Searching for up to 100 curated homologs for WP_094506056.1 NCBI__GCF_002252445.1:WP_094506056.1 (287 a.a.)

Found high-coverage hits (≥70%) to 28 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

1ydnA / Q8YEF2 Crystal structure of the hmg-coa lyase from brucella melitensis, northeast structural genomics target lr35. (see paper)
    86% identity, 99% coverage of query (503 bits)

SM_b21125 Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Sinorhizobium meliloti 1021
    62% identity, 98% coverage of query (348 bits)

HMGC2_RAT / D4A5C3 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; EC 4.1.3.4 from Rattus norvegicus (Rat) (see paper)
    53% identity, 95% coverage of query (296 bits)

HMGCL_ARATH / O81027 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    54% identity, 95% coverage of query (290 bits)

HMGC2_HUMAN / Q8TB92 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; HMGCL-like 1; Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase; er-cHL; EC 4.1.3.4 from Homo sapiens (Human) (see 2 papers)
    51% identity, 95% coverage of query (286 bits)

HMGCL_RAT / P97519 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Rattus norvegicus (Rat) (see paper)
P97519 hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Rattus norvegicus (see paper)
    52% identity, 95% coverage of query (283 bits)

HMGCL_MOUSE / P38060 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Mus musculus (Mouse) (see paper)
    52% identity, 95% coverage of query (283 bits)

HMGCL / P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC 4.1.3.4) from Homo sapiens (see 9 papers)
HMGCL_HUMAN / P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Homo sapiens (Human) (see 18 papers)
P35914 hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Homo sapiens (see 4 papers)
    51% identity, 95% coverage of query (283 bits)

2cw6A / P35914 Crystal structure of human hmg-coa lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria (see paper)
    51% identity, 95% coverage of query (282 bits)

3mp3B Crystal structure of human lyase in complex with inhibitor hg-coa
    51% identity, 95% coverage of query (282 bits)

liuE / Q9I2A0 hydroxymethylglutaryl-CoA lyase subunit (EC 4.1.3.26; EC 4.1.3.4) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
LIUE_PSEAE / Q9I2A0 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase; HIHG-CoA lyase; HMG-CoA lyase; (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase; 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase; EC 4.1.3.26; EC 4.1.3.4 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9I2A0 3-Hydroxy-3-isohexenylglutaryl-CoA lyase (EC 4.1.3.26) from Pseudomonas aeruginosa PAO1 (see paper)
    52% identity, 94% coverage of query (279 bits)

3mp5B Crystal structure of human lyase r41m in complex with hmg-coa
    50% identity, 95% coverage of query (279 bits)

mvaB / P13703 hydroxymethylglutaryl-CoA lyase monomer (EC 4.1.3.4) from Pseudomonas mevalonii (see 8 papers)
mvaB / GB|AAA25895.1 hydroxymethylglutaryl-CoA lyase; EC 4.1.3.4 from Pseudomonas mevalonii (see paper)
    48% identity, 94% coverage of query (259 bits)

P13703 Hydroxymethylglutaryl-CoA lyase; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Pseudomonas mevalonii
    48% identity, 94% coverage of query (259 bits)

hlyA 3-hydroxy-3-methylglutaryl-coenzyme A lyase/3-methylglutaconyl-coenzyme A hydratase; EC 4.1.3.4; EC 4.2.1.18 from Emericella nidulans (see paper)
    48% identity, 94% coverage of query (244 bits)

HMGCL_BACSU / O34873 Hydroxymethylglutaryl-CoA lyase YngG; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Bacillus subtilis (strain 168) (see paper)
    47% identity, 94% coverage of query (242 bits)

6ndsA / A0A0D5YK08 Structure of an hmg-coa lyase from acenitobacter baumannii in complex with coenzyme a and 3-methylmalate
    39% identity, 94% coverage of query (208 bits)

CCL_CHLAA / A9WGE2 (R)-citramalyl-CoA lyase; EC 4.1.3.46 from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
    35% identity, 95% coverage of query (177 bits)

CA265_RS13115 Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Pedobacter sp. GW460-11-11-14-LB5
    30% identity, 93% coverage of query (127 bits)

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Build an alignment for WP_094506056.1 and 19 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

6ktqA / Q4J989 Crystal structure of catalytic domain of homocitrate synthase from sulfolobus acidocaldarius (sahcs(dram)) in complex with alpha- ketoglutarate/zn2+/coa (see paper)
    21% identity, 97% coverage of query (52.8 bits)

HOSA_SULAC / Q4J989 Homocitrate synthase; HCS; EC 2.3.3.14 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
Q4J989 homocitrate synthase (EC 2.3.3.14) from Sulfolobus acidocaldarius (see paper)
    21% identity, 97% coverage of query (52.4 bits)

3ivtB / Q9Y823 Homocitrate synthase lys4 bound to 2-og (see paper)
    23% identity, 80% coverage of query (51.6 bits)

HOSM_SCHPO / Q9Y823 Homocitrate synthase, mitochondrial; HCS; EC 2.3.3.14 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
lys4 / RF|NP_596458.1 homocitrate synthase (predicted); EC 2.3.3.14 from Schizosaccharomyces pombe (see 2 papers)
    23% identity, 80% coverage of query (51.2 bits)

LEU11_LEPIN / Q8F445 2-isopropylmalate synthase 1; Alpha-IPM synthase 1; Alpha-isopropylmalate synthase 1; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
    26% identity, 82% coverage of query (49.7 bits)

HOSA_SULTO / Q971S5 Homocitrate synthase; HCS; EC 2.3.3.14 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
    25% identity, 81% coverage of query (46.2 bits)

LYS20 / P48570 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
HOSC_YEAST / P48570 Homocitrate synthase, cytosolic isozyme; HCS; EC 2.3.3.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P48570 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (see 2 papers)
    21% identity, 80% coverage of query (46.2 bits)

5ks8D / Q1H157 Crystal structure of two-subunit pyruvate carboxylase from methylobacillus flagellatus (see paper)
    25% identity, 97% coverage of query (43.1 bits)

5ks8C / Q1H157 Crystal structure of two-subunit pyruvate carboxylase from methylobacillus flagellatus (see paper)
    25% identity, 97% coverage of query (42.7 bits)

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