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Searching for up to 100 curated homologs for WP_101586818.1 NCBI__GCF_900169175.1:WP_101586818.1 (498 a.a.)

Found high-coverage hits (≥70%) to 17 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PRPD2_CORGL / Q8NSL3 2-methylcitrate dehydratase 2; 2-MC dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see paper)
    70% identity, 95% coverage of query (676 bits)

PRPD1_CORGL / Q8NSH9 2-methylcitrate dehydratase 1; 2-MC dehydratase; EC 4.2.1.79 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see paper)
    68% identity, 93% coverage of query (647 bits)

PRPD_MYCTE / H8F0D6 2-methylcitrate dehydratase; 2-MC dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) (see paper)
    62% identity, 98% coverage of query (627 bits)

PRPD_MYCTU / O06582 2-methylcitrate dehydratase; 2-MC dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
    62% identity, 98% coverage of query (627 bits)

Build an alignment

Build an alignment for WP_101586818.1 and 4 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

PRPD_YEAST / Q12428 Probable 2-methylcitrate dehydratase; 2-MC dehydratase; (2S,3S)-2-methylcitrate dehydratase; EC 4.2.1.79 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    28% identity, 82% coverage of query (105 bits)

Q2L8W4 2-methylcitrate dehydratase (EC 4.2.1.79) from Toxoplasma gondii (see paper)
    27% identity, 88% coverage of query (105 bits)

PRPD_YARLI / Q6C354 2-methylcitrate dehydratase, mitochondrial; EC 4.2.1.79 from Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) (see 2 papers)
    27% identity, 73% coverage of query (102 bits)

prpD / P74840 2-methylcitrate dehydratase (EC 4.2.1.79) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
PRPD_SALTY / P74840 2-methylcitrate dehydratase; 2-MC dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
P74840 2-methylcitrate dehydratase (EC 4.2.1.79) from Salmonella enterica (see paper)
    26% identity, 80% coverage of query (90.5 bits)

PRPD_CUPNE / Q937N6 2-methylcitrate dehydratase; 2-MC dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha) (see paper)
    27% identity, 77% coverage of query (89.7 bits)

AcnC / b0334 2-methylcitrate dehydratase (EC 4.2.1.79) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
prpD / P77243 2-methylcitrate dehydratase (EC 4.2.1.79) from Escherichia coli (strain K12) (see 5 papers)
PRPD_ECOLI / P77243 2-methylcitrate dehydratase; 2-MC dehydratase; (2S,3S)-2-methylcitrate dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Escherichia coli (strain K12) (see 4 papers)
P77243 2-methylcitrate dehydratase (EC 4.2.1.79) from Escherichia coli (see 3 papers)
prpD / PDB|1SZQ 2-methylcitrate dehydratase; EC 4.2.1.79 from Escherichia coli K12 (see 4 papers)
    27% identity, 81% coverage of query (87.4 bits)

MMGE_BACSU / P45859 Citrate/2-methylcitrate dehydratase; EC 4.2.1.- from Bacillus subtilis (strain 168) (see 2 papers)
P45859 2-methylcitrate dehydratase (EC 4.2.1.79) from Bacillus subtilis (see 2 papers)
    26% identity, 75% coverage of query (85.1 bits)

PHII_FUNX7 / A0A348HAY4 Alkylcitrate dehydratase phiI; ACDH; Phomoidride biosynthesis cluster protein I; EC 4.2.1.- from Fungal sp. (strain ATCC 74256) (see 2 papers)
    25% identity, 88% coverage of query (66.2 bits)

IRG1_MOUSE / P54987 Cis-aconitate decarboxylase; CAD; Aconitate decarboxylase; Aconitate decarboxylase 1; Cis-aconitic acid decarboxylase; Immune-responsive gene 1 protein; EC 4.1.1.6 from Mus musculus (Mouse) (see 8 papers)
P54987 cis-aconitate decarboxylase (EC 4.1.1.6) from Mus musculus (see paper)
    25% identity, 81% coverage of query (58.2 bits)

TSTI_TALSN / B8MKZ4 Alkylcitrate dehydratase phiI; ACDH; Phomoidride biosynthesis cluster protein I; EC 4.2.1.- from Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum) (see 3 papers)
    22% identity, 75% coverage of query (55.8 bits)

6r6uA / A6NK06 Crystal structure of human cis-aconitate decarboxylase (see paper)
    23% identity, 81% coverage of query (53.1 bits)

ACOD1 / A6NK06 cis-aconitate decarboxylase (EC 4.1.1.6) from Homo sapiens (see 6 papers)
IRG1_HUMAN / A6NK06 Cis-aconitate decarboxylase; CAD; Aconitate decarboxylase; Aconitate decarboxylase 1; Cis-aconitic acid decarboxylase; Immune-responsive gene 1 protein; EC 4.1.1.6 from Homo sapiens (Human) (see 4 papers)
A6NK06 cis-aconitate decarboxylase (EC 4.1.1.6) from Homo sapiens (see paper)
    24% identity, 81% coverage of query (52.8 bits)

CAD_ASPTN / Q0C8L3 Cis-aconitate decarboxylase; CAD; aCAD; Aconitate decarboxylase; Cis-aconitic acid decarboxylase; EC 4.1.1.6 from Aspergillus terreus (strain NIH 2624 / FGSC A1156) (see 2 papers)
    21% identity, 90% coverage of query (49.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory