Searching for up to 100 curated homologs for WP_072905980.1 NCBI__GCF_900142125.1:WP_072905980.1 (437 a.a.)
Found high-coverage hits (≥70%) to 95 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Q6JGI2 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Geobacter sulfurreducens (see paper)
72% identity, 100% coverage of query (654 bits)
gltA / A0A7C6A739 citrate synthase (EC 2.3.3.3) from Desulfurella acetivorans (see 4 papers)
70% identity, 100% coverage of query (627 bits)
CISY_THET7 / A0A0S3QTD0 Citrate synthase; CS; EC 2.3.3.16 from Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6) (see paper)
55% identity, 99% coverage of query (462 bits)
6cscA / P23007 Chicken citrate synthase complex with trifluoroacetonyl-coa and citrate
50% identity, 99% coverage of query (438 bits)
1cssA Alpha-fluoro acid and alpha-fluoro amide analogs of acetyl-coa as inhibitors of of citrate synthase: effect of pka matching on binding affinity and hydrogen bond length
50% identity, 99% coverage of query (438 bits)
1csrA Alpha-fluoro acid and alpha-fluoro amide analogs of acetyl-coa as inhibitors of of citrate synthase: effect of pka matching on binding affinity and hydrogen bond length
50% identity, 99% coverage of query (438 bits)
1csiA A very short hydrogen bond provides only moderate stabilization of an enzyme: inhibitor complex of citrate synthase
50% identity, 99% coverage of query (438 bits)
1cshA A very short hydrogen bond provides only moderate stabilization of an enzyme: inhibitor complex of citrate synthase
50% identity, 99% coverage of query (438 bits)
1amzA Chicken citrate synthase complex with nitromethylde-coa and malate
50% identity, 99% coverage of query (438 bits)
1al6A Chicken citrate synthase complex with n-hydroxyamido-coa and oxaloacetate
50% identity, 99% coverage of query (438 bits)
O00098 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Aspergillus nidulans (see paper)
citA citrate synthase, mitochondrial; EC 2.3.3.1 from Emericella nidulans (see 2 papers)
52% identity, 97% coverage of query (435 bits)
Q9P8D6 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Aspergillus niger (see paper)
50% identity, 99% coverage of query (435 bits)
Q0GNE1 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Amblyrhynchus cristatus (see paper)
50% identity, 97% coverage of query (433 bits)
Q0GNE0 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Iguana iguana (see paper)
50% identity, 97% coverage of query (433 bits)
CSY4 / P20115 citrate synthase (mitochondrial) (EC 2.3.3.3) from Arabidopsis thaliana (see 6 papers)
CISY4_ARATH / P20115 Citrate synthase 4, mitochondrial; EC 2.3.3.16 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
P20115 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Arabidopsis thaliana (see 2 papers)
52% identity, 98% coverage of query (433 bits)
CISY_DROME / Q9W401 Probable citrate synthase, mitochondrial; Protein knockdown; EC 2.3.3.16 from Drosophila melanogaster (Fruit fly) (see paper)
50% identity, 98% coverage of query (432 bits)
Q29RK1 Citrate synthase, mitochondrial; Citrate (Si)-synthase; EC 2.3.3.1 from Bos taurus (Bovine)
49% identity, 97% coverage of query (432 bits)
CS / O75390 citrate synthase monomer (EC 2.3.3.3) from Homo sapiens (see 4 papers)
CISY_HUMAN / O75390 Citrate synthase, mitochondrial; Citrate (Si)-synthase; EC 2.3.3.1 from Homo sapiens (Human) (see 3 papers)
O75390 citrate (Si)-synthase (EC 2.3.3.1) from Homo sapiens (see 2 papers)
49% identity, 97% coverage of query (427 bits)
CISY_PIG / P00889 Citrate synthase, mitochondrial; Citrate (Si)-synthase; EC 2.3.3.1 from Sus scrofa (Pig) (see paper)
P00889 citrate (Si)-synthase (EC 2.3.3.1); citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Sus scrofa (see 3 papers)
50% identity, 97% coverage of query (427 bits)
CISY1_YEAST / P00890 Citrate synthase, mitochondrial; EC 2.3.3.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
P00890 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Saccharomyces cerevisiae (see paper)
50% identity, 98% coverage of query (427 bits)
Q9CZU6 citrate (Si)-synthase (EC 2.3.3.1) from Mus musculus (see paper)
49% identity, 97% coverage of query (427 bits)
CS / O80433 citrate synthase (mitochondrial) (EC 2.3.3.3) from Daucus carota (see paper)
O80433 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Daucus carota (see paper)
52% identity, 98% coverage of query (427 bits)
2ctsA Crystallographic refinement and atomic models of two different forms of citrate synthase at 2.7 and 1.7 angstroms resolution
50% identity, 97% coverage of query (427 bits)
3enjA Structure of pig heart citrate synthase at 1.78 a resolution
50% identity, 97% coverage of query (427 bits)
CISY_RAT / Q8VHF5 Citrate synthase, mitochondrial; Citrate (Si)-synthase; EC 2.3.3.1 from Rattus norvegicus (Rat) (see paper)
49% identity, 97% coverage of query (422 bits)
Q9HFI1 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Podospora anserina (see paper)
49% identity, 97% coverage of query (415 bits)
PRPC_YARLI / Q6C793 2-methylcitrate synthase, mitochondrial; Methylcitrate synthase; (2S,3S)-2-methylcitrate synthase; Citrate synthase 2; EC 2.3.3.5; EC 2.3.3.16 from Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) (see paper)
49% identity, 99% coverage of query (414 bits)
M4QLE7 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Fasciola hepatica (see paper)
50% identity, 98% coverage of query (412 bits)
Q6T8H1 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Citrus junos (see paper)
50% identity, 98% coverage of query (412 bits)
CISY2_YEAST / P08679 Citrate synthase, peroxisomal; EC 2.3.3.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
49% identity, 98% coverage of query (412 bits)
8gr9A / P08679 Crystal structure of peroxisomal citrate synthase (cit2) from saccharomyces cerevisiae in complex with oxaloacetate and coenzyme-a (see paper)
49% identity, 98% coverage of query (410 bits)
cit1 / RF|NP_593718.1 citrate synthase Cit1; EC 2.3.3.1 from Schizosaccharomyces pombe (see 2 papers)
48% identity, 98% coverage of query (408 bits)
CISY_SCHPO / Q10306 Probable citrate synthase, mitochondrial; EC 2.3.3.16 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
48% identity, 98% coverage of query (408 bits)
CISY_CHICK / P23007 Citrate synthase, mitochondrial; Citrate (Si)-synthase; EC 2.3.3.1 from Gallus gallus (Chicken) (see paper)
P23007 citrate (Si)-synthase (EC 2.3.3.1) from Gallus gallus (see paper)
48% identity, 97% coverage of query (408 bits)
CISY5_ARATH / Q9M1D3 Citrate synthase 5, mitochondrial; EC 2.3.3.16 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
49% identity, 98% coverage of query (407 bits)
CIT1 citrate synthase from Candida albicans (see 2 papers)
53% identity, 88% coverage of query (407 bits)
6ctsA Proposed mechanism for the condensation reaction of citrate synthase. 1.9-angstroms structure of the ternary complex with oxaloacetate and carboxymethyl coenzyme a
49% identity, 97% coverage of query (402 bits)
3cscA Structure of ternary complexes of citrate synthase with d-and l- malate: mechanistic implications
49% identity, 97% coverage of query (402 bits)
2cscA Structure of ternary complexes of citrate synthase with d-and l- malate: mechanistic implications
49% identity, 97% coverage of query (402 bits)
1cscA Structure of ternary complexes of citrate synthase with d-and l- malate: mechanistic implications
49% identity, 97% coverage of query (402 bits)
P83372 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Fragaria x ananassa (see paper)
48% identity, 98% coverage of query (384 bits)
CISY_TETTH / P24118 Citrate synthase, mitochondrial; 14 nm filament-forming protein; 49 kDa protein; EC 2.3.3.16 from Tetrahymena thermophila (see paper)
43% identity, 97% coverage of query (369 bits)
5uquB Crystal structure of mutant 2-methylcitrate synthase (mcsag352a) from aspergillus fumigatus
44% identity, 98% coverage of query (366 bits)
PRPC_ASPFC / B0YD89 2-methylcitrate synthase, mitochondrial; Methylcitrate synthase; (2S,3S)-2-methylcitrate synthase; Citrate synthase 2; EC 2.3.3.5; EC 2.3.3.16 from Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10) (Neosartorya fumigata) (see 2 papers)
PRPC_ASPFM / Q50I20 2-methylcitrate synthase, mitochondrial; Methylcitrate synthase; (2S,3S)-2-methylcitrate synthase; Citrate synthase 1; EC 2.3.3.5; EC 2.3.3.16 from Aspergillus fumigatus (Neosartorya fumigata) (see 2 papers)
Q50I20 2-methylcitrate synthase (EC 2.3.3.5) from Aspergillus fumigatus (see 2 papers)
mcsA / GI|63028051 methylcitrate synthase; EC 2.3.3.5 from Aspergillus fumigatus (see paper)
mcsA / CAI61947.1 methylcitrate synthase from Aspergillus fumigatus (see paper)
44% identity, 98% coverage of query (365 bits)
5uqrB Crystal structure of 2-methylcitrate synthase from aspergillus fumigatus
44% identity, 98% coverage of query (364 bits)
5uqrA / B0YD89 Crystal structure of 2-methylcitrate synthase from aspergillus fumigatus (see paper)
44% identity, 98% coverage of query (363 bits)
PRPC_FUSSL / C7C435 2-methylcitrate synthase, mitochondrial; Methylcitrate synthase; (2S,3S)-2-methylcitrate synthase; Citrate synthase 2; EC 2.3.3.5; EC 2.3.3.16 from Fusarium solani (Filamentous fungus) (see paper)
45% identity, 97% coverage of query (363 bits)
PRPC_GIBMO / C7C436 2-methylcitrate synthase, mitochondrial; Methylcitrate synthase; (2S,3S)-2-methylcitrate synthase; Citrate synthase 2; EC 2.3.3.5; EC 2.3.3.16 from Gibberella moniliformis (Maize ear and stalk rot fungus) (Fusarium verticillioides) (see paper)
45% identity, 97% coverage of query (362 bits)
PRPC_EMENI / Q9TEM3 2-methylcitrate synthase, mitochondrial; Methylcitrate synthase; (2S,3S)-2-methylcitrate synthase; Citrate synthase 2; EC 2.3.3.5; EC 2.3.3.16 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 7 papers)
Q9TEM3 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Aspergillus nidulans (see paper)
mcsA / GI|5763968 methylcitrate synthase; EC 2.3.3.5 from Emericella nidulans (see 4 papers)
45% identity, 94% coverage of query (357 bits)
CISY3_YEAST / P43635 Citrate synthase 3, mitochondrial; EC 2.3.3.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
40% identity, 98% coverage of query (324 bits)
Build an alignment for WP_072905980.1 and 50 homologs with ≥ 30% identity
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CISY3_ARATH / Q9SJH7 Citrate synthase 3, peroxisomal; EC 2.3.3.16 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
29% identity, 87% coverage of query (125 bits)
CISY2_ARATH / Q9LXS6 Citrate synthase 2, peroxisomal; EC 2.3.3.16 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
28% identity, 84% coverage of query (124 bits)
Q8ZWP2 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Pyrobaculum aerophilum (see paper)
31% identity, 87% coverage of query (122 bits)
Q974S5 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Sulfurisphaera tokodaii (see paper)
28% identity, 84% coverage of query (121 bits)
G8XQY5 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Streptomyces diastaticus (see paper)
29% identity, 92% coverage of query (120 bits)
1aj8A / Q53554 Citrate synthase from pyrococcus furiosus (see paper)
28% identity, 82% coverage of query (118 bits)
Q53554 citrate (Si)-synthase (EC 2.3.3.1) from Pyrococcus furiosus (see paper)
28% identity, 82% coverage of query (118 bits)
CISY_PSEAE / P14165 Citrate synthase; EC 2.3.3.16 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
28% identity, 86% coverage of query (116 bits)
3msuB / Q5NIJ6 Crystal structure of citrate synthase from francisella tularensis
27% identity, 86% coverage of query (114 bits)
3msuA Crystal structure of citrate synthase from francisella tularensis
27% identity, 86% coverage of query (113 bits)
4jaeA / P0ABH7 Structural determination of the a50t:s279g:s280k:v281k:k282e:h283n variant of citrate synthase from e. Coli complexed with s- carboxymethyl-coa (see paper)
27% identity, 86% coverage of query (112 bits)
4jagA Structural determination of the a50t:s279g:s280k:v281k:k282e:h283n variant of citrate synthase from e. Coli complexed with oxaloacetate
27% identity, 86% coverage of query (112 bits)
ctsA / AAA52231.1 citrate synthase from Bacillus coagulans (see paper)
28% identity, 90% coverage of query (110 bits)
2h12B / P20901 Structure of acetobacter aceti citrate synthase complexed with oxaloacetate and carboxymethyldethia coenzyme a (cmx) (see paper)
27% identity, 86% coverage of query (109 bits)
GluT / b0720 citrate synthase (EC 2.3.3.16; EC 2.3.3.1) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gltA / P0ABH7 citrate synthase (EC 2.3.3.3) from Escherichia coli (strain K12) (see 45 papers)
P0ABH7 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Escherichia coli (see 2 papers)
27% identity, 86% coverage of query (109 bits)
P0ABH7 Citrate synthase; EC 2.3.3.16 from Escherichia coli (strain K12)
27% identity, 86% coverage of query (109 bits)
aarA / P20901 citrate synthase monomer (EC 2.3.3.3) from Acetobacter aceti (see 2 papers)
28% identity, 77% coverage of query (108 bits)
1ixeA Crystal structure of citrate synthase from thermus thermophilus hb8
27% identity, 87% coverage of query (108 bits)
Q59977 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Synechocystis sp. PCC 6803 (see paper)
26% identity, 88% coverage of query (107 bits)
A4YGX6 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Metallosphaera sedula (see 2 papers)
27% identity, 82% coverage of query (107 bits)
6abyA / A4YGX6 Crystal structure of citrate synthase (msed_1522) from metallosphaera sedula in complex with oxaloacetate (see paper)
27% identity, 82% coverage of query (107 bits)
Q5SIM6 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Thermus thermophilus (see paper)
27% identity, 87% coverage of query (107 bits)
8bp7E / Q31QM5 Citrate-bound hexamer of synechococcus elongatus citrate synthase (see paper)
26% identity, 88% coverage of query (107 bits)
1iomA / Q5SIM6 Crystal structure of citrate synthase from thermus thermophilus hb8 (see paper)
27% identity, 87% coverage of query (107 bits)
P9WPD5 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Mycobacterium tuberculosis (see paper)
28% identity, 87% coverage of query (107 bits)
1owbA Three dimensional structure analysis of the variant r109l nadh complex of type ii citrate synthase from e. Coli
27% identity, 86% coverage of query (107 bits)
6abxA Crystal structure of citrate synthase (msed_1522) from metallosphaera sedula in complex with citrate
27% identity, 82% coverage of query (107 bits)
P9WPD5 Citrate synthase 1; EC 2.3.3.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
28% identity, 87% coverage of query (107 bits)
Q9R6Y4 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
25% identity, 86% coverage of query (106 bits)
1nxgA The f383a variant of type ii citrate synthase complexed with nadh
27% identity, 86% coverage of query (105 bits)
Q96ZM7 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Sulfurisphaera tokodaii (see paper)
29% identity, 88% coverage of query (103 bits)
CISYC_DICDI / Q86AV6 Citrate synthase; EC 2.3.3.16 from Dictyostelium discoideum (Social amoeba) (see paper)
28% identity, 82% coverage of query (102 bits)
6abwA / A4YDF6 Crystal structure of citrate synthase (msed_0281) from metallosphaera sedula in complex with acetyl-coa (see paper)
28% identity, 86% coverage of query (100 bits)
6s87D / Q9I5E3 Crystal structure of 2-methylcitrate synthase (prpc) from pseudomonas aeruginosa in complex with oxaloacetate.
25% identity, 85% coverage of query (98.2 bits)
4tvmA / P9WPD5 Structure of citrate synthase from mycobacterium tuberculosis (see paper)
26% identity, 87% coverage of query (85.9 bits)
P39120 Citrate synthase 2; Citrate synthase II; EC 2.3.3.16 from Bacillus subtilis (strain 168)
27% identity, 75% coverage of query (85.1 bits)
PRPC_ABDS2 / O34002 2-methylcitrate synthase; 2-MCS; MCS; Citrate synthase; EC 2.3.3.5; EC 2.3.3.16 from Antarctic bacterium DS2-3R (see 3 papers)
O34002 citrate (Si)-synthase (EC 2.3.3.1) from antarctic bacterium DS2-3R (see paper)
25% identity, 84% coverage of query (77.4 bits)
PRPC_MYCTE / H8F0D7 2-methylcitrate synthase; 2-MCS; MCS; Citrate synthase; CS; EC 2.3.3.5; EC 2.3.3.16 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) (see paper)
PRPC_MYCTU / I6Y9Q3 2-methylcitrate synthase; 2-MCS; MCS; Citrate synthase; EC 2.3.3.5; EC 2.3.3.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
26% identity, 77% coverage of query (77.4 bits)
1a59A / O34002 Cold-active citrate synthase (see paper)
25% identity, 84% coverage of query (77.0 bits)
CISY_BACSU / P39119 Citrate synthase 1; Citrate synthase I; EC 2.3.3.16 from Bacillus subtilis (strain 168) (see paper)
24% identity, 89% coverage of query (74.7 bits)
2c6xA / P39119 Structure of bacillus subtilis citrate synthase
24% identity, 89% coverage of query (74.7 bits)
4yboB Structure of citrate synthase from the thermoacidophilic euryarchaeon thermolasma acidophilum
26% identity, 84% coverage of query (73.6 bits)
2r9eA The structure of the binary complex of citryl dethia coa and citrate synthase from the thermophilic archaeonthermoplasma acidophilum
26% identity, 84% coverage of query (73.6 bits)
2r26A The structure of the ternary complex of carboxymethyl coenzyme a and oxalateacetate with citrate synthase from the thermophilic archaeonthermoplasma acidophilum
26% identity, 84% coverage of query (73.6 bits)
2ifcC / P21553 The structure of the binary complex of oxalateacetate with citrate synthase from the thermophilic archaeon thermolasma acidophilum
26% identity, 84% coverage of query (73.6 bits)
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