Searching for up to 100 curated homologs for WP_085984847.1 NCBI__GCF_000007345.1:WP_085984847.1 (328 a.a.)
Found high-coverage hits (≥70%) to 48 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
47% identity, 96% coverage of query (260 bits)
DRRA3_STRC4 / P0DXU7 Daunorubicin resistance ATP-binding protein DrrA3; EC 7.6.2.2 from Streptomyces coeruleorubidus (see paper)
39% identity, 95% coverage of query (214 bits)
DRRA_STRPE / P32010 Daunorubicin/doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.2 from Streptomyces peucetius (see 2 papers)
P32010 ABC-type xenobiotic transporter (EC 7.6.2.2) from Streptomyces peucetius (see paper)
TC 3.A.1.105.1 / P32010 DrrA, component of Daunorubicin, doxorubicin etc. (multidrug resistance) exporter, DrrAB from Streptomyces peucetius (see 2 papers)
38% identity, 94% coverage of query (214 bits)
DRRA1_STRC4 / P0DXG8 Daunorubicin resistance ATP-binding protein DrrA1; EC 7.6.2.2 from Streptomyces coeruleorubidus (see paper)
38% identity, 94% coverage of query (213 bits)
DRRA2_STRC4 / P0DXU5 Daunorubicin resistance ATP-binding protein DrrA2; EC 7.6.2.2 from Streptomyces coeruleorubidus (see paper)
35% identity, 97% coverage of query (202 bits)
LNRL_BACSU / P94440 Linearmycin resistance ATP-binding protein LnrL; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 2 papers)
34% identity, 94% coverage of query (194 bits)
TC 3.A.1.105.2 / Q53716 OleC4, component of Oleandomycin (drug resistance) exporter from Streptomyces antibioticus (see paper)
34% identity, 92% coverage of query (186 bits)
TC 3.A.1.105.3 / Q70J75 CmrA, component of The 4A-4E-O-dideacetyl-chromomycin A3 (biosynthetic precursor of chromomycin) exporter (may also export chromomycin and mithramycin from Streptomyces griseus subsp. griseus
38% identity, 93% coverage of query (185 bits)
DRRA_MYCTU / P9WQL9 Doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
37% identity, 93% coverage of query (185 bits)
TC 3.A.1.105.8 / Q7UE58 ABC-type multidrug transport system, ATPase component, component of ABC-2 transporter from Rhodopirellula baltica (strain SH1)
35% identity, 89% coverage of query (183 bits)
sagG / GI|23305059 ABC transporter, ATP-binding protein SagG from Streptococcus iniae (see paper)
33% identity, 94% coverage of query (181 bits)
nodI / GB|AAB16898.1 nodulation ATP-binding protein I from Rhizobium sp. N33 (see paper)
37% identity, 95% coverage of query (181 bits)
TC 3.A.1.102.1 / P50332 NodI, component of Lipooligosaccharide exporter (nodulation proteins, NodIJ) from Rhizobium galegae (see paper)
35% identity, 93% coverage of query (175 bits)
TC 3.A.1.132.1 / O30489 GldA, component of The GldAFG putative ABC transporter required for ratchet-type gliding motility; may function in secretion of a macromolecule such as an exopolysaccharide. (Agarwal et al., 1997; Hunnicutt et al., 2002; McBride and Zhu 2013). Soluble GldG homologues (no TMSs) are found in eukaryotes (e.g. intraflagellar protein transporter, IPT52 of Chlamydomonas reinhardtii; XP_001692161) from Cytophaga johnsonae (Flavobacterium johnsoniae) (see paper)
36% identity, 91% coverage of query (175 bits)
7roqA / O95477 Alternative structure of human abca1
35% identity, 86% coverage of query (166 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
35% identity, 87% coverage of query (162 bits)
7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
34% identity, 85% coverage of query (160 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
37% identity, 78% coverage of query (155 bits)
AB9A_ARATH / Q9FLT5 ABC transporter A family member 9; ABC transporter ABCA.9; AtABCA9; ABC2 homolog 11 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
32% identity, 93% coverage of query (151 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
31% identity, 87% coverage of query (141 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
32% identity, 77% coverage of query (140 bits)
ABCA3_RAT / A0A0G2K1Q8 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Rattus norvegicus (Rat) (see paper)
32% identity, 77% coverage of query (140 bits)
8y1pA / Q8IZY2 Cryo-em structure of human abca7 in dops-bound state
31% identity, 85% coverage of query (140 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
34% identity, 71% coverage of query (139 bits)
Build an alignment for WP_085984847.1 and 24 homologs with ≥ 30% identity
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ABCA2_MOUSE / P41234 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Mus musculus (Mouse) (see 5 papers)
27% identity, 94% coverage of query (134 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
27% identity, 94% coverage of query (133 bits)
TC 3.A.1.211.3 / Q9BZC7 Multidrug resistance pump, ABCA2 (ABC2) from Homo sapiens (Human) (see 6 papers)
ABCA2 / GI|55962682 ATP-binding cassette sub-family A member 2 from Homo sapiens
27% identity, 94% coverage of query (133 bits)
ABCA2_RAT / Q9ESR9 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Rattus norvegicus (Rat) (see 6 papers)
26% identity, 94% coverage of query (132 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp (see paper)
30% identity, 88% coverage of query (132 bits)
YbhF / b0794 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
ybhF / P0A9U1 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli (strain K12) (see 6 papers)
YBHF_ECOLI / P0A9U1 Probable multidrug ABC transporter ATP-binding protein YbhF from Escherichia coli (strain K12) (see paper)
ybhF / MB|P0A9U1 uncharacterized ABC transporter ATP-binding protein ybhF from Escherichia coli K12 (see paper)
29% identity, 94% coverage of query (131 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
28% identity, 98% coverage of query (125 bits)
TC 3.A.1.211.1 / P41233 The cholesterol/phospholipid flippase, ABC1 (called ABCA1 in humans; Tangier disease proteins; 2261 aas; sp: O95477). An amphipathic helical region of the N-terminal barrel of the phospholipid transfer protein (PLTP) is critical for ABCA1-dependent cholesterol efflux (Oram et al., 2008). PLTP helix 144-163 removes lipid domains formed by ABCA1, stabilizing ABCA1, interacting with phospholipids, and promoting phospholipid transfer by direct interactions with ABCA1. May transport sphingosine-1-phosphate (Kobayashi et al., 2009). May protect from cardiovascular disease and diabetes from Mus musculus (Mouse) (see 7 papers)
Abca1 ATP-binding cassette sub-family A member 1 from Mus musculus (see paper)
28% identity, 98% coverage of query (125 bits)
ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
29% identity, 90% coverage of query (121 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
27% identity, 98% coverage of query (119 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
28% identity, 71% coverage of query (114 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
27% identity, 88% coverage of query (113 bits)
ECSA_BACSU / P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.143.1 / P55339 ABC-type transporter ATP-binding protein EcsA, component of The exoprotein (including α-amylase) secretion system, EcsAB(C) (Leskelä et al., 1999). Also may play roles in sporulation, competence (Leskelä et al., 1996) and transformation using purified DNA (Takeno et al., 2011). An involvement of EcsC in transport is not established, but it is homologous to the C-terminus of the P-type ATPase, 3.A.3.31.2 from Bacillus subtilis (strain 168) (see 3 papers)
27% identity, 71% coverage of query (109 bits)
6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
27% identity, 70% coverage of query (103 bits)
5lilA / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
28% identity, 70% coverage of query (102 bits)
5lj7A / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
28% identity, 70% coverage of query (102 bits)
7o12B / P19844 Abc transporter nosdfy, amppnp-bound in gdn (see paper)
26% identity, 93% coverage of query (100 bits)
7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc
25% identity, 93% coverage of query (99.4 bits)
7chaI / Q9HVW1 Cryo-em structure of p.Aeruginosa mlafebd with amppnp (see paper)
27% identity, 77% coverage of query (91.7 bits)
MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
27% identity, 78% coverage of query (83.6 bits)
4q9iA P-glycoprotein cocrystallised with qz-ala
29% identity, 70% coverage of query (81.3 bits)
ABCB7_ORYLA / H2LNR5 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial from Oryzias latipes (Japanese rice fish) (Japanese killifish) (see paper)
26% identity, 75% coverage of query (80.9 bits)
8qcmA Abcg2 in complex with mz82 and 5d3 fab
29% identity, 70% coverage of query (79.0 bits)
8pxoA Abcg2 in complex with az99 and 5d3 fab
29% identity, 70% coverage of query (79.0 bits)
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Lawrence Berkeley National Laboratory