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Searching for up to 100 curated homologs for WP_068223024.1 NCBI__GCF_001592965.1:WP_068223024.1 (572 a.a.)

Found high-coverage hits (≥70%) to 40 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

pgcA / P18159 α-phosphoglucomutase (EC 5.4.2.2) from Bacillus subtilis (strain 168) (see paper)
PGCA_BACSU / P18159 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
    48% identity, 91% coverage of query (491 bits)

pgmA / CAB96418.1 phosphoglucomutase from Streptococcus thermophilus (see paper)
    40% identity, 98% coverage of query (407 bits)

PGCA_STAA8 / Q2FVC1 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
    36% identity, 93% coverage of query (341 bits)

PGM2 / Q96G03 phosphoglucomutase-2 (EC 5.4.2.2; EC 5.4.2.7) from Homo sapiens (see 2 papers)
PGM2_HUMAN / Q96G03 Phosphopentomutase; Glucose phosphomutase 2; Phosphodeoxyribomutase; Phosphoglucomutase-2; EC 5.4.2.7; EC 5.4.2.2 from Homo sapiens (Human) (see 2 papers)
    32% identity, 94% coverage of query (293 bits)

PGM2_MOUSE / Q7TSV4 Phosphopentomutase; Glucose phosphomutase 2; Phosphodeoxyribomutase; Phosphoglucomutase-1; Phosphoglucomutase-2; PGM 2; EC 5.4.2.7; EC 5.4.2.2 from Mus musculus (Mouse) (see paper)
    31% identity, 94% coverage of query (290 bits)

PGM2L_MOUSE / Q8CAA7 Glucose 1,6-bisphosphate synthase; Phosphoglucomutase-2-like 1; EC 2.7.1.106 from Mus musculus (Mouse) (see paper)
    32% identity, 95% coverage of query (283 bits)

PGM3_SCHPO / O74478 Probable phosphoribomutase; PRM; Phosphoglucomutase 3 homolog; PGM 3 homolog; EC 5.4.2.7 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    31% identity, 98% coverage of query (282 bits)

PGM2L_HUMAN / Q6PCE3 Glucose 1,6-bisphosphate synthase; PMMLP; Phosphoglucomutase-2-like 1; EC 2.7.1.106 from Homo sapiens (Human) (see 3 papers)
    32% identity, 95% coverage of query (281 bits)

C6L2F4 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Toxoplasma gondii (see paper)
    33% identity, 94% coverage of query (268 bits)

PGM3_YEAST / Q03262 Phosphoribomutase; PRM; Phosphoglucomutase 3; PGM 3; EC 5.4.2.7 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
    31% identity, 96% coverage of query (244 bits)

Build an alignment

Build an alignment for WP_068223024.1 and 10 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

PGMMM_THEKO / Q68BJ6 Phosphoglucomutase/phosphomannomutase; PGM/PMM; EC 5.4.2.2; EC 5.4.2.8 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    25% identity, 90% coverage of query (108 bits)

PH0923 / O58651 phosphomannose mutase (EC 5.4.2.8) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
1wqaA / O58651 Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
    25% identity, 89% coverage of query (101 bits)

celB / AAA21561.1 phosphoglucomutase from Komagataeibacter xylinus (see paper)
    24% identity, 94% coverage of query (94.7 bits)

ST0242 / Q976E4 hexose-6-phosphate mutase/isomerase (EC 5.3.1.8; EC 5.3.1.9; EC 5.4.2.10; EC 5.4.2.13) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (see paper)
PGMUT_SULTO / Q976E4 Phosphoglucosamine/phosphogalactosamine mutase; PGlcNM; EC 5.4.2.10; EC 5.4.2.13 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
Q976E4 phosphogalactosamine mutase (EC 5.4.2.13) from Sulfurisphaera tokodaii (see paper)
    22% identity, 77% coverage of query (80.5 bits)

Blu / b0688 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 11 papers)
pgm / P36938 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli (strain K12) (see 11 papers)
PGM_ECOLI / P36938 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Escherichia coli (strain K12) (see 2 papers)
pgm / GB|ABB65241.1 phosphoglucomutase; EC 5.4.2.2 from Escherichia coli K12 (see 6 papers)
    23% identity, 90% coverage of query (76.3 bits)

P74027 glucose-1,6-bisphosphate synthase from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    24% identity, 88% coverage of query (69.7 bits)

PGM_EMENI / Q9P931 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
pgmB phosphoglucomutase; EC 5.4.2.2 from Emericella nidulans (see paper)
    23% identity, 75% coverage of query (68.9 bits)

5jn5A Crystal structure of the d263y missense variant of human pgm1
    24% identity, 88% coverage of query (68.2 bits)

PGM_SCHPO / O74374 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    25% identity, 75% coverage of query (67.8 bits)

6snoA / P36871 Crystal structures of human pgm1 isoform 2 (see paper)
    24% identity, 90% coverage of query (67.8 bits)

PGM1 / P36871 phosphoglucomutase-1 (EC 5.4.2.2) from Homo sapiens (see 3 papers)
PGM1_HUMAN / P36871 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Homo sapiens (Human) (see 8 papers)
P36871 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Homo sapiens (see 4 papers)
    24% identity, 88% coverage of query (67.0 bits)

6snqA Crystal structures of human pgm1 isoform 2
    24% identity, 90% coverage of query (64.7 bits)

PGM1_RABIT / P00949 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Oryctolagus cuniculus (Rabbit) (see 3 papers)
    25% identity, 73% coverage of query (63.9 bits)

3pmgA Structure of rabbit muscle phosphoglucomutase at 2.4 angstroms resolution. Use of freezing point depressant and reduced temperature to enhance diffractivity
    25% identity, 73% coverage of query (63.9 bits)

1c4gA Phosphoglucomutase vanadate based transition state analog complex
    25% identity, 73% coverage of query (63.9 bits)

1c47A Binding driven structural changes in crystaline phosphoglucomutase associated with chemical reaction
    25% identity, 73% coverage of query (63.9 bits)

6mlwA Crystal structure of x. Citri phosphoglucomutase in complex with 2- fluoro mannosyl-1-methyl-phosphonic acid
    24% identity, 81% coverage of query (61.2 bits)

5bmpA Crystal structure of phosphoglucomutase from xanthomonas citri complexed with glucose-1-phosphate (see paper)
    24% identity, 81% coverage of query (61.2 bits)

6nqhA Xanthomonas citri dephospho-pgm in complex with xylose-1-phosphate
    24% identity, 81% coverage of query (61.2 bits)

6np8A Xanthomonas citri phospho-pgm in complex with mannose-6-phosphate
    24% identity, 81% coverage of query (61.2 bits)

6nolA Xanthomonas citri dephospho-pgm in complex with mannose-1-phosphate
    24% identity, 81% coverage of query (61.2 bits)

6nnpA Xanthomonas citri dephospho-pgm in complex with glucose-6-phosphate
    24% identity, 81% coverage of query (61.2 bits)

6nn2A Xanthomonas citri pgm apo-phospho
    24% identity, 81% coverage of query (61.2 bits)

6n1eA Crystal structure of x. Citri phosphoglucomutase in complex with 1- methyl-glucose 6-phosphate
    24% identity, 81% coverage of query (61.2 bits)

6mnvA Crystal structure of x. Citri phosphoglucomutase in complex with ch2fg1p
    24% identity, 81% coverage of query (61.2 bits)

6mlhA Crystal structure of x. Citri phosphoglucomutase in complex with glucopyranosyl-1-methyl-phosphonic acid
    24% identity, 81% coverage of query (61.2 bits)

6mlfA Crystal structure of x. Citri phosphoglucomutase in complex with 6- fluoro glucose 1-phosphate
    24% identity, 81% coverage of query (61.2 bits)

5kl0A Crystal structure of phosphoglucomutase from xanthomonas citri citri complexed with glucose-1,6-biphosphate
    24% identity, 81% coverage of query (61.2 bits)

1kfqA / P47244 Crystal structure of exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutse) from paramecium. Open form (see paper)
    24% identity, 72% coverage of query (60.5 bits)

1kfiA Crystal structure of the exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutase) from paramecium
    24% identity, 72% coverage of query (60.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory