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Searching for up to 100 curated homologs for WP_078429048.1 NCBI__GCF_002019605.1:WP_078429048.1 (580 a.a.)

Found high-coverage hits (≥70%) to 37 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

pgcA / P18159 α-phosphoglucomutase (EC 5.4.2.2) from Bacillus subtilis (strain 168) (see paper)
PGCA_BACSU / P18159 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
    65% identity, 100% coverage of query (783 bits)

pgmA / CAB96418.1 phosphoglucomutase from Streptococcus thermophilus (see paper)
    49% identity, 100% coverage of query (567 bits)

PGCA_STAA8 / Q2FVC1 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
    41% identity, 90% coverage of query (373 bits)

PGM2 / Q96G03 phosphoglucomutase-2 (EC 5.4.2.2; EC 5.4.2.7) from Homo sapiens (see 2 papers)
PGM2_HUMAN / Q96G03 Phosphopentomutase; Glucose phosphomutase 2; Phosphodeoxyribomutase; Phosphoglucomutase-2; EC 5.4.2.7; EC 5.4.2.2 from Homo sapiens (Human) (see 2 papers)
    34% identity, 89% coverage of query (288 bits)

C6L2F4 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Toxoplasma gondii (see paper)
    33% identity, 97% coverage of query (283 bits)

PGM2_MOUSE / Q7TSV4 Phosphopentomutase; Glucose phosphomutase 2; Phosphodeoxyribomutase; Phosphoglucomutase-1; Phosphoglucomutase-2; PGM 2; EC 5.4.2.7; EC 5.4.2.2 from Mus musculus (Mouse) (see paper)
    32% identity, 93% coverage of query (281 bits)

PGM3_SCHPO / O74478 Probable phosphoribomutase; PRM; Phosphoglucomutase 3 homolog; PGM 3 homolog; EC 5.4.2.7 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    34% identity, 95% coverage of query (281 bits)

PGM2L_MOUSE / Q8CAA7 Glucose 1,6-bisphosphate synthase; Phosphoglucomutase-2-like 1; EC 2.7.1.106 from Mus musculus (Mouse) (see paper)
    33% identity, 93% coverage of query (275 bits)

PGM2L_HUMAN / Q6PCE3 Glucose 1,6-bisphosphate synthase; PMMLP; Phosphoglucomutase-2-like 1; EC 2.7.1.106 from Homo sapiens (Human) (see 3 papers)
    34% identity, 93% coverage of query (274 bits)

PGM3_YEAST / Q03262 Phosphoribomutase; PRM; Phosphoglucomutase 3; PGM 3; EC 5.4.2.7 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
    31% identity, 90% coverage of query (221 bits)

Build an alignment

Build an alignment for WP_078429048.1 and 10 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

PH0923 / O58651 phosphomannose mutase (EC 5.4.2.8) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
1wqaA / O58651 Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
    28% identity, 91% coverage of query (109 bits)

P74027 glucose-1,6-bisphosphate synthase from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    25% identity, 90% coverage of query (108 bits)

celB / AAA21561.1 phosphoglucomutase from Komagataeibacter xylinus (see paper)
    27% identity, 87% coverage of query (99.4 bits)

PGMMM_THEKO / Q68BJ6 Phosphoglucomutase/phosphomannomutase; PGM/PMM; EC 5.4.2.2; EC 5.4.2.8 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    26% identity, 82% coverage of query (98.6 bits)

A0A0H3NJ17 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
Q8ZQW9 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    25% identity, 87% coverage of query (82.4 bits)

2fuvA / Q8ZQW9 Phosphoglucomutase from salmonella typhimurium.
    25% identity, 87% coverage of query (82.4 bits)

Blu / b0688 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 11 papers)
pgm / P36938 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli (strain K12) (see 11 papers)
PGM_ECOLI / P36938 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Escherichia coli (strain K12) (see 2 papers)
pgm / GB|ABB65241.1 phosphoglucomutase; EC 5.4.2.2 from Escherichia coli K12 (see 6 papers)
    27% identity, 73% coverage of query (81.3 bits)

GLMM_METMP / Q6LYB4 Phosphoglucosamine mutase; EC 5.4.2.10 from Methanococcus maripaludis (strain DSM 14266 / JCM 13030 / NBRC 101832 / S2 / LL) (see paper)
Q6LYB4 phosphoglucosamine mutase (EC 5.4.2.10) from Methanococcus maripaludis (see paper)
    26% identity, 78% coverage of query (77.8 bits)

pgmA / I6Y2G3 phosphoglucomutase (EC 5.4.2.2) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
I6Y2G3 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Mycobacterium tuberculosis (see paper)
    26% identity, 88% coverage of query (76.3 bits)

MANB_METJA / Q57842 Phosphomannomutase; PMM; Phosphoglucomutase; EC 5.4.2.8 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
    24% identity, 83% coverage of query (72.4 bits)

GLMM_BACSU / O34824 Phosphoglucosamine mutase; EC 5.4.2.10 from Bacillus subtilis (strain 168) (see 2 papers)
    25% identity, 88% coverage of query (70.5 bits)

A8N8Z1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Coprinopsis cinerea (see paper)
    24% identity, 87% coverage of query (70.1 bits)

7ojrA / O34824 Bacillus subtilis phosphoglucomutase glmm (phosphate bound) (see paper)
    25% identity, 88% coverage of query (70.1 bits)

7omlA Bacillus subtilis phosphoglucomutase glmm (metal bound)
    25% identity, 88% coverage of query (70.1 bits)

A0A2H5BEG8 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Ganoderma lucidum (see paper)
    25% identity, 72% coverage of query (69.3 bits)

AGM / Q868I7 phosphoacetylglucosamine mutase (EC 5.4.2.3) from Giardia intestinalis (see 3 papers)
    23% identity, 83% coverage of query (67.8 bits)

Q980S1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2); phosphomannomutase (EC 5.4.2.8) from Saccharolobus solfataricus (see paper)
    25% identity, 77% coverage of query (67.0 bits)

PGM_DROME / Q9VUY9 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Drosophila melanogaster (Fruit fly) (see paper)
    24% identity, 87% coverage of query (58.5 bits)

4hjhA Iodide sad phased crystal structure of a phosphoglucomutase from brucella melitensis complexed with glucose-6-phosphate
    23% identity, 87% coverage of query (56.6 bits)

PGM1 / P36871 phosphoglucomutase-1 (EC 5.4.2.2) from Homo sapiens (see 3 papers)
PGM1_HUMAN / P36871 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Homo sapiens (Human) (see 8 papers)
P36871 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Homo sapiens (see 4 papers)
    24% identity, 75% coverage of query (55.5 bits)

PGM1_RABIT / P00949 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Oryctolagus cuniculus (Rabbit) (see 3 papers)
    24% identity, 75% coverage of query (52.8 bits)

3pmgA Structure of rabbit muscle phosphoglucomutase at 2.4 angstroms resolution. Use of freezing point depressant and reduced temperature to enhance diffractivity
    24% identity, 75% coverage of query (52.8 bits)

1c4gA Phosphoglucomutase vanadate based transition state analog complex
    24% identity, 75% coverage of query (52.8 bits)

1c47A Binding driven structural changes in crystaline phosphoglucomutase associated with chemical reaction
    24% identity, 75% coverage of query (52.8 bits)

6snoA / P36871 Crystal structures of human pgm1 isoform 2 (see paper)
    24% identity, 75% coverage of query (52.4 bits)

5jn5A Crystal structure of the d263y missense variant of human pgm1
    24% identity, 75% coverage of query (51.2 bits)

7s0wB / P36871 Crystal structure of the t337m variant of human pgm-1 (see paper)
    24% identity, 72% coverage of query (49.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory