtilis (strain 168) (see paper)
34% identity, 96% coverage of query (168 bits)
MDH_THET7 / A0A0S3QTC6 Malate dehydrogenase; MDH; EC 1.1.1.37 from Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6) (see paper)
34% identity, 98% coverage of query (168 bits)
3pqdB / P13714 Crystal structure of l-lactate dehydrogenase from bacillus subtilis complexed with fbp and NAD+
34% identity, 96% coverage of query (168 bits)
4pltB / A0A075B5H0 Crystal structure of ancestral apicomplexan malate dehydrogenase with oxamate. (see paper)
35% identity, 88% coverage of query (164 bits)
LDH_GEOSE / P00344 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 3 papers)
33% identity, 98% coverage of query (164 bits)
4plyA Crystal structure of ancestral apicomplexan malate dehydrogenase with malate.
35% identity, 88% coverage of query (164 bits)
1ldnA / P00344 Structure of a ternary complex of an allosteric lactate dehydrogenase from bacillus stearothermophilus at 2.5 angstroms resolution (see paper)
37% identity, 75% coverage of query (163 bits)
LDH_PEDAC / Q59645 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Pediococcus acidilactici (see paper)
36% identity, 80% coverage of query (162 bits)
E7CXT1 L-lactate dehydrogenase (EC 1.1.1.27) from Thermoanaerobacterium saccharolyticum (see paper)
36% identity, 99% coverage of query (162 bits)
6j9uA Complex structure of lactobacillus casei lactate dehydrogenase penta mutant with pyruvate
36% identity, 84% coverage of query (162 bits)
Q5FMB0 L-lactate dehydrogenase (EC 1.1.1.27) from Lactobacillus acidophilus (see paper)
33% identity, 86% coverage of query (160 bits)
W8CXQ9 L-lactate dehydrogenase (EC 1.1.1.27) from Weizmannia coagulans (see paper)
36% identity, 84% coverage of query (160 bits)
MDH_PROVB / P0C890 Malate dehydrogenase; EC 1.1.1.37 from Prosthecochloris vibrioformis (Chlorobium vibrioforme) (see paper)
32% identity, 94% coverage of query (160 bits)
MDH_AERPE / Q9YEA1 Malate dehydrogenase; EC 1.1.1.299 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) (see paper)
34% identity, 98% coverage of query (159 bits)
8ab3A / K9Z684 Crystal structure of the lactate dehydrogenase of cyanobacterium aponinum in complex with oxamate, nadh and fbp. (see paper)
36% identity, 74% coverage of query (159 bits)
LDH_LACLN / D8KFT1 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Lactococcus lactis subsp. cremoris (strain NZ9000) (see paper)
34% identity, 96% coverage of query (159 bits)
LDH_LACHE / O32765 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Lactobacillus helveticus (Lactobacillus suntoryeus) (see paper)
34% identity, 84% coverage of query (158 bits)
1guzA / P0C890,P80039 Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases (see paper)
32% identity, 94% coverage of query (158 bits)
P00345 L-lactate dehydrogenase (EC 1.1.1.27) from Priestia megaterium (see paper)
34% identity, 88% coverage of query (157 bits)
ldh / P26283 L-lactate dehydrogenase subunit (EC 1.1.1.27) from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see 4 papers)
P26283 L-lactate dehydrogenase (EC 1.1.1.27) from Streptococcus mutans serotype c (see paper)
30% identity, 99% coverage of query (156 bits)
B1A4R6 L-lactate dehydrogenase (EC 1.1.1.27) from Thermoanaerobacter ethanolicus (see paper)
33% identity, 97% coverage of query (155 bits)
MDH_CHLTE / P80039 Malate dehydrogenase; EC 1.1.1.37 from Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum) (see paper)
32% identity, 94% coverage of query (155 bits)
ldh1 L-lactate dehydrogenase 1; EC 1.1.1.27 from Lactobacillus plantarum (see paper)
34% identity, 87% coverage of query (155 bits)
3zznA 5-mutant (r79w, r151a, e279a, e299a,e313a) lactate-dehydrogenase from thermus thermophillus
36% identity, 76% coverage of query (155 bits)
2xxbA Penta-mutant of thermus thermophilus lactate dehydrogenase, complex with amp
36% identity, 76% coverage of query (155 bits)
P49814 Malate dehydrogenase; Vegetative protein 69; VEG69; EC 1.1.1.37 from Bacillus subtilis (strain 168)
31% identity, 96% coverage of query (155 bits)
1ez4B / P56511 Crystal structure of non-allosteric l-lactate dehydrogenase from lactobacillus pentosus at 2.3 angstrom resolution (see paper)
34% identity, 87% coverage of query (154 bits)
LDH_LACPE / P56511 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Lactiplantibacillus pentosus (Lactobacillus pentosus) (see 2 papers)
ldh L-lactate dehydrogenase; EC 1.1.1.27 from Lactobacillus pentosus (see paper)
34% identity, 87% coverage of query (154 bits)
7f8dA / A0A143T1U9 Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) g218y mutant (see paper)
31% identity, 98% coverage of query (154 bits)
7byaA Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) complexed with oxaloacetic acid (oaa) and adenosine 5'- diphosphoribose (apr)
31% identity, 98% coverage of query (154 bits)
7by9A Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) complexed with oxaloacetic acid (oaa) and nicotinamide adenine dinucleotide (NAD)
31% identity, 98% coverage of query (154 bits)
LDH_THET8 / Q5SJA1 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 2 papers)
2e37C / Q5SJA1 Structure of tt0471 protein from thermus thermophilus
36% identity, 74% coverage of query (153 bits)
LDH_STRPN / P0A3M9 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (see paper)
LDH_STRP2 / Q04K99 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) (see paper)
31% identity, 98% coverage of query (152 bits)
LDH_THEAQ / P13715 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Thermus aquaticus (see paper)
37% identity, 74% coverage of query (151 bits)
ldh / AAA99896.1 L-lactate:NAD+ oxidoreductase from Lactococcus lactis (see 2 papers)
ldh / AAA25172.1 lactate dehydrogenase from Lactococcus lactis (see paper)
31% identity, 86% coverage of query (151 bits)
Q8CMZ0 L-lactate dehydrogenase (EC 1.1.1.27) from Staphylococcus epidermidis (see paper)
34% identity, 77% coverage of query (151 bits)
ldhA L-lactate dehydrogenase 1; EC 1.1.1.27 from Lactococcus lactis subsp. lactis (see paper)
31% identity, 86% coverage of query (151 bits)
MDH_FLAFR / Q25QU7 Malate dehydrogenase; EC 1.1.1.37 from Flavobacterium frigidimaris (see 2 papers)
33% identity, 95% coverage of query (150 bits)
ldhA / AAF74436.1 lactate dehydrogenase from Rhizopus oryzae (see paper)
33% identity, 96% coverage of query (150 bits)
LDH_THECA / P06150 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Thermus caldophilus (see 3 papers)
35% identity, 74% coverage of query (149 bits)
3pqdD Crystal structure of l-lactate dehydrogenase from bacillus subtilis complexed with fbp and NAD+
33% identity, 96% coverage of query (149 bits)
3vphA L-lactate dehydrogenase from thermus caldophilus gk24 complexed with oxamate, nadh and fbp
35% identity, 74% coverage of query (149 bits)
4plfB / A0A075B5G8 Crystal structure of ancestral apicomplexan lactate dehydrogenase with lactate. (see paper)
35% identity, 83% coverage of query (147 bits)
MDH_CHLAA / P80040 Malate dehydrogenase; EC 1.1.1.37 from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see 3 papers)
34% identity, 98% coverage of query (147 bits)
MDH_ARCFU / O08349 Malate dehydrogenase; EC 1.1.1.37 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see 2 papers)
O08349 malate dehydrogenase (EC 1.1.1.37); L-2-hydroxycarboxylate dehydrogenase [NAD(P)+] (EC 1.1.1.375) from Archaeoglobus fulgidus (see 2 papers)
2x0iA / O08349 2.9 a resolution structure of malate dehydrogenase from archaeoglobus fulgidus in complex with nadh (see paper)
34% identity, 87% coverage of query (147 bits)
mdh / Q84FY8 malate dehydrogenase subunit (EC 1.1.1.37) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see paper)
Q84FY8 malate dehydrogenase (EC 1.1.1.37) from Methylorubrum extorquens (see paper)
32% identity, 95% coverage of query (147 bits)
6h9sB / A9BGZ9 Crystal dimeric structure of petrotoga mobilis lactate dehydrogenase with nadh
38% identity, 77% coverage of query (147 bits)
4plcA Crystal structure of ancestral apicomplexan lactate dehydrogenase with malate.
35% identity, 83% coverage of query (147 bits)
2x0jA 2.8 a resolution structure of malate dehydrogenase from archaeoglobus fulgidus in complex with etheno-NAD
34% identity, 87% coverage of query (147 bits)
4rosA / A9W386 Crystal structure of methylobacterium extorquens malate dehydrogenase complexed with oxaloacetate and adenosine-5-diphosphoribose
32% identity, 95% coverage of query (146 bits)
MDH_PYRIL / A1RS58 Malate dehydrogenase; EC 1.1.1.37 from Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) (see paper)
32% identity, 97% coverage of query (146 bits)
LDH1_STAAE / A6QDL6 L-lactate dehydrogenase 1; L-LDH 1; EC 1.1.1.27 from Staphylococcus aureus (strain Newman) (see paper)
LDH1_STAAC / Q5HJD7 L-lactate dehydrogenase 1; L-LDH 1; EC 1.1.1.27 from Staphylococcus aureus (strain COL) (see paper)
32% identity, 97% coverage of query (146 bits)
5ujkA Malate dehydrogenase from methylobacterium extorquens, complexed with NAD
32% identity, 95% coverage of query (146 bits)
1uxgA / P80040 Large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface. (see paper)
34% identity, 98% coverage of query (145 bits)
3h3jB / Q5HJD7 Crystal structure of lactate dehydrogenase mutant (a85r) from staphylococcus aureus complexed with NAD and pyruvate
32% identity, 97% coverage of query (145 bits)
1ldbA / P00344 Structure determination and refinement of bacillus stearothermophilus lactate dehydrogenase (see paper)
35% identity, 77% coverage of query (145 bits)
3gvhA / Q2YLR9 Crystal structure of lactate/malate dehydrogenase from brucella melitensis
32% identity, 80% coverage of query (145 bits)
2ldbA Structure determination and refinement of bacillus stearothermophilus lactate dehydrogenase
36% identity, 77% coverage of query (145 bits)
3wswA Crystal structure of minor l-lactate dehydrogenase from enterococcus mundtii in the ligands-bound form (see paper)
33% identity, 98% coverage of query (144 bits)
1gv0A / P80039 Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases (see paper)
31% identity, 94% coverage of query (144 bits)
P59390 L-lactate dehydrogenase (EC 1.1.1.27) from Lactiplantibacillus plantarum (see paper)
32% identity, 95% coverage of query (144 bits)
A3MWU9 malate dehydrogenase (EC 1.1.1.37) from Pyrobaculum calidifontis (see paper)
31% identity, 97% coverage of query (141 bits)
Q7Z0X7 L-lactate dehydrogenase (EC 1.1.1.27) from Babesia bovis (see paper)
CH_024078 L-lactate dehydrogenase; EC 1.1.1.27 from Babesia bovis T2Bo (see paper)
32% identity, 97% coverage of query (139 bits)
2hjrB / Q5CYZ3 Crystal structure of cryptosporidium parvum malate dehydrogenase (see paper)
31% identity, 84% coverage of query (137 bits)
7epmA / P07864 Human ldhc complexed with NAD+ and ethylamino acetic acid (see paper)
32% identity, 97% coverage of query (135 bits)
MDH_HALMA / Q07841 Malate dehydrogenase; EC 1.1.1.37 from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) (see 4 papers)
Q07841 malate dehydrogenase (EC 1.1.1.37) from Haloarcula marismortui (see 5 papers)
33% identity, 88% coverage of query (134 bits)
1hlpA Structural features stabilizing halophilic malate dehydrogenase from an archaebacterium
33% identity, 80% coverage of query (134 bits)
1d3aA / Q07841 Crystal structure of the wild type halophilic malate dehydrogenase in the apo form (see paper)
33% identity, 80% coverage of query (134 bits)
6k13A / I7J7V6 Crystal structure basis for bmldh complex (see paper)
31% identity, 97% coverage of query (134 bits)
LDHB_HUMAN / P07195 L-lactate dehydrogenase B chain; LDH-B; LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46; EC 1.1.1.27 from Homo sapiens (Human) (see 12 papers)
30% identity, 97% coverage of query (134 bits)
1t2fA Human b lactate dehydrogenase complexed with NAD+ and 4-hydroxy-1,2,5- oxadiazole-3-carboxylic acid
30% identity, 97% coverage of query (134 bits)
7dbjA / P07195 Crystal structure of human ldhb in complex with nadh, oxamate, and axko-0046 (see paper)
30% identity, 97% coverage of query (134 bits)
LDHB_PIG / P00336 L-lactate dehydrogenase B chain; LDH-B; LDH heart subunit; LDH-H; EC 1.1.1.27 from Sus scrofa (Pig) (see paper)
P00336 L-lactate dehydrogenase (EC 1.1.1.27) from Sus scrofa (see paper)
30% identity, 97% coverage of query (132 bits)
5ytaA Pig heart lactate dehydrogenase in complex with nadh and oxamate
30% identity, 97% coverage of query (132 bits)
3gviA Crystal structure of lactate/malate dehydrogenase from brucella melitensis in complex with adp
31% identity, 80% coverage of query (132 bits)
1sowA T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxalate
33% identity, 81% coverage of query (131 bits)
3czmB / Q27797 T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxq
33% identity, 81% coverage of query (131 bits)
LDHA_SQUAC / P00341 L-lactate dehydrogenase A chain; LDH-A; LDH-M; EC 1.1.1.27 from Squalus acanthias (Spiny dogfish) (see paper)
31% identity, 97% coverage of query (131 bits)
5ldhA Structure of the active ternary complex of pig heart lactate dehydrogenase with s-lac-NAD at 2.7 angstroms resolution
30% identity, 97% coverage of query (130 bits)
6vdjA Crystal structure of ancestral apicomplexan lactate dehydrogenase with sulfate and nadh4.
34% identity, 83% coverage of query (130 bits)
6r8gC / Q6VVP7 Crystal structure of malate dehydrogenase from plasmodium falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine
31% identity, 84% coverage of query (129 bits)
4ajiA Rat ldha in complex with 2-((3,4-dimethoxyphenyl)methyl))propanedioic acid
32% identity, 93% coverage of query (128 bits)
4ajhA Rat ldha in complex with n-(2-methyl-1,3-benzothiazol-6-yl)-3-ureido- propanamide and 2-(4-bromophenoxy)propanedioic acid
32% identity, 93% coverage of query (128 bits)
4ajeA Rat ldha in complex with 2-(4-bromophenoxy)propanedioic acid
32% identity, 93% coverage of query (128 bits)
4aj2A Rat ldha in complex with 5-(2-chlorophenyl)-1h-tetrazole
32% identity, 93% coverage of query (128 bits)
4aj1A Rat ldha in complex with n-(2-(methylamino)-1,3-benzothiazol-6-yl) acetamide
32% identity, 93% coverage of query (128 bits)
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