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Searching for up to 100 curated homologs for WP_104485437.1 NCBI__GCF_002936955.1:WP_104485437.1 (232 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

5hfkA / P77526 Crystal structure of a glutathione s-transferase protein from escherichia coli och 157:h7 str. Sakai (ecs3186, target efi-507414) with bound glutathione
    44% identity, 84% coverage of query (169 bits)

YfcG / b2302 disulfide reductase from Escherichia coli K-12 substr. MG1655 (see 3 papers)
yfcG / P77526 disulfide bond oxidoreductase YfcG from Escherichia coli (strain K12) (see 4 papers)
YFCG_ECOLI / P77526 Disulfide-bond oxidoreductase YfcG; GSH-dependent disulfide-bond oxidoreductase YfcG; GST N1-1; GST-like protein YfcG; Organic hydroperoxidase; EC 1.8.4.-; EC 1.11.1.- from Escherichia coli (strain K12) (see 2 papers)
    44% identity, 84% coverage of query (166 bits)

3gx0A Crystal structure of gsh-dependent disulfide bond oxidoreductase
    44% identity, 84% coverage of query (165 bits)

4l8eA / D3VKV1 Crystal structure of a glutathione transferase family member from xenorhabdus nematophila, target efi-507418, with two gsh per subunit
    43% identity, 85% coverage of query (163 bits)

gstA theta class glutathione S-transferase; EC 2.5.1.18 from Emericella nidulans (see paper)
    41% identity, 85% coverage of query (156 bits)

4ecjA Crystal structure of glutathione s-transferase prk13972 (target efi- 501853) from pseudomonas aeruginosa pacs2 complexed with glutathione
    43% identity, 84% coverage of query (150 bits)

6tahB 6tahB
    43% identity, 84% coverage of query (148 bits)

isoJ / CAB55824.1 glutathione S-transferase from Rhodococcus sp. AD45 (see paper)
    43% identity, 83% coverage of query (145 bits)

CH_124240 putative glutathione S-transferase [Botryotinia fuckeliana] from Magnaporthe grisea 70-15 (see paper)
    34% identity, 85% coverage of query (138 bits)

3c8eA / Q46845 Crystal structure analysis of yghu from e. Coli (see paper)
    38% identity, 83% coverage of query (136 bits)

YghU / b2989 disulfide reductase / organic hydroperoxide reductase from Escherichia coli K-12 substr. MG1655 (see 2 papers)
yghU / Q46845 disulfide reductase / organic hydroperoxide reductase from Escherichia coli (strain K12) (see 3 papers)
YGHU_ECOLI / Q46845 Disulfide-bond oxidoreductase YghU; GSH-dependent disulfide-bond oxidoreductase YghU; GST N2-2; Organic hydroperoxidase; EC 1.8.4.-; EC 1.11.1.- from Escherichia coli (strain K12) (see paper)
    38% identity, 83% coverage of query (136 bits)

4zb6D / A0A0R4I980 Crystal structure of glutathione transferase ure2p4 from phanerochaete chrysosporium in complex with oxidized glutathione. (see paper)
    39% identity, 81% coverage of query (134 bits)

4f0bA / I7A570 Crystal structure of the glutathione transferase ure2p1 from phanerochaete chrysosporium. (see paper)
    41% identity, 80% coverage of query (132 bits)

4mf6A / B1FXZ2 Crystal structure of glutathione transferase bgramdraft_1843 from burkholderia graminis, target efi-507289, with two glutathione molecules bound per one protein subunit
    41% identity, 83% coverage of query (129 bits)

4zb8A / A0A0R4I981 Crystal structure of the glutathione transferase ure2p6 from phanerochaete chrysosporium in complex with oxidized glutathione. (see paper)
    35% identity, 84% coverage of query (126 bits)

4nhzH Crystal structure of glutathione transferase bbta-3750 from bradyrhizobium sp., Target efi-507290, with one glutathione bound
    37% identity, 86% coverage of query (126 bits)

4zbdA Crystal structure of the glutathione transferase ure2p6 from phanerochaete chrysosporium in complex with glutathione reduced by x- ray irradiation at 100k
    35% identity, 84% coverage of query (126 bits)

4ikhA / Q4KED9 Crystal structure of a glutathione transferase family member from pseudomonas fluorescens pf-5, target efi-900003, with two glutathione bound
    36% identity, 85% coverage of query (124 bits)

4puaA Crystal structure of glutathione transferase yghu from streptococcus pneumoniae atcc 700669, complexed with glutathione, target efi-507284
    36% identity, 83% coverage of query (124 bits)

4f0cA / I7B368 Crystal structure of the glutathione transferase ure2p5 from phanerochaete chrysosporium (see paper)
    37% identity, 81% coverage of query (122 bits)

4zbaA / A0A0R4I985 Crystal structure of the glutathione transferase ure2p8 from phanerochaete chrysosporium with oxidized glutathione. (see paper)
    35% identity, 84% coverage of query (120 bits)

4zbbA Crystal structure of the glutathione transferase ure2p8 from phanerochaete chrysosporium complexed with glutathionyl-s- dinitrobenzene.
    35% identity, 84% coverage of query (120 bits)

4ivfF / A5E437 Crystal structure of glutathione transferase homolog from lodderomyces elongisporus, target efi-501753, with two gsh per subunit
    36% identity, 85% coverage of query (119 bits)

1k0cA Ure2p in complex with s-p-nitrobenzylglutathione
    32% identity, 81% coverage of query (118 bits)

1jzrA / P23202 Ure2p in complex with glutathione (see paper)
    32% identity, 81% coverage of query (117 bits)

1k0aA Ure2p in complex with s-hexylglutathione
    32% identity, 81% coverage of query (117 bits)

5uunA / Q2G542 Crystal structure of saro_2595 from novosphingobium aromaticivorans (see paper)
    35% identity, 91% coverage of query (115 bits)

1k0cC Ure2p in complex with s-p-nitrobenzylglutathione
    31% identity, 81% coverage of query (115 bits)

GEDE_ASPTN / Q0CCY0 Glutathione S-transferase-like protein gedE; Geodin synthesis protein E; EC 2.5.1.- from Aspergillus terreus (strain NIH 2624 / FGSC A1156) (see 7 papers)
    35% identity, 84% coverage of query (112 bits)

GST2_SCHPO / O59827 Glutathione S-transferase 2; GST-II; EC 2.5.1.18 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
gst2 / GI|3136036 glutathione S-transferase Gst2; EC 2.5.1.18 from Schizosaccharomyces pombe (see 3 papers)
    35% identity, 80% coverage of query (111 bits)

4mzwA / A3CNR0 Crystal structure of nu-class glutathione transferase yghu from streptococcus sanguinis sk36, complex with glutathione disulfide, target efi-507286
    35% identity, 81% coverage of query (110 bits)

5o00A Ure2p5 from phanerochaete chrysosporium cocrystallized with 1-(s- glutathionyl)-2,4-dinitrobenzene.
    36% identity, 81% coverage of query (110 bits)

Build an alignment

Build an alignment for WP_104485437.1 and 32 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

URE2_YEAST / P23202 Transcriptional regulator URE2; Disulfide reductase; Glutathione peroxidase; EC 1.8.4.-; EC 1.11.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 11 papers)
    29% identity, 81% coverage of query (109 bits)

1jzrC / P23202 Ure2p in complex with glutathione (see paper)
    29% identity, 81% coverage of query (109 bits)

URE2 protein URE2 from Candida albicans (see paper)
    29% identity, 83% coverage of query (108 bits)

gst1 / GB|AAF21054.1 glutathione S-transferase Gst1; EC 2.5.1.18 from Schizosaccharomyces pombe (see 2 papers)
    35% identity, 79% coverage of query (108 bits)

TPCF_ASPFU / Q4WQZ2 Glutathione S-transferase-like protein tpcF; Trypacidin synthesis protein E; EC 2.5.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
    33% identity, 84% coverage of query (100 bits)

3m3mA / Q4K8I0 Crystal structure of glutathione s-transferase from pseudomonas fluorescens [pf-5]
    32% identity, 79% coverage of query (95.1 bits)

Q8DMB4 glutathione transferase (EC 2.5.1.18) from Thermosynechococcus vestitus (see paper)
    29% identity, 84% coverage of query (91.3 bits)

8ai8A / Q55139 Crystal structure of glutathione transferase chi 1 from synechocystis sp. Pcc 6803 in complex with glutathione (see paper)
    32% identity, 83% coverage of query (86.3 bits)

7pkaA Synechocystis sp. Pcc6803 glutathione transferase chi 1, gsoh bound
    32% identity, 83% coverage of query (86.3 bits)

OPS6_BEAB2 / J4UHQ8 Glutathione S-transferase-like protein OpS6; Oosporein biosynthesis protein 6; EC 2.5.1.- from Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus) (Tritirachium shiotae) (see paper)
    32% identity, 84% coverage of query (84.3 bits)

GSTD3_DROME / Q9VG97 Inactive glutathione S-transferase D3 from Drosophila melanogaster (Fruit fly) (see paper)
    31% identity, 71% coverage of query (84.3 bits)

6ezyB / O80852 Arabidopsis thaliana gstf9, gsh and gsoh bound (see paper)
    28% identity, 83% coverage of query (82.0 bits)

GSTF9_ARATH / O80852 Glutathione S-transferase F9; AtGSTF9; AtGSTF7; GST class-phi member 9; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    28% identity, 83% coverage of query (82.0 bits)

6f01B Arabidopsis thaliana gstf9, gso3 and gsoh bound
    28% identity, 83% coverage of query (82.0 bits)

7ncuA Glutathione-s-transferase glig mutant k127g in complex with oxidized glutathione
    30% identity, 80% coverage of query (82.0 bits)

4nhwD Crystal structure of glutathione transferase smc00097 from sinorhizobium meliloti, target efi-507275, with one glutathione bound per one protein subunit
    33% identity, 74% coverage of query (81.6 bits)

gliG / A4GYZ0 glutathione S-transferase (EC 2.5.1.18) from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (see 3 papers)
GLIG_ASPFU / A4GYZ0 Glutathione S-transferase gliG; Gliotoxin biosynthesis protein G; EC 2.5.1.18 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 11 papers)
    30% identity, 80% coverage of query (80.5 bits)

GSTF8 / Q96266 glutathione S-transferase F8 monomer (EC 2.5.1.18) from Arabidopsis thaliana (see 6 papers)
GSTF8_ARATH / Q96266 Glutathione S-transferase F8, chloroplastic; AtGSTF8; AtGSTF5; GST class-phi member 8; Glutathione S-transferase 6; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    27% identity, 81% coverage of query (79.7 bits)

1f2eA / O33705 Structure of sphingomonad, glutathione s-transferase complexed with glutathione
GST / AAC46031.1 glutathione S-transferase from Sphingomonas paucimobilis (see paper)
    33% identity, 84% coverage of query (79.3 bits)

7nc5A / B0Y813 Glutathione-s-transferase glig in complex with reduced glutathione (see paper)
    29% identity, 80% coverage of query (79.0 bits)

7nc6A Glutathione-s-transferase glig in complex with cyclo[l-phe-l-ser]-bis- glutathione-adduct
    29% identity, 80% coverage of query (79.0 bits)

A0T2X7 glutathione transferase (EC 2.5.1.18) from Vitis vinifera (see paper)
    28% identity, 79% coverage of query (77.8 bits)

gst3b / CAB38119.1 Glutathione transferase III(b) from Zea mays (see paper)
    27% identity, 79% coverage of query (75.5 bits)

6m1tA / O30347 Bacterial beta class sphingomonas chungbukensis glutathione s- transferase
    32% identity, 84% coverage of query (75.5 bits)

Q2G4B4 glutathione transferase (subunit 2/2) (EC 2.5.1.18) from Novosphingobium aromaticivorans (see paper)
    29% identity, 82% coverage of query (75.1 bits)

4ri6A / A9PHH6 Crystal structure of poplar glutathione transferase f1 (see paper)
    25% identity, 81% coverage of query (74.3 bits)

gst3a / CAB38118.1 Glutathione transferase III(a) from Zea mays (see paper)
    27% identity, 79% coverage of query (74.3 bits)

8ix7B / A2XC69 Functional significance of serine 13 in the active site of rice phi- class glutathione s-transferase f3.
    29% identity, 79% coverage of query (74.3 bits)

GSTF_HYOMU / P46423 Glutathione S-transferase; 25 kDa auxin-binding protein; GST class-phi; EC 2.5.1.18 from Hyoscyamus muticus (Egyptian henbane) (see paper)
    26% identity, 81% coverage of query (73.6 bits)

ligF / P30347 LigF β-etherase monomer from Sphingobium sp. (strain NBRC 103272 / SYK-6) (see 3 papers)
ligF / BAA02031.1 beta-etherase from Sphingomonas paucimobilis (see 2 papers)
    30% identity, 81% coverage of query (73.6 bits)

4xt0A / G2IN92 Crystal structure of beta-etherase ligf from sphingobium sp. Strain syk-6 (see paper)
    30% identity, 81% coverage of query (73.2 bits)

A6MN06 glutathione transferase (EC 2.5.1.18) from Alitta succinea (see paper)
    29% identity, 81% coverage of query (72.4 bits)

GSTD2_DROME / Q9VG98 Glutathione S-transferase D2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
Q9VG98 glutathione transferase (EC 2.5.1.18) from Drosophila melanogaster (see paper)
    29% identity, 71% coverage of query (72.0 bits)

3lszA / Q3IZT6 Crystal structure of glutathione s-transferase from rhodobacter sphaeroides
    28% identity, 81% coverage of query (71.2 bits)

8agqA / B9MWW0 Crystal structure of anthocyanin-related gstf8 from populus trichocarpa in complex with (-)-catechin and glutathione (see paper)
    26% identity, 79% coverage of query (71.2 bits)

GST3_SCHPO / Q9P6M1 Glutathione S-transferase 3; GST-III; EC 2.5.1.18 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
    28% identity, 81% coverage of query (70.5 bits)

GSTT1_MOUSE / Q64471 Glutathione S-transferase theta-1; GST class-theta-1; EC 2.5.1.18 from Mus musculus (Mouse) (see paper)
    28% identity, 88% coverage of query (67.8 bits)

3qawA / B9VX79 Crystal structure of a glutathione-s-transferase from antarctic clam laternula elliptica in a complex with glutathione (see paper)
    26% identity, 81% coverage of query (67.4 bits)

A1ZB72 glutathione transferase (EC 2.5.1.18) from Drosophila melanogaster (see paper)
4pngB / A1ZB72 Glutathione s-transferase from drosophila melanogaster - isozyme e7 (see paper)
    27% identity, 86% coverage of query (67.4 bits)

1byeA / P12653 Glutathione s-transferase i from mais in complex with atrazine glutathione conjugate (see paper)
    27% identity, 82% coverage of query (66.6 bits)

5f06A / U5GTL0 Crystal structure of glutathione transferase f7 from populus trichocarpa (see paper)
    27% identity, 80% coverage of query (66.6 bits)

1axdA Structure of glutathione s-transferase-i bound with the ligand lactoylglutathione
    27% identity, 80% coverage of query (66.2 bits)

GSTD1_DROME / P20432 Glutathione S-transferase D1; DDT-dehydrochlorinase; EC 2.5.1.18; EC 4.5.1.1 from Drosophila melanogaster (Fruit fly) (see 2 papers)
    25% identity, 80% coverage of query (66.2 bits)

GTT2 / Q12390 glutathione transferase 2 monomer (EC 2.5.1.18) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 13 papers)
GST2_YEAST / Q12390 Glutathione S-transferase 2; GST-II; EC 2.5.1.18 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    29% identity, 86% coverage of query (65.5 bits)

4kh7B / Q8Z859 Crystal structure of a glutathione transferase family member from salmonella enterica ty2, target efi-507262, with bound glutathione
    27% identity, 80% coverage of query (65.1 bits)

3ibhA Crystal structure of saccharomyces cerevisiae gtt2 in complex with glutathione
    29% identity, 84% coverage of query (64.7 bits)

3ergA / Q12390 Crystal structure of gtt2 from saccharomyces cerevisiae in complex with glutathione sulfnate (see paper)
    29% identity, 84% coverage of query (64.7 bits)

4pxoA / C5ATQ9 Crystal structure of maleylacetoacetate isomerase from methylobacteriu extorquens am1 with bound malonate and gsh (target efi-507068)
    31% identity, 84% coverage of query (64.3 bits)

3makA / P20432 Crystal structure of glutathione transferase dmgstd1 from drosophila melanogaster, in complex with glutathione (see paper)
    25% identity, 80% coverage of query (63.9 bits)

7db0A Crystal structure of drosophila melanogaster noppera-bo, glutathione s-transferase epsilon 14 (dmgste14), in dimedone-bound form
    25% identity, 82% coverage of query (62.4 bits)

7db3A Crystal structure of drosophila melanogaster noppera-bo, glutathione s-transferase epsilon 14 (dmgste14), in tdp011-bound form
    25% identity, 82% coverage of query (62.4 bits)

7daxA Crystal structure of drosophila melanogaster noppera-bo, glutathione s-transferase epsilon 14 (dmgste14), in tdp013-bound form
    25% identity, 82% coverage of query (62.4 bits)

7db4A Crystal structure of drosophila melanogaster noppera-bo, glutathione s-transferase epsilon 14 (dmgste14), in tdp012- and glutathione-bound form
    25% identity, 82% coverage of query (62.4 bits)

6keoAA Glutathione S-transferase E14
    25% identity, 82% coverage of query (62.4 bits)

7dazA Crystal structure of drosophila melanogaster noppera-bo, glutathione s-transferase epsilon 14 (dmgste14), in tdp015- and gsh-bound form
    25% identity, 82% coverage of query (62.4 bits)

1jlvA / Q7KIF2 Anopheles dirus species b glutathione s-transferases 1-3 (see paper)
    28% identity, 71% coverage of query (62.0 bits)

4gf0A Crystal structure of glutahtione transferase homolog from sulfitobacter, target efi-501084, with bound glutathione
    29% identity, 76% coverage of query (62.0 bits)

6t2tA / Q7JYX0 Crystal structure of drosophila melanogaster glutathione s-transferase epsilon 14 in complex with glutathione and 2-methyl-2,4-pentanediol (see paper)
    26% identity, 82% coverage of query (61.6 bits)

6zb6C / M5BPX4 Crystal structure of lolium rigidum gstf in complex with s-(p- nitrobenzyl) glutathione (see paper)
    26% identity, 80% coverage of query (61.2 bits)

6zb6D Crystal structure of lolium rigidum gstf in complex with s-(p- nitrobenzyl) glutathione
    26% identity, 80% coverage of query (60.8 bits)

5ft3B / Q5PY77 Aedes aegypti gste2
    25% identity, 93% coverage of query (60.8 bits)

GST1D_ANOGA / Q93113 Glutathione S-transferase 1, isoform D; AgGst1-alpha; Aggst1-1; Aggst1-6; Aggst2-1; DDT-dehydrochlorinase; GST class-theta; EC 2.5.1.18; EC 4.5.1.1 from Anopheles gambiae (African malaria mosquito) (see 3 papers)
1pn9A / Q93113 Crystal structure of an insect delta-class glutathione s-transferase from a ddt-resistant strain of the malaria vector anopheles gambiae (see paper)
GSTd1-6 / CAB03593.1 GSTD1-6 protein, partial from Anopheles gambiae (see 2 papers)
    30% identity, 71% coverage of query (60.5 bits)

1fw1A / O43708 Glutathione transferase zeta/maleylacetoacetate isomerase (see paper)
    28% identity, 81% coverage of query (59.7 bits)

GSTZ1 / O43708 maleylacetoacetate isomerase/glutathione transferase ζ monomer (EC 2.5.1.18; EC 5.2.1.2) from Homo sapiens (see 11 papers)
MAAI_HUMAN / O43708 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Homo sapiens (Human) (see 3 papers)
O43708 glutathione transferase (EC 2.5.1.18); maleylacetoacetate isomerase (EC 5.2.1.2) from Homo sapiens (see 8 papers)
    28% identity, 81% coverage of query (59.3 bits)

6nv6B Crystal structure of the theta class glutathione s-transferase from the citrus canker pathogen xanthomonas axonopodis pv. Citri with glutathione bound (see paper)
    27% identity, 84% coverage of query (58.9 bits)

4pnfB / Q7JZM3 Glutathione s-transferase from drosophila melanogaster - isozyme e6 (see paper)
    29% identity, 80% coverage of query (58.9 bits)

3vwxC / Q9U795 Structural analysis of an epsilon-class glutathione s-transferase from housefly, musca domestica (see paper)
    27% identity, 79% coverage of query (58.5 bits)

4hz2B / A7ILT8 Crystal structure of glutathione s-transferase xaut_3756 (target efi- 507152) from xanthobacter autotrophicus py2
    26% identity, 83% coverage of query (58.5 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory