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Searching for up to 100 curated homologs for WP_084936388.1 NCBI__GCF_002095475.1:WP_084936388.1 (448 a.a.)

Found high-coverage hits (≥70%) to 38 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

GudX / b2788 glucarate dehydratase-related protein from Escherichia coli K-12 substr. MG1655 (see 2 papers)
GUDX_ECOLI / Q46915 Glucarate dehydratase-related protein; GDH-RP; GlucDRP; EC 4.2.1.- from Escherichia coli (strain K12) (see paper)
gudX / RF|NP_417268 glucarate dehydratase-related protein from Escherichia coli K12
    82% identity, 99% coverage of query (754 bits)

3n6hB / A6VQF6 Crystal structure of mandelate racemase/muconate lactonizing protein from actinobacillus succinogenes 130z complexed with magnesium/sulfate
    69% identity, 99% coverage of query (625 bits)

3pfrA Crystal structure of d-glucarate dehydratase related protein from actinobacillus succinogenes complexed with d-glucarate
    69% identity, 98% coverage of query (617 bits)

YgcX / b2787 D-glucarate dehydratase (EC 4.2.1.40) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
gudD / P0AES2 D-glucarate dehydratase (EC 4.2.1.40) from Escherichia coli (strain K12) (see 5 papers)
GUDD_ECOLI / P0AES2 Glucarate dehydratase; GDH; GlucD; D-glucarate dehydratase; EC 4.2.1.40 from Escherichia coli (strain K12) (see 3 papers)
gudD / RF|NP_417267 glucarate dehydratase; EC 4.2.1.40 from Escherichia coli K12 (see 8 papers)
    65% identity, 99% coverage of query (602 bits)

1ec9D / P0AES2 E. Coli glucarate dehydratase bound to xylarohydroxamate (see paper)
    65% identity, 98% coverage of query (601 bits)

1ecqA E. Coli glucarate dehydratase bound to 4-deoxyglucarate
    65% identity, 98% coverage of query (601 bits)

1ec8A E. Coli glucarate dehydratase bound to product 2,3-dihydroxy-5-oxo- hexanedioate
    65% identity, 98% coverage of query (601 bits)

1jctA Glucarate dehydratase, n341l mutant orthorhombic form
    65% identity, 98% coverage of query (597 bits)

gudD / Q6FFQ2 D-glucarate dehydratase subunit (EC 4.2.1.40) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
GUDD_ACIAD / Q6FFQ2 Glucarate dehydratase; GDH; GlucD; EC 4.2.1.40 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
Q6FFQ2 glucarate dehydratase (EC 4.2.1.40) from Acinetobacter baylyi (see paper)
    63% identity, 98% coverage of query (588 bits)

gudD / P42206 D-glucarate dehydratase subunit (EC 4.2.1.40) from Pseudomonas putida (see paper)
GUDD_PSEPU / P42206 Glucarate dehydratase; GDH; GlucD; EC 4.2.1.40 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
    67% identity, 98% coverage of query (580 bits)

3p0wB / B2UIZ1 Crystal structure of d-glucarate dehydratase from ralstonia solanacearum complexed with mg and d-glucarate
    64% identity, 98% coverage of query (563 bits)

3nxlC / Q39KL8 Crystal structure of glucarate dehydratase from burkholderia cepacia complexed with magnesium
    63% identity, 98% coverage of query (528 bits)

3nfuA / Q1QUN0 Crystal structure of probable glucarate dehydratase from chromohalobacter salexigens dsm 3043 complexed with magnesium
    58% identity, 98% coverage of query (501 bits)

4it1D / Q3KB33 Crystal structure of enolase pfl01_3283 (target efi-502286) from pseudomonas fluorescens pf0-1 with bound magnesium, potassium and tartrate
    37% identity, 96% coverage of query (240 bits)

3va8A Crystal structure of enolase fg03645.1 (target efi-502278) from gibberella zeae ph-1 complexed with magnesium, formate and sulfate
    34% identity, 96% coverage of query (229 bits)

3vc6A / D6Y7Y6 Crystal structure of enolase tbis_1083(target efi-502310) from thermobispora bispora dsm 43833 complexed with magnesium and formate
    35% identity, 97% coverage of query (224 bits)

Build an alignment

Build an alignment for WP_084936388.1 and 16 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

araD / Q97U96 D-arabinonate dehydratase subunit (EC 4.2.1.5) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
ARAD_SACS2 / Q97U96 Arabinonate dehydratase; EC 4.2.1.5 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q97U96 Arabinonate dehydratase (EC 4.2.1.5) from Saccharolobus solfataricus (see paper)
    26% identity, 80% coverage of query (73.6 bits)

3cb3A / Q12GE3 Crystal structure of l-talarate dehydratase from polaromonas sp. Js666 complexed with mg and l-glucarate
    25% identity, 79% coverage of query (68.2 bits)

2og9A Crystal structure of mandelate racemase/muconate lactonizing enzyme from polaromonas sp. Js666
    25% identity, 79% coverage of query (68.2 bits)

5olcC / G0L7B8 Crystal structure of the 3,6-anhydro-d-galactonate cycloisomerase from zobellia galactanivorans (see paper)
    23% identity, 85% coverage of query (66.2 bits)

2ps2A / Q2U1E8 Crystal structure of putative mandelate racemase/muconate lactonizing enzyme from aspergillus oryzae
    23% identity, 90% coverage of query (64.3 bits)

TAGAD_SALTY / Q8ZL58 L-talarate/galactarate dehydratase; TalrD/GalrD; StTGD; EC 4.2.1.156; EC 4.2.1.42 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
Q8ZL58 L-talarate dehydratase (EC 4.2.1.156); galactarate dehydratase (EC 4.2.1.42) from Salmonella enterica subsp. enterica serovar Typhimurium (see 2 papers)
    24% identity, 81% coverage of query (63.2 bits)

2pp1A / Q8ZL58 Crystal structure of l-talarate/galactarate dehydratase from salmonella typhimurium lt2 liganded with mg and l-lyxarohydroxamate (see paper)
    24% identity, 81% coverage of query (63.2 bits)

3sjnA / A8H9D1 Crystal structure of enolase spea_3858 (target efi-500646) from shewanella pealeana with magnesium bound
    24% identity, 81% coverage of query (62.4 bits)

3fcpA / A6T9N5 Crystal structure of muconate lactonizing enzyme from klebsiella pneumoniae
    25% identity, 83% coverage of query (61.6 bits)

2pp3A Crystal structure of l-talarate/galactarate dehydratase mutant k197a liganded with mg and l-glucarate
    24% identity, 81% coverage of query (60.8 bits)

3ozmA / A0A0H3LT39 Crystal structure of enolase superfamily member from bordetella bronchiseptica complexed with mg, m-xylarate and l-lyxarate
    25% identity, 82% coverage of query (60.5 bits)

3ozmD Crystal structure of enolase superfamily member from bordetella bronchiseptica complexed with mg, m-xylarate and l-lyxarate
    25% identity, 82% coverage of query (60.1 bits)

3op2A Crystal structure of putative mandelate racemase from bordetella bronchiseptica rb50 complexed with 2-oxoglutarate/phosphate
    25% identity, 82% coverage of query (57.4 bits)

4m0xA / Q8G9L1 Crystal structure of 2-chloromuconate cycloisomerase from rhodococcus opacus 1cp (see paper)
    27% identity, 83% coverage of query (56.2 bits)

catB / BAE46388.1 cis,cis-muconate cycloisomerase from Rhodococcus sp. AN-22 (see paper)
    24% identity, 83% coverage of query (53.1 bits)

CH_124262 putative galactonate dehydratase from Magnaporthe grisea 70-15 (see 2 papers)
    25% identity, 81% coverage of query (51.2 bits)

4h83F / A4AFX2 Crystal structure of mandelate racemase/muconate lactonizing enzyme (efi target:502127)
    22% identity, 90% coverage of query (51.2 bits)

2qq6B / Q1AYK7 Crystal structure of mandelate racemase/muconate lactonizing enzyme- like protein from rubrobacter xylanophilus dsm 9941
    24% identity, 77% coverage of query (50.8 bits)

NSAR_THET8 / Q5SJX8 N-succinylamino acid racemase; NSAR; N-acylamino acid racemase; NAAAR; o-succinylbenzoate synthase; OSB synthase; OSBS; EC 5.1.1.-; EC 4.2.1.113 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 2 papers)
    22% identity, 75% coverage of query (49.7 bits)

3no1A Crystal structure of mandelate racemase/muconate lactonizing enzyme from a marine actinobacterium in complex with magnesium
    22% identity, 77% coverage of query (48.5 bits)

4gmeC Crystal structure of mannonate dehydratase (target efi-502209) from caulobacter crescentus cb15 complexed with magnesium and d-mannonate
    23% identity, 88% coverage of query (46.2 bits)

MAND2_CAUVC / Q9AAR4 D-mannonate dehydratase CC0532; ManD; EC 4.2.1.8 from Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus) (see paper)
A0A0H3C643 mannonate dehydratase (EC 4.2.1.8) from Caulobacter vibrioides (see paper)
4gmeA / Q9AAR4 Crystal structure of mannonate dehydratase (target efi-502209) from caulobacter crescentus cb15 complexed with magnesium and d-mannonate
    23% identity, 88% coverage of query (46.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory