Searching for up to 100 curated homologs for WP_068332286.1 NCBI__GCF_001650345.1:WP_068332286.1 (210 a.a.)

Found high-coverage hits (≥70%) to 24 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q0K1X1 2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) from Cupriavidus necator (see paper)
    45% identity, 98% coverage of query (182 bits)

Kga / b1850 KHG/KDPG aldolase (EC 4.1.2.55; EC 4.1.2.14; EC 4.1.3.42; EC 4.1.1.112) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
eda / P0A955 KHG/KDPG aldolase (EC 4.1.2.55; EC 4.1.3.42; EC 4.1.1.112) from Escherichia coli (strain K12) (see 2 papers)
ALKH_ECOLI / P0A955 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Escherichia coli (strain K12) (see 5 papers)
P0A955 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16); (4S)-4-hydroxy-2-oxoglutarate aldolase (EC 4.1.3.42) from Escherichia coli (see 5 papers)
eda / RF|NP_416364 KHG/KDPG aldolase; EC 4.1.2.14; EC 4.1.3.16 from Escherichia coli K12 (see 4 papers)
    47% identity, 88% coverage of query (182 bits)

1euaA Schiff base intermediate in kdpg aldolase from escherichia coli
    47% identity, 88% coverage of query (182 bits)

kdgA / P38448 2-dehydro-3-deoxy-D-gluconate-6-phosphate aldolase (EC 4.1.2.55) from Dickeya dadantii (strain 3937) (see 2 papers)
    44% identity, 94% coverage of query (181 bits)

ALKD_PSEA6 / Q15X88 2-dehydro-3-deoxy-phosphogluconate aldolase; 2-keto-3-deoxy-6-phospho-D-gluconate aldolase; KDPG aldolase; EC 4.1.2.14 from Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
    43% identity, 91% coverage of query (181 bits)

2c0aB / P0A955 Mechanism of the class i kdpg aldolase (see paper)
    47% identity, 88% coverage of query (180 bits)

1wauA Structure of kdpg aldolase e45n mutant
    47% identity, 88% coverage of query (180 bits)

3vcrA / D2YW47 Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica (see paper)
    44% identity, 92% coverage of query (172 bits)

1mxsA / P00885 Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. (see paper)
    39% identity, 93% coverage of query (162 bits)

P00885 2-dehydro-3-deoxy-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase; EC 4.1.2.14 from Pseudomonas putida (Arthrobacter siderocapsulatus)
    39% identity, 93% coverage of query (160 bits)

eda / CAE53635.1 2-dehydro-3-deoxyphosphogluconate aldolase from Nonomuraea gerenzanensis (see paper)
    45% identity, 89% coverage of query (157 bits)

6oviA / Q5ZYF2 Crystal structure of kdpg aldolase from legionella pneumophila with pyruvate captured at low ph as a covalent carbinolamine intermediate
    40% identity, 91% coverage of query (142 bits)

Q00384 2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) from Zymomonas mobilis subsp. mobilis (see paper)
    44% identity, 81% coverage of query (139 bits)

5xsfA / Q00384 Crystal structure of the 2-keto-3-deoxy-6-phosphogluconate aldolase of zymomonas mobilis zm4 with 3-phosphoglycerate
    44% identity, 81% coverage of query (139 bits)

ALKH_BACSU / P50846 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Bacillus subtilis (strain 168) (see paper)
    37% identity, 78% coverage of query (112 bits)

TM0066 / Q9WXS1 4-hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16; EC 4.1.2.55) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    33% identity, 80% coverage of query (108 bits)

1wa3D / Q9WXS1 Mechanism of the class i kdpg aldolase (see paper)
    33% identity, 80% coverage of query (108 bits)

D4GV57 2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) from Haloferax volcanii (see paper)
    31% identity, 99% coverage of query (103 bits)

Build an alignment

Build an alignment for WP_068332286.1 and 18 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

CA265_RS19860 2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) from Pedobacter sp. GW460-11-11-14-LB5
    25% identity, 98% coverage of query (74.7 bits)

lgnG / BAM68210.1 2-keto-3-deoxy-6-phosphogalactonate aldolase lgnG from Paracoccus laeviglucosivorans (see 2 papers)
    31% identity, 70% coverage of query (70.1 bits)

DGOA_RHIME / Q92RN8 Probable 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; 2-oxo-3-deoxygalactonate 6-phosphate aldolase; 6-phospho-2-dehydro-3-deoxygalactonate aldolase; 6-phospho-2-keto-3-deoxygalactonate aldolase; KDPGal; EC 4.1.2.21 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
    31% identity, 81% coverage of query (69.7 bits)

A0A0B6VQ18 2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) from Flavobacterium sp. UMI-01 (see paper)
    24% identity, 96% coverage of query (69.7 bits)

2v82A / Q6BF16 Kdpgal complexed to kdpgal (see paper)
    29% identity, 70% coverage of query (65.1 bits)

YidU / b4477 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC 4.1.2.55; EC 4.1.2.21) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
dgoA / Q6BF16 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC 4.1.2.55) from Escherichia coli (strain K12) (see 5 papers)
DGOA_ECOLI / Q6BF16 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; 2-oxo-3-deoxygalactonate 6-phosphate aldolase; 6-phospho-2-dehydro-3-deoxygalactonate aldolase; 6-phospho-2-keto-3-deoxygalactonate aldolase; KDPGal; EC 4.1.2.21 from Escherichia coli (strain K12) (see 3 papers)
Q6BF16 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC 4.1.2.21) from Escherichia coli (see paper)
dgoA / RF|YP_026238 2-dehydro-3-deoxy-6-phosphogalactonate aldolase from Escherichia coli K12 (see 2 papers)
    29% identity, 70% coverage of query (65.1 bits)

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