Searching for up to 100 curated homologs for WP_068105520.1 NCBI__GCF_001653335.1:WP_068105520.1 (347 a.a.)
Found high-coverage hits (≥70%) to 51 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.24.4 / Q8NSN2 Methionine import ATP-binding protein metN, component of L-Methionine uptake porter, MetQNI from Corynebacterium glutamicum (see paper)
54% identity, 89% coverage of query (325 bits)
METN_BACSU / O32169 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.24.2 / O32169 MetN (C) (aka YusC), component of The L- and D-methionine porter (also transports methionine sulfoxide from Bacillus subtilis subsp. subtilis str. 168 (see 2 papers)
46% identity, 95% coverage of query (299 bits)
TC 3.A.1.24.5 / Q9HT70 Methionine import ATP-binding protein MetN 2, component of L-Histidine uptake porter, MetIQN from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
45% identity, 97% coverage of query (265 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
42% identity, 95% coverage of query (263 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
43% identity, 95% coverage of query (263 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
42% identity, 95% coverage of query (262 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
42% identity, 95% coverage of query (262 bits)
TC 3.A.1.24.3 / Q8K8K8 AtmD (MetN), component of The methionine porter, AtmBDE from Streptococcus pyogenes serotype M3 (see 2 papers)
39% identity, 95% coverage of query (240 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
43% identity, 72% coverage of query (195 bits)
ARTM_BACSU / P54537 Arginine transport ATP-binding protein ArtM from Bacillus subtilis (strain 168) (see paper)
41% identity, 71% coverage of query (192 bits)
GlnQ / b0809 L-glutamine ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
GlnQ / P10346 L-glutamine ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli (strain K12) (see paper)
GLNQ_ECOLI / P10346 Glutamine transport ATP-binding protein GlnQ from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.2 / P10346 GlnQ aka B0809, component of Three component ABC L-glutamine porter. The basal ATPase activity (ATP hydrolysis in the absence of substrate) is mainly caused by the docking of the closed-unliganded state of GlnH onto the transporter domain of GlnPQ. Unlike glutamine, arginine binds both GlnH domains, but does not trigger their closing. Comparison of the ATPase activity in nanodiscs with glutamine transport in proteoliposomes suggested that the stoichiometry of ATP per substrate is close to two from Escherichia coli (see 5 papers)
glnQ / GB|ABB65374.1 glutamine ABC transporter, ATP-binding protein GlnQ from Escherichia coli K12 (see 5 papers)
41% identity, 70% coverage of query (182 bits)
TC 3.A.1.5.36 / Q8CJS2 Putative peptide transport system ATP-binding subunit, component of Peptide transporter encoded adjacent to the putative transport system with TC#3.A.1.5.35 (Akanuma et al. 2011). Induced by exogenous S-adenosylmethionine (SAM) at a concentration of 2muM which also enhanced antibiotic production and inhibited morphological development (Park et al. 2005). SAM can be imported into cells. Mutants in the bldK genes confer resistance to the toxic tripeptide, bialaphos from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
38% identity, 76% coverage of query (181 bits)
OPPF_LACLA / P0A2V4 Oligopeptide transport ATP-binding protein OppF; EC 7.4.2.6 from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) (see paper)
TC 3.A.1.5.10 / P0A2V4 OppF, component of Oligopeptide porter (transports peptides of 4-35) amino acyl residues; di- and tripeptides are not transported; hydrophobic basic peptides are preferred). OppA determines the specificity of the system (Doeven et al., 2004). A large cavity in OppA binds proline-rich peptides preferentially (Berntsson et al., 2009). Two crystal structures of OppA with different nonapeptides show binding in different registers from Lactococcus lactis subsp. lactis (Streptococcus lactis) (see 2 papers)
37% identity, 82% coverage of query (181 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
40% identity, 71% coverage of query (180 bits)
TC 3.A.1.3.7 / Q52666 BztD, component of Glutamate/glutamine/aspartate/asparagine porter from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (see paper)
38% identity, 73% coverage of query (179 bits)
OPUAA_BACSU / P46920 Glycine betaine transport ATP-binding protein OpuAA; Quaternary-amine-transporting ATPase; EC 7.6.2.9 from Bacillus subtilis (strain 168) (see 2 papers)
P46920 ABC-type quaternary amine transporter (EC 7.6.2.9) from Bacillus subtilis (see paper)
TC 3.A.1.12.2 / P46920 OPAA aka OpuAA, component of Glycine betaine OpuAA/AB/AC porter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate) from Bacillus subtilis (see 4 papers)
36% identity, 70% coverage of query (177 bits)
TC 3.A.1.5.37 / B1W1L8 Putative peptide ABC transporter ATP-binding protein, component of The ABC BldKA-E (SGR_2418-2414) oligopeptide transport system. It controls aerial mycelium formation on glucose media. Probably involved in extracellular peptide signalling (Akanuma et al. 2011). Probably orthologous to 3.A.1.5.35 from Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
36% identity, 74% coverage of query (177 bits)
TC 3.A.1.3.8 / Q52815 AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
aapP / CAA57936.1 general amino acid ABC type transporter from Rhizobium leguminosarum (see paper)
38% identity, 73% coverage of query (177 bits)
TC 3.A.1.3.6 / P35116 NocP aka ATU6028 aka AGR_PTI_69, component of Nopaline porter from Agrobacterium tumefaciens (see 3 papers)
39% identity, 72% coverage of query (177 bits)
GBUA_LISM4 / Q9RR46 Glycine betaine/carnitine transport ATP-binding protein GbuA; EC 7.6.2.9 from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
37% identity, 71% coverage of query (177 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
32% identity, 92% coverage of query (149 bits)
1g291 / Q9YGA6 Malk (see paper)
32% identity, 73% coverage of query (148 bits)
8hprD Lpqy-sugabc in state 4
32% identity, 89% coverage of query (147 bits)
8hprC Lpqy-sugabc in state 4
32% identity, 89% coverage of query (147 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
32% identity, 73% coverage of query (145 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
32% identity, 72% coverage of query (144 bits)
ECFA2_STRT2 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA 1, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
37% identity, 72% coverage of query (142 bits)
4fwiB / Q8RDH4 Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
33% identity, 75% coverage of query (120 bits)
DPPD_CALS4 / Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
33% identity, 72% coverage of query (118 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
33% identity, 73% coverage of query (113 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
33% identity, 73% coverage of query (113 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
33% identity, 73% coverage of query (113 bits)
7ch6C / P63386 Cryo-em structure of e.Coli mlafeb with amppnp (see paper)
32% identity, 73% coverage of query (112 bits)
6xgyA Crystal structure of e. Coli mlafb abc transport subunits in the dimeric state
32% identity, 73% coverage of query (112 bits)
8wooA Structure of the wild-type arabidopsis abcb19 in the brassinolide and amp-pnp bound state
34% identity, 74% coverage of query (112 bits)
8womA / Q9LJX0 Structure of the wild-type arabidopsis abcb19 in the brassinolide- bound state (see paper)
34% identity, 74% coverage of query (112 bits)
7cgnB The overall structure of the mlafedb complex in atp-bound eqtall conformation (mutation of e170q on mlaf)
31% identity, 73% coverage of query (110 bits)
8wp0A Structure of the arabidopsis e529q/e1174q abcb19 in the atp bound state
33% identity, 74% coverage of query (110 bits)
TGD3_ARATH / Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.27.2 / Q9AT00 Tdg3, component of The chloroplast lipid (trigalactosyl diacyl glycerol (TDG)) transporter, Tdg1,2,3 (Lu et al., 2007). Lipids such as mono- and digalactolipids are synthesized in the endoplasmic reticulum (ER) of plant cells and transferred to the thylakoid membranes of chloroplasts. Mutations in an outer chloroplastic envelope protein with 350 aas and 7 putative TMSs in the last 250 residues may catalyze translocation as part of a lipid transfer complex from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
31% identity, 71% coverage of query (109 bits)
Build an alignment for WP_068105520.1 and 39 homologs with ≥ 30% identity
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ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
28% identity, 77% coverage of query (106 bits)
8pmjA / O95342 Vanadate-trapped bsep in nanodiscs (see paper)
33% identity, 71% coverage of query (106 bits)
ABCBB_HUMAN / O95342 Bile salt export pump; ATP-binding cassette sub-family B member 11; EC 7.6.2.- from Homo sapiens (Human) (see 21 papers)
TC 3.A.1.201.2 / O95342 Bile salt export pump, BSEP, ABCB11 or SPGP in the canalicular membrane of liver cells, is associated with progressive familial intrahepatic cholestasis-2 and benign recurrent intrahepatic cholestasis (Kagawa et al., 2008; Stindt et al. 2013; Park et al. 2016). It exports unconjugaged bile salts and glycine conjugates > taurine conjugates as well as the statin, pravastatin (Nigam 2015). BSEP mediates biliary excretion of bile acids from hepatocytes. Compounds based on GW4064 (Q96RI1), a representative farnesoid X receptor (RXR) agonist, enhance E297G BSEP transport activity from Homo sapiens (Human) (see 11 papers)
33% identity, 71% coverage of query (105 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
28% identity, 82% coverage of query (94.0 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
28% identity, 82% coverage of query (93.6 bits)
7lkpA Structure of atp-free human abca4
28% identity, 82% coverage of query (93.6 bits)
ABCB7_ORYLA / H2LNR5 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial from Oryzias latipes (Japanese rice fish) (Japanese killifish) (see paper)
29% identity, 77% coverage of query (93.6 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
28% identity, 82% coverage of query (92.4 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
25% identity, 88% coverage of query (92.4 bits)
7lkzA Structure of atp-bound human abca4
27% identity, 82% coverage of query (92.0 bits)
ABCAD_MOUSE / Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see 3 papers)
28% identity, 72% coverage of query (91.7 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
27% identity, 82% coverage of query (85.9 bits)
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Lawrence Berkeley National Laboratory