Searching for up to 100 curated homologs for WP_075858773.1 NCBI__GCF_001950255.1:WP_075858773.1 (349 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
O66740 threonine synthase (EC 4.2.3.1) from Aquifex aeolicus (see paper)
65% identity, 99% coverage of query (450 bits)
2zsjA / O66740 Crystal structure of threonine synthase from aquifex aeolicus vf5
65% identity, 99% coverage of query (450 bits)
6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
62% identity, 99% coverage of query (427 bits)
6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
62% identity, 99% coverage of query (427 bits)
6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
61% identity, 99% coverage of query (409 bits)
thrC / CAA82669.1 threonine synthase from Bacillus sp. (see paper)
61% identity, 98% coverage of query (402 bits)
P83823 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see paper)
Q5SL02 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see 2 papers)
3aexA / Q5SL02 Catalytic intermediate analogue of threonine synthase from thermus thermophilus hb8 (see paper)
60% identity, 92% coverage of query (389 bits)
3aeyA Apo form of threonine synthase from thermus thermophilus hb8
60% identity, 92% coverage of query (389 bits)
1uimA Crystal structure of threonine synthase from thermus thermophilus hb8, orthorhombic crystal form
60% identity, 92% coverage of query (389 bits)
1v7cA Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue
60% identity, 92% coverage of query (389 bits)
A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
58% identity, 97% coverage of query (386 bits)
THRC_MYCTU / P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG59 threonine synthase (EC 4.2.3.1) from Mycobacterium tuberculosis (see 2 papers)
59% identity, 94% coverage of query (383 bits)
2d1fA / P9WG59 Structure of mycobacterium tuberculosis threonine synthase (see paper)
59% identity, 94% coverage of query (382 bits)
THRC_METAC / Q8TQD4 Threonine synthase; TS; EC 4.2.3.1 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
GB|AAM05023.1 threonine synthase; EC 4.2.3.1 from Methanosarcina acetivorans C2A (see paper)
52% identity, 97% coverage of query (336 bits)
THRC1_ARATH / Q9S7B5 Threonine synthase 1, chloroplastic; Protein METHIONINE OVER-ACCUMULATOR 2; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
33% identity, 99% coverage of query (192 bits)
2c2bA Crystallographic structure of arabidopsis thaliana threonine synthase complexed with pyridoxal phosphate and s-adenosylmethionine
33% identity, 99% coverage of query (192 bits)
THRC2_ARATH / Q9SSP5 Threonine synthase 2, chloroplastic; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
32% identity, 99% coverage of query (189 bits)
2c2gA / Q9S7B5 Crystal structure of threonine synthase from arabidopsis thaliana in complex with its cofactor pyridoxal phosphate (see paper)
33% identity, 99% coverage of query (176 bits)
DvMF_1945 threonine synthase (EC 4.2.3.1) from Desulfovibrio vulgaris Miyazaki F
36% identity, 91% coverage of query (170 bits)
Build an alignment for WP_075858773.1 and 19 homologs with ≥ 30% identity
Or download the sequences
ILV1 putative uncharacterized protein ILV1 from Candida albicans (see paper)
29% identity, 84% coverage of query (87.4 bits)
Q54HH2 D-Serine ammonia-lyase (EC 4.3.1.18) from Dictyostelium discoideum (see paper)
27% identity, 83% coverage of query (80.1 bits)
8y1jA / Q9I6G0 Structure of the pyridoxal 5'-phosphate-dependent (plp) threonine deaminase ilva1 from pseudomonas aeruginosa pao1 (see paper)
29% identity, 78% coverage of query (80.1 bits)
B1N2N4 L-serine ammonia-lyase (EC 4.3.1.17) from Entamoeba histolytica (see paper)
29% identity, 83% coverage of query (78.6 bits)
Ga0059261_3694 threonine deaminase (EC 4.3.1.19) from Sphingomonas koreensis DSMZ 15582
29% identity, 74% coverage of query (78.6 bits)
Q8VBT2 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse)
27% identity, 81% coverage of query (77.8 bits)
LTHAD_YEAST / P36007 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; EC 4.3.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
27% identity, 77% coverage of query (77.4 bits)
1pwhA / P09367 Rat liver l-serine dehydratase- complex with pyridoxyl-(o-methyl- serine)-5-monophosphate (see paper)
27% identity, 77% coverage of query (76.6 bits)
trpB1 / P50909 β subunit of tryptophan synthase (EC 4.2.1.122) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
P50909 tryptophan synthase (EC 4.2.1.20) from Thermotoga maritima (see paper)
29% identity, 89% coverage of query (76.3 bits)
MA_3297 / Q8TKU7 cysteate synthase monomer (EC 2.5.1.76) from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
CYAS_METAC / Q8TKU7 Cysteate synthase; CS; Cya synthase; EC 2.5.1.76 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
Q8TKU7 cysteate synthase (EC 2.5.1.76) from Methanosarcina acetivorans (see paper)
26% identity, 97% coverage of query (75.5 bits)
CA265_RS15860 threonine deaminase (EC 4.3.1.19) from Pedobacter sp. GW460-11-11-14-LB5
27% identity, 77% coverage of query (74.7 bits)
Q93968 serine racemase (EC 5.1.1.18) from Caenorhabditis elegans (see paper)
25% identity, 85% coverage of query (74.7 bits)
A0QX60 threonine ammonia-lyase (EC 4.3.1.19) from Mycolicibacterium smegmatis (see paper)
29% identity, 77% coverage of query (73.2 bits)
L0N5C4 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. N99 (see paper)
26% identity, 83% coverage of query (72.4 bits)
8egzB / P50909 Engineered tyrosine synthase (tmtyrs1) derived from t. Maritima trpb with ser bound as the amino-acrylate intermediate
29% identity, 89% coverage of query (72.0 bits)
8eh0A Engineered tyrosine synthase (tmtyrs1) derived from t. Maritima trpb with ser bound as the amino-acrylate intermediate and complexed with quinoline n-oxide
29% identity, 89% coverage of query (72.0 bits)
8egyA Engineered holo tyrosine synthase (tmtyrs1) derived from t. Maritima trpb
29% identity, 89% coverage of query (72.0 bits)
TSAL_THEMA / Q9WYJ1 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine dehydratase; EC 4.3.1.19; EC 4.3.1.17 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
30% identity, 72% coverage of query (71.6 bits)
SDSL_MOUSE / Q8R238 Serine dehydratase-like; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; SDH; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse) (see paper)
26% identity, 84% coverage of query (70.9 bits)
8eh1A Engineered tyrosine synthase (tmtyrs1) derived from t. Maritima trpb with ser bound as the amino-acrylate intermediate and complexed with 4-hydroxyquinoline
28% identity, 88% coverage of query (70.9 bits)
ortB / C1FW07 AKP thiolase β subunit (EC 2.3.1.263) from Unknown prokaryotic organism (see 2 papers)
ORTB_UNKP / C1FW07 2-amino-4-ketopentanoate thiolase beta subunit; AKP thiolase; AKPT; EC 2.3.1.263 from Unknown prokaryotic organism (see paper)
C1FW07 2-amino-4-oxopentanoate thiolase (subunit 2/2) (EC 2.3.1.263) from Acetoanaerobium sticklandii (see paper)
28% identity, 82% coverage of query (70.1 bits)
5tciH / P9WFX9 Crystal structure of tryptophan synthase from m. Tuberculosis - brd4592-bound form (see paper)
28% identity, 86% coverage of query (68.9 bits)
6u6cB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form
28% identity, 86% coverage of query (68.9 bits)
TRPB_MYCTU / P9WFX9 Tryptophan synthase beta chain; EC 4.2.1.20 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
28% identity, 86% coverage of query (68.6 bits)
SDS / P20132 L-serine dehydratase (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens (see 2 papers)
SDHL_HUMAN / P20132 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Homo sapiens (Human) (see 2 papers)
P20132 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens (see 3 papers)
28% identity, 78% coverage of query (68.6 bits)
6usaB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk1-bound form
28% identity, 86% coverage of query (68.6 bits)
6dweB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and brd0059-bound form
28% identity, 86% coverage of query (68.6 bits)
5ocwB Structure of mycobacterium tuberculosis tryptophan synthase in space group f222
28% identity, 86% coverage of query (68.6 bits)
6uapB Crystal structure of tryptophan synthase from m. Tuberculosis - open form with brd6309 bound
28% identity, 86% coverage of query (68.6 bits)
Q60142 tryptophan synthase (EC 4.2.1.20) from Bacillus subtilis (see paper)
29% identity, 84% coverage of query (68.2 bits)
7nbhAAA structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen
28% identity, 83% coverage of query (67.8 bits)
7nbgAAA structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
28% identity, 83% coverage of query (67.8 bits)
7nbcAAA / Q9GZT4 structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
28% identity, 83% coverage of query (67.4 bits)
Ile / b3772 threonine deaminase (EC 4.3.1.19) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ilvA / P04968 threonine deaminase (EC 4.3.1.19) from Escherichia coli (strain K12) (see 21 papers)
ILVA_ECOLI / P04968 L-threonine dehydratase biosynthetic IlvA; Threonine deaminase; EC 4.3.1.19 from Escherichia coli (strain K12) (see 4 papers)
P04968 threonine ammonia-lyase (EC 4.3.1.19) from Escherichia coli (see paper)
28% identity, 89% coverage of query (67.4 bits)
SRR / Q9GZT4 Serine racemase (EC 5.1.1.10) from Homo sapiens (see 4 papers)
SRR_HUMAN / Q9GZT4 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Homo sapiens (Human) (see 8 papers)
28% identity, 83% coverage of query (67.4 bits)
7nbfAAA structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen
28% identity, 83% coverage of query (67.4 bits)
7nbdAAA structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen
28% identity, 83% coverage of query (67.4 bits)
7nbcCCC structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen
28% identity, 83% coverage of query (67.4 bits)
1tdjA / P04968 Threonine deaminase (biosynthetic) from e. Coli (see paper)
28% identity, 89% coverage of query (67.0 bits)
7nbgDDD structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
28% identity, 83% coverage of query (66.2 bits)
1p5jA / P20132 Crystal structure analysis of human serine dehydratase (see paper)
27% identity, 78% coverage of query (65.9 bits)
A0A0U5AKI6 serine racemase (EC 5.1.1.18) from Crassostrea gigas (see paper)
28% identity, 78% coverage of query (65.9 bits)
Q04513 threonine ammonia-lyase (EC 4.3.1.19) from Corynebacterium glutamicum (see paper)
26% identity, 83% coverage of query (65.9 bits)
3l6bA X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor
28% identity, 83% coverage of query (65.9 bits)
A0A0U4MRI4 serine racemase (EC 5.1.1.18) from Penaeus monodon (see paper)
26% identity, 80% coverage of query (65.5 bits)
A0A220K8F1 L-3-cyanoalanine synthase (EC 4.4.1.9) from Aporia crataegi (see paper)
26% identity, 86% coverage of query (65.5 bits)
K1QH67 aspartate racemase (EC 5.1.1.13) from Crassostrea gigas (see paper)
27% identity, 77% coverage of query (64.7 bits)
CysM / b2421 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1; EC 4.4.1.28) from Escherichia coli K-12 substr. MG1655 (see 18 papers)
cysM / P16703 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1) from Escherichia coli (strain K12) (see 15 papers)
CYSM_ECOLI / P16703 Cysteine synthase B; CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B; EC 2.5.1.47 from Escherichia coli (strain K12) (see paper)
25% identity, 84% coverage of query (63.9 bits)
STDH_YEAST / P25379 Catabolic L-serine/threonine dehydratase; EC 4.3.1.17; EC 4.3.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
23% identity, 88% coverage of query (63.2 bits)
5xemA / Q8RE94 Crystal structure of a hydrogen sulfide-producing enzyme (fn1220) from fusobacterium nucleatum in complex with l-lanthionine-plp schiff base
25% identity, 82% coverage of query (63.2 bits)
6zspAAA serine racemase bound to atp and malonate.
28% identity, 83% coverage of query (63.2 bits)
5xenA Crystal structure of a hydrogen sulfide-producing enzyme (fn1220) from fusobacterium nucleatum in complex with l-serine-plp schiff base
25% identity, 82% coverage of query (63.2 bits)
5ey5B Lbcats
27% identity, 84% coverage of query (62.8 bits)
trpB / CAB55324.2 tryptophan synthase beta subunit from Rhizobium etli (see paper)
26% identity, 84% coverage of query (62.8 bits)
cdl / Q8L0X3 L-cysteine desulfhydrase (EC 4.4.1.1) from Fusobacterium nucleatum (see paper)
Q8L0X3 L-cysteine desulfidase (EC 4.4.1.28) from Fusobacterium nucleatum (see paper)
24% identity, 84% coverage of query (62.0 bits)
ILV / CAA10977.1 threonine deaminase from Blastobotrys adeninivorans (see paper)
28% identity, 79% coverage of query (61.6 bits)
7mfjBBB / T1KF23 7mfjBBB (see paper)
28% identity, 84% coverage of query (60.8 bits)
P09367 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Rattus norvegicus (Rat)
24% identity, 77% coverage of query (59.3 bits)
6hulB / P50383 Sulfolobus solfataricus tryptophan synthase ab complex (see paper)
26% identity, 85% coverage of query (59.3 bits)
SRR_SCHPO / O59791 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
O59791 serine racemase (EC 5.1.1.18) from Schizosaccharomyces pombe (see 2 papers)
24% identity, 78% coverage of query (58.5 bits)
2zr8A Crystal structure of modified serine racemase complexed with serine
24% identity, 78% coverage of query (58.5 bits)
2zpuA / O59791 Crystal structure of modified serine racemase from s.Pombe. (see paper)
24% identity, 78% coverage of query (58.5 bits)
1wtcA Crystal structure of s.Pombe serine racemase complex with amppcp
24% identity, 78% coverage of query (58.2 bits)
1v71A Crystal structure of s.Pombe serine racemase
24% identity, 78% coverage of query (58.2 bits)
6xo2A / T1KF23 Structural characterization of beta cyanoalanine synthase from tetranychus urticae (two-spotted spider mite) (see paper)
25% identity, 85% coverage of query (58.2 bits)
thadh / A4F2N8 L-threo-3-hydroxy aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. (see 2 papers)
LTHAD_PSESP / A4F2N8 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; L-THA DH; EC 4.3.1.16 from Pseudomonas sp. (see 2 papers)
A4F2N8 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. T62 (see paper)
24% identity, 83% coverage of query (57.0 bits)
2rkbA / Q96GA7 Serine dehydratase like-1 from human cancer cells (see paper)
27% identity, 87% coverage of query (55.8 bits)
SDSL / Q96GA7 Serine dehydratase-like (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens (see paper)
SDSL_HUMAN / Q96GA7 Serine dehydratase-like; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; SDHL; L-threonine dehydratase; TDH; Serine dehydratase 2; SDH 2; EC 4.3.1.19; EC 4.3.1.17 from Homo sapiens (Human) (see paper)
Q96GA7 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens (see paper)
27% identity, 87% coverage of query (55.8 bits)
6am8B Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9 with trp bound as e(aex2)
24% identity, 86% coverage of query (55.5 bits)
5vm5D Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9, with ser bound
25% identity, 86% coverage of query (55.1 bits)
5ixjD / Q8U093 Tryptophan synthase beta-subunit from pyrococcus furiosus with l- threonine non-covalently bound in the active site (see paper)
25% identity, 87% coverage of query (55.1 bits)
7rnpA Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9_h275e with 4-cl-trp non-covalently bound
24% identity, 86% coverage of query (54.7 bits)
6cuzA Engineered trpb from pyrococcus furiosus, pftrpb7e6 with (2s,3r)- ethylserine bound as the amino-acrylate
24% identity, 86% coverage of query (54.7 bits)
5dw0A Trpb from pyrococcus furiosus with l-serine bound as the external aldimine
24% identity, 87% coverage of query (54.7 bits)
6cutA Engineered holo trpb from pyrococcus furiosus, pftrpb7e6 with (2s,3s)- isopropylserine bound as the external aldimine
24% identity, 86% coverage of query (54.7 bits)
1ve5A / Q5SLL4 Crystal structure of t.Th. Hb8 threonine deaminase
29% identity, 89% coverage of query (54.3 bits)
5dw3A Tryptophan synthase beta-subunit from pyrococcus furiosus with product l-tryptophan non-covalently bound in the active site
24% identity, 86% coverage of query (53.9 bits)
4pcuA Crystal structure of delta516-525 e201s human cystathionine beta- synthase with adomet
24% identity, 82% coverage of query (53.9 bits)
SRR_MOUSE / Q9QZX7 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Mus musculus (Mouse) (see 6 papers)
27% identity, 83% coverage of query (53.9 bits)
5t6mA Structure of the tryptophan synthase b-subunit from pyroccus furiosus with b-methyltryptophan non-covalently bound
25% identity, 86% coverage of query (53.5 bits)
SRR_RAT / Q76EQ0 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Rattus norvegicus (Rat) (see 3 papers)
Q76EQ0 serine racemase (EC 5.1.1.18) from Rattus norvegicus (see 6 papers)
26% identity, 83% coverage of query (53.1 bits)
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