Searching for up to 100 curated homologs for WP_078715671.1 NCBI__GCF_900167125.1:WP_078715671.1 (437 a.a.)
Found high-coverage hits (≥70%) to 91 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
G8XQY5 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Streptomyces diastaticus (see paper)
53% identity, 97% coverage of query (479 bits)
P9WPD5 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Mycobacterium tuberculosis (see paper)
52% identity, 98% coverage of query (474 bits)
P9WPD5 Citrate synthase 1; EC 2.3.3.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
52% identity, 98% coverage of query (474 bits)
2h12B / P20901 Structure of acetobacter aceti citrate synthase complexed with oxaloacetate and carboxymethyldethia coenzyme a (cmx) (see paper)
49% identity, 97% coverage of query (435 bits)
aarA / P20901 citrate synthase monomer (EC 2.3.3.3) from Acetobacter aceti (see 2 papers)
49% identity, 97% coverage of query (432 bits)
ccsA / AAB97876.1 citrate synthase from Rhizobium tropici (see paper)
49% identity, 97% coverage of query (432 bits)
pcsA / CAA84274.1 citrate synthase from Rhizobium tropici (see paper)
48% identity, 97% coverage of query (418 bits)
A0A0H3C985 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Caulobacter vibrioides (see paper)
45% identity, 97% coverage of query (417 bits)
4jaeA / P0ABH7 Structural determination of the a50t:s279g:s280k:v281k:k282e:h283n variant of citrate synthase from e. Coli complexed with s- carboxymethyl-coa (see paper)
47% identity, 95% coverage of query (400 bits)
4jagA Structural determination of the a50t:s279g:s280k:v281k:k282e:h283n variant of citrate synthase from e. Coli complexed with oxaloacetate
47% identity, 95% coverage of query (400 bits)
GluT / b0720 citrate synthase (EC 2.3.3.16; EC 2.3.3.1) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gltA / P0ABH7 citrate synthase (EC 2.3.3.3) from Escherichia coli (strain K12) (see 45 papers)
P0ABH7 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Escherichia coli (see 2 papers)
46% identity, 96% coverage of query (397 bits)
P0ABH7 Citrate synthase; EC 2.3.3.16 from Escherichia coli (strain K12)
46% identity, 96% coverage of query (397 bits)
1owbA Three dimensional structure analysis of the variant r109l nadh complex of type ii citrate synthase from e. Coli
46% identity, 95% coverage of query (394 bits)
CISY_PSEAE / P14165 Citrate synthase; EC 2.3.3.16 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
45% identity, 97% coverage of query (391 bits)
1nxgA The f383a variant of type ii citrate synthase complexed with nadh
46% identity, 95% coverage of query (391 bits)
4tvmA / P9WPD5 Structure of citrate synthase from mycobacterium tuberculosis (see paper)
45% identity, 96% coverage of query (377 bits)
CISYC_DICDI / Q86AV6 Citrate synthase; EC 2.3.3.16 from Dictyostelium discoideum (Social amoeba) (see paper)
42% identity, 98% coverage of query (369 bits)
CISYP_DICDI / Q8MQU6 Citrate synthase, peroxisomal; EC 2.3.3.16 from Dictyostelium discoideum (Social amoeba) (see paper)
42% identity, 98% coverage of query (363 bits)
CISY3_ARATH / Q9SJH7 Citrate synthase 3, peroxisomal; EC 2.3.3.16 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
41% identity, 98% coverage of query (357 bits)
CISY2_ARATH / Q9LXS6 Citrate synthase 2, peroxisomal; EC 2.3.3.16 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
41% identity, 95% coverage of query (354 bits)
3msuB / Q5NIJ6 Crystal structure of citrate synthase from francisella tularensis
44% identity, 95% coverage of query (353 bits)
3msuA Crystal structure of citrate synthase from francisella tularensis
43% identity, 95% coverage of query (335 bits)
CISY1_ARATH / Q9LXS7 Citrate synthase 1, peroxisomal; EC 2.3.3.16 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
41% identity, 91% coverage of query (326 bits)
gltA / P56062 citrate synthase monomer (EC 2.3.3.3) from Helicobacter pylori (strain ATCC 700392 / 26695) (see 2 papers)
40% identity, 92% coverage of query (320 bits)
A8YCJ7 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Microcystis aeruginosa (see paper)
37% identity, 88% coverage of query (251 bits)
Q59977 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Synechocystis sp. PCC 6803 (see paper)
36% identity, 88% coverage of query (246 bits)
Q9R6Y4 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
37% identity, 88% coverage of query (244 bits)
8bp7E / Q31QM5 Citrate-bound hexamer of synechococcus elongatus citrate synthase (see paper)
36% identity, 88% coverage of query (236 bits)
Q8ZWP2 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Pyrobaculum aerophilum (see paper)
36% identity, 90% coverage of query (234 bits)
6abyA / A4YGX6 Crystal structure of citrate synthase (msed_1522) from metallosphaera sedula in complex with oxaloacetate (see paper)
35% identity, 87% coverage of query (227 bits)
A4YGX6 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Metallosphaera sedula (see 2 papers)
35% identity, 87% coverage of query (227 bits)
Q974S5 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Sulfurisphaera tokodaii (see paper)
36% identity, 87% coverage of query (227 bits)
6abxA Crystal structure of citrate synthase (msed_1522) from metallosphaera sedula in complex with citrate
35% identity, 87% coverage of query (227 bits)
Q5SIM6 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Thermus thermophilus (see paper)
35% identity, 86% coverage of query (219 bits)
1iomA / Q5SIM6 Crystal structure of citrate synthase from thermus thermophilus hb8 (see paper)
35% identity, 86% coverage of query (219 bits)
CISY_SACS2 / P80148 Citrate synthase; EC 2.3.3.16 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
P80148 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Saccharolobus solfataricus (see 4 papers)
32% identity, 87% coverage of query (218 bits)
6abwA / A4YDF6 Crystal structure of citrate synthase (msed_0281) from metallosphaera sedula in complex with acetyl-coa (see paper)
33% identity, 86% coverage of query (218 bits)
1ixeA Crystal structure of citrate synthase from thermus thermophilus hb8
34% identity, 86% coverage of query (218 bits)
ORYE_ASPOR / Q2TXF1 Citrate synthase-like protein oryE; Oryzines biosynthesis cluster protein E; EC 2.3.3.- from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) (see paper)
32% identity, 87% coverage of query (212 bits)
1aj8A / Q53554 Citrate synthase from pyrococcus furiosus (see paper)
32% identity, 86% coverage of query (207 bits)
Q53554 citrate (Si)-synthase (EC 2.3.3.1) from Pyrococcus furiosus (see paper)
32% identity, 86% coverage of query (207 bits)
CISY_HALVD / D4GS06 Citrate synthase; EC 2.3.3.16 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
D4GS06 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Haloferax volcanii (see paper)
32% identity, 86% coverage of query (206 bits)
Q96ZM7 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Sulfurisphaera tokodaii (see paper)
32% identity, 87% coverage of query (204 bits)
PRPC1_CORGL / Q8NSH7 2-methylcitrate synthase 1; 2-MCS; MCS; Citrate synthase 1; CS; EC 2.3.3.5; EC 2.3.3.16 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see paper)
Q8NSH7 2-methylcitrate synthase (EC 2.3.3.5) from Corynebacterium glutamicum (see paper)
30% identity, 87% coverage of query (197 bits)
CISY_BACSU / P39119 Citrate synthase 1; Citrate synthase I; EC 2.3.3.16 from Bacillus subtilis (strain 168) (see paper)
33% identity, 85% coverage of query (193 bits)
2c6xA / P39119 Structure of bacillus subtilis citrate synthase
33% identity, 85% coverage of query (192 bits)
P39120 Citrate synthase 2; Citrate synthase II; EC 2.3.3.16 from Bacillus subtilis (strain 168)
33% identity, 89% coverage of query (192 bits)
citA / CAA74489.1 Citrate synthase I from Bacillus subtilis (see 3 papers)
33% identity, 85% coverage of query (191 bits)
YahS / b0333 2-methylcitrate synthase (EC 2.3.3.5) from Escherichia coli K-12 substr. MG1655 (see 11 papers)
prpC / P31660 2-methylcitrate synthase (EC 2.3.3.5) from Escherichia coli (strain K12) (see 9 papers)
PRPC_ECOLI / P31660 2-methylcitrate synthase; 2-MCS; MCS; (2S,3S)-2-methylcitrate synthase; Citrate synthase; EC 2.3.3.5; EC 2.3.3.16 from Escherichia coli (strain K12) (see 7 papers)
P31660 2-methylcitrate synthase (EC 2.3.3.5) from Escherichia coli (see 4 papers)
prpC / GB|AP_000985.1 2-methylcitrate synthase; EC 2.3.3.5 from Escherichia coli K12 (see 4 papers)
30% identity, 87% coverage of query (189 bits)
Pf6N2E2_6062 2-methylcitrate synthase (EC 2.3.3.5) from Pseudomonas fluorescens FW300-N2E2
31% identity, 84% coverage of query (188 bits)
prpC / Q56063 2-methylcitrate synthase (EC 2.3.3.5) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
PRPC_SALTY / Q56063 2-methylcitrate synthase; 2-MCS; mcs; Citrate synthase; EC 2.3.3.5; EC 2.3.3.16 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
Q56063 2-methylcitrate synthase (EC 2.3.3.5) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
31% identity, 87% coverage of query (187 bits)
citZ / Q5UZI9 citrate synthase (EC 2.3.3.3) from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (see paper)
31% identity, 86% coverage of query (187 bits)
MFR3_PHOSM / A0A3G1DJJ8 Citrate synthase-like protein; Squalestatin S1 biosynthesis cluster protein R3; EC 2.3.3.- from Phoma sp. (strain ATCC 20986 / MF5453) (see 4 papers)
33% identity, 86% coverage of query (187 bits)
Q8X694 2-methylcitrate synthase (EC 2.3.3.5) from Escherichia coli (see paper)
30% identity, 87% coverage of query (185 bits)
Q9I5E3 2-methylcitrate synthase (EC 2.3.3.5) from Pseudomonas aeruginosa (see paper)
31% identity, 87% coverage of query (185 bits)
6s87D / Q9I5E3 Crystal structure of 2-methylcitrate synthase (prpc) from pseudomonas aeruginosa in complex with oxaloacetate.
31% identity, 84% coverage of query (185 bits)
Q2Z1A8 2-methylcitrate synthase (EC 2.3.3.5) from Cupriavidus necator (see paper)
31% identity, 87% coverage of query (183 bits)
PRPC_CUPNE / Q937N9 2-methylcitrate synthase; 2-MCS; MCS; Citrate synthase; EC 2.3.3.5; EC 2.3.3.16 from Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha) (see paper)
Q937N9 2-methylcitrate synthase (EC 2.3.3.5) from Cupriavidus metallidurans (see 2 papers)
31% identity, 87% coverage of query (181 bits)
PRPC2_CORGL / Q8NSL1 2-methylcitrate synthase 2; 2-MCS; MCS; Citrate synthase 2; CS; EC 2.3.3.5; EC 2.3.3.16 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see paper)
Q8NSL1 2-methylcitrate synthase (EC 2.3.3.5) from Corynebacterium glutamicum (see paper)
31% identity, 85% coverage of query (178 bits)
Build an alignment for WP_078715671.1 and 59 homologs with ≥ 30% identity
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2ifcC / P21553 The structure of the binary complex of oxalateacetate with citrate synthase from the thermophilic archaeon thermolasma acidophilum
29% identity, 86% coverage of query (178 bits)
4yboB Structure of citrate synthase from the thermoacidophilic euryarchaeon thermolasma acidophilum
29% identity, 86% coverage of query (178 bits)
PRPC_ABDS2 / O34002 2-methylcitrate synthase; 2-MCS; MCS; Citrate synthase; EC 2.3.3.5; EC 2.3.3.16 from Antarctic bacterium DS2-3R (see 3 papers)
O34002 citrate (Si)-synthase (EC 2.3.3.1) from antarctic bacterium DS2-3R (see paper)
31% identity, 87% coverage of query (177 bits)
1a59A / O34002 Cold-active citrate synthase (see paper)
31% identity, 87% coverage of query (177 bits)
2r9eA The structure of the binary complex of citryl dethia coa and citrate synthase from the thermophilic archaeonthermoplasma acidophilum
29% identity, 85% coverage of query (176 bits)
2r26A The structure of the ternary complex of carboxymethyl coenzyme a and oxalateacetate with citrate synthase from the thermophilic archaeonthermoplasma acidophilum
29% identity, 85% coverage of query (176 bits)
PRPC_MYCTE / H8F0D7 2-methylcitrate synthase; 2-MCS; MCS; Citrate synthase; CS; EC 2.3.3.5; EC 2.3.3.16 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) (see paper)
PRPC_MYCTU / I6Y9Q3 2-methylcitrate synthase; 2-MCS; MCS; Citrate synthase; EC 2.3.3.5; EC 2.3.3.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
31% identity, 85% coverage of query (169 bits)
8gi7A C143a variant of citrate synthase (cita) in mycobacterium tuberculosis
28% identity, 85% coverage of query (134 bits)
8glbD / P9WPD3 Selenomethionine derivatized citrate synthase (cita) in mycobacterium tuberculosis with pyruvate (see paper)
28% identity, 85% coverage of query (134 bits)
8gmiA Citrate synthase (cita) in mycobacterium tuberculosis modified by ebselen at c143 residue
28% identity, 85% coverage of query (134 bits)
2ctsA Crystallographic refinement and atomic models of two different forms of citrate synthase at 2.7 and 1.7 angstroms resolution
26% identity, 86% coverage of query (112 bits)
3enjA Structure of pig heart citrate synthase at 1.78 a resolution
26% identity, 86% coverage of query (112 bits)
CISY_PIG / P00889 Citrate synthase, mitochondrial; Citrate (Si)-synthase; EC 2.3.3.1 from Sus scrofa (Pig) (see paper)
P00889 citrate (Si)-synthase (EC 2.3.3.1); citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Sus scrofa (see 3 papers)
26% identity, 86% coverage of query (111 bits)
Q29RK1 Citrate synthase, mitochondrial; Citrate (Si)-synthase; EC 2.3.3.1 from Bos taurus (Bovine)
26% identity, 86% coverage of query (111 bits)
6ctsA Proposed mechanism for the condensation reaction of citrate synthase. 1.9-angstroms structure of the ternary complex with oxaloacetate and carboxymethyl coenzyme a
26% identity, 86% coverage of query (109 bits)
3cscA Structure of ternary complexes of citrate synthase with d-and l- malate: mechanistic implications
26% identity, 86% coverage of query (109 bits)
2cscA Structure of ternary complexes of citrate synthase with d-and l- malate: mechanistic implications
26% identity, 86% coverage of query (109 bits)
1cscA Structure of ternary complexes of citrate synthase with d-and l- malate: mechanistic implications
26% identity, 86% coverage of query (109 bits)
8gr9A / P08679 Crystal structure of peroxisomal citrate synthase (cit2) from saccharomyces cerevisiae in complex with oxaloacetate and coenzyme-a (see paper)
26% identity, 80% coverage of query (107 bits)
CS / O75390 citrate synthase monomer (EC 2.3.3.3) from Homo sapiens (see 4 papers)
CISY_HUMAN / O75390 Citrate synthase, mitochondrial; Citrate (Si)-synthase; EC 2.3.3.1 from Homo sapiens (Human) (see 3 papers)
O75390 citrate (Si)-synthase (EC 2.3.3.1) from Homo sapiens (see 2 papers)
25% identity, 86% coverage of query (107 bits)
CISY2_YEAST / P08679 Citrate synthase, peroxisomal; EC 2.3.3.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
26% identity, 80% coverage of query (105 bits)
1cssA Alpha-fluoro acid and alpha-fluoro amide analogs of acetyl-coa as inhibitors of of citrate synthase: effect of pka matching on binding affinity and hydrogen bond length
25% identity, 87% coverage of query (104 bits)
1csrA Alpha-fluoro acid and alpha-fluoro amide analogs of acetyl-coa as inhibitors of of citrate synthase: effect of pka matching on binding affinity and hydrogen bond length
25% identity, 87% coverage of query (104 bits)
1csiA A very short hydrogen bond provides only moderate stabilization of an enzyme: inhibitor complex of citrate synthase
25% identity, 87% coverage of query (104 bits)
1cshA A very short hydrogen bond provides only moderate stabilization of an enzyme: inhibitor complex of citrate synthase
25% identity, 87% coverage of query (104 bits)
1amzA Chicken citrate synthase complex with nitromethylde-coa and malate
25% identity, 87% coverage of query (104 bits)
1al6A Chicken citrate synthase complex with n-hydroxyamido-coa and oxaloacetate
25% identity, 87% coverage of query (104 bits)
6cscA / P23007 Chicken citrate synthase complex with trifluoroacetonyl-coa and citrate
25% identity, 87% coverage of query (103 bits)
CISY1_YEAST / P00890 Citrate synthase, mitochondrial; EC 2.3.3.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
P00890 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Saccharomyces cerevisiae (see paper)
26% identity, 82% coverage of query (101 bits)
5uquB Crystal structure of mutant 2-methylcitrate synthase (mcsag352a) from aspergillus fumigatus
26% identity, 74% coverage of query (88.2 bits)
5uqrA / B0YD89 Crystal structure of 2-methylcitrate synthase from aspergillus fumigatus (see paper)
26% identity, 74% coverage of query (87.8 bits)
5uqrB Crystal structure of 2-methylcitrate synthase from aspergillus fumigatus
26% identity, 74% coverage of query (87.8 bits)
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Lawrence Berkeley National Laboratory