Sites on a Tree

 

Searching for up to 100 curated homologs for WP_074201472.1 NCBI__GCF_900141795.1:WP_074201472.1 (264 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
    61% identity, 97% coverage of query (333 bits)

7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
    61% identity, 97% coverage of query (333 bits)

7chaI / Q9HVW1 Cryo-em structure of p.Aeruginosa mlafebd with amppnp (see paper)
    60% identity, 97% coverage of query (332 bits)

6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
    62% identity, 95% coverage of query (329 bits)

ttg2 / GI|4336798 toluene tolerance protein Ttg2A from Pseudomonas putida (see paper)
    60% identity, 97% coverage of query (325 bits)

7ch6C / P63386 Cryo-em structure of e.Coli mlafeb with amppnp (see paper)
    62% identity, 98% coverage of query (322 bits)

YrbF / b3195 intermembrane phospholipid transport system, ATP binding subunit MlaF from Escherichia coli K-12 substr. MG1655 (see 6 papers)
MLAF_ECOLI / P63386 Intermembrane phospholipid transport system ATP-binding protein MlaF; EC 7.6.2.- from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.27.3 / P63386 Probable phospholipid import ATP-binding protein mlaF, component of ABC transporter maintaining outer membrane (OM) lipid asymmetry, MlaABCDEF (YrbABCDEF) (Malinverni and Silhavy, 2009). MlaA (VacJ) is a "spreading" protein, essential for Shigella from Escherichia coli (strain K12) (see 3 papers)
yrbF / RF|NP_417662 uncharacterized ABC transporter ATP-binding protein yrbF from Escherichia coli K12 (see paper)
    62% identity, 98% coverage of query (322 bits)

6xgyA Crystal structure of e. Coli mlafb abc transport subunits in the dimeric state
    62% identity, 98% coverage of query (322 bits)

7cgnB The overall structure of the mlafedb complex in atp-bound eqtall conformation (mutation of e170q on mlaf)
    61% identity, 98% coverage of query (321 bits)

7ch8I Cryo-em structure of p.Aeruginosa mlafebd with adp-v
    59% identity, 97% coverage of query (311 bits)

TC 3.A.1.27.4 / Q0SD37 ABC superfamily, ATP-binding component, component of The cholesterol uptake porter (Mohn et al., 2008). Takes up cholesterol, 5-α-cholestanol, 5-α-cholestanone, β-sitosterol, etc. (It is not established that all of these proteins comprise the system or that other gene products are not involved.) from Rhodococcus sp. (strain RHA1) (see paper)
    40% identity, 92% coverage of query (198 bits)

TC 3.A.1.27.4 / Q0SFA1 Probable bifunctional ABC transport system, component of The cholesterol uptake porter (Mohn et al., 2008). Takes up cholesterol, 5-α-cholestanol, 5-α-cholestanone, β-sitosterol, etc. (It is not established that all of these proteins comprise the system or that other gene products are not involved.) from Rhodococcus sp. (strain RHA1) (see paper)
    40% identity, 92% coverage of query (197 bits)

TC 3.A.1.27.5 / P63357 Probable ribonucleotide transport ATP-binding protein mkl, component of The Mce/Yrb/Mlk (Mammalian cell entry) ABC-type putative steroid uptake transporter (involved in several aspects of mycobacterial pathogenesis) from Mycobacterium tuberculosis (see 2 papers)
    40% identity, 94% coverage of query (195 bits)

TGD3_ARATH / Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.27.2 / Q9AT00 Tdg3, component of The chloroplast lipid (trigalactosyl diacyl glycerol (TDG)) transporter, Tdg1,2,3 (Lu et al., 2007). Lipids such as mono- and digalactolipids are synthesized in the endoplasmic reticulum (ER) of plant cells and transferred to the thylakoid membranes of chloroplasts. Mutations in an outer chloroplastic envelope protein with 350 aas and 7 putative TMSs in the last 250 residues may catalyze translocation as part of a lipid transfer complex from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
    38% identity, 94% coverage of query (169 bits)

TC 3.A.1.27.1 / A4PCH8 Putative ATPase component of ABC transporter system aka LinL, component of The γ-hexachlorocyclohexane (γHCH) uptake permease, LinKLMN (most similar to 3.A.1.12.4, the QAT family) from Sphingobium japonicum (see paper)
    37% identity, 90% coverage of query (162 bits)

MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
    35% identity, 99% coverage of query (148 bits)

TC 3.A.1.1.14 / Q97UF2 AraV, component of Arabinose, fructose, xylose porter from Sulfolobus solfataricus (see paper)
    38% identity, 86% coverage of query (147 bits)

6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
    34% identity, 99% coverage of query (147 bits)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
    34% identity, 99% coverage of query (147 bits)

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
    34% identity, 99% coverage of query (147 bits)

OUSV_DICD3 / E0SCY1 Glycine betaine/choline transport system ATP-binding protein OusV from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see paper)
    38% identity, 83% coverage of query (143 bits)

TC 3.A.1.12.9 / Q8U4S5 OtaA, component of The salt-induced glycine betaine OtaABC transporter from Methanosarcina mazei (see 2 papers)
    34% identity, 89% coverage of query (140 bits)

TC 3.A.1.1.38 / Q9WYQ2 Glycerol-3-phosphate-transporting ATPase, component of Inositol phosphate porter (Rodionova et al. 2013). Binds inositol phosphate with low Kd and inositol with a lower affinity from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    36% identity, 91% coverage of query (139 bits)

CysA / b2422 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
CysA / P16676 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.6.1 / P16676 CysA aka B2422, component of Sulfate/thiosulfate porter from Escherichia coli (see 5 papers)
    37% identity, 85% coverage of query (139 bits)

TC 3.A.1.3.25 / Q9CES4 Glutamine ABC transporter ATP-binding protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity from Lactococcus lactis subsp. lactis (strain IL1403)
    33% identity, 91% coverage of query (138 bits)

TMOW_PELUB / Q4FL37 Trimethylamine N-oxide transport system ATP-binding protein TmoW; TMAO transport system ATP-binding protein TmoW; EC 7.6.2.9 from Pelagibacter ubique (strain HTCC1062) (see paper)
    35% identity, 92% coverage of query (137 bits)

TC 3.A.1.24.4 / Q8NSN2 Methionine import ATP-binding protein metN, component of L-Methionine uptake porter, MetQNI from Corynebacterium glutamicum (see paper)
    36% identity, 86% coverage of query (137 bits)

TC 3.A.1.6.3 / P0A4W2 Sulfate/thiosulfate import ATP-binding protein CysA aka RV2397C aka MT2468 aka MTCY253.24, component of Sulfate porter from Mycobacterium tuberculosis (see 3 papers)
    37% identity, 85% coverage of query (137 bits)

3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
    33% identity, 87% coverage of query (134 bits)

3c4jA Abc protein artp in complex with atp-gamma-s
    33% identity, 87% coverage of query (134 bits)

2olkA Abc protein artp in complex with adp-beta-s
    33% identity, 87% coverage of query (134 bits)

2oljA Abc protein artp in complex with adp/mg2+
    33% identity, 87% coverage of query (134 bits)

PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
    35% identity, 82% coverage of query (129 bits)

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    33% identity, 86% coverage of query (128 bits)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    33% identity, 86% coverage of query (128 bits)

GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
    33% identity, 86% coverage of query (128 bits)

6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
    32% identity, 87% coverage of query (126 bits)

4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
    31% identity, 91% coverage of query (125 bits)

7ahhC Opua inhibited inward-facing, sbd docked
    34% identity, 82% coverage of query (125 bits)

7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
    34% identity, 82% coverage of query (125 bits)

1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
    33% identity, 85% coverage of query (123 bits)

2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
    38% identity, 78% coverage of query (123 bits)

7ahdC Opua (e190q) occluded
    34% identity, 78% coverage of query (122 bits)

LolD / b1117 lipoprotein release complex - ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 2 papers)
LolD / P75957 lipoprotein release complex - ATP binding subunit from Escherichia coli (strain K12) (see paper)
LOLD_ECOLI / P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
TC 3.A.1.125.1 / P75957 LolD aka B1117, component of Lipoprotein translocation system (translocates lipoproteins from the inner membrane to periplasmic chaperone, LolA, which transfers the lipoproteins to an outer membrane receptor, LolB, which anchors the lipoprotein to the outer membrane of the Gram-negative bacterial cell envelope) (see 1.B.46; Narita et al., 2003; Ito et al., 2006; Watanabe et al., 2007). The structure of ligand-bound LolCDE has been solved (Ito et al., 2006). LolC and LolE each have 4 TMSs (1+3). Unlike most ATP binding cassette transporters mediating the transmembrane flux of substrates, the LolCDE complex catalyzes the extrusion of lipoproteins anchored to the outer leaflet of the inner membrane. The LolCDE complex is unusual in that it can be purified as a liganded form, which is an intermediate of the lipoprotein release reaction (Taniguchi and Tokuda, 2008). LolCDE has been reconstituted from separated subunits from Escherichia coli (see 5 papers)
lolD / GB|BAA35937.2 lipoprotein releasing system, ATP-binding protein; EC 3.6.3.- from Escherichia coli K12 (see 5 papers)
    35% identity, 84% coverage of query (121 bits)

FTSE_MYCTA / A5U7B7 Cell division ATP-binding protein FtsE from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) (see 2 papers)
    36% identity, 83% coverage of query (121 bits)

8igqA / O05779 Cryo-em structure of mycobacterium tuberculosis adp bound ftsex/ripc complex in peptidisc (see paper)
    36% identity, 83% coverage of query (121 bits)

8iddA Cryo-em structure of mycobacterium tuberculosis atp bound ftsex/ripc complex in peptidisc
    36% identity, 83% coverage of query (121 bits)

7mdyC Lolcde nucleotide-bound
    36% identity, 83% coverage of query (120 bits)

6b89A E. Coli lptb in complex with adp and novobiocin
    32% identity, 85% coverage of query (120 bits)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
    32% identity, 85% coverage of query (120 bits)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
    32% identity, 85% coverage of query (120 bits)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
    32% identity, 85% coverage of query (120 bits)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
    32% identity, 85% coverage of query (120 bits)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
    32% identity, 85% coverage of query (120 bits)

7v8iD / P75957 Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
    35% identity, 84% coverage of query (120 bits)

4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
    32% identity, 93% coverage of query (119 bits)

6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
    32% identity, 85% coverage of query (119 bits)

7arlD Lolcde in complex with lipoprotein and adp
    35% identity, 83% coverage of query (119 bits)

4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
    32% identity, 90% coverage of query (118 bits)

8tzjA / Q9KVJ5 Cryo-em structure of vibrio cholerae ftse/ftsx complex (see paper)
    34% identity, 76% coverage of query (118 bits)

5xu1B / Q8DQF8 Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
    35% identity, 84% coverage of query (118 bits)

8j5qD / P9WQJ5 Cryo-em structure of mycobacterium tuberculosis oppabcd in the pre- translocation state (see paper)
    35% identity, 87% coverage of query (117 bits)

1g291 / Q9YGA6 Malk (see paper)
    34% identity, 84% coverage of query (117 bits)

5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
    37% identity, 86% coverage of query (116 bits)

8j5tD Cryo-em structure of mycobacterium tuberculosis oppabcd in the catalytic intermediate state
    35% identity, 87% coverage of query (116 bits)

8j5sD Cryo-em structure of mycobacterium tuberculosis oppabcd in the pre- catalytic intermediate state
    35% identity, 87% coverage of query (116 bits)

8i6rB / Q9I6C0 Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
    34% identity, 76% coverage of query (116 bits)

Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
    33% identity, 85% coverage of query (115 bits)

4hluA / Q9WY65 Structure of the ecfa-a' heterodimer bound to adp (see paper)
    31% identity, 87% coverage of query (113 bits)

8w6iD / P0A9R7 Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
    34% identity, 78% coverage of query (113 bits)

FtsE / b3463 cell division protein FtsE from Escherichia coli K-12 substr. MG1655 (see 9 papers)
FTSE_ECOLI / P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see 4 papers)
ftsE cell division ATP-binding protein ftsE from Escherichia coli K12 (see 3 papers)
    34% identity, 78% coverage of query (113 bits)

8wm7D / Q8YZ75 Cryo-em structure of cyanobacterial nitrate/nitrite transporter nrtbcd in complex with signalling protein pii (see paper)
    35% identity, 77% coverage of query (112 bits)

4zirA Crystal structure of ecfaa' heterodimer bound to amppnp
    31% identity, 87% coverage of query (112 bits)

8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
    34% identity, 78% coverage of query (112 bits)

1f3oA / Q58206 Crystal structure of mj0796 atp-binding cassette (see paper)
    33% identity, 80% coverage of query (112 bits)

P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
    32% identity, 82% coverage of query (111 bits)

8w9mD Cryo-em structure of the cyanobacterial nitrate transporter nrtbcd in complex with atp
    34% identity, 77% coverage of query (111 bits)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette
    32% identity, 80% coverage of query (110 bits)

8bmsA Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
    32% identity, 86% coverage of query (110 bits)

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution
    32% identity, 78% coverage of query (110 bits)

FTSE_STRP2 / A0A0H2ZM82 Cell division ATP-binding protein FtsE from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) (see 3 papers)
FTSE_STRR6 / Q8DQH4 Cell division ATP-binding protein FtsE from Streptococcus pneumoniae (strain ATCC BAA-255 / R6) (see paper)
6z4wA / Q8DQH4 Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
    32% identity, 78% coverage of query (110 bits)

5d3mA / Q1GBJ0 Folate ecf transporter: amppnp bound state (see paper)
    32% identity, 86% coverage of query (107 bits)

8bmpA Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp
    33% identity, 86% coverage of query (106 bits)

1b0uA / P02915 Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
    32% identity, 90% coverage of query (105 bits)

HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
    32% identity, 86% coverage of query (105 bits)

ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
    32% identity, 82% coverage of query (105 bits)

ECFA2_STRT2 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA 1, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
    32% identity, 86% coverage of query (103 bits)

P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    37% identity, 70% coverage of query (102 bits)

1q12A Crystal structure of the atp-bound e. Coli malk
    33% identity, 85% coverage of query (102 bits)

MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
    33% identity, 85% coverage of query (102 bits)

3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
    33% identity, 85% coverage of query (102 bits)

3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
    33% identity, 85% coverage of query (102 bits)

3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
    33% identity, 85% coverage of query (102 bits)

3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
    33% identity, 85% coverage of query (102 bits)

2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    33% identity, 85% coverage of query (102 bits)

ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
    33% identity, 83% coverage of query (102 bits)

Build an alignment

Build an alignment for WP_074201472.1 and 96 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
    28% identity, 85% coverage of query (102 bits)

8wm7C / Q8YZ76 Cryo-em structure of cyanobacterial nitrate/nitrite transporter nrtbcd in complex with signalling protein pii (see paper)
    32% identity, 81% coverage of query (102 bits)

8f5bA / P78363 Human abca4 structure in complex with amp-pnp
    33% identity, 83% coverage of query (101 bits)

MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    33% identity, 85% coverage of query (101 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory